DrugBank ID: db00331
DrugCentral: metformin
Synonymous :1,1-dimethylbiguanide | dimethylbiguanid | metformin | metformina | metformine | metforminum

Drug Sentece Context

Table 1. Analysis of context sentence of metformin gene in 23 abstracts.

pmid sentence
32328850 Particularly, drugs that show superior maternal and fetal safety are worthy of consideration for pregnant women with COVID-19, such as chloroquine, metformin, statins, lobinavir/ritonavir, glycyrrhizic acid, and nanoparticle-mediated drug delivery (NMDD), etc.
32382358 We discuss the potential contribution of two traditional oral antidiabetic agents, metformin and pioglitazone, to the improvement of liver injury in COVID-19.
32420614 She had a body mass index (BMI) of 35, type 2 diabetes mellitus (T2DM) on metformin and insulin, renal tubular acidosis, asthma and vitamin D deficiency.
32446312 Metformin was proposed to be a candidate for host-directed therapy for COVID-19. […] In this study, we compared the outcome of metformin users and nonusers in hospitalized COVID-19 patients with diabetes. […] Hospitalized diabetic patients with confirmed COVID-19 in the Tongji Hospital of Wuhan, China, from January 27, 2020 to March 24, 2020, were grouped into metformin and no-metformin groups according to the diabetic medications used. […] A total of 283 patients (104 in the metformin and 179 in the no-metformin group) were included in this study. […] The fasting blood glucose level of the metformin group was higher than that of the no-metformin group at admission and was under effective control in both groups after admission. […] The length of hospital stay did not differ between the two groups (21.0 days for metformin versus 19.5 days for no metformin, P = 0.74). […] However, in-hospital mortality was significantly lower in the metformin group (3/104 (2.9%) versus 22/179 (12.3%), P = 0.01). […] Antidiabetic treatment with metformin was associated with decreased mortality compared with diabetics not receiving metformin. […] This retrospective analysis suggests that metformin may offer benefits in patients with COVID-19 and that further study is indicated.
32463794 Metformin is capable of suppressing one of the molecular triggers of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca2+ release-activated Ca2+ channels (CRAC)/IL-6 cascade. […] Given the linkage between mitochondrial functionality, ion channels, and inflamm-aging, the ability of metformin to target mitochondrial electron transport and prevent ROS/CRAC-mediated IL-6 release might illuminate new therapeutic avenues to quell the raging of the cytokine and thrombotic-like storms that are the leading causes of COVID-19 morbidity and mortality in older people. […] The incorporation of infection rates, severity and lethality of SARS-CoV-2 infections as new outcomes of metformin usage in elderly populations at risk of developing severe COVID-19, together with the assessment of bronchial/serological titers of inflammatory cytokines and D-dimers, could provide a novel mechanistic basis for the consideration of metformin as a therapeutic strategy against the inflammatory and thrombotic states underlying the gerolavic traits of SARS-CoV-2 infection.
32482587 The analyzed drugs were paracetamol, ascorbic acid, dapagliflozin plus metformin, rosuvastatin plus ezetimibe, formoterol, and hydroxychloroquine, as these pharmaceutical substances registered the highest growth rate in sales and shortages when compared to the same period in the previous year.
32495148 A recent experimental study has suggested an increased toxicity of hydroxychloroquine in association with metformin in mice. […] The present study was undertaken to investigate the reality of this putative drug-drug interaction between hydroxychloroquine and metformin using pharmacovigilance data. […] Data with hydroxychloroquine (or metformin) alone were compared with the association hydroxychloroquine + metformin. […] In comparison with hydroxychloroquine alone, hydroxychloroquine + metformin was associated with an ROR value of 57.7 (23.9-139.3). […] In comparison with metformin alone, hydroxychloroquine + metformin was associated with an ROR value of 6.0 (2.6-13.8). […] Our study identified a signal for the association hydroxychloroquine + metformin that appears to be more at risk of fatal outcomes (particularly by completed suicides) than one of the two drugs when given alone.
32592841 Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19.
32413342 Metformin and SGLT2 inhibitors should be discontinued in patients with severe forms of COVID-19 owing to the risks of lactic acidosis and ketoacidosis.
32668399 A combination of Metformin and Sulfonylureas (SU) was most commonly associated with the risk of hypoglycemia (65.75%) followed by insulin (33.56%). […] Subjects who received insulin reported a lower blood glucose value (50.75 ± 8.20 mg/dL) as compared to those receiving a combination of metformin and SU (60.95 ± 7.10 mg/dl).
32685191 There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D.
32750451 Metformin remains the first-line pharmacological choice for the management of hyperglycaemia in T2DM. […] Because metformin exerts various effects beyond its glucose-lowering action, among which are anti-inflammatory effects, it may be speculated that this biguanide might positively influence the prognosis of patients with T2DM hospitalized for COVID-19. […] The present concise review summarizes the available data from observational retrospective studies that have shown a reduction in mortality in metformin users compared with non-users, and briefly discusses the potential underlying mechanisms that might perhaps explain this favourable impact.
