PROPOFOL

DrugBank ID: db00818
DrugCentral: propofol
Synonymous :2,6-bis(1-methylethyl)phenol | 2,6-diisopropylphenol | propofol | propofolum


Drug Sentece Context


Table 1. Analysis of context sentence of propofol gene in 15 abstracts.

pmid sentence
32133829 Midazolam, Propofol and Morphine or fentanyl were used for sedation and analgesia, avoiding patients cough and agitated during the procedure.
32343413 Propofol was briefly used.
32473756 Fentanyl, propofol, and rocuronium were also given.
32505994 Usage of total intravenous anesthesia (propofol and remifentanil) over volatile gas anesthesia (e.g., sevoflurane) may increase the number of patients able to safely receive care by reducing potential spread of the virus through reduction in coughing and significantly decreasing the time spent in the recovery room.
32550090 All four patients were on propofol at some point during bradycardia with patients 1, 2, and 3 also receiving dexmedetomidine.
32712675 The net quantity of drug charge units per day for midazolam, propofol, ketamine, cisatracurium, and fentanyl also increased during the study period. […] This analysis describes the increased use, beginning in mid-March 2020, of hydroxychloroquine, chloroquine, midazolam, propofol, ketamine, cisatracurium, and fentanyl in 47 hospitals in New York State.
33070121 Induced coma can be achieved with fast-acting anesthetics, a combination of propofol with midazolam is the most frequently used one.
33219896 Anesthesia with propofol was used, and ablations were performed with a contact force catheter.
33253920 We also provide a description of, and clinical rationale for, each of the EA- or EUA-approved drugs (e.g. remdesivir, convalescent plasma, propofol 2%, hydroxychloroquine, ruxolitinib, bamlanivimab, baricitinib, casirivimab plus imdevimab) during the pandemic and concluding reflections on the EA program and its potential future uses.
33354676 To characterize the incidence and characteristics of propofol-associated hypertriglyceridemia in coronavirus disease 2019 versus noncoronavirus disease 2019 acute respiratory distress syndrome. […] Patients with acute respiratory distress syndrome admitted from April 7, 2020, to May 15, 2020, requiring continuous propofol administration. […] Patients with coronavirus disease 2019 acute respiratory distress syndrome experienced a higher rate of propofol-associated hypertriglyceridemia than noncoronavirus disease 2019 acute respiratory distress syndrome patients, even after accounting for differences in propofol administration.
33428871 Infusion with sedatives while on mechanical ventilation was common: 1337 (64·0%) of 2088 patients were given benzodiazepines for a median of 7·0 days (4·0 to 12·0) and 1481 (70·9%) were given propofol for a median of 7·0 days (4·0 to 11·0).
33490957 To report the prevalence of, and evaluate risk factors for, the development of hypertriglyceridemia (defined as a serum triglyceride level of > 400 mg/dL) in patients with coronavirus disease 2019 who received propofol. […] All ICU patients who with coronavirus disease 19 who received propofol between March 1, 2020, and April 20, 2020. […] The major outcome of this analysis was to report the prevalence of, and risk factors for, the development of hypertriglyceridemia in patients with coronavirus disease 19 who received propofol. […] Minor outcomes included the development of acute pancreatitis and description of propofol metrics. […] There was no difference in the dose or duration of propofol in patients who developed hypertriglyceridemia compared with those who did not. […] In the patients who developed hypertriglyceridemia, 35 patients (58.5%) continued receiving propofol for a median duration of 105 hours. […] Hypertriglyceridemia was commonly observed in critically ill patients with coronavirus disease 2019 who received propofol. […] Neither the cumulative dose nor duration of propofol were identified as a risk factor for the development of hypertriglyceridemia. […] Due to the incidence of hypertriglyceridemia in this patient population, monitoring of serum triglyceride levels should be done frequently in patients who require more than 24 hours of propofol. […] Many patients who developed hypertriglyceridemia were able to continue propofol in our analysis after reducing the dose.