SULFASALAZINE

DrugBank ID: db00795
DrugCentral: sulfasalazine
Synonymous :2-hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid | 2-hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid | 4-(pyridyl-2-amidosulfonyl)-3’-carboxy-4’-hydroxyazobenzene | 5-((p-(2-pyridylsulfamoyl)phenyl)azo)salicylic acid | 5-(4-(2-pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid | 5-(p-(2-pyridylsulfamyl)phenylazo)salicylic acid | azopyrin | salazosulfapiridina | salazosulfapyridine | salazosulfapyridinum | salicylazosulfapyridine | sulfasalazin | sulfasalazina | sulfasalazine | sulfasalazinum


Drug Sentece Context


Table 1. Analysis of context sentence of sulfasalazine gene in 11 abstracts.

pmid sentence
32348046 In case of SARS-CoV-2 infection, immunosuppressive drugs should be temporarily stopped, except for glucocorticoids, hydroxychloroquine and sulfasalazine. […] Leur arrêt n’est recommandé qu’en cas d’infection avérée à SARS-CoV-2, à l’exception de la prednisone, de l’hydroxychloroquine et de la sulfasalazine qui peuvent être poursuivis.
32425234 Risk factors for severe COVID-19 among IBD patients included increasing age (adjusted odds ratio [aOR] 1.04, 95% CI 1.01-1.02), ≥2 comorbidities (aOR 2.9, 95% CI 1.1-7.8), systemic corticosteroids (aOR 6.9, 95% CI 2.3-20.5), and sulfasalazine or 5-aminosalicylate use (aOR 3.1, 95% CI 1.3-7.7).
32493514 Immunosuppressive therapy (e.g. mycophenolate, azathioprine, methotrexate, biologicals, prednisolone >10mg/d; exceptions are: prednisolone ≤ 10mg/d, sulfasalazine or hydroxychloroquine)9.
32744823 In the case of exposure, with the exception of hydroxyhcloroquine and sulfasalazine, immunosuppression should be held for 2 weeks.
32837197 Treatment with sulfasalazine, methotrexate, leflunomide, immunosuppressants and biological agents other than interluekin-6 receptor inhibitors and JAK inhibitors should be stopped or withheld.
32864627 In this multinational, retrospective study, new user cohort studies in patients with rheumatoid arthritis aged 18 years or older and initiating hydroxychloroquine were compared with those initiating sulfasalazine and followed up over 30 days, with 16 severe adverse events studied. […] The study included 956 374 users of hydroxychloroquine, 310 350 users of sulfasalazine, 323 122 users of hydroxychloroquine plus azithromycin, and 351 956 users of hydroxychloroquine plus amoxicillin. […] No excess risk of severe adverse events was identified when 30-day hydroxychloroquine and sulfasalazine use were compared.
32931985 Available data suggest no increased frequency or risk of respiratory viral events with NSAIDs, hydroxychloroquine, sulfasalazine, methotrexate, azathioprine, mycophenolate mofetil, cyclophosphamide, or apremilast.
33020333 Visiting private clinic and receiving hydroxychloroquine/chloroquine sulfate or sulfasalazine were related to perception that autoimmune conditions would make them more prone to COVID-19.
33082265 Any mesalamine/sulfasalazine compared with no mesalamine/sulfasalazine use was associated with an increased risk (aOR 1.70, 95% CI 1.26 to 2.29).
33504483 Rituximab (4.04, 2.32 to 7.03), sulfasalazine (3.60, 1.66 to 7.78), immunosuppressants (azathioprine, cyclophosphamide, ciclosporin, mycophenolate or tacrolimus: 2.22, 1.43 to 3.46) and not receiving any disease-modifying anti-rheumatic drug (DMARD) (2.11, 1.48 to 3.01) were associated with higher odds of death, compared with methotrexate monotherapy. […] Caution may be required with rituximab, sulfasalazine and some immunosuppressants.