KYNURENINE
DrugBank ID: db02070
DrugCentral: kynurenine
Synonymous :(2s)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid | 3-anthraniloyl-l-alanine | l-kynurenine
Drug Sentece Context
Table 1. Analysis of context sentence of kynurenine gene in 2 abstracts.
| pmid | sentence |
|---|---|
| 32559180 | Targeted and untargeted metabolomics analyses identified altered tryptophan metabolism into the kynurenine pathway, which regulates inflammation and immunity. |
| 32597823 | After entry into cells, corona viruses (CoV) activate aryl hydrocarbon receptors (AhRs) by an indoleamine 2,3-dioxygenase (IDO1)-independent mechanism, bypassing the IDO1-kynurenine-AhR pathway. […] The IDO1-kynurenine-AhR signaling pathway is used by multiple viral, microbial and parasitic pathogens to activate AhRs and to establish infections. […] Because lack of physical exercise activates AhRs via the IDO1-kynurenine-AhR signaling pathway increasing risk of infection, physical exercise should be encouraged during quarantines and stay-at-home orders during pandemic outbreaks. |
| 32806897 | Key discriminant metabolites included markers of inflammation including elevated α-1-acid glycoprotein and an increased kynurenine/tryptophan ratio. |
| 32867244 | The rise in pro-inflammatory cytokines during the ‘cytokine storm’ induce indoleamine 2,3-dioxygenase (IDO), leading to an increase in kynurenine that activates the AhR, thereby heightening the initial pro-inflammatory cytokine phase and suppressing the endogenous anti-viral response. |