NIFEDIPINE
DrugBank ID: db01115
DrugCentral: nifedipine
Synonymous :4-(2’-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsäuredimethylester | nifedipine | nifedipino | nifedipinum
Drug Sentece Context
Table 1. Analysis of context sentence of nifedipine gene in 15 abstracts.
| pmid | sentence |
|---|---|
| 32226695 | Other therapeutics to consider that are also directed towards decreased pulmonary pressure include Nifedipine and Phosphodiesterase inhibitors. […] Acetazolamide, Nifedipine and Phosphodiesterase inhibitors may be potential countermeasures. |
| 32411566 | With 65 patients left, 24 were found to have been administered either amlodipine or nifedipine (CCB group) and 41 were not (No-CCB group). […] Nifedipine and amlodipine were found to be associated with significantly improved mortality and a decreased risk for intubation and mechanical ventilation in elderly patients hospitalized with COVID-19. […] Including either nifedipine or amlodipine in medication regimens for elderly patients with hypertension hospitalized for COVID-19 may be considered. |
| 33269470 | Such patients are often concomitantly treated with antiviral and antihypertensive agents, including ritonavir and nifedipine. […] Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the combination of ritonavir and nifedipine can potentially cause drug-drug interactions. […] This study provides guidance on nifedipine treatment during and after coadministration with ritonavir-containing regimens, using a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) analysis. […] The PBPK/PD models for 3 formations of nifedipine were developed based on the Simcyp nifedipine model and the models were verified using published data. […] The effects of ritonavir on nifedipine exposure and systolic blood pressure (SBP) were assessed for instant-release, sustained-release and controlled-release formulations in patients. […] Various nifedipine regimens were investigated when coadministered with or without ritonavir. of nifedipine 17.92-48.85-fold and the AUC 63.30-84.01-fold at steady state and decreased the SBP by >40 mmHg. […] Thus, the combination of nifedipine and ritonavir could lead to severe hypotension. […] Ritonavir significantly affects the pharmacokinetics and antihypertensive effect of nifedipine. […] It is not recommended for patients to take nifedipine- and ritonavir-containing regimens simultaneously. |