GUANINE

DrugBank ID: db02377
DrugCentral: guanine
Synonymous : None


Drug Sentece Context


Table 1. Analysis of context sentence of guanine gene in 16 abstracts.

pmid sentence
32181901 Among the nonstructural proteins, the leader protein (nsp1), the papain-like protease (nsp3), the nsp4, the 3C-like protease (nsp5), the nsp7, the nsp8, the nsp9, the nsp10, the RNA-directed RNA polymerase (nsp12), the helicase (nsp13), the guanine-N7 methyltransferase (nsp14), the uridylate-specific endoribonuclease (nsp15), the 2’-O-methyltransferase (nsp16), and the ORF7a protein could be built on the basis of homology templates.
32376987 Herein, we found that a guanine rich tract, capable of forming intramolecular G-quadruplex in the presence of potassium ions, in the promoter region of human TMPRSS2 gene was quite important for gene transcriptional activity, hence affecting its function.
32451923 G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA.
32461321 For coronaviruses, RNA cap structure is first methylated at guanine N-7 (G-N-7) position by nonstructural protein 14 (nsp14), which facilitates and precedes the subsequent ribose 2’-O methylation by nsp16-nsp10 complex.
32484220 Molecular docking model suggests that nsp13 distorts the G-quadruplex structure by allowing the guanine bases to be flipped away from the guanine quartet planes.
32536162 In the present contribution we study, by all-atom equilibrium and enhanced sampling molecular dynamics simulations, the interaction between the SARS Unique Domain and RNA guanine quadruplexes, a process involved in eluding the defensive response of the host thus favoring viral infection of human cells. […] The results obtained evidence two stable binding modes with guanine quadruplexes, driven either by electrostatic (dimeric mode) or by dispersion (monomeric mode) interactions, are proposed being the dimeric mode the preferred one, according to the analysis of the corresponding free energy surfaces. […] This work also constitutes a first step of the possible rational design of efficient therapeutic agents aiming at perturbing the interaction between SARS Unique Domain and guanine quadruplexes, hence enhancing the host defenses against the virus.
32567979 One of the attractive drug targets is guanine-N7 methyltransferase which plays the main role in capping the 5’-ends of viral genomic RNA and sub genomic RNAs, to escape the host’s innate immunity.
32679620 Presenting antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) (TLR9 agonist) adjuvant.
32730589 Additionally, we show a new pattern of relative absent words (RAWs), characterized by the progressive increase of GC content (Guanine and Cytosine) according to the decrease of RAWs length, contrarily to the virus and host genome distributions.
32791468 G-quadruplex is a non-canonical nucleic acid structure formed by the folding of guanine rich DNA or RNA.
32845720 The tight control of Rho GTPase function by Guanine nucleotide Exchange Factors (GEFs) and GTPase Activating Proteins (GAPs) strongly suggests that localized control of these Rho regulators may contribute to TNT assembly and disassembly.
32923004 SARS-CoV-2 nonstructural protein 14 (NSP14) carrying RNA cap guanine N7-methyltransferase and 3’-5’ exoribonuclease activities could be a potential drug target for intervention.
32938769 The bifunctional nsp14 contains 3’-to-5’ exoribonuclease (ExoN) and guanine-N7-methyltransferase (N7-MTase) domains. […] Our study strongly suggests CoV nsp14 ExoN to have an additional function, which apparently is critical for primary viral RNA synthesis and thus differs from the proofreading function that - based on previous MHV and SARS-CoV studies - was proposed to boost longer-term replication fidelity.IMPORTANCE The bifunctional nsp14 subunit of the coronavirus replicase contains 3’-to-5’ exoribonuclease (ExoN) and guanine-N7-methyltransferase domains.
33076559 Herein, we summarize the present knowledge about base pairs containing the products of oxidative guanine damage and guanine. […] In addition, we describe base pairs that target the RNA-dependent RNA polymerase (RdRp) of RNA viruses and describe implications for the 2019 novel coronavirus (SARS-CoV-2): When products of oxidative guanine damage are adapted for the ribonucleoside analogs, mimics of oxidative guanine damages, which can form base pairs, may become antiviral agents for SARS-CoV-2.
33082451 For the C-to-U mutations, the context of the upstream uracil and downstream guanine from mutated position was found to be most prevalent.
33521757 Here, we reveal that Favipiravir, as a pyrazine derivative, could be incorporated into the viral RNA products by mimicking both adenine and guanine nucleotides. […] This structure provides a missing snapshot for visualizing the catalysis dynamics of coronavirus polymerase, and reveals an unexpected base-pairing pattern between Favipiravir and pyrimidine residues that may explain its capacity for mimicking both adenine and guanine nucleotides.