DrugBank ID: db00172
DrugCentral: proline
Synonymous :(-)-2-pyrrolidinecarboxylic acid | (−)-(s)-proline | (−)-2-pyrrolidinecarboxylic acid | (−)-proline | (2s)-pyrrolidine-2-carboxylic acid | (s)-2-carboxypyrrolidine | (s)-2-pyrrolidinecarboxylic acid | (s)-pyrrolidine-2-carboxylic acid | 2-pyrrolidinecarboxylic acid | l-(−)-proline | l-alpha-pyrrolidinecarboxylic acid | l-prolin | l-proline | l-pyrrolidine-2-carboxylic acid | l-α-pyrrolidinecarboxylic acid | p | prolina | proline | prolinum

Drug Sentece Context

Table 1. Analysis of context sentence of proline gene in 4 abstracts.

pmid sentence
32083328 Position 723 in the COVID-2019 has a serine instead a glycine residue, while at aminoacidic position 1010 a proline instead an isoleucine.
32336957 The results revealed that the identified ORF1ab polyprotein belongs to a part of nonstructural protein 1 (nsp1) with the high antigenicity residues in a glycine-proline or hydrophobic amino acid rich domain.
32488835 Through this paper, we provided the list of possible chemical ligands (Meglumine, Vidarabine, Adenosine, D-Sorbitol, D-Mannitol, Sodium_gluconate, Ganciclovir and Chlorobutanol) and peptide drugs (combination of isoleucine, lysine and proline) from the databases to guide the experimental scientists and validate the molecules which can combat the virus in a shorter time.
32503918 Furthermore, both electrostatic effects and enhanced hydrophobic packing due to removal of four out of five proline residues in a short 12-residue loop lead to conformation shift toward a more tilted binding groove in the complex in comparison with the SARS-CoV complex.
32703906 Testing combinations of beneficial substitutions resulted in the identification of HexaPro, a variant with six beneficial proline substitutions exhibiting higher expression than its parental construct (by a factor of 10) as well as the ability to withstand heat stress, storage at room temperature, and three freeze-thaw cycles.
32757352 Phosphoramidates of proline hydrolyzed fast, with a half-life time as short as 2.4 h for Pro-AMP in ethylimidazole-containing buffer at 37 °C; 45-fold faster than Ala-AMP and 120-fold faster than Phe-AMP.
33037310 Further, we describe a surprising finding that the two serines at the edges of the insert SPRRAR↓SV can be efficiently phosphorylated by proline-directed and basophilic protein kinases.