FUROSEMIDE


DrugBank ID: db00695
DrugCentral: furosemide
Synonymous :2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid | 4-chloro-5-sulfamoyl-n-furfuryl-anthranilic acid | 4-chloro-n-(2-furylmethyl)-5-sulfamoylanthranilic acid | 4-chloro-n-furfuryl-5-sulfamoylanthranilic acid | frusemide | furosemid | furosemida | furosemide | furosemidu | furosemidum



Drug Sentece Context


Table 1. Analysis of context sentence of furosemide gene in 12 abstracts.

pmid sentence
32622469 Inhaled furosemide, a small molecule capable of inhibiting IL-6 and TNFα, may be an agent capable of treating the Coronavirus Disease 2019 cytokine storm in both resource-rich and developing countries. […] Furosemide is a “repurpose-able” small molecule therapeutics, that is safe, easily synthesized, handled, and stored, and is available in reasonable quantities worldwide.
32628137 Chronic users of ACEi, ARB, or other antihypertensive drugs were matched according to age, sex, sick days before hospitalization, comorbidities, smoking, number of antihypertensive regimens, doxazosin use, furosemide use, and serum creatinine level.
32704455 This has enabled us to identify the loop diuretic furosemide as a candidate molecule. […] To pre-clinically evaluate furosemide as a putative COVID-19 therapeutic, we studied its anti-inflammatory activity on RAW264.7, THP-1 and SIM-A9 cell lines stimulated by lipopolysaccharide (LPS). […] Upon treatment with furosemide, LPS-induced production of pro-inflammatory cytokines was reduced, indicating that furosemide suppresses the M1 polarization, including IL-6 and TNF-α release. […] In addition, we found that furosemide promotes the production of anti-inflammatory cytokine products (IL-1RA, arginase), indicating M2 polarization. […] Accordingly, we conclude that furosemide is a reasonably potent inhibitor of IL-6 and TNF-α that is also safe, inexpensive and well-studied.
32799423 The expression level of TMPRSS2 was increased with a number of medications, such as diclofenac, furosemide, and dexamethasone, whereas other medications, such as allopurinol, suppressed the expression of this gene.
33008479 Hypokalemic or taking oral furosemide or steroids 7.