DrugBank ID: db10632
DrugCentral: date
Synonymous : None

Drug Sentece Context

Table 1. Analysis of context sentence of date gene in 1440 abstracts.

pmid sentence
31986261 No data on person-to-person or nosocomial transmission have been published to date.
31997390 To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok, Thailand) were analyzed.
32023775 We reviewed the currently available literature to provide up-to-date guidance on control measures to be implemented by public health authorities.
32031570 Retrospective, single-center case series of the 138 consecutive hospitalized patients with confirmed NCIP at Zhongnan Hospital of Wuhan University in Wuhan, China, from January 1 to January 28, 2020; final date of follow-up was February 3, 2020.
32037389 The remaining patient with severe pneumonia had shown signs of improvement by the cutoff date for data collection.
32056249 Based on the advice of the International Health Regulations Emergency Committee and the fact that to date 24 other countries also reported cases, the WHO Director-General declared that the outbreak of 2019-nCoV constitutes a Public Health Emergency of International Concern on 30 January 2020.
32079150 Using publicly available event-date data from the ongoing epidemic, the present study investigated the incubation period and other time intervals that govern the epidemiological dynamics of COVID-19 infections.
32083985 To date, CT findings have been recommended as major evidence for clinical diagnosis of COVID-19 in Hubei, China.
32087334 To date, there are no clinically approved vaccines or antiviral drugs available for these human coronavirus infections.
32105680 Clinicians should continue to follow the Centers for Disease Control and Prevention website to stay up to date with the latest information (
32125362 Descriptive case series of the first 18 patients diagnosed with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection at 4 hospitals in Singapore from January 23 to February 3, 2020; final follow-up date was February 25, 2020.
32141588 To date, the outbreak has spread to most provinces in China and 25 other countries within a relatively short period.
32143502 Although the fatality rate of SARS-CoV-2 is currently lower than SARS-CoV, the virus seems to be highly contagious based on the number of infected cases to date.
32145719 To date, the controlling of outbreak of corona virus disease 2019 (COVID-19) has entered into a critical period in China.
32155789 Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety.
32166607 There have been around 96,000 reported cases of coronavirus disease 2019 (COVID-2019) and 3300 reported deaths to date (05/03/2020).
32167524 The final date of follow-up was February 13, 2020.
32171059 The four datasets we fitted to were: daily number of new internationally exported cases (or lack thereof), by date of onset, as of Jan 26, 2020; daily number of new cases in Wuhan with no market exposure, by date of onset, between Dec 1, 2019, and Jan 1, 2020; daily number of new cases in China, by date of onset, between Dec 29, 2019, and Jan 23, 2020; and proportion of infected passengers on evacuation flights between Jan 29, 2020, and Feb 4, 2020. […] We used an additional two datasets for comparison with model outputs: daily number of new exported cases from Wuhan (or lack thereof) in countries with high connectivity to Wuhan (ie, top 20 most at-risk countries), by date of confirmation, as of Feb 10, 2020; and data on new confirmed cases reported in Wuhan between Jan 16, 2020, and Feb 11, 2020.
32171869 Final date of follow-up was February 25, 2020.
32171872 The primary endpoint was a negative conversion rate of coronavirus from the date of COVID-19 diagnosis(day7, day14), and assessed whether the pneumonia was progressing or improving by chest CT (day7).
32173241 To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China.
32175421 Several studies have been done to estimate the basic reproduction number in the early phase of this outbreak, yet there are no reliable estimates of case fatality rate (CFR) for COVID-19 to date.
32176772 All patients were confirmed to be infected with SARS-CoV-2 and the final date of follow-up was February 4, 2020.
32178768 Contacts were people with exposure to a patient with COVID-19 on or after the patient’s symptom onset date.
32179124 No systematic reviews on COVID-19 have been published to date.
32180292 From reports of 32 women to date affected by COVID-19 in pregnancy, delivering 30 babies (one set of twins, three ongoing pregnancies), seven (22%) were asymptomatic and two (6%) were admitted to the intensive care unit (ICU), one of whom remained on extracorporeal membrane oxygenation. […] No maternal deaths have been reported to date. […] Compared with SARS and MERS, COVID-19 appears less lethal, acknowledging the limited number of cases reported to date and that one woman remains in a critical condition.
32183901 To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care.
32186952 However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS.
32196406 While these common sense points will always be helpful, it is important that you keep up to date with the advice being given by the Centers for Disease Control and Prevention (CDC) and NHS England and how it might affect you personally. […] These suggestions have been produced using the most up-to-date advice available to us from our Scientific and Medical Advisors and are not intended to replace or supersede advice you may have been given from your health care professional.
32196426 Expected final online publication date for the Annual Review of Virology, Volume 7 is September 29, 2020.
32205090 Evidencing eTCB effectiveness is Taiwan’s success to date in containing and controlling the community-hospital-community transmission cycle.
32210236 All data are geo-coded and, where available, include symptoms, key dates (date of onset, admission, and confirmation), and travel history.
32211816 This cohort study was conducted from January 20, 2020, to February 10, 2020, in a single center at Renmin Hospital of Wuhan University, Wuhan, China; the final date of follow-up was February 15, 2020.
32212779 To date, there is no scientific guideline regarding management of cancer patients in a background of coronavirus outbreak.<br />.
32213786 As the situation with COVID-19 rapidly unfolds, it is critical that obstetricians keep up to date.
32216717 The severity of CXR findings peaked at 10-12 days from the date of symptom onset.
32217113 To date, the outcomes of 55 pregnant women infected with COVID-19 and 46 neonates have been reported in the literature, with no definite evidence of vertical transmission.
32219428 The study was conducted at the infectious disease department, Shenzhen Third People’s Hospital in Shenzhen, China, from January 20, 2020, to March 25, 2020; final date of follow-up was March 25, 2020.
32220284 The final date of follow-up was Feb 12, 2020.
32224151 To date, the clinical characteristics of COVID-19-infected cancer patients are largely unknown.
32225133 Assuming an arithmetical growth in the second variation of the data, we present a cubic adjustment model in which we estimate over 100 000 cases at 120 days consistent with the data recorded to date.
32232520 Since our hospital received the first patient with COVID-19 in Singapore, our centre has managed 16 COVID-19 cases to date.
32232652 By the end of follow-up date (Mar. 3, 2020), there were 16 non-severe cases (64%) and 9 severe cases (36%), 5 cases were dead (20%).
32233034 To date, multiple position statements and guidelines have been issued by various professional organizations to recommend practices in endoscopic procedures.
32234451 Although related to the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), COVID-19 shows some peculiar pathogenetic, epidemiological and clinical features which have not been completely understood to date.
32234466 Coronavirus disease 2019 (COVID-19) originated in the city of Wuhan, Hubei Province, Central China, and has spread quickly to 72 countries to date.
32234728 Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date.
32235085 It spread rapidly and to date has killed 3,242 persons with more than 81,000 cases of infection in China and causing over 126,000 global cases and 5,414 deaths in 166 other countries around the world, especially Italy.
32240128 Among 23 (30%) residents with positive test results, 10 (43%) had symptoms on the date of testing, and 13 (57%) were asymptomatic.
32241244 To date, computed tomography (CT) findings have been recommended as major evidence for the clinical diagnosis of COVID-19 in Hubei, China.
32241328 Following this date, attention quickly increased and has remained high over time.
32245904 To date, no effective treatment has been identified and management for critically ill patients relies on management in intensive care units.
32247050 Based on recently published literatures, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infection.
32247326 We used the date of the fourth revision of the case definition (Jan 27) to divide the epidemic into two time periods (Dec 24 to Jan 27, and Jan 28 to Feb 17) as the date of symptom onset.
32250385 Date of final follow-up was March 25, 2020.
32250958 The aim of this paper is to describe the utilization of a dedicated mobile health (mHealth) platform to disseminate up-to-date and validated information about SARS-CoV-2 to all medical staff of the Children’s Hospital at the University Hospitals of Geneva.
32251794 To date, no specific treatment has been proven to be effective for SARS-CoV-2 infection.
32251848 This article delineates some of those challenges and the responses to them which are known, to date.
32252141 The purpose of this review is to summarize known-to-date information about SARS-CoV-2, transmission of SARS-CoV-2, and clinical features.
32254064 To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19.
32255382 Demographic, clinical, laboratory, and treatment data were collected and analyzed, and final date of follow-up was February 24, 2020.
32258351 It is imperative for public health practitioners and the One Health community to stay up to date on the most promising potential therapeutic options that are under investigation. […] Thus, the purpose of this review is to synthesize the knowledge to date about remdesivir as a therapeutic option for coronaviruses, with a special focus on information relevant to the One Health community.
32259155 The aim of this paper is to review all the up to date evidence, including experiences from China and Italy, to guide the safe management of such patients when undergoing gynaecological procedures.
32259279 Unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, cases with suspected COVID-19 that were not confirmed by a laboratory test, and unreported maternal or perinatal outcomes were excluded.
32264957 To date, we have found it is one of the greatest challenges to human beings in fighting against COVID-19 in the history, because SARS-CoV-2 is different from SARS-CoV and MERS-CoV in terms of biological features and transmissibility, and also found the containment strategies including the non-pharmaceutical public health measures implemented in China are effective and successful.
