DrugBank ID: db05173
DrugCentral: ptc299
Synonymous : None

Drug Sentece Context

Table 1. Analysis of context sentence of ptc299 gene in 3 abstracts.

pmid sentence
33249060 PTC299 also blocked replication of other RNA viruses, including Ebola virus. […] Consistent with known DHODH requirements for immunomodulatory cytokine production, PTC299 inhibited the production of interleukin (IL)-6, IL-17A (also called IL-17), IL-17 F, and vascular endothelial growth factor (VEGF) in tissue culture models. […] The combination of anti-SARS-CoV-2 activity, cytokine inhibitory activity, and previously established favorable pharmacokinetic and human safety profiles render PTC299 a promising therapeutic for COVID-19.