MARAVIROC

DrugBank ID: db04835
DrugCentral: maraviroc
Synonymous :maraviroc | maravirocum

Drug Sentece Context

Table 1. Analysis of context sentence of maraviroc gene in 7 abstracts.

pmid	sentence
32441299	Using well-defined computational methods, we identified Glecaprevir and Maraviroc as the best inhibitors CoV-2 Mpro. […] Glecaprevir and Maraviroc bind to the conserved substrate-binding pocket of SARS-CoV-2 Mpro. […] This work provides sufficient evidence for the use of Glecaprevir and Maraviroc for the therapeutic management of COVID-19.
32573355	In addition to the selected compounds, 4 nucleoside analogs of anti-viral (Raltgravir, Maraviroc and Favipiravir) and anti-inflammatory (Prednisolone) drugs were selected for further investigations. […] The results showed that Raltegravir and Maraviroc among other compounds can bind strongly to the active site of the protein compared to sinefungin, and can be potential candidates to inhibit NSP-16. […] Also, the MD simulation results suggested that the Maraviroc and Raltegravir are more effective drug candidates than Sinefungin for inhibiting the enzyme. […] It is concluded that Raltegravir and Maraviroc which may be used in the treatment of COVID-19 after Invitro and invivo studies and clinical trial for final confirmation of drug effectiveness.Communicated by Ramaswamy H.
32739404	Interestingly, the CCR5-specific antagonist maraviroc did not show any anti-SARS-CoV-2 activity.
33260370	The results revealed some drugs that bind to hinge site amino acids (varenicline, or steroids such as betamethasone while other drugs bind to crucial amino acids in the RBM (naldemedine, atovaquone, cefotetan) or FP (azilsartan, maraviroc, and difluprednate); saquinavir binds both the RBM and the FP.
33292147	Results revealed that among the conventional antiviral drugs, the protease inhibitors, lopinavir, amprenavir, indinavir, maraviroc, saquinavir, and daclatasvir showed high binding affinity and interacted with amino acid residues of the binding site.