TELMISARTAN
DrugBank ID: db00966
DrugCentral: telmisartan
Synonymous :4’-((1,4’-dimethyl-2’-propyl(2,6’-bi-1h-benzimidazol)-1’-yl)methyl)-(1,1’-biphenyl)-2-carboxylic acid | 4’-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid | 4’-[(1,4’-dimethyl-2’propyl[2,6’-bi-1h-benzimidazol]-1’-yl)methyl]-[1,1’-biphenyl]-2-carboxylic acid | 4’-[(1,7’-dimethyl-2’-propyl-1h,3’h-2,5’-bibenzimidazol-3’-yl)methyl]biphenyl-2-carboxylic acid | telmisartan
Drug Sentece Context
Table 1. Analysis of context sentence of telmisartan gene in 4 abstracts.
| pmid | sentence |
|---|---|
| 32356926 | Recently, Gurwitz proposed the tentative use of agents such as losartan and telmisartan as alternative options for treating COVID-19 patients prior to development of ARDS. […] In this commentary article, the authors make the case for the election of telmisartan as such alternative on the basis of its pharmacokinetic and pharmacodynamic properties and present an open-label randomized phase II clinical trial for the evaluation of telmisartan in COVID-19 patients (NCT04355936). |
| 33050924 | Participants are recruited either at home, nursing homes, general practices, primary care centres or hospital outpatient consultations. , 2020) are: (1) Hydroxychloroquine 200 mg, 2 tablets BID on day 0, 2 tablets QD from day 1 to 9; (2) Imatinib 400 mg, 1 tablet QD from day 0 to 9; (3) Favipiravir 200 mg, 12 tablets BID on day 0, 6 tablets BID from day 1 to 9; (4) Telmisartan 20 mg, 1 tablet QD from day 0 to 9. […] In protocol version 1.2 (April 8th, 2020): People in the control arm will receive a combination of vitamins and trace elements; people in the experimental arms will receive hydroxychloroquine, or favipiravir, or imatinib, or telmisartan. […] Participants already treated with an ARB or ACEI are randomized to receive the comparator or one of the experimental drugs except telmisartan (i.e.: hydroxychloroquine, imatinib, or favipiravir). |
| 33310740 | In healthy young mice, neither the ACE inhibitor ramipril nor the AT1 receptor blocker telmisartan affected lung or kidney ACE2 or TMPRSS2, except for a small increase in kidney ACE2 protein with ramipril. […] ACE2 was similarly upregulated in the kidneys of mice with comorbid diabetes compared to aged controls, whereas TMPRSS2 (primarily distal nephron) was highest in telmisartan-treated animals. |
| 33447763 | Telmisartan, a second class RAAS inhibitors, did not affect ACE2 levels. |