PIPERINE


DrugBank ID: db12582
DrugCentral: piperine
Synonymous :bioperine



Drug Sentece Context


Table 1. Analysis of context sentence of piperine gene in 4 abstracts.

pmid sentence
32573351 The bioactive ligands such as Cucurbitacin E, Orientin, Bis-andrographolide, Cucurbitacin B, Isocucurbitacin B, Vitexin, Berberine, Bryonolic acid, Piperine and Magnoflorine targeted the hotspot residues of SARS-CoV-2 main protease.
32656311 Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.
32938313 We have found that though all the molecules bind actively with the SARS-CoV-2 RBD Spro and Mpro, but Piperine has the highest binding affinity among the 30 screened molecules. […] Besides, the comparative study between Piperine and currently used drugs show that Piperine is more effective. […] The interaction of Piperine with RBD Spro and Mpro is further validated by the molecular dynamics (MD) simulation studies. […] The free energy landscape and binding free energy results also, support for the stable complex formation of Piperine with RBD Spro and Mpro.
32943302 In conclusion, the present study successfully demonstrated the binding of phytochemicals such as sarsasapogenin, ursonic acid, curcumin, ajmalicine, novobiocin, silymarin and aranotin, piperine, gingerol, rosmarinic acid, and alpha terpinyl acetate to Nsp15 viral protein and they might play a key role in inhibiting SARS-CoV-2 replication.
32964485 The major bioactive piperine in TS was isolated and quantified.