ENZALUTAMIDE
DrugBank ID: db08899
DrugCentral: enzalutamide
Synonymous :enzalutamida | enzalutamide
Drug Sentece Context
Table 1. Analysis of context sentence of enzalutamide gene in 2 abstracts.
| pmid | sentence |
|---|---|
| 32549073 | In metastatic as well as castration resistant PCa stages, adding androgen receptor targeted agents (abiraterone, apalutamide, darolutamide or enzalutamide) to androgen-deprivation therapy (ADT) could be considered in high risk patients. […] In regard to metastatic and castration resistant PCa, combination therapies with abiraterone, apalutamide, darolutamide or enzalutamide could be considered. |
| 32570240 | Both patients were receiving LHRH agonist therapy, and 1 patient was receiving enzalutamide. |
| 32824674 | Antiandrogens, such as bicalutamide and enzalutamide, are also under investigation. |
| 33558541 | Among these drugs, a second-generation antiandrogen agent, enzalutamide, was proposed because it reduces the expression of transmembrane serine protease 2 (TMPRSS2), a key component mediating SARS-CoV-2-driven entry, in prostate cancer cells. […] However, definitive evidence for the therapeutic efficacy of enzalutamide in COVID-19 is lacking. […] Here, we evaluated the antiviral efficacy of enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and Ad-ACE2-transduced mice. […] Enzalutamide effectively inhibited SARS-CoV-2 infection in human prostate cells, however, such antiviral efficacy was lacking in human lung cells and organoids. […] Accordingly, enzalutamide showed no antiviral activity due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells. […] Thus, our findings do not support the postulated protective role of enzalutamide in treating COVID-19 through reducing TMPRSS2 expression in lung cells. |