OXYTOCIN


DrugBank ID: db00107
DrugCentral: oxytocin
Synonymous :oxitocina | oxytocin



Drug Sentece Context


Table 1. Analysis of context sentence of oxytocin gene in 11 abstracts.

pmid sentence
32514104 The neuropeptide oxytocin has attracted great attention of the general public, basic neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social, anxiolytic, and “anti-stress” behavioral and physiological effects, and its potential application for treatment of mental diseases associated with altered socio-emotional competence. […] During the last decade, substantial progress has been achieved in understanding the complex neurobiology of the oxytocin system, including oxytocinergic pathways, local release patterns, and oxytocin receptor distribution in the brain, as well as intraneuronal oxytocin receptor signaling. […] However, the picture of oxytocin actions remains far from being complete, and the central question remains: “How does a single neuropeptide exert such pleotropic actions? […]” Although this phenomenon, typical for many of about 100 identified neuropeptides, may emerge from the anatomical divergence of oxytocin neurons, their multiple central projections, distinct oxytocin-sensitive cell types in different brain regions, and multiple intraneuronal signaling pathways determining the specific cellular response, further basic studies are required. […] In conjunction, numerous reports on positive effects of intranasal application of oxytocin on human brain networks controlling socio-emotional behavior in health and disease require harmonic tandems of basic researchers and clinicians. […] During the COVID-19 crisis in 2020, oxytocin research seems central as question of social isolation-induced inactivation of the oxytocin system, and buffering effects of either activation of the endogenous system or intranasal application of synthetic oxytocin need to be thoroughly investigated.
32809918 Here, we are proposing intravenous oxytocin (OXT) as a candidate for adjunctive therapy for COVID-19.
32845008 Growing research on the impact of physical touch on health has revealed links to lower blood pressure, higher oxytocin levels, and better sleep, but links to inflammation have not been fully explored.
32914674 Based on its well-documented anti-inflammatory and restorative properties we propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 patients. […] We searched for, retrieved, and commented on specific literature regarding multiple functions of oxytocin with a special focus on its modulation of inflammatory, immune, and restorative functions. […] Available data gathered in animals and humans support the anti-inflammatory properties of oxytocin. […] The multiple anti-inflammatory effects of oxytocin have been demonstrated in vitro and in vivo in various animal models and also in humans in response to intravenous infusion of oxytocin. […] Furthermore, oxytocin has been documented to activate several types of protective and restorative mechanisms and to exert positive effects on the immune system. […] In addition, to being anti-inflammatory, it may be hypothesised, that oxytocin may be less suppressive on adaptive immune systems, as compared with glucocorticoids. […] Finally, by its restorative effects coupled with its anti-stress and healing properties, oxytocin may shorten the recovery period of the Covid-19 patients.
32914732 This article summarizes the benefits of Oxytocin (OT) in the attenuation of coronavirus infectious disease (COVID-19) pathogenesis.