DrugBank ID: db00627
Synonymous :3-carboxypyridine | 3-pyridinecarboxylic acid | 3-pyridylcarboxylic acid | acide nicotinique | ácido nicotínico | acidum nicotinicum | anti-pellagra vitamin | m-pyridinecarboxylic acid | niacin | niacina | nicotinic acid | nikotinsäure | pyridine-β-carboxylic acid | β-pyridinecarboxylic acid
Drug Sentece Context
Table 1. Analysis of context sentence of niacin gene in 3 abstracts.
|32707945||Vitamin B3, or niacin, is one of the most important compounds of the B-vitamin complex.|
|32787337||Herein, using ligand- and protein-observed fragment screening approaches, we identified niacin and hit 1 binding to the catalytic pocket of the main protease (Mpro) of SARS-CoV-2, thereby modestly inhibiting the enzymatic activity of Mpro. […] We further searched for low-molecular-weight drugs containing niacin or hit 1 pharmacophores with enhanced inhibiting activity, e.g., carmofur, bendamustine, triclabendazole, emedastine, and omeprazole, in which omeprazole is the only one binding to the C-terminal domain of SARS-CoV-2 Mpro.|
|32853469||NAD can be synthesized de novo starting with tryptophan, or from salvage pathways starting with NAD precursors like nicotinic acid (NA), nicotinamide (NAM) or nicotinamide riboside (NR), referred to as niacin/B3 vitamins, arising from dietary supply or from cellular NAD catabolism.|