NEOPTERIN


DrugBank ID: db15050
DrugCentral: neopterin
Synonymous : None



Drug Sentece Context


Table 1. Analysis of context sentence of neopterin gene in 4 abstracts.

pmid sentence
32860465 Neopterin produced by macrophages on stimulation with interferon-gamma, which is an important cytokine in the antiviral immune response, hence it can be used to predict the severity of disease in COVID-19 cases. […] In this study, it was aimed to determine the prognostic value of the neopterin for the prediction of severe disease in patients with COVID-19. […] Severe and mild COVID-19 cases were compared in terms of clinical and laboratory findings as well as serum neopterin levels on hospital admission. […] To assess the prognostic utility of neopterin between the severe and mild COVID-19 groups, a receiver-operating characteristic (ROC) curve was generated, and the area under the curve (AUC) was calculated. […] The median serum neopterin level was four times higher in COVID-19 patients than the healthy controls (46 vs. 12 nmol/L; p < .001). […] The AUC value of serum neopterin was 0.914 (95% confidence interval, 0.85-0.97). […] The sensitivity and specificity of serum neopterin for the cut-off value of 90 nmol/L to identify severe COVID-19 cases were 100% and 76%, respectively. […] Serum neopterin levels on hospitalization were significantly higher in severe COVID-19 disease than mild COVID-19 patients. […] Neopterin levels can be used as an early prognostic biomarker for COVID-19 on admission.
33004602 We assessed CSF SARS-CoV-2 RNA along with CSF biomarkers of intrathecal inflammation (CSF white blood cell count, neopterin, β2-microglobulin (β2M) and immunoglobulin G-index), blood-brain-barrier (BBB) integrity (albumin ratio), and axonal injury (CSF neurofilament light chain protein [NfL]) in 6 patients with moderate to severe COVID-19 and neurologic symptoms who had undergone a diagnostic lumbar puncture. […] CSF neopterin (median, 43.0 nmol/L) and β2-microglobulin (median, 3.1 mg/L) were increased in all.