DrugBank ID: db00806
DrugCentral: pentoxifylline
Synonymous :oxpentifylline | pentoxifilina | pentoxifyllin | pentoxifylline | pentoxifyllinum

Drug Sentece Context

Table 1. Analysis of context sentence of pentoxifylline gene in 5 abstracts.

pmid sentence
32473070 Pentoxifylline is a methyl-xanthine and it inhibits phosphodiesterase IV (PDE IV). […] This is a scoping review, in which all related articles on COVID-19 and the probable benefits of Pentoxifylline against COVID-19 pathogenesis, in Medline, Scopus, Web of Sciences and Google Scholar up to March 20, 2020 with proper keywords including: pentoxifylline, Pentoxil, COVID-19, coronavirus, treatment, anti-inflammatory, immunomodulatory, anti-fibrosis, oxygenation, circulation, bronchodilator, ARDS and organ failure. […] We found many confirmatory data on proper efficacy of pentoxifylline n controlling COVID-19 and its consequences.
32540603 Pentoxifylline (PTX) is a phosphodiesterase inhibitor that increases cyclic adenosine monophosphate levels, which in turn activate protein kinase, leading to a reduction in the synthesis of proinflammatory cytokines to ultimately influence the renin-angiotensin system (RAS) in vitro by inhibiting angiotensin 1 receptor (AT1R) expression.