ROFLUMILAST


DrugBank ID: db01656
DrugCentral: roflumilast
Synonymous :roflumilast | roflumilastum



Drug Sentece Context


Table 1. Analysis of context sentence of roflumilast gene in 2 abstracts.

pmid sentence
33011243 One of the effective therapeutic approaches investigated to reduce neutrophil-associated inflammatory lung diseases with few adverse effects was roflumilast. […] Being a highly selective phosphodiesterase-4 inhibitors (PDE4i), roflumilast acts by enhancing the level of cyclic adenosine monophosphate (cAMP), that probably potentiates its anti-inflammatory action via increasing neprilysin (NEP) activity. […] Because activating NEP was previously reported to mitigate several airway inflammatory ailments; this review thoroughly discusses the proposed NEP-based therapeutic properties of roflumilast, which may be of great importance in curing COVID-19.