HISTIDINE

Drug Sentece Context

Table 1. Analysis of context sentence of histidine gene in 11 abstracts.

pmid	sentence
32553046	These parasites lack or have altered genes encoding histidine-rich proteins (HRPs) 2 and 3, the antigens recognized by HRP2-based RDTs.
32658489	The controversial and unprovable concept of aromaticity here enjoys being the agent that rationalizes the seemingly innocent role of histidine (His41 of Mpro).
32683439	A pair of histidine residues that are conserved in coronavirus spike proteins are predicted to be electrostatically frustrated at acidic pH in both pre- and post-fusion conformations. […] We suggest that an intermediate expanded conformation at endosomal pH could relax the frustration, allowing histidine protonation, and facilitating conformational conversion of coronavirus spike protein.
32765939	It is suggested that the non-toxic dipeptide carnosine (beta-alanyl-L-histidine) should be examined as a potential protective agent against COVID-19 infection and inflammatory consequences especially in the elderly.
32855259	A rare variant at bp 23463 of the SARS-CoV-2 genome was found, which corresponds to the S1 subunit of the spike protein, changing an arginine (R) residue to histidine (H).
32871846	Ivermectin docked in the region of leucine 91 of the spike and histidine 378 of the ACE2 receptor.
32919067	From analyses of spike protein sequences we identify patches of histidine and carboxylate groups that could be involved in transient proton binding.
32979815	The relative binding poses of Z93 fitted well in the binding site of both proteases and showed consensus π-π stacking and H-bond interactions with histidine and aspartate/asparagine residues of the catalytic triad.
33101829	Furthermore, we identified a specific substitution of tyrosine to histidine at position 41 in ACE2 that likely reduces the affinity to SARS-CoV-2 in horses and greater horseshoe bats.
33130280	The catalytic triad consisting of Serine-441, Histidine-296 and Aspartic acid-345 was identified as active binding site of TMPRSS2 using existing ligands.
33503560	The binding energy of the nonbonding interaction with Histidine 41 and Cysteine 145, present a clear view that 2(2E)-methyl-2-[(4-oxo-4H-chromen-3-yl)methylidene]-hydrazinecarbothioamide can irreversibly interact with SARS-CoV-2 protease.