32265182 To date, there are no medical treatments for COVID-19 with proven effectiveness.
32267098 In this review article, we summarized the published literatures to date concerning four different aspects: (a) gastrointestinal manifestations of COVID-19 infection; (b) microbiologic and virological investigations; (c) the role of fecal-oral transmission; and (d) prevention/control infection in the digestive endoscopy room.
32269177 To date, only three centers have performed a catheterization on a confirmed COVID-19 positive patient.
32270371 To date, there is no specific therapy for COVID-19.
32270521 This research statistically analyzed the effect of sex, region, infection reasons, birth year, and released or diseased date on the reported numbers of recovered and deceased cases.
32271458 The proposed classifier used different seven variables, namely, country, infection reason, sex, group, confirmation date, birth year, and region.
32271722 In the four clusters for which the date of exposure could be determined, presymptomatic transmission occurred 1-3 days before symptom onset in the presymptomatic source patient.
32281052 However, no standard treatment for this disease has been discovered to date.
32281213 Although pre-clinical results are promising, till date, there is dearth of evidence to support the efficacy of CQ or HCQ in preventing COVID-19.
32281330 Documents were screened following the inclusion criteria, and data were extracted in regard to registration date, study objective, type of design, sponsor, patient, sample size, intervention, and evaluation index.
32282022 No therapies have been shown effective to date.
32283052 To date, considerable knowledge gaps remain regarding the chest CT imaging features of COVID-19. […] We performed a systematic review and meta-analysis of results from published studies to date to provide a summary of evidence on detection of COVID-19 by chest CT and the expected CT imaging manifestations.
32283108 To date, the most promising broad-spectrum class of viral RdRp inhibitors are nucleoside analogues (NAs), with over 25 approved for the treatment of several medically important viral diseases.
32283185 To ensure availability of donor cells on the scheduled date of infusion, many sites now collect cryopreserve grafts before the start of pretransplant conditioning.
32285338 Few studies have been performed on viral transmission during surgery, but to date there is no study that demonstrates or can suggest the ability for a virus to be transmitted during surgical treatment whether open or laparoscopic.
32286607 To date, SARS-CoV-2 is known to enter the host cells via the angiotensin-converting enzyme 2 protein.
32288415 Furthermore, we propose the BAT model, which is composed of three parts: simulation of the return rush (Back), analytic hierarchy process (AHP) method, and technique for order preference by similarity to an ideal solution (TOPSIS) method, to figure out the best return date for university students.
32288418 We also evaluate the effectiveness of the quarantine measures and schedule the date to reopen Hubei Province.
32289472 To date, COVID-19 has affected over 944,181 people worldwide, resulting in over 47,312 reported deaths. […] As new findings emerge, there is an urgent need for up-to-date management guidelines.
32291505 To date there is no specific treatment available-the main goal of supportive therapy is to ascertain adequate oxygenation.
32291526 Several hypotheses have been proposed to date regarding the net effect of ACEI/ARB on COVID-19 infections.
32292517 No patient has died in our hospital to date.
32292529 As the epicentre of the initial outbreak, China has been updating the National COVID-19 Diagnostic and Treatment Guideline with up-to-date information about the disease. […] Medical professionals should diagnose and treat patients according to up-to-date guidelines.
32292686 To date, there is no specific therapy for COVID-19.
32292697 The Coronavirus disease 2019 (COVID-19) reminds us of the SARS outbreak in 2003, and up to date, corticosteroid is commonly administrated to severe patients with COVID-19.
32292826 While there is no intervention for the prevention or treatment of COVID-19 with proven clinical efficacy to date, tools to distil the current research landscape by intervention, level of evidence and those studies likely powered to address future research questions is essential.
32292911 Its accuracy has been 1.29% for the last day added and predicted by the 57 previous WHO situation reports (the date 18 March 2020).
32293020 Based on the evidence to date, there are several treatment options to consider for the relief of fever (acetaminophen, NSAID, oral glucocorticoids), cough (morphine), breathlessness (morphine, oxygen, fan), anxiety (benzodiazepines) and pain (NSAID, morphine).
32293875 Since the emergence of a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was firstly reported from Wuhan, China, to date, neither a specific vaccine nor antiviral drug against SARS-CoV-2 is available.
32294617 Individuals should get the most up to date information from the CDC website.].
32294718 To date, no case series have been published in Brazil.
32295811 Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date.
32298035 This document consolidates best available evidence to date and presents recommendations to minimize the risks of aerosolization and SARS-CoV-2 exposures in both the inpatient and outpatient settings.
32298149 The purpose of this article is to critically review some of the most frequently cited studies on the use of CT for detecting COVID-19. CONCLUSION. To date, the radiology literature on COVID-19 has consisted of limited retrospective studies that do not substantiate the use of CT as a diagnostic test for COVID-19.
32298480 FDA/EMA-approved monitoring guidelines, clinical practice guidelines, and relevant, up-to-date publications regarding initiation and monitoring of beta-blocker therapy were used to inform the recommendations.
32298767 But no studies to date have systematically described liver test abnormalities in patients with COVID-19.
32298982 and Aims: No valid treatment or preventative strategy has evolved till date to counter the SARS CoV 2 (Novel Coronavirus) epidemic that originated in China in late 2019 and have since wrought havoc on millions across the world with illness, socioeconomic recession and death.
32301746 Objectives The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to date, the epidemic has gradually spread to 209 countries worldwide with more than 1.5 million infected people and 100,000 deaths.
32302927 In radiology, much of the literature to date has focused on chest CT manifestations of COVID-19 (Zhou et al.
32302935 The COVID-19 pandemic is a major health crisis affecting several nations, with over 720,000 cases and 33,000 confirmed deaths reported to date.
32302954 The final date of follow-up was February 23, 2020.
32305269 The country might not be screening optimally, considering the number of COVID-19 tests conducted to date and the suspected cases who missed testing.
32305459 The most comprehensively tested case reported to date confirmed that the vertical transmission of COVID is unlikely, but still, more evidence is needed.
32307014 To date, there have been more than 1,260,000 COVID-19 patients, with a mortality rate of approximately 5.44%.
32308494 Most studies to date on COVID-19 have focused on disease etiology and the genomics of 2019-nCoV, with few reports on the epidemiologic and clinical characteristics of infected patients.
32310028 In this narrative review we discuss current evidence around detection of SARS-CoV-2 in human tears and forms of transmissions reported to date.
32310815 To date, we have enrolled 159 participants.
32312018 To our knowledge, there has been no prospective multicentre imaging study of COVID-19 to date.We proposed a hypothesis: There are some specific CT features on Chest CT of COVID-19 patients.
32312158 The widespread impact and chronicity of this pandemic makes it unique from any crisis faced by our training programs to date.
32313463 All cases reported to date have shown radiographic evidence of pneumonia. 2019-nCoV is diagnosed by real-time reverse transcriptase polymerase chain reaction.
32313660 To date, the anti-malaria drug hydroxychloroquine found to be a treatment option for SARS-CoV-2.
32313807 To date, only one case of GBS associated with this infection has been described.
32313824 No Food and Drug Administration approved treatment is available till date.
32313879 We estimate that Feb. 11, 2020 was the date with the highest transmission risk in Wuhan, which is consistent with the actual peak period of the reported case number (Feb.
32314868 Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date.
32315451 We did not apply any date limit or language limits.
32315963 Till to date, no epidemiological data on mental health problems due to outbreak of the COVID-19 and mass isolation were not available.
32317050 We analysed the sources, publication date, type and topic of the retrieved articles/studies.ResultsWe included 249 articles in this scoping review.
32317225 While clinical reports from China to date demonstrate that the majority of cases remain relatively mild and recover with supportive care, it is also crucial to be well prepared for severe cases warranting intensive care.
32320003 Among the 3066 patients who remained hospitalized at the final study follow-up date (median age, 65 years [IQR, 54-75]), the median follow-up at time of censoring was 4.5 days (IQR, 2.4-8.1).
32320509 The 10th of April saw the highest number of UK daily deaths (980) to date.
32321075 In 2020, hospitalizations for SARI, compiled from the date of the first confirmed case of COVID-19 up to the 12th week, exceeded the numbers observed during the same period in each of the previous 10 years.
32321524 To date, several drugs targeting RdRp enzymes are being employed for SARS-CoV-2 infection treatment.
32322159 While NIOSH has standardized N95 and N98 at 300nm, to-date there is no filter standards, nor special filter technologies, tailored for capturing airborne viruses and 100nm nano-aerosols.
32322398 The limited clinical data about the virus’s behavior to date, especially extrapulmonary symptoms, suggest that we should be aware of the possibility of initial cerebrovascular manifestations of COVID-19.
32322478 No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation.
32322654 To date, the world perhaps has never waited for the summer so impatiently in the entire Anthropocene, owing to the debate whether increasing temperature and humidity will decrease the environmental endurance of SARS-CoV-2.
32324358 As several healthcare interventions are essential even during pandemics, it is necessary for professionals working in such fields to get up-to-date information about the virus and its aspects that can influence patient care and suggested actions.
