NIFUROXAZIDE
DrugBank ID: db13855
DrugCentral: nifuroxazide
Synonymous : None
Drug Sentece Context
Table 1. Analysis of context sentence of nifuroxazide gene in 3 abstracts.
| pmid | sentence |
|---|---|
| 32504751 | The current study provides evidence on the ameliorative impact of nifuroxazide, and FDA approved antidiarrheal drug in attenuation of lipopolysaccharide (LPS)-induced ALI and myocarditis when administrated either in prophylactic or curative regimens. […] Nifuroxazide administration was associated with a significant improvement in lung and heart histopathological characteristics and architecture with retraction of LPS-induced inflammatory-infiltration. […] Nifuroxazide administration was associated with a significant improvement in both lung and heart oxidative status. […] Such positive outcomes were underlined by a significant inhibitory effect of nifuroxazide on lung and heart contents of toll-like receptor (4) (TLR4)/the inflammasome NALPR3/interleukin- 1β (IL-1β). […] In conclusion: Nifuroxazide attenuates LPS-induced ALI and myocardial injury via interruption of TLR4/NALPR3/IL-1β signaling. |