GLISOXEPIDE


DrugBank ID: db01289
DrugCentral: glisoxepide
Synonymous : None



Drug Sentece Context


Table 1. Analysis of context sentence of glisoxepide gene in 6 abstracts.

pmid sentence
32462970 Two drugs Glisoxepide and Idarubicin used for treatment for diabetes and leukemia respectively were selected as stronger binder of EndoU. […] The binding free energies for Glisoxepide and Idarubicin were calculated to be -141 ± 11 and -136 ± 16 kJ/mol respectively. […] The IC50 were predicted to be 9.2µM and 30µM for Glisoxepide and Idarubicin respectively. […] Comparative structural analysis showed the stronger binding of EndoU to Glisoxepide and Idarubicin than uridine monophosphate (UMP). […] Surface area calculations showed buried are of 361.8Å2 by Glisoxepide which is almost double of the area occupied by UMP suggesting stronger binding of the drug than the ribonucleotide.