SQUALENE
DrugBank ID: db11460
DrugCentral: squalene
Synonymous :(all-e)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene | (e,e,e,e)-squalene | spinacene | squalene | supraene
Drug Sentece Context
Table 1. Analysis of context sentence of squalene gene in 2 abstracts.
| pmid | sentence |
|---|---|
| 32548259 | The nanoparticles are made by conjugating squalene, a natural lipid, to adenosine, an endogenous immunomodulator, and then encapsulating α-tocopherol, as antioxidant. |
| 32864794 | To address this, alum is packed on the squalene/water interphase is packed, forming an alum-stabilized Pickering emulsion (PAPE). […] “Inheriting” from alum and squalene, PAPE demonstrates a good biosafety profile. |
| 33051497 | The triterpene oil squalene is an essential component of nanoemulsion vaccine adjuvants. […] Squalene has historically been harvested from shark liver oil, which is undesirable for a variety of reasons. […] In this study, we have demonstrated the use of a Synthetic Biology (yeast) production platform to generate squalene and novel triterpene oils, all of which are equally as efficacious as vaccine adjuvants based on physiochemical properties and immunomodulating activities in a mouse model. […] Injection site morphology and serum cytokine levels did not suggest any reactogenic effects of the yeast-derived squalene or novel triterpenes, suggesting their safety in adjuvant formulations. […] These results support the advantages of yeast produced triterpene oils to include completely controlled growth conditions, just-in-time and scalable production, and the capacity to produce novel triterpenes beyond squalene. |
| 33436573 | Mice are vaccinated with soluble RBD or CLP-displayed RBD, formulated in Squalene-Water-Emulsion. |