DrugBank ID: db02338
DrugCentral: nadph
Synonymous :dihydronicotinamide-adenine dinucleotide phosphate | reduced nicotinamide adenine dinucleotide phosphate | tpnh

Drug Sentece Context

Table 1. Analysis of context sentence of nadph gene in 2 abstracts.

pmid sentence
32532805 The signalling mechanism whereby these stimuli evoke TF expression entails activation of NADPH oxidase, upstream from activation of the NF-kappaB transcription factor that drives the induced transcription of the TF gene. […] When single-stranded RNA viruses are taken up into cellular endosomes, they stimulate endosomal formation and activation of NADPH oxidase complexes via RNA-responsive toll-like receptor 7. […] It is therefore proposed that SARS-CoV-2 infection of endothelial cells evokes the expression of TF which is contingent on endosomal NADPH oxidase activation.
32811354 The overexpression of glutathione, glutathione peroxidase, and superoxide dismutase, and down-regulation of NADPH oxidase are induced by VD to reduce the oxidative stress.
32990980 However, it may also facilitate viral entry by increasing ACE2 as the main SARS-CoV-2 receptor and mediates ROS production through NADPH oxidase, as a double-edged sword effect.