DrugBank ID: db00773
DrugCentral: etoposide
Synonymous :(−)-etoposide | 4-demethylepipodophyllotoxin β-d-ethylideneglucoside | 4’-demethylepipodophyllotoxin 9-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside) | 9-((4,6-o-ethylidine-beta-d-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3’,4’’:6,7)naptho-(2,3-d)-1,3-dioxol-6(5ah)-one | etoposide | etoposido | etoposidum | trans-etoposide

Drug Sentece Context

Table 1. Analysis of context sentence of etoposide gene in 6 abstracts.

pmid sentence
32416415 Etoposide-based protocol including dexametasone is the standard of care for secondary HLH.
32628591 Anti-inflammatory medications like, corticosteroids, tocilizumab, glycyrrhetinic acid, as well as etoposide may be very advantageous in decreasing the COVID-19 burden because, their mode of action targets the cytokine storms initiated by the CoV-19.
32895676 Since 1983, etoposide (VP-16) is being used in frontline cancer therapy against various cancer types, such as small cell lung cancer and testicular cancer. […] The treatment aims at dampening the cytokine storm and is based on etoposide in the case of central nervous system.
32931823 We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. […] Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. […] To our knowledge, this is the first reported case of use of etoposide in COVID-19.
33119257 An RMSD cutoff winnowed down the pool to 12, and free energy analysis (MM/PBSA) produced the final selection of 9 drugs: dihydroergotamine, midostaurin, ziprasidone, etoposide, apixaban, fluorescein, tadalafil, rolapitant, and palbociclib.
33254502 We further propose the combination of irinotecan (an in-market topoisomerase I inhibitor) and etoposide (an in-market topoisomerase II inhibitor) could potentially be an exceptionally effective treatment to protect critically ill patients from death caused by COVID-19-specific cytokine storms triggered by sepsis, ARDS, and other fatal comorbidities.
33364090 The patient was diagnosed with HLH as per HLH-2004 criteria and treated with dexamethasone and etoposide.
33523540 Standard therapy with high-dose glucocorticoids and etoposide used in adults is extrapolated from pediatric trials, with significant toxicity in older patients and those with poor performance status.