MEMANTINE
DrugBank ID: db01043
DrugCentral: memantine
Synonymous :1-amino-3,5-dimethyladamantane | 1,3-dimethyl-5-adamantanamine | 3,5-dimethyl-1-adamantanamine | 3,5-dimethyl-1-aminoadamantane | 3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine | memantina | memantine | memantinum
Drug Sentece Context
Table 1. Analysis of context sentence of memantine gene in 3 abstracts.
| pmid | sentence |
|---|---|
| 32388458 | They were receiving treatment with either amantadine (n=15) or memantine (n=7) in stable registered doses. |
| 32436995 | Memantine, a moderate affinity, uncompetitive N-Methyl-D-aspartic acid (NMDA) receptor antagonist which prevents excess calcium entry into cells is commonly utilized in treating patients with Alzheimer’s disease, and may inhibit the neurotoxicity induced by SARS-CoV-2 in the medullary brain stem to avoid development of ARDS. […] Memantine and related adamantine such as amantadine, which is utilized in Parkinson’s disease and influenza, may have some anti-viral potential as well. […] Memantine and similar adamantines may have potential as repurposed medicines for treating Covid19 with inhibition of neurotoxicity, ARDS and viral replication, since Memantine appears to be lysosomotropic. |