32758336 As the diabetic MODY-5 patient (mutation of HNF1B, Val2Leu) was on low dose Riomet® while eliminating insulin gradually, a simple analytical method for metformin assay was recommended to ensure its concentration before use as it is not approved yet by the Egyptian QC labs.
32808185 The expression level of TMPRSS2 was increased noticeably with a number of medications such as metformin.
32818905 Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression.
32838195 Firstly, AMPK mediated phosphorylation of ACE-2 by metformin as well as the drug’s alkaline properties may interrupt the natural disease progression.
32844132 Metformin is one of the drugs which is most commonly used for the treatment of diabetes patients. […] This study aims to analyze the potential benefit of metformin use in reducing the mortality rate from COVID-19 infection. […] All articles published on COVID-19 and metformin were retrieved. […] Our meta-analysis showed that metformin use is associated with reduction in mortality rate from COVID-19 infections [RR 0.54 (95% CI 0.32-0.90), p = 0.02, I2 = 54%, random-effect modelling]. […] Metformin has shown benefits in reducing the mortality rate from COVID-19 infections. […] Patients with diabetes should be advised to continue taking metformin drugs despite COVID-19 infection status.
32861268 Metformin is the most commonly prescribed first-line medication for T2D, but its impact on the outcomes of individuals with COVID-19 and T2D remains to be clarified. […] Our current retrospective study in a cohort of 1,213 hospitalized individuals with COVID-19 and pre-existing T2D indicated that metformin use was significantly associated with a higher incidence of acidosis, particularly in cases with severe COVID-19, but not with 28-day COVID-19-related mortality. […] Furthermore, metformin use was significantly associated with reduced heart failure and inflammation. […] Our findings provide clinical evidence in support of continuing metformin treatment in individuals with COVID-19 and pre-existing T2D, but acidosis and kidney function should be carefully monitored in individuals with severe COVID-19.
32900588 The present narrative review discusses the potential anti-inflammatory properties of certain antidiabetic drugs (i.e. metformin, pioglitazone, sitagliptin, linagliptin, vildagliptin, alogliptin, saxagliptin, liraglutide, dulaglutide, exenatide, lixisenatide, semaglutide, empagliflozin, dapagliflozin, canagliflozin), with a focus on CRP, IL-6 and ferritin.
32902818 We review the possibility of this approach by examining available evidence in metformin: a generic drug with a proven safety record that will be used in a large-scale multicenter clinical trial. […] Though rigorous translational research and clinical trials are needed to test this empirically, metformin may improve host immune defenses and confer protection against long-term health consequences of infectious disease, age-related chronic diseases, and geriatric syndromes.
32933031 In combination with or independent of the latest tested approaches, we propose the evaluation, in the short term, of treatments with DNase-1, with the anti-diabetic Metformin, or with drugs targeting elastase (i.e., Silvelestat).
32955785 Although metformin has been recommended as a host-directed therapy for COVID-19, there are some opposite views. […] The effects of metformin on the disease severity of patients with COVID-19 with diabetes during hospitalization remains unclear. […] This study aimed to determine the effect of metformin on disease severity. […] We enrolled 110 hospitalized patients with COVID-19 with diabetes prescribed either metformin or non-metformin hypoglycemic treatment for a case-control study. […] Blood glucose and lactate dehydrogenase levels of the metformin group were higher than those of the non-metformin group at admission. […] Strikingly, the percentage of patients who experienced life-threatening complications was significantly higher in the metformin group (28.6% (16/56) vs. […] Antidiabetic therapy with metformin was associated with a higher risk of disease progression in patients with COVID-19 with diabetes during hospitalization (adjusted odds ratio = 3.964, 95% confidence interval 1.034-15.194, P = 0.045). […] This retrospective analysis suggested a potential safety signal for metformin, the use of which was associated with a higher risk of severe COVID-19. […] We propose that metformin withdrawal in patients with COVID-19 be considered to prevent disease progression.
32973814 Metformin, a widely used drug to treat type 2 diabetes (T2D) mellitus and metabolic syndrome, has immunomodulatory activity that reduces the production of proinflammatory cytokines using macrophages and causes the formation of neutrophil extracellular traps (NETs). […] Metformin also inhibits the cytokine production of pathogenic Th1 and Th17 cells. […] Importantly, treatment with metformin alleviates various lung injuries in preclinical animal models. […] In addition, a recent proteomic study revealed that metformin has the potential to directly inhibit SARS-CoV-2 infection. […] Furthermore, retrospective clinical studies have revealed that metformin treatment reduces the mortality of T2D with COVID-19. […] Therefore, metformin has the potential to be repurposed to treat patients with COVID-19 at risk of developing severe illness. […] This review summarizes the immune pathogenesis of SARS-CoV-2 and addresses the effects of metformin on inhibiting cytokine storms and preventing SARS-CoV-2 infection, as well as its side effects.