TIPIRACIL
DrugBank ID: db09343
DrugCentral: tipiracil
Synonymous :5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1h,3h)-pyrimidinedione | 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1h-pyrimidine-2,4-dione | tipiracil | tipiracilo
Drug Sentece Context
Table 1. Analysis of context sentence of tipiracil gene in 3 abstracts.
| pmid | sentence |
|---|---|
| 32962867 | The drugs such as arbutin, terbutaline, barnidipine, tipiracil and aprepitant identified as potential hits. […] Among the drugs, tipiracil and aprepitant interacted with the Mpro consistently, and they turned out to be most promising. […] This study shows the possible exploration for drug repurposing using computer-aided docking tools and the potential roles of tipiracil and aprepitant, which can be explored further in the treatment of COVID-19. |
| 33564093 | This acquired knowledge was instrumental in identifying Tipiracil, an FDA approved drug that is used in the treatment of colorectal cancer, as a potential anti-COVID-19 drug. […] Using crystallography, biochemical, and whole-cell assays, we demonstrate that Tipiracil inhibits SARS-CoV-2 Nsp15 by interacting with the uridine binding pocket in the enzyme’s active site. |