NEOPTERIN

DrugBank ID: db15050
DrugCentral: neopterin
Synonymous : None


Drug Sentece Context


Table 1. Analysis of context sentence of neopterin gene in 6 abstracts.

pmid sentence
32860465 Neopterin produced by macrophages on stimulation with interferon-gamma, which is an important cytokine in the antiviral immune response, hence it can be used to predict the severity of disease in COVID-19 cases. […] In this study, it was aimed to determine the prognostic value of the neopterin for the prediction of severe disease in patients with COVID-19. […] Severe and mild COVID-19 cases were compared in terms of clinical and laboratory findings as well as serum neopterin levels on hospital admission. […] To assess the prognostic utility of neopterin between the severe and mild COVID-19 groups, a receiver-operating characteristic (ROC) curve was generated, and the area under the curve (AUC) was calculated. […] The median serum neopterin level was four times higher in COVID-19 patients than the healthy controls (46 vs. 12 nmol/L; p < .001). […] The AUC value of serum neopterin was 0.914 (95% confidence interval, 0.85-0.97). […] The sensitivity and specificity of serum neopterin for the cut-off value of 90 nmol/L to identify severe COVID-19 cases were 100% and 76%, respectively. […] Serum neopterin levels on hospitalization were significantly higher in severe COVID-19 disease than mild COVID-19 patients. […] Neopterin levels can be used as an early prognostic biomarker for COVID-19 on admission.
33004602 We assessed CSF SARS-CoV-2 RNA along with CSF biomarkers of intrathecal inflammation (CSF white blood cell count, neopterin, β2-microglobulin (β2M) and immunoglobulin G-index), blood-brain-barrier (BBB) integrity (albumin ratio), and axonal injury (CSF neurofilament light chain protein [NfL]) in 6 patients with moderate to severe COVID-19 and neurologic symptoms who had undergone a diagnostic lumbar puncture. […] CSF neopterin (median, 43.0 nmol/L) and β2-microglobulin (median, 3.1 mg/L) were increased in all.
33302893 Serum levels of the immune activation marker neopterin has shown to be of prognostic value in patients with SARS. […] The aim of this study was to investigate whether serum neopterin is associated with the severity of COVID-19. […] Concentrations of serum neopterin, tryptophan, and kynurenine were measured at and repeatedly after inclusion. […] We found a more than two-fold higher mean concentration of neopterin in severely ill patients (mean value 42.0 nmol/L (SD 18.2)) compared to patients with mild symptoms (16.9 nmol/L (SD 11.0)). […] All of the severe cases had elevated neopterin concentrations (> 9.1 nmol/L) at the initial sampling with values ranging from 17.2 to 86.7 nmol/L. […] In comparison, 10 of 15 patients with mild disease had neopterin levels above 9.1 nmol/L, with concentrations in the range from 4.9 to 31.6 nmol/L. […] Neopterin levels gradually decreased during the course of COVID-19, but severe cases maintained elevated levels for a longer period. […] In conclusion, we found that serum neopterin levels are associated with the severity of COVID-19. […] Our findings suggest that neopterin could be used as a prognostic marker, but further studies are needed to elucidate how it can be used in the clinic.
33438988 Neopterin is a surrogate marker for viral inflammation, and its production by macrophages is driven by interferon-γ. […] We measured fecal neopterin in 37 hospitalized COVID-19 patients not requiring intensive care measures and 22 healthy controls. […] Fecal neopterin was elevated in stool samples from COVID-19 patients compared with that in samples from healthy controls. […] Especially, patients reporting gastrointestinal symptoms exhibited increased fecal neopterin values.
33442554 This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with coronavirus disease 2019 (COVID-19). […] Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for intensive care unit admission, need for mechanical ventilation, and death. […] Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.
33564258 Neopterin is a macrophage activation marker produced by monocytes and macrophages upon activation by interferon-gamma (IFN-γ). […] Neopterin is a well-established marker in a variety of diseases, and recent evidence indicates that it could be helpful in early prediction of the severity of COVID-19 disease and serve as a prognostic marker. […] Here, we outline the role of macrophage activation syndrome in the pathogenesis of SARS-CoV-2 and suggest that neopterin could be used as a biomarker for progression of COVID-19.