32327383 Ultrasound is highly sensitive in the detection of multiple lung pathologies which can be demonstrated in conjunction with COVID-19 however to date there are no specific, nor pathognomonic findings which relate to COVID-19 on ultrasound.
32328363 To date, data on the behavioral distress and psychiatric morbidity of those suspected or diagnosed with the 2019-nCoV and their treating health professionals are lacking.
32328367 Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling of patients worldwide.
32329432 Reverse transcriptase-polymerase chain reaction testing, our primary diagnostic tool to date, has sensitivity and timing concerns, owing to sampling/handling errors, as well as a complex virus-host interaction.
32329522 To date, the statistics of COVID-19 reported cases show that more than 80% of infected are mild cases of disease, around 14% of infected have severe complications, and about 5% are categorized as critical disease victims.
32333185 To date, biomedical forms of curative and preventative treatments for COVID-19 are at best limited.
32334502 To date, no definitive treatment orvaccine application exists for COVID-19.
32335244 COVID 19 been declared recently as a pandemic, to date has affected over 1,8881,365 with over 119,403 deaths in accordance to the global pandemic Real-Time Report.
32336927 In the last two decades, this is the 3rd deadliest Coronavirus pandemic, following SARS which lasted between 2002 and 2003 and Middle East Respiratory Syndrome (MERS) from 2012 till date.
32337148 She was successfully treated with coronary revascularization and stent placement, and remains on the ventilator to date as she quickly developed acute respiratory distress syndrome.
32337862 This article details the correct procedure required for effective hand hygiene and emphasises the need for nurses to keep up to date with evidence-based guidelines.
32339723 Afterward, instant fatality rate was calculated according to the number of deaths and cured cases on the same estimated diagnosis date.
32340050 To date, to our knowledge there are no studies regarding attitudes and experiences of outpatient medical personnel during a pandemic.
32341103 While relevant preclinical, experimental models to date favor a protective effect of RAAS-SCoV-axis inhibition on both lung injury and survival, clinical data related to the role of RAAS modulation in the setting of SARS-CoV-2 remains limited.
32341718 In the non-Hubei region of China it is expected that the epidemic will cease on the 30th of March 2020 and following this date no new confirmed patient will be expected.
32341913 This article addresses all information collected to date on the virus, in accordance with the guidelines of international health care institutions, and provides a comprehensive protocol for managing possible exposure to patients or those suspected of having coronavirus.
32342026 Articles listed in PubMed and Google sources for up-to-date information.
32342849 This is to our knowledge the longest duration of viral shedding reported to date.
32343428 All contacts of three clusters have been isolated and no new confirmed cases have been identified to date.
32344456 The goal of this review is to provide up-to-date, evidence-based recommendations or expert opinion when evidence is limited, for performing regional anaesthesia procedures in patients with suspected or confirmed COVID-19 infection.
32344679 To date, there are no available vaccines or specific therapeutic drugs to treat the virus.
32345226 To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described.
32346490 To date, no licensed antiviral drugs or vaccines are available against COVID-19 although several clinical trials are underway to test possible therapies.
32347685 The first part focused on the epidemiology until that date.
32347743 No arrhythmogenic deaths were reported. Conclusions - In the largest reported cohort of COVID-19 patients to date treated with chloroquine/hydroxychloroquine {plus minus} azithromycin, no instances of TdP or arrhythmogenic death were reported.
32348045 To date, there is no evidence to support an increase in complications of COVID-19 in these patients.
32348588 To date, there is no evidence of any effective treatment for COVID-19.
32348591 This document provides clinical practice guidelines based on available evidence to date to balance the risks of SARS-CoV-2 exposure with the risks associated with dysphagia.
32348598 Patients should exercise social distancing, optimise co-morbidities and be up to date with influenza and pneumococcal vaccines.
32348627 From November 2019 to date, almost six thousand papers have been published on COVID-19, the disease caused by SARS-CoV-2 infection.
32350048 To date, there is limited comparison data for these different testing platforms.
32351037 The onset date of the first case in Shanghai was 28 December, with the peak appearing on 27 January.
32351056 The date of population expansion was calculated based on the expansion parameter tau ( τ) using the formula t= τ/2 u.
32351243 Multiple gastroenterology associations have issued guidance and statements that would help healthcare providers in navigating these unprecedented and difficult times, and the Saudi Gastroenterology Association has provided this statement in an effort to bring the most up to date information for the management of endoscopy units in terms of resources, manpower planning, scheduling, as well as infection control policies and leadership.
32353457 Most studies on previous respiratory virus epidemics to date suggest surgical masks are not inferior compared with N95 respirators in terms of protective efficacy among healthcare workers.
32353723 Three megacities were differentiated by the spatial patterns and quantities of infected communities, average cases per community, the percentages of imported cases, as well as the potential risks, although their COVID-19 infection situations have been preliminarily contained to date.
32356654 The impact of dietary patterns and the commensal microbiome on susceptibility to and severity of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has been largely ignored to date.
32356867 The final follow-up date was April 2, 2020.
32356910 This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date.
32357381 This article aims to provide an overview of the various methods and their evidence till date.
32358406 To date, 1 patient was discharged from hospital, while the other had been transferred to the rehabilitation department.
32359226 The results demonstrated that to date, neonatal COVID-19 infection is uncommon, generally acquired postnatally, and associated with favorable respiratory outcomes.
32359227 To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available.
32359819 Herein, we briefly describe the affects of COVID-19 on Interventional Radiology residency training and summarize up to date guidance by governing bodies and key stakeholders.
32360053 Patient information was collected and organized by date of visit, sex, age, and systemic disease history.
32360108 All data were reported at death or after a minimum of 14 days from date of admission with COVID-19 disease.
32360480 Further, chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may limit spread of SARS-CoV-2 and morbidity and mortality of COVID-19 pandemic.
32361446 Data started from 12 February 2020-09 April 2020 (the date on Covid-19 was detected in Spain).
32362424 In the largest number of cases described to date of hospitalized patients with SARS-CoV-2 disease (2019-nCoViD), 26% required care in an intensive care unit (ICU). […] This narrative literature review aims to gather the main contributions in the area of intensive care to date in relation to the epidemiology, clinic, diagnosis and management of 2019-nCoViD.
32365233 To date the group, comprising UK-based specialists in diabetes, pharmacy and psychology, have produced two sets of guidelines which will be continually revised as new evidence emerges.
32367558 To date, there are no data in the literature on the comorbid dermatologic diseases and COVID-19.
32367683 From November 1, 2019 to March 31, 2020, we compared outcome of patients admitted for acute ST-elevation MI (STEMI) and non-ST elevation MI (NSTEMI) before (group 1) and after (group 2) January 25, 2020 which was the date when Hong Kong hospitals launched emergency response measures to combat COVID-19.
32370766 To date, there is no specific anti-COVID-19 treatment.
32370984 The goal of the present article is to provide up-to-date information on potential mental health risks associated with exposure of health professionals to the COVID-19 pandemic. […] Stress may also be caused by organizational factors, such as depletion of personal protection equipment, concerns about not being able to provide competent care if deployed to new area, concerns about rapidly changing information, lack of access to up-to-date information and communication, lack of specific drugs, the shortage of ventilators and intensive care unit beds necessary to care for the surge of critically ill patients, and significant change in their daily social and family life.
32370986 Moreover, to date there is no evidence that ACEi or ARB administration facilitates SARS-COV2 cell entry by increasing ACE2 tissue expression in either animal or human studies.
32371558 To date there is no evidence from randomized controlled trials that any single therapy improves outcomes in patients infected with COVID-19.
32372877 To-date, unfortunately there are no test standards for nano-aerosols (≤100 nm).
32374903 The major mutation detected to date in the SARS-CoV-2 viral envelope spike protein, which is responsible for virus attachment to the host and is also the main target for host antibodies, is a mutation of an aspartate (D) at position 614 found frequently in Chinese strains to a glycine (G).
32375067 Under moderate control of scenario two, the number of infected people will increase by 1.43-1.55 times of that in scenario one, the date of the epidemic being controlled will be delayed by about 10 days, and Algeria, Nigeria, and Kenya are in accordance with this situation.
32375144 There is, to date, minimal, unconfirmed evidence of spontaneous vertical transmission, though it may theoretically be increased with some procedures.
32375488 The severe acute respiratory syndrome coronavirus 2 pandemic is to date affecting more than a million of patients and is challenging healthcare professionals around the world.
32375909 According to the contents of the reports, we recorded in detail the gender, age, first symptom date, death date, primary symptoms, chronic fundamental diseases, and other data of the patients, and carried out analyses and discussion.
32376350 Assuming a service restoration date of either June 1 or July 1, we calculated the need to perform 216% or 263% of monthly baseline volume, respectively, to clear the backlog in one month.
32377486 To date, the number of confirmed cases and deaths has risen exponentially in more than 200 countries, with an estimated crude mortality ratio of at least over 2%.
32377576 Chatbots, if effectively designed and deployed, could help us by sharing up-to-date information quickly, encouraging desired health impacting behaviors, and lessening the psychological damage caused by fear and isolation.
32377638 To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an effective medicine for treating COVID-19, thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19.
