FINGOLIMOD


DrugBank ID: db08868
DrugCentral: fingolimod
Synonymous :fingolimod | fingolimodum



Drug Sentece Context


Table 1. Analysis of context sentence of fingolimod gene in 5 abstracts.

pmid sentence
32408155 Fingolimod is used for immune therapy in patients with multiple sclerosis. […] Patients with coronavirus disease 2019 (COVID-19) under Fingolimod treatment have not been described. […] We report a 57-year old female patient with a relapsing remitting multiple sclerosis under fingolimod treatment who experienced a severe COVID-19 infection in March 2020 (Extended Disability Status Scale: 2.0). […] Having peripheral lymphopenia typical for fingolimod treatment (total lymphocytes 0.39/nL [reference range 1.22-3.56]), the patient developed bilateral interstitial pneumonia with multiple ground-glass opacities on chest CT. […] Fingolimod medication was stopped. […] The implications fingolimod has on COVID-19 are complex. […] As an S1P analogue, fingolimod might enhance lung endothelial cell integrity. […] Future studies are needed to explore the risks and therapeutic effects of fingolimod in COVID-19 patients.
32416330 Case report RESULTS: We report a fingolimod-treated MS patient who developed severe COVID-19 but recovered after treatment with tocilizumab.
32505908 A multiple sclerosis patient infected by SARS-CoV-2 during fingolimod therapy was hospitalized with moderate clinical features, and recovered in 15 days. […] This study suggests that fingolimod-immunosuppressed patients, despite the low circulating lymphocytes, may rapidly expand antibody-secreting cells and mount an effective immune response that favors COVID-19 recovery after drug discontinuation.
32568969 These therapies include immunomodulators (i.e. intravenous immunoglobulin, thymosin α-1, IL-6, tocilizumab, cyclosporine, thalidomide, fingolimod), Chinese medicines (i.e. glycyrrhizin, baicalin, Xuebijing), anti-vascular endothelial growth factors (bevacizumab), estrogen modulating drugs, statins and nutritional supplements (i.e. vitamin A, B, C, D, E and zinc).