DrugBank ID: db00458
Synonymous :10,11-dihydro-n,n-dimethyl-5h-dibenz[b,f]azepine-5-propanamine | 5-[3-(dimethylamino)propyl]-10,11-dihydro-5h-dibenz[b,f]azepine | imipramin | imipramina | imipramine | imipraminum | imizine | n-(gamma-dimethylaminopropyl)iminodibenzyl | n-(γ-dimethylaminopropyl)iminodibenzyl
Drug Sentece Context
Table 1. Analysis of context sentence of imipramine gene in 1 abstracts.
|32975484||We find that fluoxetine, a widely used antidepressant and a functional inhibitor of acid sphingomyelinase (FIASMA), efficiently inhibited the entry and propagation of SARS-CoV-2 in the cell culture model without cytotoxic effects and also exerted potent antiviral activity against two currently circulating influenza A virus subtypes, an effect which was also observed upon treatment with the FIASMAs amiodarone and imipramine.|
|33163980||Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the enzyme prevents infection of cultured cells or freshy isolated human nasal epithelial cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vesicular stomatitis virus (VSV) pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 spike), a bona fide system mimicking SARS-CoV-2 infection.|