DrugBank ID: db00860
DrugCentral: prednisolone
Synonymous :(11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione | 1,4-pregnadiene-11β,17α,21-triol-3,20-dione | 1,4-pregnadiene-3,20-dione-11β,17α,21-triol | 3,20-dioxo-11β,17α,21-trihydroxy-1,4-pregnadiene | delta-dehydrocortisol | delta-dehydrohydrocortisone | delta-hydrocortisone | delta(1)-dehydrocortisol | delta(1)-dehydrohydrocortisone | delta(1)-hydrocortisone | hydroretrocortine | metacortandralone | prdl | prednisolona | prednisolone | prednisolonum

Drug Sentece Context

Table 1. Analysis of context sentence of prednisolone gene in 48 abstracts.

pmid sentence
32256705 Low-dose prednisolone and tacrolimus may have beneficial impacts on COVID-19.
32363963 He was receiving mycophenolate mofetil (MMF) for one month and 30 mg prednisolone for three months until his hospitalization. […] Prednisolone was tapered to 15 mg when current COVID-19 was suspected, considering his recent cough, dyspnea, and fever.
32379699 We also comment on suggested dosing for patients who usually take modified release hydrocortisone or prednisolone.
32476308 A proper combination of antiviral agents, immune modulators such as prednisolone, and anticoagulants such as heparin and anti-C5a antagonists could be employed to minimize lung damage and prevent systemic involvements.
32493514 Immunosuppressive therapy (e.g. mycophenolate, azathioprine, methotrexate, biologicals, prednisolone >10mg/d; exceptions are: prednisolone ≤ 10mg/d, sulfasalazine or hydroxychloroquine)9.
32526068 There was no association between prednisolone dose and concern.
32541245 CD4 and CD8 T cells frequencies decreased because of prednisolone, followed by a plateauing increase whereas CD19CD20 B cell increased strongly and was unaffected by COVID-19 infection. […] Although activated Tregs (CD4CD45RAFOXP3) strongly increased upon prednisolone, it decreased afterwards. […] Furthermore, regulatory B cells (Bregs: CD19CD20CD24CD38) declined sharply owing to prednisolone. […] We hypothesize that continuing with low level of prednisolone without azathioprine may have abrogated activated Tregs, Bregs and IL-6 production and therefore permitting the activation of CD8 T cells, clearing the virus.
32562159 According to the drug regimen, the patients were divided into two groups; group I who received regimen I consisting azithromycin, prednisolone, naproxen, and lopinavir/ritonavir and group II who received regimen II including meropenem, levofloxacin, vancomycin, hydroxychloroquine, and oseltamivir. […] This study revealed the beneficial effect of the short-term use of low-dose prednisolone in combination with azithromycin, naproxen and lopinavir/ritonavir (regimen I), in decreasing ALOS compared to regimen II.
32573355 In addition to the selected compounds, 4 nucleoside analogs of anti-viral (Raltgravir, Maraviroc and Favipiravir) and anti-inflammatory (Prednisolone) drugs were selected for further investigations.
32585765 A 58-year-old 2 years post kidney transplant recipient, with maintenance immunosuppression of tacrolimus, mycophenolate mofetil (MMF) and prednisolone, presented with acute diarrhea which followed by fever on day 12.
32591970 Substantial clinical improvement was obtained following a management plan, which included tocilizumab, hydroxychloroquine, prednisolone and enoxaparin sodium.
32681756 We decreased the dose of immunosuppression and started stress dose of intravenous hydrocortisone or equivalent oral prednisolone.
32690572 The patient was admitted for 1 day; immunosuppressive therapy with tacrolimus and low-dose prednisolone was continued; and the patient recovered successfully without the use of antiviral agents or oxygen therapy.
32715804 She received lopinavir/ritonavir and azithromycin as well as early methyl prednisolone therapy.
32760206 Hydrocortisone showed the strongest effect on ACE2 activation, followed by prednisolone, dexamethasone, and methylprednisolone.
32763890 For patients diagnosed most recently, there was evidence of more rapid initial prescribing of corticosteroids (prednisolone) and earlier referral for NMR therapy.
32843231 Patients had previously received combinations of azithromycin, hydroxy-chloroquine, and methyl-prednisolone.
32868989 He received 30 mg prednisolone for five days with antiviral drug of favipiravir, and was successfully extubated on day five.
32879154 A 69-year-old woman with lymphoma-type ATL was treated using cyclophosphamide, doxorubicin, vincristine, prednisolone and mogamulizumab (M-CHOP) with substantial efficacy.
32960899 To analyze the effects of a short course of methyl-prednisolone pulses (MP) during the second week of disease (week-2) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia.
32983161 With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA).
32986289 Low dose prednisolone should be considered on an individualized basis.
33043249 We present a case of a patient previously considered recovered from nosocomially transmitted asymptomatic COVID-19 illness, who presented with new respiratory, radiological, and RT-PCR findings consistent with COVID-19, while on high-dose prednisolone due to a suspected secondary demyelinating disease.
33091817 All patients responded to oral prednisolone within a median of five days (IQR = 4; ranged 2-14).
33094701 Six well-known corticosteroids (cortisone, hydrocortisone, prednisolone, methylprednisolone, betamethasone and dexamethasone) and two repurposed drugs (darunavir and lopinavir) against COVID-19 were subjected for molecular docking studies.