32377709 To date, COVID‑19 has infected more than 3,000,000 people worldwide and killed more than 200,000 people.
32378464 A summary of available clinical guidelines with recommendations is presented, to provide community nurses with the up-to-date information required for protecting individuals living with a number of long-term conditions.
32378471 Much more serious than SARS-CoV in 2002, the current SARS-CoV-2 infection has been spreading to more than 213 countries, areas or territories and causing more than two million cases up to date (17 April 2020).
32378648 We provided a rapid review to critically assess the potential anti-coronavirus effect of remdesivir on COVID-19 and other coronaviruses based on the most up-to-date evidence.
32379077 Additionally, limited recommendations to date have been issued regarding scene investigative protocol, and there are a paucity of publications characterizing COVID-19 postmortem gross and histologic findings.
32381442 We highlight the value of engaging in humanitarian medical work, contributions of the hip and knee arthroplasty community to date, and future needs after the resolution of the pandemic.
32382737 To date, real-time RT-PCR is the only test able to confirm this infection.
32384153 With a run time of 15 to 20 minutes and first results being available in under 7 minutes for high RNA concentrations, the reported assay constitutes one of the fastest nucleic acid based detection methods for SARS-CoV-2 to date and may provide a simple to use alternative to RT-qPCR for first-line screening at the point of need.
32384397 Thirty-five children with COVID-19 infection matched for age, sex and date of admission, and who classified as non-severe type, were randomly selected from the hospital admissions.
32385799 To date, however, no specific recommendations are available for cardiothoracic robotic assisted surgery in COVID-19 positive patients.
32385985 The outbreak of coronavirus disease 2019 (COVID-19) is serious and there is no effective treatment to date.
  1. To date, previous cases reported urticaria as one of the cutaneous manifestations in COVID-19.(
32387384 The initial phase of the epidemic, from February 17th to March 23rd, 2020, is used to estimate the contact rates, infectious periods and mortality rate using both confirmed cases (by date of symptoms initiation), and daily mortality.
32387562 To date, the coding potential of SARS-CoV-2 remains partially unknown.
32387564 The first whole genome sequence was published on January 5 2020, and thousands of genomes have been sequenced since this date. […] We identify regions of the SARS-CoV-2 genome that have remained largely invariant to date, and others that have already accumulated diversity.
32389150 SARS-CoV-2, has been implicated in the largest recorded CoV outbreak to date.Initially the majority of COVID-19 cases were in China, but the virus has spread to more than 184 countries worldwide with the United States currently having more cases than any other country.
32389538 The service to date has been shown to be effective, safe, largely reproducible and reflective.
32389893 To date, the literature has predominantly consisted of case reports, case series, and systemic protocols for dealing with this deadly disease from a plethora of specialties with larger observational and randomized studies only now starting to emerge.
32391369 The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition.
32392282 The date of final follow-up was April 24, 2020.
32392288 While there is evidence that the burden of COVID-19 infection in hospitalized children is lesser than in their adult counterparts, to date, there are only limited reports describing COVID-19 in pediatric intensive care units (PICUs).
32393147 The groups that enable these inspirational collaborative accomplishments through their dedication, innovation, and imagination are the practicing physicians who have given freely and generously of their time and talents to help the whole health care community provide the most up-to-date care possible.
32393394 In these three MRT applications, potential cases of word misuse were evaluated by the regulator who then notified the practitioner to comply with existing regulations by a specific date. […] The MRT was then used on that date to determine compliance.
32393973 The case presentation is followed by a review of the literature to date on COVID-19 in regard to inflammatory bowel disease and pregnancy, respectively.
32395909 Medline was systematically searched using PubMed (search date March 19, 2020) for relevant studies in accordance with PRISMA guidelines.
32397511 To date, it is unclear why some patients develop severe symptoms.
32397688 To address this global crisis, up-to-date information on viral genomics and transcriptomics is crucial for understanding the origins and global dispersion of the virus, providing insights into viral pathogenicity, transmission, and epidemiology, and enabling strategies for therapeutic interventions, drug discovery, and vaccine development.
32398569 In this review, we summarize the epidemiologic and clinical features of children infected with SARS-CoV-2 reported in pediatric case series to date. […] Children rarely needed admission to intensive care units (3%), and to date, only a small number of deaths have been reported in children globally.
32399507 We estimated the reproduction number, R, during the early transmission phase in Lima from the daily series of imported and autochthonous cases by the date of symptoms onset as of March 30th, 2020. […] Prior to the implementation of the social distancing measures in Lima, the local incidence curve by the date of symptoms onset displays near exponential growth dynamics with the mean scaling of growth parameter, p, estimated at 0.9 (95%CI: 0.9,1.0) and the reproduction number at 2.3 (95% CI: 2.0, 2.5).
32399515 On the same date (also the date of this review), Africa had reported 5,999 confirmed cases, of which 3,838 (almost 65%) occurred in South Africa, Algeria, Egypt, Morocco and Tunisia, with the remaining 2,071 cases distributed unevenly across the other African countries.
32399995 To date, no study attempted to quantify the impact of the Covid-19 outbreak on incidence and treatment of acute stroke.
32402329 In the present paper, we provide an up-to-date review of the literature currently available on animal CoVs, focusing on the molecular mechanisms that are responsible for the emergence of novel CoV strains with different antigenic, biologic and/or pathogenetic features.
32403261 To date, most of the effective hand sanitizer products are alcohol-based formulations containing 62%-95% of alcohol as it can denature the proteins of microbes and the ability to inactivate viruses.
32404225 The country’s “go hard, go early” policy serves as an exemplar for the rest of the world to date. […] Though there has been no significant rise in referrals to secondary mental health services to date (4 May 2020), a rapid surge in mental health presentations is widely anticipated.
32404257 In the absence of concrete economic measures to date, and the scenario of economic uncertainty, we conclude that it is not possible to prevent gender-based violence in a comprehensive way, without considering the increase in unemployment, temporary and instability employment, economic dependency or the overload of household chores and reproductive tasks, among other elements that facilitate it.
32404498 We should adapt CME sessions to keep trainees up to date with core clinical competencies as they will continue to manage both COVID-19 and non-COVID-19 cases and this pandemic may last until year’s end.
32404630 To date there was one minor bleeding due to postoperative therapeutic anticoagulation.
32405603 Extracted data included author; date; study design; country; patient demographics; number of participants in severe and non-severe disease groups; prevalence of clinical gastrointestinal symptoms such as vomiting, nausea, diarrhoea, loss of appetite, abdominal pain, and belching; and digestive system comorbidities including liver disease and gastrointestinal diseases.
32406374 To date, the literature is widely heterogeneous regarding the loss of smell; therefore, we advise home isolation measures and/or social distancing, and to carry out diagnostic tests for SARS-CoV-2 when possible in those patients with sudden and severe loss of smell who cannot be promptly evaluated.
32408547 To date, there is no specific drug registered to combat the disease it causes, named coronavirus disease 2019 (COVID-19).
32410225 We urge policy-makers to ensure that nurses’ voices and perspectives are integrated into both local and global decision-making so as to minimize the structural injustices many nurses have faced to date.
32410714 The duration from the date of ICU admission to the study date was 11 (5-17) days, and the duration from onset of symptoms to the study date was 31 (24-36) days.
32410913 Children have had a relatively lower rate and a less serious course of infection as reported in the literature to date.
32412509 To date, there is no specific therapy for SARS-CoV-2 infection.
32413112 This estimate of excess cases represents 30.4% of the 716 total cases in those Iowa counties by that date.
32413502 In this comprehensive and up to date review we assess changes to working practices through the lens of each surgical specialty.
32414522 To the best of our knowledge, there was only one literature to date documented SARS-CoV-2 induced rhabdomyolysis as a late complication of COVID-19 patient.
32414622 To date, Coronavirus Disease 2019 (COVID-19) has affected at least 100,000 individuals worldwide, reaching thousands of mortalities (Zhou et al., 2020; World Health Organization, 2020).
32414678 To date, April 12, 2020, the virus has reached 209 nations, affecting 1.8 million people and causing more than 110,000 deaths.
32415519 Measures therefore need to be taken concerning the transmission of up to date and accurate information to medical students.
32415860 To date, data are limited regarding the trend of liver biochemistries over the course of illness.
32416074 Notably, RmYN02 shares 93.3% nucleotide identity with SARS-CoV-2 at the scale of the complete virus genome and 97.2% identity in the 1ab gene, in which it is the closest relative of SARS-CoV-2 reported to date.
32416357 Although to date, and by obvious reasons, the number of studies on this issue are still scarce, most results indicate that chronic exposure to air pollutants delays/complicates recovery of patients of COVID-19 and leads to more severe and lethal forms of this disease.
32416785 As a reference group, we randomly sampled ten patients per case, individually matched for age, sex, region (ie, Madrid), and date of admission to hospital (month and day; index date), from Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria (BIFAP), a Spanish primary health-care database, in its last available year (2018). […] We extracted information on comorbidities and prescriptions up to the month before index date (ie, current use) from electronic clinical records of both cases and controls.
32416984 We review our experience with the virus to date, our strategic approach to burn center function under these circumstances, and lessons learned.
32417380 Final date of follow-up was May 7, 2020.
32417802 The COVID-19 pandemic represents the greatest challenge to date faced by the medical community in the 21st century.
