NATALIZUMAB


DrugBank ID: db00108
DrugCentral: natalizumab
Synonymous :anti-alpha4 integrin | anti-vla4



Drug Sentece Context


Table 1. Analysis of context sentence of natalizumab gene in 3 abstracts.

pmid sentence
32388451 Development of PML or other serious opportunistic infections during treatment with natalizumab forces to consider whether de-risking strategies are needed in this particular context and how to manage a high-efficacy treatment. […] In this paper we report on a patient treated with natalizumab for relapsing MS who developed COVID-19 and recovered in a few days without complications. […] After recovery natalizumab has been administered in the window of the extended interval dosing (EID), without reporting any worsening or new symptoms.
32531754 Natalizumab, approved for Multiple Sclerosis (MS) treatment, acts blocking α4-integrin. […] We report a MS patient treated with natalizumab who develops COVID-19, with excellent recovery and repeated negative results in 5 consecutive microbiological studies. […] We postulate this may be due to the blockade of integrins induced by natalizumab.
32590314 Platform therapies, dimethyl-fumarate and natalizumab are considered safe options to initiate in naive patients. decision-making about MS and NMOSD patients has become even more complex in order to adapt to the COVID-19 pandemic.