PIPERINE
DrugBank ID: db12582
DrugCentral: piperine
Synonymous :bioperine
Drug Sentece Context
Table 1. Analysis of context sentence of piperine gene in 4 abstracts.
| pmid | sentence |
|---|---|
| 32573351 | The bioactive ligands such as Cucurbitacin E, Orientin, Bis-andrographolide, Cucurbitacin B, Isocucurbitacin B, Vitexin, Berberine, Bryonolic acid, Piperine and Magnoflorine targeted the hotspot residues of SARS-CoV-2 main protease. |
| 32656311 | Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells. |
| 32938313 | We have found that though all the molecules bind actively with the SARS-CoV-2 RBD Spro and Mpro, but Piperine has the highest binding affinity among the 30 screened molecules. […] Besides, the comparative study between Piperine and currently used drugs show that Piperine is more effective. […] The interaction of Piperine with RBD Spro and Mpro is further validated by the molecular dynamics (MD) simulation studies. […] The free energy landscape and binding free energy results also, support for the stable complex formation of Piperine with RBD Spro and Mpro. |
| 32943302 | In conclusion, the present study successfully demonstrated the binding of phytochemicals such as sarsasapogenin, ursonic acid, curcumin, ajmalicine, novobiocin, silymarin and aranotin, piperine, gingerol, rosmarinic acid, and alpha terpinyl acetate to Nsp15 viral protein and they might play a key role in inhibiting SARS-CoV-2 replication. |
| 32964485 | The major bioactive piperine in TS was isolated and quantified. |