32418278 Hence, there is a need for simple, digestible, up-to-date, and accurate information on COVID-19 that is electronically disseminated and easy to obtain.
32418715 To date, no specific therapeutic drugs or vaccines are available to treat COVID-19 patients.
32418793 The 2013-2016 West Africa EBOV epidemic was the biggest EBOV outbreak to date.
32419769 To date, there have been zero incidences of radiographer healthcare worker transmission within our institution during the course of work.
32420652 To date, the coronavirus (COVID-19) outbreak that started in Wuhan, in the Hubei province of China, in late December 2019 seems to be eclipsing all of these previous infectious diseases in terms of its global reach and impact (Wang, Horby, Hayden, & Gao, 2020).
32420921 Italy is one of the most afflicted Country by this epidemic with 136,110 confirmed cases and 16,654 deaths on 9.4.2020 (at the same date, the Ministry of Health was reporting 143,626 cases).
32420923 From that date, the Regional Emergency Medical Services (EMS) Trust (AREU) of the Lombardy region decided to apply Business Intelligence (BI) to the management of EMS during the epidemic.
  1. What strategies have been employed to date and how successful have they been? […] The most widely adopted strategies for dealing with the COVID-19 pandemic to date have involved the epidemiological approach of encouraging good hygiene practices and social distancing, including orders to “shelter in place,” quarantine of high-risk individuals, and isolation of infected individuals.
32421858 A systematic review showed there was insufficient evidence to support the exclusive use of either CBEs or OBEs in assessment, however the studies conducted to date have rarely looked at high-stakes assessments due to concerns about the validity of OBEs1 .
32422341 The search strategy included clinical date published until May 9, 2020.
32423922 Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date.
32425316 This article, therefore, presents a critical review of hand sanitation approaches and products available on the market in light of the scientific evidence available to date.
32425470 To date, most of the medical literature, including Center for Disease Control guidelines, has relied on three necessary symptoms in making the diagnosis of COVID-19: fever, cough and shortness of breath.
32425484 From all the documents located, information was extracted on the date of publication, country of publication, type of study, assessment of the level of evidence and degree of recommendation, and results of interest to answer the research question.
32425486 A bibliographic search was conducted in the Medline, CINAHL, Scopus and WOS main databases, with no date limit and using the keywords “transmission”, “infection”, “contagious”, “spreads”, “coronavirinae”, “coronavirus”, “COVID 19”, “sars cov 2”, “nurses” and “nursing”.
32425490 A bibliographic search was made, without date limit, in Medline, CINAHL, PsycINFO, Scopus and Web of Science databases using the following keywords: “emotional management”; “health crisis” and “health crisis response”.
32425663 Published reports to date suggest that perinatal transmission of SARSCoV- 2 can occur but is rare.
32426202 VANISH has been utilized regularly in an anesthesia practice of 30+ providers and, to date, there have been no documented COVID-19 infections.
32426864 Up to date, a total of 1177 COVID-19 patients have been hospitalized.
32427103 To date, no work has assessed how this guidance differs across governments.
32428207 The median time to seropositivity observed for a reactive IgM and IgG result from the date of a positive PCR was 5 days (IQR: 2.75-9 days) and 4 days (IQR: 2.75-6.75 days), respectively.
32429249 When reviewing the literature it became obvious that keeping up-to-date with all relevant publications is almost impossible.
32429679 It would aid in emphasizing the up-to-date situation in a nutshell and the measures taken by the health sector of Pakistan to abate the risk of communication.
32430286 Here we review what is currently known on the mechanisms of action of CQ and HCQ as anti-viral, anti-inflammatory and anti-thrombotic drugs and discuss the up-to-date experimental evidence on the potential mechanisms of action of CQ/HCQ in Sars-Cov2 infection and the current clinical knowledge on their efficacy in the treatment of COVID-19 patients.
32430459 Based on one of the largest genome-wide association studies on type 2 diabetes mellitus (T2DM) to date (N = 898,130), T2DM was causally linked to raised ACE2 expression (P = 2.91E-03; MR-IVW).
32430840 To date, non-pharmacological interventions (NPI) have been the mainstay for controlling the coronavirus disease-2019 (COVID-19) pandemic. […] We employed a multivariate prediction model, based on up-to-date transmission and clinical parameters, to simulate outbreak trajectories in 16 countries, from diverse regions and economic categories.
32430957 We conducted a comprehensive literature search using PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure Database and Wan Fang Data until 20 April 2020 (studies were identified through PubMed alert after that date). […] Exclusion criteria were non-peer-reviewed or unpublished reports, unspecified date and location of the study, suspicion of duplicate reporting, and unreported maternal or perinatal outcomes.
32431120 The aim of the present study is to review the up-to-date professional literature dealing with the psychological impact of a pandemic outbreak on medical staff.
32432217 To date the FDA has given emergency use authorization (EUA) to 48 COVID-19 in vitro diagnostic tests and 21 high complexity molecular-based laboratory developed tests, as well as implemented policies that give broad authority to clinical laboratories and commercial manufacturers in the development, distribution, and use of COVID-19 diagnostic tests.
32433345 To date, several direct anti-SARS-CoV-2 agents have demonstrated promising in vitro and clinical efficacy.
32433799 According to the largest case series to date, most of the symptomatic patients complain of a mild respiratory syndrome (81%), while approximately 14% develop a severe disease requiring hospitalization and a further 5% need intensive care3 .
32434788 To date, there is no effective treatment.
32436005 In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic.
32437052 The data were obtained from the website of health organizations of 36 European countries and the website of WHO until the date of May 11, 2020.
32437340 Changes in vaccine doses administered to children and the effects of those changes on up-to-date status were examined for vaccinations recommended at milestone ages corresponding to the end of an Advisory Committee on Immunization Practices (ACIP) recommendation period for one or more vaccines (4).
32437912 To date, globally, over 30,000 people have died from this emerging disease.
32437930 We considered outbreak information where the first case registered in Marche with onset symptoms (26 February 2020) to the present date (20 April 2020).
32438330 As on date, no specific treatment is available for devastating COVID-19 (SARS-CoV-2) infection.
32438579 There were some family infections of coronavirus disease 2019 (COVID-19) in Taiwan to date.
32440666 To date, only a few studies have reported the distribution of lung lesions by segment.
32441351 To date, there is a paucity of patient selection criteria and prognosticators to facilitate decision making and enhance precious ICU capacity.
32441666 The final date of follow-up was March 20, 2020.
32442684 After this date, 39 patients with a diagnosis of cancer were operated on in our clinic.
32443459 To date, assays based on the reverse-transcription polymerase chain reaction (RT-PCR) in respiratory samples are the gold standard for COVID-19 diagnosis. […] To date, few studies have been conducted concerning the potential utilization of rapid testing for COVID-19, with some conflicting results. […] We can conclude that: (1) rapid diagnostic tests for COVID-19 are necessary, but should be adequately sensitive and specific; (2) few studies have been carried out to date; (3) the studies included are characterized by low numbers and low sample power, and (4) in light of these results, the use of available tests is currently questionable for clinical purposes and cannot substitute other more reliable molecular tests, such as assays based on RT-PCR.
32443871 With this prediction model, the overall infections, the infection peak, and date can accurately be predicted one week before they occur.
32444366 The final date of follow up was 5 May 2020.
32444393 The final date of follow-up was March 19, 2020.
32444460 Overall, 41% (8199/20 133) of patients were discharged alive, 26% (5165/20 133) died, and 34% (6769/20 133) continued to receive care at the reporting date. 17% (3001/18 183) required admission to high dependency or intensive care units; of these, 28% (826/3001) were discharged alive, 32% (958/3001) died, and 41% (1217/3001) continued to receive care at the reporting date.
32445776 To date, 23 confirmed cases of infections (0.4% of all HCWs) have been reported in a 30-day observation period.
32445839 The purpose of this review is to provide information, up-to-date as of the date of submission of the manuscript to the journal, on the various tests that have been developed, their scientific basis and their interpretation.
32447630 This review addresses the preliminary observations regarding the neurological disorders reported with COVID-19 to date and describes some of the disorders that are anticipated from prior experience with similar coronaviruses.
32449192 With over 4 700 000 infections to date across 188 countries and more than 310 000 deaths worldwide over the course of just 5 months, we were remarkably unprepared.[
32449374 To date, more comprehensive systematic reviews of laboratory findings on COVID-19 are missing.
32450087 To-date, there has not been a clear signal suggesting that asthma or treatment with inhaled steroids are a risk factor for severe COVID-19 disease.
32450344 To date, specific indications to treat this condition are lacking.
32451162 The last date of research for this study was April 4, 2020.
32451260 To date, there have been more than 2.3 million confirmed cases and more than 160,000 deaths globally caused by COVID-19.
32451301 Up to date, there are no reported deaths in pregnant women with Covid-19, while in the cases that have presented pneumonia because of Covid-19, the symptoms have been moderate and with a good prognosis in recovery.
32451351 We agree with the authors that, despite conflicting clinical data to date, it is possible that HCQ may have a protective effect in the setting of COVID-19.
