TAMOXIFEN

DrugBank ID: db00675
DrugCentral: tamoxifen
Synonymous :(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine | (z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylamine | 1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene | 1-para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene | tamoxifen | tamoxifène | tamoxifene | tamoxifeno | tamoxifenum | trans-tamoxifen


Drug Sentece Context


Table 1. Analysis of context sentence of tamoxifen gene in 1 abstracts.

pmid sentence
32493494
  1. Previous infection with SARS CoV2 (positive coronavirus PCR or positive serology with SARS Cov2 negative PCR and absence of symptoms); 2) Current treatment with hydroxychloroquine or chloroquine; 3) Hypersensitivity, allergy or any contraindication for taking hydroxychloroquine, in the technical sheet; 4) Previous or current treatment with tamoxifen or raloxifene; 5) Previous eye disease, especially maculopathy; 6) Known heart failure (Grade III to IV of the New York Heart Association classification) or prolonged QTc; 7) Any type of cancer (except basal cell) in the last 5 years; 6) Refusal to give informed consent; 8) Evidence of any other unstable or clinically significant untreated immune, endocrine, hematological, gastrointestinal, neurological, neoplastic or psychiatric illness; 9) Antibodies positive for the human immunodeficiency virus; 10) Significant kidney or liver disease; 11) Pregnancy or lactation.
32663742 Tamoxifen and other anti-estrogen drugs are used in breast cancer patients who have a positive estrogen receptor (ER). […] While angiotensin II plays a key role in breast cancer etiology and causes tamoxifen resistance, angiotensin 1-7 has been reported to may reduce the spread and invasion of breast cancer. […] Tamoxifen treatment causes down-regulation, mutation, or loss in estrogen receptors. […] In the long-term use of tamoxifen, its effects on estrogen receptors can be permanent. […] Tamoxifen is a P-glycoprotein inhibitor, independent of its effect on estrogen receptors. […] We think tamoxifen may increase the COVID-19 risk due to its antiestrogen and P-glycoprotein inhibitory effects.
33522308 The emerging picture is that some patient groups may be particularly susceptible to SARS-CoV-2 infection and may benefit from antiandrogen- or tamoxifen-based therapies.