33109497 A similar process is also seen with the anti-inflammatory drugs methyl prednisolone and dexamethasone, used for Covid-19 patients. […] Methyl prednisolone and dexamethasone are methide quinones, and possess only one carbonyl moiety, instead of two for embelin. […] All show structural similarities with embelin, dexamethasone and methyl prednisolone results.
33160178 Additionally, no interference was observed when samples were spiked with: conjugated bilirubin 0.4 mg/ml; unconjugated bilirubin 0.4 mg/ml; hemoglobin 5 mg/ml; prednisolone 0.12 mg/ml; triglycerides 15 mg/ml.
33196625 Risk factors associated with survival were older age, odds ratio (OR): 1.07 (1.00-1.13), P = 0.041; receiving prednisolone, OR: 5.98 (1.65-21.60), P < 0.01 and the absence of diabetes, OR: 0.27 (0.07-0.99), P = 0.047.
33213130 A 40-year-old man with a history of rheumatoid arthritis treated with prednisolone, Disease-Modifying Anti-Rheumatic Drugs (DMARDs), and biologic agents was admitted with chief complaints of fever, chills, malaise, myalgia, and dyspnea. […] The methotrexate dose was decreased, and the dose of prednisolone was increased to 30 mg for 10 days.
33235798 Administration of prednisolone dramatically improved the patient’s clinical condition and chest radiograph findings, which were consistent with the clinical course of AEP.
33235888 Fifty-seven patients received treatment alone, and 35 patients received treatment with adjunctive prednisolone.
33240733 The rash started after he took azithromycin, oseltamivir, ribavirin, lopinavir, hydroxychloroquine, prednisolone, ceftriaxone, clindamycin, interferon (IFN) beta, and ceftazidime for COVID-19.
33318924 This is a case series of four patients on methyl-prednisolone pulses for the late phase of Coronavirus disease 2019 (COVID-19) with respiratory failure in our hospital.
33330807 However, several doses of methylprednisolone (or prednisolone) have been attempted, ranging from about 40 mg/day to 2 mg/kg/day.
33384516 Eighteen children received pulse methyl-prednisolone, eleven intravenous immunoglobulins, and four tocilizumab. […] Early and aggressive management of shock and immune modulation with methyl-prednisolone and intravenous immunoglobulin were used.
33431539 Supportive management was provided, baseline immunosuppression with everolimus was continued, and oral prednisolone was increased.
33433263 Determine the incidence of and describe the progression of persistent inflammatory interstitial lung disease (ILD) following SARS-CoV2 when treated with prednisolone.
33442587 She was treated with colchicine 500 μg twice daily, ibuprofen 400 mg three times day, and prednisolone 30 mg per day, and her symptoms and weakness improved.
33460984 All were on prednisolone and 18(47.4 %) received azathioprine.
33494816 After one week of treatment with prednisolone (30 mg daily) and hydroxychloroquine, paresthesia, proteinuria, and edema continued.
33504483 Independent factors associated with COVID-19-related death were age (66-75 years: OR 3.00, 95% CI 2.13 to 4.22; >75 years: 6.18, 4.47 to 8.53; both vs ≤65 years), male sex (1.46, 1.11 to 1.91), hypertension combined with cardiovascular disease (1.89, 1.31 to 2.73), chronic lung disease (1.68, 1.26 to 2.25) and prednisolone-equivalent dosage >10 mg/day (1.69, 1.18 to 2.41; vs no glucocorticoid intake).
33522942 The patient was thereafter treated with prednisolone and antibiotics for over 2 weeks. […] The anti-PD-1 related pneumonitis mixed with bacterial infection was clinically diagnosed based on the laboratory and radiological evidences and good response to the prednisolone and antibiotics.
33527634 In all these cases the active phase of coronavirus infection had no effect on Hansen’s disease and those on prednisolone for their lepra reaction had a more favorable outcome, with two cases manifesting exacerbation of their lepra reactions in the follow period.
33539527 Inhaled corticosteroids (ICS), prednisolone and antibiotics all play a crucial role in the management of respiratory diseases. […] This was followed by a decrease in ICS and prednisolone prescribing in the following months.
33541953 Our patient was treated with prednisolone, after which both his clinical condition and eosinophil concentrations markedly improved.
33547007 Transbronchial lung cryobiopsy revealed pathological features of organizing pneumonia with alveolar epithelial injury, and prednisolone administration led to alleviation of respiratory symptoms and recovery of respiratory function.
33555845 In subgroup analyses, all-cause mortality was significantly lower among COVID-19 patients being accompanied by severe ARDS but not mild ARDS, taking low-dose or pulse glucocorticoids, being critically severe but not only severe, being of critical severity and old but not young, being of critical severity and men but not women, non-early taking glucocorticoids, taking dexamethasone or methylprednisolone, and with the increased inflammatory state; but for SARS, lower mortality was observed among those who were taking medium-high dose glucocorticoids, being severe or critically severe, early taking glucocorticoids, and taking methylprednisolone or prednisolone.
33584148 The 2017 American Heart Association (AHA) treatment guidelines have included changes in aspirin dosing (including both 80-100 mg/kg/day and 30-50 mg/kg/day treatment options), consideration of the use of adjuvant corticosteroid therapy in patients at high risk of IVIG resistance, and the change in steroid regimen for refractory KD to include both pulse-dose IVMP and longer course of prednisolone with an oral taper.