32451367 There is great uncertainty regarding how countries’ characteristics will affect the spread of the epidemic; to date, there are few studies that attempt to predict the spread of the epidemic in African countries.
32451808 This global pandemic has affected almost the whole planet and caused the death of more than 315,131 patients as of the date of this article.
32452050 In this review, we provide a comprehensive and up-to-date overview of the different types of Clinical and Para-clinical diagnostic methods and their practical features, which can help understand better the applications and capacities of various diagnostic approaches for COVID-19 infected cases.
32452804 To our knowledge, this infoveillance study employs the largest, most comprehensive, and most fine-grained social media data to date to predict COVID-19 case counts in mainland China.
32452888 Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge.
32453411 The modelled epidemic with the full ban fitted the observed incidence of cases well, predicting 57 cases on March 6th in Australia, compared to 66 observed on this date, however we did not account for imported cases from other countries.
32453494 To date, few investigations have been carried out to ascertain the presence of SARS-CoV-2 in the seminal fluid with contrasting results.
32454808 No breast milk samples were positive for SARS-CoV-2 and, to date, there is no evidence on the presence of SARS-CoV-2 in breast milk of pregnant women with COVID-19.
32454981 Since no therapies have been formally approved and completely effective and safe to date, the best clinical choice is acquired only after consistent and fair communication and collaboration between licensed clinicians, researchers, regulatory authorities, manufacturers and patients.
32455534 To this date, no specific drugs or vaccines are available to treat SARS-CoV-2 despite its close relation to the SARS-CoV virus that caused a similar epidemic in 2003.
32455859 To date, despite no universal guidelines are available for dental procedures in pediatric dentistry during COVID-19 outbreak, routine dental practice should be postponed and only severe dental emergencies must be treated.
32456944 Most cases are managed as outpatients, however severe symptoms are also appearing and mortality to date is 16.2%.
32457048 We conducted a comparative cohort study of patients with rheumatic disease and COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR), compared in a 1:2 ratio with matched comparators on age, sex and date of COVID-19 diagnosis, between 1 March and 8 April 2020, at Partners HealthCare System in the greater Boston, Massachusetts area.
32458712 Only 187 urine samples have been reported to have been tested in the literature to date despite over 4 million cases of respiratory Covid 19 positive cases being reported worldwide.
32459192 The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 has been established to synthesize up-to-date information on the epidemiology, pathogenesis, and laboratory diagnosis and monitoring of COVID-19, as well as to develop practical recommendations on the use of molecular, serological, and biochemical tests in disease diagnosis and management.
32459675 First, they propose delaying the date that programs can access applicant data through the Electronic Residency Application Service, thereby affording students more time to complete clinical experiences, solidify their specialty decision, and strengthen their residency application.
32460208 Unfortunately, to date, there is no specific antiviral treatment for COVID-19.
32461194 This article, therefore, presents a critical review of hand sanitation approaches and products available on the market in light of the scientific evidence available to date.
32462701 These infection models have already been useful for studies of transmission and immunity, but to date only partially model the mechanisms implicated in human severe COVID-19.
32462756 A total of 166 patients receiving colorectal surgery from 20th December 2019 to 20th March 2020 at Department of General Surgery in Chinese General Hospital of People’s Liberation Army were enrolled, and further divided into two groups based on before or after admission date of 20th January 2020.
32463377 On that date there were 134,576 reported cases and 4,981 deaths worldwide.
32463716 To date, there has not been any broad assessment of urological surgery residency changes and concerns during the COVID-19 pandemic.
32464668 What explains the anemic global response to date?
32470120 In regression analyses controlling for demographic variables and survey date, older adult age was associated with perceiving larger risks of dying if getting COVID-19, but with perceiving less risk of getting COVID-19, getting quarantined, or running out of money, as well as less depression and anxiety.
32472683 Although RNA has been detected in various clinical samples, no reports to date have documented SARS-CoV-2 in human milk.
32472687 Characteristics of each season, including the rate of influenza-like illness (ILI), duration of epidemic, date of termination of epidemic, distribution of influenza virus strain and hospitalization were analyzed.
32473007 To date, no specific estimate of R0 for SARS-CoV-2 is available for healthcare settings.
32473151 Limited data exists to-date on the laboratory findings in children with COVID-19, warranting the conduction of this study, in which we pool the currently available literature data on the laboratory findings seen in children with mild and severe COVID-19.
32467561 To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19 and the current standard care relies on supportive treatments.
32468508 To date there are no studies in the literature that demonstrate its feasibility and efficacy in the context of the worldwide SARS-CoV-2 epidemic.
32470470 There are over 2118 on-going clinical trials underway, but to date none of these drugs have consistently proven effective.
32471004 The manifestations of COVID-19 in solid organ transplant recipients are only beginning to be understood with cases reported to date in transplant recipients on chronic immunosuppression.
32471009 There are now over 1 million confirmed cases of COVID-19 globally with more than 270,000 recorded deaths to date.
32474026 Till date, no drug has been approved for the treatment of this infection.
32474093 Indeed, in this review we discuss several neurologic aspects reported in the literature to date including the evidence and pathways of neuroinvasion in COVID-19 and the main neurologic disorders reported in the literature to date, as well as future perspectives and the potential long-term consequence of current neuroinfection in COVID-19 patients.
32474860 The last follow-up date was Feb.
32476001 In fact, within the SECURE-IBD database, there have been only 4 Greek IBD patients, to date, who have been reported as positive for SARS-CoV-2.
32476394 It was found out that to date there is very little data on the state of loro organs in patients with SARS-CoV-2 and no data on anosmia in the pediatric population.
32476607 Results were analysed in combination with sera collection date and clinical information.
32476796 In this review, we summarize the data on GI involvement to date, as well as the impact of COVID-19 on underlying GI diseases.
32479246 To date, no specific treatment has been proven to be effective for coronavirus disease 2019 (COVID-19).
32479632 To date, no report on COVID-19 pediatric patients in a large urban center with data on underlying comorbidities and co-infection for hospitalized cases has been published.
32479766 To date no evidence confirmed COVID-19 vertical transmission from infected pregnant mother to their fetus.
32479816 SARS-CoV-2 infection in pregnant women does not lead to fetus mortality, unlike other zoonotic coronaviruses such as SARS-CoV and MERS-CoV, and there is, to date, no evidence of intrauterine transmission to neonates.
32481690 This is especially true for the newly identified COVID-19 caused by SARS coronavirus 2 (SARS-CoV-2) for which, to date, no specific antiviral drugs or vaccines have been approved.
32481719 We summarize the most up-to-date information on the role of miRNAs in ASL homeostasis and host-pathogen interactions in the airway and discuss concepts for miRNA-directed therapy.
32485299 Using the Medicare POSPUF database, aerosol-generating procedures (AGPs) were mapped based on hospital referral regions, against up-to-date COVID-19 case distribution data, as of April 24, 2020.
32490842 This up-to-date analysis may elucidate the evolution of the COVID-19 pandemic in Italy.
32490972 The evidence generated on COVID-19 and ophthalmology to date is limited, although this is understandable given the circumstances.
32491297 To date the European experience with COVID-19 mortality has been different to the observed in China and Asia. […] We have adapted our predictive model of COVID-19-related mortality, which rested on the observed mortality within the first weeks of the outbreak and the date of the respective lockdown in each country.
32492529 To date, our hospital has treated thousands of COVID-19 positive patients and sits at the forefront of the United States response to this pandemic.
32493447 The name of the trial register is Iranian registry of clinical trial (IRCT), registration number is IRCT20120826010664N6, date of trial registration is April 7, 2020, FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32493460 The protocol version number is 1.0 and the date is 18 May 2020.
32493466 Here we estimate the effective reproduction number, Rt, of COVID-19 in Singapore from the publicly available daily case series of imported and autochthonous cases by date of symptoms onset, after adjusting the local cases for reporting delays as of March 17, 2020.
32493468 Secondary outcomes include mortality from the date of randomization until the last day of the study which will be the day all of the patients have had at least one of the following outcomes: 1) Improvement of two points on a seven-category ordinal scale. […] Duration of hospitalization from date of randomization until the date of hospital discharge or date of death from any cause, whichever comes first. […] Incidence of new mechanical ventilation uses from date of randomization until the last day of the study. […] Recruitment is finished, the start date of recruitment was on 9th April 2020 and the end date was on 14th April 2020.
32493475 Primary outcome will be measured until the end of treatment for each participant (until the date of the last dose taken by each patient). […] EU Clinical Trials Register: 2020-001530-35; Date of trial registration: 13th of April 2020; FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32493478 Protocol version: 1.2 05 April 2020 Recruitment is ongoing, started March 31 and anticipated end date is September 30, 2020. […], Protocol Registry Number: NCT04328961 Date of registration: April 1, 2020, retrospectively registered FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32493740 To date, persuasive evidence of important benefit in COVID-19 does not exist for any antiviral treatments, although for each treatment evidence has not excluded important benefit.
32494546 To date, there is no approved targeted treatment, and many investigational therapeutic agents and vaccine candidates are being considered for the treatment of COVID-19.
32494567 To date (17th April 2020) a total of 2,230,439 cases of COVID-19; 150,810 cases of deaths and 564,210 recovered cases have been reported worldwide. […] To date, there is no vaccine or no specific treatment for COVID-19.
