TACROLIMUS


DrugBank ID: db00864
DrugCentral: tacrolimus
Synonymous :anhydrous tacrolimus | tacrolimus | tacrolimus anhydrous | tacrolimus, anhydrous



Drug Sentece Context


Table 1. Analysis of context sentence of tacrolimus gene in 26 abstracts.

pmid sentence
32256705 Using Ovid MEDLINE, we reviewed current evidence for immune-suppressing or -stimulating drugs: cytotoxic chemotherapy, low-dose steroids, tumour necrosis factorα (TNFα) blockers, interlukin-6 (IL-6) blockade, Janus kinase (JAK) inhibitors, IL-1 blockade, mycophenolate, tacrolimus, anti-CD20 and CTLA4-Ig. 89 studies were included. […] Low-dose prednisolone and tacrolimus may have beneficial impacts on COVID-19.
32279418 Immunosuppressant levels were closely monitored, and we observed very high tacrolimus trough levels despite initial dose reduction.
32337859 However, the unexpected fluctuations in tacrolimus trough levels needed to be managed because of drug-to-drug interaction.
32351040 Nine patients were on tacrolimus and a mycophenolic antimetabolite, and 70% were on prednisone.
32362392 Of these, 21.3% of recipients had pre-existing lymphopenia, and 87.2% of recipients had a therapeutic concentration of tacrolimus (5-12 ng/ml).
32400931 His maintenance immunosuppressive regime was consisted of tacrolimus (TAC, 1mg twice a day, orally), mycophenolate mofetil (MMF, 0.5g twice a day, orally) and prednisone (Pred, 5mg daily, orally) triple combination.
32471001 Tacrolimus was withdrawn in 70%.
32513289 Current use of CYP 3A4 or P-gp inhibitor drugs such as quinidine, amiodarone, diltiazem, spironolactone, verapamil, clarithromycin, erythromycin, itraconazole, ketoconazole, cyclosporine, tacrolimus, indinavir, ritonavir or cobicistat.
32529737 Two therapeutic strategies were compared: Group 1) minimization of calcineurin inhibitors (N=6); Group 2) cyclosporine-based therapy (N=23), with 15 patients switched from tacrolimus.
32541471 He was treated with modified immunosuppressants (unchanged dose of tacrolimus and oral corticosteroids while discontinuing mycophenolate mofetil (MMF)), antibiotics, interferon α-2b inhalation and traditional Chinese medicine.
32583620 All five patients were on immunosuppressive therapy with mycophenolate mofetil (MMF) and tacrolimus and three that were transplanted within the prior two months were additionally on prednisone.
32585765 A 58-year-old 2 years post kidney transplant recipient, with maintenance immunosuppression of tacrolimus, mycophenolate mofetil (MMF) and prednisolone, presented with acute diarrhea which followed by fever on day 12. […] Patient has been transferred to our hospital on day 2 of admission which tacrolimus together with MMF were discontinued. […] Drug interaction between tacrolimus and anti-viral treatment lead to severely high level of tacrolimus which caused reversible acute kidney injury (AKI) after supportive treatment.
32627319 In the overall population, dyspnea was associated with the risk of ARDS and age older than 60 years and dyspnea were associated with the risk of death with only a trend toward an increased risk of death for patients on tacrolimus.
32640747 Finally, we made a critical analysis of a number of substances, not yet utilized, but potentially useful in SARS-CoV-2 patients, such as IFN lambda, TNF blockers, ulinastatin, siponimod, tacrolimus, mesenchymal stem cells, inhibitors of mononuclear macrophage recruitment, IL-1 family antagonists, JAK-2 or STAT-3 inhibitors.
32646657 It is also important to pay attention to possible drug interactions, especially in the case of tacrolimus, with some of the treatments with antiviral effect given in the context of COVID 19 (lopinavir/ritonavir, azithromycin).
32678882 In the hospitalized group, tacrolimus dosage was reduced in 46% of patients and mycophenolate mofetil (MMF) therapy was stopped in 61% of patients. […] None of the ambulatory patients had tacrolimus reduction or discontinuation of MMF.
32690572 The patient was admitted for 1 day; immunosuppressive therapy with tacrolimus and low-dose prednisolone was continued; and the patient recovered successfully without the use of antiviral agents or oxygen therapy.
32703929 Kidney transplant patients encountered COVID-19 were maintained on tacrolimus (Tac, 92%), mycophenolate mofetil (MMF, 78.8%), and prednisone (Pred, 77%) and were manage by holding MMF in 79.1% of patients and holding Tac in 34.4% of patients.
32835277 Despite continued corticosteroid and tacrolimus therapy, he remained aviremic.
32862472 Mycophenolate mofetil was discontinued in all cases upon admission, whereas baseline steroids were maintained and tacrolimus dose was reduced.
32892322 Three months posttransplant a recurrence of podocytopathy was successfully managed by plasma exchange, ivIG, and a conversion from tacrolimus to belatacept (initial proteinuria > 6 g/l decreased to 169 mg/l).
32979013 Patient received standard prednisone and tacrolimus-based immunosuppression without induction therapy following transplant.
33032841 Paradoxically, the patient with more risks of developing a severe disease, a 64-year-old woman, 2-years liver transplant recipient under treatment with tacrolimus, presented a similar outcome compared to the two other members of the family. […] The present clinical observation raises the question about the possible beneficial effect of tacrolimus in patients with COVID-19. […] Indeed, tacrolimus (FK-506) have an inhibitory effect on human coronaviruses by: 1) an antiviral effect by binding to the FK-506-binding proteins (FKBP) with a subsequent inhibition of their peptidyl-prolyl cis/trans isomerase (PPIase) activity, which seems to be important for the coronavirus life cycle; and 2) regulating the immune response by the inhibition of the activity of the nuclear factor of activated T-cells (NFAT) required for immunosuppression. […] The present observation states that liver recipients’ patients with COVID-19 may not have worse outcomes when compared with other patients that have COVID-19 risk factors and puts in evidence the two mechanisms related to tacrolimus.
33039144 Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection.
33041077 The large proportion of infected individuals were minorities (Hispanic 65.9%, black 14.6%), on prednisone, tacrolimus, and mycophenolate mofetil (95.1%, 87.8%, and 87.8%, respectively), and had excellent allograft function (median 1.25 mg/dL).
33043603 Initial CT values from upper respiratory tract samples were significantly higher in patients on tacrolimus, but were not associated with admission severity nor highest clinical acuity.
33048372 We compared three groups based on immunosuppression regimen 7-12 months posttransplant: 1) tacrolimus (Tac)+mycophenolic acid (MPA)+prednisone (Pred) (referent group, 77.7%); 2) Tac+MPA+Pred+HCQ (16.5%); or 3) other immunosuppression+HCQ (5.7%).