DrugBank ID: db00755
Synonymous :(all-e)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid | 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ecl) | acide retinoique | all trans retinoic acid | all trans-retinoic acid | all-(e)-retinoic acid | all-trans-beta-retinoic acid | all-trans-retinoic acid | all-trans-tretinoin | all-trans-vitamin a acid | all-trans-vitamin a1 acid | atra | beta-retinoic acid | retinoic acid | retionic acid | trans-retinoic acid | tretin m | tretinoin | tretinoina | trétinoïne | tretinoinum | vitamin a acid
Drug Sentece Context
Table 1. Analysis of context sentence of tretinoin gene in 4 abstracts.
|33126128||We used a combination of virtual database screening, molecular docking, all-atom molecular dynamics simulation and MM-PBSA analysis to test four FDA approved drugs - Tretinoin, Mefenamic Acid, Ondansetron and Artemether - as potential inhibitors of ion channels formed by SARS-CoV-2 E protein. […] Interaction and binding energy analysis showed that electrostatic interactions and polar solvation energy were the major driving forces for binding of the drugs, with Tretinoin being the most promising inhibitor. […] Tretinoin bound within the lumen of the channel formed by E protein, which is lined by hydrophobic residues like Phe, Val and Ala, indicating its potential for blocking the channel and inhibiting the viroporin functionality of E. […] In control simulations, tretinoin demonstrated a lower binding energy with a known target as compared to SARS-CoV-2 E protein. […] This work thus highlights the possibility of exploring Tretinoin as a potential SARS-CoV-2 E protein ion channel blocker and virus assembly inhibitor, which could be an important therapeutic strategy in the treatment for coronaviruses.|
|33458805||We present a male patient who had two melanoma-in-situs (MISs) that were treated during the COVID-19 pandemic with a combination of topical imiquimod 5% cream, 5-fluorouracil 2% solution, and tretinoin 0.1% cream.|