LEPTIN

DrugBank ID: db05098
DrugCentral: leptin
Synonymous : None


Drug Sentece Context


Table 1. Analysis of context sentence of leptin gene in 15 abstracts.

pmid sentence
32512493 The relations among immune system parameters, leptin, leptin receptor, adenosin mono phosphate-activated protein kinase, peroxisome proliferator activated receptor-gamma have also been interpreted. […] Leptin’s role in boosting proinflammatory cytokines and in appetite decreasing suggest the possible beneficial effect of decreasing the concentration of this proinflammatory adipose tissue hormone in relieving some symptoms detected during COVID-19 infection. […] In conclusion, Allium sativum may be an acceptable preventive measure against COVID-19 infection to boost immune system cells and to repress the production and secretion of proinflammatory cytokines as well as an adipose tissue derived hormone leptin having the proinflammatory nature.
32647360 Elevated circulating leptin concentrations are a hallmark of obesity, which is associated with a leptin-resistant state. […] Leptin is secreted by adipocytes in proportion to body fat and regulates appetite and metabolism through signaling in the hypothalamus. […] However, leptin also signals through the Jak/STAT and Akt pathways, among others, to modulate T cell number and function. […] Thus, leptin connects metabolism with the immune response. […] We propose that leptin may be the link between obesity and its high prevalence as a comorbidity of the SARS-CoV-2 infection.
32779790 Further, adipocyte secretion of leptin is pro-inflammatory and high circulating levels of leptin have been associated with mortality in patients with acute respiratory distress syndrome.
32837031 High baseline C-Reactive Protein, interleukin 6, hyperleptinemia with Leptin resistance and hypoadiponectinemia associated with obesity explains the preexisting inflammatory state in obese individuals which predisposes them to worse outcomes and fatality.
32844126 Leptin produced in visceral fat might play a role in the deterioration to mechanical ventilation. […] SARS-CoV-2 infected patients with a similar BMI as control patients appear to have significantly higher levels of serum leptin. […] The mean leptin level was 21.2 (6.0-85.2) vs 5.6 (2.4-8.2) ug/L for SARS-CoV-2 and controls respectively (p = 0.0007). […] This might be enhanced by an increase in leptin production induced by SARS-CoV-2 infection of visceral fat. […] Leptin receptors in the lungs are now more activated to enhance local pulmonary inflammation. […] Visceral fat, lung tissue and leptin production play an interconnecting role.
32941186 The recently discovered relationship between vitamin D and the infection pathway of the virus via the renin–angiotensin system (RAS) and the adipokines leptin and adiponectin play an important role.
32969629 Many evidences suggest an important role of adipose tissue in the production of pro-inflammatory cytokines (Leptin, adiponectin, TNFα, IL-6, MCP-1, PAI-1), involved in the pathogenesis and the exacerbations of these skin diseases.
32995660 Furthermore, this study underlines the use of immune modulators such as Leptin sensitizers, rather than immune suppressors as anti-inflammation therapies to switch the inflammatory response from a drastic immunological type 1 response to a beneficial type 2 effective one.
33045426 Impaired adipocyte-mediated immune function results in chronically high leptin levels and low adiponectin levels and anti-inflammatory adipokines.
33160363 Moreover, leptin, released by adipose tissue, helps to increase inflammatory milieu with a dysregulation of the immune response.
33206653 This finding suggests that a signal proportional to body fat mass, such as the hormone leptin, impairs the body’s ability to clear SARS-CoV-2 before pneumonia develops.
33250935 Sedentary group presented lower adiponectin (7573 ± 232 pg/mL), higher leptin (16,250 ± 1825 pg/mL) plasma concentration, and higher lymphocyte production of IL-17, IFN-gamma, TNF-, IL-2 in relation to active group, suggesting predominance of Th1 response.
33404078 Using a cytokine array containing 174 inflammation-related cytokines, we found significantly altered cytokine profiles in severe COVID-19 patients compared with those in mild patients or healthy controls, and identified leptin, CXCL-10, IL-6, IL-10, IL-12, and TNF-α as the top differentially expressed cytokines. […] Notably, leptin showed high consistency with CXCL-10 and TNF-α in predicting disease severity, and correlated with body mass index, decreased lymphocyte counts, and disease progression. […] Further analysis demonstrated that monocytes in severe patients with higher leptin levels were inclined toward M1 polarization. […] Mechanistic studies revealed that leptin synergistically up-regulated expression levels of inflammatory cytokines and surface markers with IL-6 in monocytes through STAT3 and NF-κB signaling pathways. […] Collectively, our results suggest that overweight COVID-19 patients were prone to have higher leptin levels, which further activated monocytes, resulting in amplified or dysregulated immune responses. […] Taken together, our findings argue that leptin correlates severity of COVID-19 and may indicate a possible mechanism by which overweight patients have a greater tendency to develop severe conditions.
33486829 We analysed furin, leptin, adipocyte fatty acid-binding protein, triglycerides, interleukin (IL)-6, IL-8 and C-reactive protein in serum from 166 children in the Pediatric Osteoporosis Prevention (POP) study collected at mean age (SD) 9.9 (0.6) years.
33512658 Key principals of the management of patients with genetic obesity during COVID-19 pandemic for patients that have contracted COVID-19 are to be aware of: possible adrenal insufficiency (e.g., POMC deficiency, PWS); a more severe course in patients with concomitant immunodeficiency (e.g., LEP and LEPR deficiency), although defective leptin signalling could also be protective against the pro-inflammatory phenotype of COVID-19; disease severity being masked by insufficient awareness of symptoms in syndromic obesity patients with intellectual deficit (in particular PWS); to adjust medication dose to increased body size, preferably use dosing in m2; the high risk of malnutrition in patients with Sars-Cov2 infection, even in case of obesity.