DrugBank ID: db01033
Synonymous :6 mp | 6-mercaptopurine | 6-mp | 6-thiohypoxanthine | 6-thioxopurine | mercaptopurina | mercaptopurine | mercaptopurine anhydrous | mercaptopurinum | mercapurin
Drug Sentece Context
Table 1. Analysis of context sentence of mercaptopurine gene in 1 abstracts.
|32194980||Using network proximity analyses of drug targets and HCoV-host interactions in the human interactome, we prioritize 16 potential anti-HCoV repurposable drugs (e.g., melatonin, mercaptopurine, and sirolimus) that are further validated by enrichment analyses of drug-gene signatures and HCoV-induced transcriptomics data in human cell lines. […] We further identify three potential drug combinations (e.g., sirolimus plus dactinomycin, mercaptopurine plus melatonin, and toremifene plus emodin) captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV-host subnetwork, but target separate neighborhoods in the human interactome network.|
|32597315||The binding patterns of these drugs were superior to the previously identified SARS CoV PLpro inhibitor, 6-mercaptopurine (6-MP), suggesting a potential for repurposing these drugs to treat COVID-19.|
|32850963||The other ligand, chemotherapy drug 6-mercaptopurine (6MP), showed little to no stable intermolecular interaction with PLpro and quickly dissociated or remained highly mobile.|