TEMOPORFIN
DrugBank ID: db11630
DrugCentral: temoporfin
Synonymous :2,3-dihydro-5,10,15,20-tetra(m-hydroxyphenyl)porphyrin | m-thpc | meso-tetrahydroxyphenylchlorin | temoporfin
Drug Sentece Context
Table 1. Analysis of context sentence of temoporfin gene in 1 abstracts.
| pmid | sentence |
|---|---|
| 33244378 | The docking of COVID-19 major protease (6LU7) with 17 selected drugs resulted in four FDA approved viral antiprotease drugs (Temoporfin, Simeprevir, Cobicistat, Ritonavir) showing the best docking scores. […] Among these 4 compounds, Temoporfin exhibited the best DOS (-202.88) and the best screened ligand with COVID-19 Mpro, followed by Simeprevir (-201.66), Cobicistat (-187.75), and Ritonavir (-186.66). […] As the best screened ligand, Temoporfin could target the Mpro with 20 different conformations, while Simeprevir, Cobicistat, and Ritonavir make 14, 10, and 10 potential conformations at the binding site, respectively. […] The findings showed that the four selected FDA approved drugs can be potent inhibitors against COVID-19; among them, Temoporfin may be more potent for the treatment of the disease. |