PHENFORMIN

Drug Sentece Context

Table 1. Analysis of context sentence of phenformin gene in 4 abstracts.

pmid	sentence
32313883	During the 1971 outbreak of influenza, diabetic patients treated with the biguanides, phenformin and buformin, had a lower incidence of infection than diabetics treated with sulfonylureas or insulin. […] Both buformin and phenformin reduce the mortality of influenza in mice; phenformin is less effective than buformin. […] The inhalation of buformin or phenformin for influenza may be an effective novel treatment strategy that would limit the risk of systemic side-effects associated with biguanides due to the low inhaled dose.
32597315	Phenformin, quercetin, and ritonavir all demonstrated prospective binding affinities for COVID-19 PLpro over 50 ns MD simulations, with binding energy values of -56.6, -40.9, and -37.6 kcal/mol, respectively. […] Energetic and structural analyses showed phenformin was more stable than quercetin and ritonavir.