MINOCYCLINE


DrugBank ID: db01017
DrugCentral: minocycline
Synonymous :(4s,4as,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide | 7-dimethylamino-6-demethyl-6-deoxytetracycline | minociclina | minociclinum | minocyclin | minocycline | minocyclinum | minomycin



Drug Sentece Context


Table 1. Analysis of context sentence of minocycline gene in 9 abstracts.

pmid sentence
32267566 Tetracyclines (e.g. tetracycline, doxycycline, and minocycline) are highly lipophilic antibiotics that are known to chelate zinc compounds on matrix metalloproteinases (MMPs)1 .
32552044 Here, we review the significant anti-inflammatory, immunomodulatory, and antiviral properties of minocycline as potential mechanisms for efficacy against the novel coronavirus and highlight the promises and pitfalls of this approach. […] As compared to other agents being investigated for COVID-19, minocycline offers distinct advantages in terms of potential efficacy in patients with life-threatening acute respiratory distress syndrome (ARDS) and myocardial injury, well-known safety and interaction profile, relatively low costs and widespread availability.
32653520 To circumvent the issue of lead compound from available drugs as antivirals, antibiotics with broad spectrum of viral activity, i.e. doxycycline, tetracycline, demeclocycline, and minocycline were chosen for molecular simulation analysis against native ligand N3 inhibitor in SARS-CoV-2 Mpro crystal structure. […] Based on combinatorial molecular simulation analysis, doxycycline and minocycline were selected as potent inhibitor against SARS-CoV-2 Mpro which can used in combinational therapy against SARS-CoV-2 infection.
32873175 Tetracycline and its derivatives (e.g. doxycycline and minocycline) are nontraditional antibiotics with a well-established safety profile, potential efficacy against viral pathogens such as dengue fever and chikungunya, and may regulate pathways important in initial infection, replication, and systemic response to SARS-CoV-2.
32952617 In fact, there are other immunosuppressants known with antiviral activities, including cyclosporine A, hydroxyurea, minocycline, mycophenolic acid, mycophenolate mofetil, leflunomide, tofacitinib, and thalidomide.
33008280 Minocycline, because of its anti-cytokine and other useful properties can be an ideal candidate for combining with HCQ. […] Here we review the need and mechanisms and reasons for combining HCQ and minocycline moderate to severe COVID-19 infection. […] We also reviewed the advantages, potential safety concerns and precautions to be taken, while combining HCQ and minocycline. […] Combining HCQ and minocycline offers many advantages in the management of moderate to severe COVID-19 infection.