TACROLIMUS


DrugBank ID: db00864
DrugCentral: tacrolimus
Synonymous :anhydrous tacrolimus | tacrolimus | tacrolimus anhydrous | tacrolimus, anhydrous



Drug Sentece Context


Table 1. Analysis of context sentence of tacrolimus gene in 6 abstracts.

pmid sentence
32256705 Using Ovid MEDLINE, we reviewed current evidence for immune-suppressing or -stimulating drugs: cytotoxic chemotherapy, low-dose steroids, tumour necrosis factorα (TNFα) blockers, interlukin-6 (IL-6) blockade, Janus kinase (JAK) inhibitors, IL-1 blockade, mycophenolate, tacrolimus, anti-CD20 and CTLA4-Ig. 89 studies were included. […] Low-dose prednisolone and tacrolimus may have beneficial impacts on COVID-19.
32279418 Immunosuppressant levels were closely monitored, and we observed very high tacrolimus trough levels despite initial dose reduction.
32337859 However, the unexpected fluctuations in tacrolimus trough levels needed to be managed because of drug-to-drug interaction.
32351040 Nine patients were on tacrolimus and a mycophenolic antimetabolite, and 70% were on prednisone.
32362392 Of these, 21.3% of recipients had pre-existing lymphopenia, and 87.2% of recipients had a therapeutic concentration of tacrolimus (5-12 ng/ml).
32400931 His maintenance immunosuppressive regime was consisted of tacrolimus (TAC, 1mg twice a day, orally), mycophenolate mofetil (MMF, 0.5g twice a day, orally) and prednisone (Pred, 5mg daily, orally) triple combination.
32471001 Tacrolimus was withdrawn in 70%.
32513289 Current use of CYP 3A4 or P-gp inhibitor drugs such as quinidine, amiodarone, diltiazem, spironolactone, verapamil, clarithromycin, erythromycin, itraconazole, ketoconazole, cyclosporine, tacrolimus, indinavir, ritonavir or cobicistat.
32529737 Two therapeutic strategies were compared: Group 1) minimization of calcineurin inhibitors (N=6); Group 2) cyclosporine-based therapy (N=23), with 15 patients switched from tacrolimus.
32541471 He was treated with modified immunosuppressants (unchanged dose of tacrolimus and oral corticosteroids while discontinuing mycophenolate mofetil (MMF)), antibiotics, interferon α-2b inhalation and traditional Chinese medicine.
32583620 All five patients were on immunosuppressive therapy with mycophenolate mofetil (MMF) and tacrolimus and three that were transplanted within the prior two months were additionally on prednisone.
32585765 A 58-year-old 2 years post kidney transplant recipient, with maintenance immunosuppression of tacrolimus, mycophenolate mofetil (MMF) and prednisolone, presented with acute diarrhea which followed by fever on day 12. […] Patient has been transferred to our hospital on day 2 of admission which tacrolimus together with MMF were discontinued. […] Drug interaction between tacrolimus and anti-viral treatment lead to severely high level of tacrolimus which caused reversible acute kidney injury (AKI) after supportive treatment.