32494931 To date, there is no licensed treatment or approved vaccine to combat the coronavirus disease of 2019 (COVID-19), and the number of new cases and mortality multiplies every day.
32495333 Taiwan’s success to date is grounded in proactive preparedness and deployment by the government and effective teamwork among government agencies, medical institutions, enterprises, and the public.
32496101 Health care providers are experiencing potentially morally injurious events that may violate their moral code or values, yet almost no research has been conducted on moral injury among health care providers to date.
32496357 Only 1 mortality (4.8%) to date, in a critically-ill heart/kidney patient who had been in the ICU prior to diagnosis.
32496919 Yet, despite an explosion in the number and availability of serologic assays to test for antibodies against SARS-CoV-2, most have undergone minimal external validation to date.
32497806 Optimal management of infectious diseases is guided by up-to-date information at the individual and public health level.
32498138 We measured the period from the date of illness onset to the date of COVID-19 confirmation. […] The estimated median period between the date of symptom onset and the date of COVID-19 confirmation was 4 days (95% confidence interval, 1-12). […] There was a delay in COVID-19 confirmation from the date of illness onset among the cases linked to the Shincheonji religious group.
32498503 Approximately 1,016,128 reported cases, 211,615 recovered cases and 53,069 deaths of COVID-2019 have been reported to date (April 2, 2020).
32498731 The relative search volume was obtained for ‘Coronavirus’, ‘handwashing’, ‘face mask’ and symptom related keywords, for the United Kingdom, from the date of the first confirmed case until numbers peaked in April.
32498752 Average preventive measure interest was calculated for the query terms “hand sanitizer,” “hand washing,” “social distancing,” and “COVID testing.” We then calculated the delay in statewide SAH orders from March 1, 2020, to the date of issuance and by-state presidential voting percentage.
32499154 The viruses remain a threat till date and are of serious concern since no vaccine or specified drug therapy has been approbated for treating human coronaviruses.
32499832 To date, clinical evidence and guidelines based on reliable data and randomized clinical trials for the treatment of COVID-19 are lacking.
32500648 In this manuscript, our goal was to provide a “up-to-date” account on this topic, through analysis of current literature and sharing our experiences during this pandemic.
32501378 The latest version of human coronavirus said to be COVID-19 came out as a sudden pandemic disease within human population and in the absence of vaccination and proper treatment till date, it daunting threats heavily to human lives, infecting more than 12, 11, 214 people and death more than 67, 666 people in 208 countries across the globe as on April 06, 2020, which is highly alarming. […] When no treatment or vaccine is available till date and to avoid COVID-19 to be transmitted in the community, social distancing is the only way to prevent the disease, which is well taken into account in our novel epidemic models as a special compartment, that is, home isolation.
32501397 To date the potential impact of previous infection history has been poorly investigated as a potential determinant of risk.
32502054 The patient reported in this case report is the youngest case reported in Chengdu, China to date.
32502319 At the date of writing this editorial, there is now agreement amongst experts that the first wave of the United Kingdom’s (UK) COVID-19 pandemic is in decline (1).
32503304 To date, data on COVID-19-related death cases among physicians from different medical specialties are incomplete and scattered.
32503352 Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans; the second-largest and most deadly outbreak to date occurred in Saudi Arabia.
32503620 Recruitment began on 20/03/2020 and the date by which the recruitment is anticipated to be completed is 30/05/2020.
32503657 Trial participants, investigators, care givers, outcome assessors, and date analysts are not blinded to group assignment. 210 patients are expected to be enrolled and allocated according to the ratio of 2 (Favipiravir group, n=140): 1(regular treatment group, n=70). […] Protocol version number 3.0, 10th April 2020 First Patient, first visit 17th March 2020; recruitment end date anticipated June 1, 2020.
32503874 The secondary endpoints will be proportion of participants relieved from clinical symptoms defined at the time (in hours) from initiation of the study treatment, all-cause mortality, discharged date, frequency of respiratory progression and treatment-emergent adverse events.
32504135 To date, no report on LU and neonates with SARS-CoV-2 infection has been published.What is new:• This study adds evidence about LU findings in neonates with SARS-CoV-2 infection.
32505220 We describe China’s strategies for prevention and control of COVID-19 (containment and suppression) and their application, from the perspective of the COVID-19 experience to date in China.
32505678 We analyzed our surgical practice since March 14th when the lockdown was declared up to date, May 14th (2 months).
32506109 Pandemic enveloped RNA Novel Corona Virus’ 2019 (SARS-CoV-2) appears as a beating reed which induce overwhelming outbreak all over the world since November 2019 to till date.
32507006 We describe our experience as the Division of Arthroplasty in the hospital at the epicenter of the COVID-19 pandemic in Singapore.Patients and methods - The number of COVID-19 cases reported both nationwide and at our institution from February 2020 to date were reviewed.
32507030 To date, the reasons for this have been generically attributed to old age and underlying diseases.
32507546 To date, there are varying levels of agreement on the optimal triaging of urologic oncology cases.
32509205 The current study reviewed published evidence of clinical interventions of severe and critical COVID-19, aiming to provide an up-to-date reference for further clinical treatment.
32510978 In this review, we highlight what is known to date about coronavirus disease 2019 and cardiovascular risk, focusing in on the putative role of the endothelium in disease susceptibility and pathogenesis.
32511245 Although double-membrane vesicles (DMVs) appear to be a pan-CoV RO element, studies to date describe an assortment of additional CoV-induced membrane structures.
32511692 The final date of follow-up was May 22, 2020.
32511859 The ongoing COVID-19 pandemic has to date infected more than one million people and led to tens of thousands of deaths across the globe.
32511912 To date, no drug or vaccine has been approved to treat the severe disease caused by this coronavirus, COVID-19.
32511989 It resulted in the maintenance of a high-volume, high-quality thoracic surgical oncology program with no Covid-19 positive cases to date.
32512950 To date, there are no specific antiviral agents available for this disease, currently known as COVID-19.
32513062 Our multidisciplinary team, at the suggestion of a parent, hosted 3 virtual “town halls” in which families could ask questions directly of pediatric otolaryngology, pediatric pulmonology and case management in order to efficiently obtain factual evidence-based up-to-date advice.
32513231 Date of trial registration: April 10, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32513299 Trial participants, investigators, care givers, outcome assessors, and date analysts are not blinded to group assignment. 750 patients are expected to be enrolled and the cases are allocated according to the ratio of 2 (Anluohuaxian combined with regular treatment group):1 (regular treatment group). […] Actual Study Start Date: April 1, 2020 Estimated Primary Completion Date: June 1, 2020 Estimated Study Completion Date: December 1, 2020 TRIAL REGISTRATION: ID: NCT04334265.
32513308 NCT04359810 Date of trial registration: April 24, 2020 Retrospectively registered FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32513502 We collected epidemiological information about «time» (date of onset of symptoms), «place» (zip code), and «person» (gender, age).
32513514 However, there have been no vaccines approved in the world to date.
32515384 The current pandemic of COVID-19 has infected around 2.5 million people with more than 125,000 deaths across the globe till date, and numbers are still rising.
32515404 Here, we present an overview of the clinical trials that are currently being conducted or have concluded to date on COVID-19 globally. […] Collectively, there are 1,528 trials reported for COVID-19 to date.
32516704 A plethora of treatments has been or is being assessed, but to date, none has been proven effective.
32516817 Guidance has come from expert opinion, professional societies and public health agencies, but to date, there is no report on how obstetrical practices have adapted these recommendations to their local situations.
32517882 To date, no effective vaccine is available which can combat the infection caused by this virus.
32518743 Although a number of improvement measures are ongoing, however, no study to date has addressed Rohingyas’ self-adopted strategies to mitigate disaster risks.
32520031 To date, no specific drug has been discovered for the treatment of COVID-19 and hence, people are in a state of anxiety.
32520135 Medical Uniforms date back from medieval times.
32520235 We chose the date of the first COVID-19 case to April 25, 2020, as the training period, and April 26 to May 3, 2020, as the test period.
32520285 In order to account for the stage of the pandemic, the baseline date was defined as the day in which the 10th death was reported.
32521062 To date there is limited information on how COVID-19 affects patients with a history migraine.
32521557 About 70 % of patients seem to experience a reduction of smell and taste in the course of the disease, with most of the studies published to date based on questionnaires and anamnestic data. […] A distinction between taste and taste disorders, i. e. a distinction between retronasal aroma taste and the olfactory system from the dysfunction of taste capsules and the further cranial nerves, was mostly not made in the studies available to date.
32522513 While much of the emphasis in obstetrics and gynecology to date has been on the as yet uncertain impacts of COVID-19 in pregnancy and on changes to surgical management, the pandemic has broad implications for ambulatory gynecologic care as well.
32523137 To date there are nearly 3 million people infected and more than 250,000 deaths caused by the disease worldwide. […] In Mexico, the first case was detected in February 2020, and to date there are 26,616 confirmed cases and 2,961 deaths throughout the country.
32523927 Coronavirus disease 2019 (COVID-19) complications include disseminated coagulation and thrombosis, but, to the best of our knowledge, the literature to date on these manifestations has been limited.
