LEUCINE


DrugBank ID: db00149
DrugCentral: leucine
Synonymous :(2s)-2-amino-4-methylpentanoic acid | (2s)-alpha-2-amino-4-methylvaleric acid | (2s)-alpha-leucine | (s)-(+)-leucine | (s)-leucine | 2-amino-4-methylvaleric acid | l | l-leucin | l-leucine | l-leuzin | leu | leucine



Drug Sentece Context


Table 1. Analysis of context sentence of leucine gene in 8 abstracts.

pmid sentence
32027036 Despite the low heterogeneity of the 2019-nCoV genomes, we could identify at least two hypervariable genomic hotspots, one of which is responsible for a Serine/Leucine variation in the viral ORF8-encoded protein.
32493627 The presence of glutamine, asparagine, leucine, phenylalanine and serine amino acids in SARS-CoV-2 enhances ACE2 binding.
32505910 IL-1β is generated by macrophages upon activation of intracellular NLRP3 (NOD-like, leucine rich repeat domains, and pyrin domain-containing protein 3), part of the functional NLRP3 inflammasome complex that detects pathogenic microorganisms and stressors, while neutrophils are enhanced by increasing levels of IL-1β.
32765942 Recent studies suggest a role for the nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome activation in lung inflammation and fibrosis in SARS-CoV and SARS-CoV-2 infections.
32871846 Ivermectin docked in the region of leucine 91 of the spike and histidine 378 of the ACE2 receptor.
32954047 Interestingly, in ORF8 substitution of Leucine, a nonpolar to Serine a polar amino acid at same position (aa84 L to S) in 23 isolates of five countries i.e.