GTS-21
DrugBank ID: db05708
DrugCentral: gts-21
Synonymous :3-(2,4-dimethoxybenzylidene)anabaseine | dimethoxybenzylidene anabaseine | dmxb-a | dmxb-anabaseine
Drug Sentece Context
Table 1. Analysis of context sentence of gts-21 gene in 2 abstracts.
| pmid | sentence |
|---|---|
| 33126860 | The aim of this study was to determine whether GTS-21 (3-(2,4-dimethoxybenzylidene) anabaseine), an α7 nicotinic acetylcholine receptor (α7nAChR) agonist, could (1) inhibit hyperoxia-induced HMGB1 release into the airways; (2) enhance macrophage phagocytosis and (3) increase bacterial clearance from the lungs in a mouse model of ventilator-associated pneumonia. ) and subsequently challenged with PA. . […] The phagocytic activity of macrophages was significantly increased by GTS-21 in a dose-dependent manner. […] In addition, GTS-21 significantly inhibited the cytoplasmic translocation and release of HMGB1 from RAW 264.7 cells and attenuated hyperoxia-induced NF-κB activation in macrophages and mouse lungs exposed to hyperoxia and infected with PA. […] Our results indicate that GTS-21 is efficacious in improving bacterial clearance and reducing acute lung injury via enhancing macrophage function by inhibiting the release of nuclear HMGB1. |