32524645 This process requires up-to-date drug information to ensure optimum use, particularly safety and efficacy profiles of the medications, until convincing evidence is reported.
32524746 To date, the world is struggling to find a cure/vaccination to this deadly virus.
32525558 To date, understanding whether acquired immunity and presence of anti SARS-Cov2 antibodies protects against reinfection is one the most important focus of the scientific community [1-2].
32525707 Hotline clinicians provided New Yorkers with clinical assessment and guidance, registered them for home symptom monitoring, connected them to social services, and provided a source of up-to-date answers to COVID-19 questions.
32526560 Details on the onset date of clinical symptoms, throat swab conversion, and course of disease were collected from medical records retrospectively.
32526721 For countries that showed a strong slowdown in the rate of infections we have extrapolated the expected saturation of the total number of infections and the expected final date.
32527257 To date, an ongoing experimental therapy with monoclonal antibody against the IL-6 receptor in Italy seems to have beneficial effects on severe lung disease and prognosis in patients with Covid-19 infection.
32527341 The clinical data of COVID-19 patients treated in the Second People’ Hospital of Fuyang City from January 20th to February 18th in 2020 were retrospective analyzed, including the demographic and epidemiological date, vital signs and hematology indexes, etc. on admission.
32529866 With limited knowledge about SARS-CoV-2, no approved treatment or vaccine is available till date.
32530314 To date its adoption for Amyotrophic Lateral Sclerosis (ALS) care is still in a preliminary stage.
32530816 For anosmia and ageusia, we assessed whether the respective GT correlated with Covid-19 cases and deaths both throughout 2020 and specifically before March 16, 2020 (i.e., the date when the media started reporting that those symptoms could be associated with Covid-19).
32531138 To date, little is known about the viral shedding duration, clinical course and treatment efficacy of COVID-19 near Hubei Province, China.
32531777 Much of the work carried out to date involves the differentiation of bacterial and viral sources of infection and often the detection of bacterial and viral co-infection.
32532356 Patients screening commenced on 16th April and an estimated date of the recruitment of the final participants will be around end of July. .
32532596 At the time of publication, this review offers the most up-to-date recommendations for clinical practitioners in radiology departments, including radiographers.
32532802 Of countries that have undertaken suppression to date, lower income countries have acted earlier.
32532933 To date, seven known strains of HCoVs belonging to four genera (i.e., α?, β?, γ, and δ-CoV) have been recognized; the latest one has been identified as the SARS-CoV-2. […] To date, despite the whole world effort to review various aspects of SARS-CoV-2, including epidemiology, clinical manifestations, diagnosis, and treatment options, there are still gaps in the knowledge of this disease and many issues remain unclear.
32532942 No systematic reviews have been published on this topic to date.
32533062 Coronavirus infections of multiple origins have spread to date worldwide, causing severe respiratory diseases. […] It has created a severe worldwide outbreak beginning in late 2019, leading to date to over 4 million cases globally.
32533197 To date, there is no specific treatment for COVID-19 induced AKI.
32533777 To date, no data have ever been reported to reflect the clinical features of Corona Virus Disease 2019 (COVID-19) among these patients with pre-existing ILD.
32534175 A hypothetical three-part prevention, diagnostic, and treatment approach based on an up-to-date scientific literature review for COVID-19 is proposed.
32534210 The clinical outcomes of these operative patients were monitored up to 12 May 2020, the final date of follow-up, a minimum of 15 days after all patients were discharged from the hospital.
32534465 With the success of slowing disease spread in many countries to date, and reduced workload due to limitations on elective surgery in many institutions, there is more time and opportunity to be proactive in implementing measures to mitigate or minimise potential adverse psychological effects and improve, restore and preserve the wellbeing of the workforce now and for years to come.
32535955 To date it has resulted in ~6.5 million confirmed cases and caused almost 400,000 related deaths worldwide.
32536205 The evidence to date indicates that CGM offers promise as an effective tool for monitoring hospitalized patients.
32537425 To date, no cases of human pancreatitis have been identified as related to a COVID-19 infection, although multiple other gastrointestinal symptoms have been described.
32537561 This review is correct as of the date published and will be updated as more diagnostic tests come to light.
32538276 To date, there is no confirmed treatment or vaccine prevention strategy against COVID-19.
32538809 Review of relevant manuscript published up to date, draft creation correctedt hough modified nominal group until final corrected manuscript.
32540268 This study considers up-to-date information on the biological determinants shared by COVID-19 and renal disease, and aims to provide evidence-based recommendations for the clinical management of RCC patients with COVID-19.
32540369 Daily numbers of confirmed cases of each category were plotted by date of onset, and the epidemic form of each category was inferred.
32540737 There is no evidence to date that pioglitazone upregulates ACE2 in the alveolar cells; rather, there is evidence from animal studies of upregulation of ACE2 in insulin sensitive tissues, which might have a protective effect on lung injury.
32541085 To date, no medication supported by randomized clinical trials has been approved for the treatment of COVID-19.
32541496 The evidence to date of Chinese medicine in treatment of coronavirus-related pneumonia will be systematically reviewed and meta-analyzed.
32542188 To-date (4-22-2020) it affected over 2.6 million people and resulted in nearly 200,000 death worldwide mainly due to severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2).
32542213 Numerous studies are ongoing focusing on anticytokine therapies, antibiotics, and antiviral agents, but none to date have focused on treating the underlying thrombotic coagulopathy in an effort to improve respiratory failure in COVID-19.
32542402 It is vital that public health officials provide clear and up-to-date information about protective measures and crucial communications to respond to information-seeking behavior across NYC.
32544281 To date, no data have ever been reported to reflect the prevalence of Corona Virus Disease 2019 (COVID-19) among these outpatients.
32544725 However, the present detailed report of up-to-date knowledge on this topic can provide a useful source for further studies focusing on more deepened investigations of SARS-CoV-2 behaviour in the environment.
32544872 In this commentary we perform a bibliometric review of the available academic literature about COVID-19 in the top 20-ranked ENT journal, with the goal of providing an overview of what has been published to date and encouraging a shift towards quantitative research.
32544884 There is, however, no effective antiviral drug that can be used to treat COVID-19 to date.
32545925 To date, there have been reports of neurologic manifestations in COVID-19 patients including ischemic strokes, Guillain-Barre Syndrome and anosmia.
32546458 The ongoing pandemic of Covid-19 caused by the SARS-CoV-2 virus has infected more than 6 million all over the world and has caused more than 3.8 lakh fatalities till date(1) Health workers are the frontline responders and are exposed to a plethora of health hazards.
32547323 Rationale: Up to date, the exploration of clinical features in severe COVID-19 patients were mostly from the same center in Wuhan, China.
32547911 In the opinion of the medical societies of hygiene and pediatrics undersigning the present statement, the analyses published to date regarding transmission of SARS-CoV-2 and the course of CoVid-19 show that children play a much less significant role in the spread of the virus than do adults. […] According to the findings available to date, not only do children and adolescents less frequently fall ill with CoVid-19, they also generally become less severely ill than do adults.
32549076 To date there is no study that demonstrates or can suggest the ability for a virus to be transmitted during surgical treatment whether open, laparoscopic or robotic.
32549337 Case confirmation was not performed in all hospitalized patients, but 72.15% of hospitalized patients had favorable outcomes to date.
32549531 Despite initial difficulties in management of such patients, the constant increase of literature in the field is to date clarifying some questions from clinicians.
32550040 To date, no evidence shows that ACEIs or ARBs increase the susceptibility and mortality of patients infected with SARS-CoV-2, and hence, it is not advisable to discontinue such drugs in patients with cardiovascular disease.
32552509 Visit volumes were assessed weekly and practice patterns were compared before and after March 15, 2020, as this was the date of a major statewide stay-at-home order in Ohio. Results: Before March 15 the mean in-person visit per week was 5129.4 and decreased to 866.7 after that date.
32552659 With the large numbers of undifferentiated patients managed by the ED to date, more than 820 patients with COVID-19 have been identified in the hospital.
32552751 To date, there is no available literature on the clinical data on COVID-19 patients in Iran.
32552794 Finally, we estimate the date when the first infected case occurred in Wuhan. […] The date of first infection is estimated as 30 November 2019.
32553503 In summary, based on the currently available evidences and as recommended by several medical societies, ACEi or ARB should not be systematically discontinued because to date no safety signal was raised with the use of these drugs.
32553562 Up to date, a lot of reports have shown that olfactory dysfunction is related to viral infections but no exact mechanism, clinical course, and definite treatment have been discovered, which is also same in COVID-19.
32554861 This study is a retrospective, single-center case series of the 238 consecutive hospitalized patients with confirmed COVID-19 at the First Hospital of Changsha city, China, from 01/21 to 02/14, 2020; the final date of follow-up was 02/27, 2020.
32554901 The most commonly used CFR is thecase fatality ratio, typically constructed using the estimated number of deaths to date divided by the estimated total number of confirmed infected cases to date.
32555565 In order to evaluate this trend, we analyzed the literature data published since the beginning of the COVID-19 pandemic to date, in addition to our intensive cardiac care unit (ICCU) experience.
32555974 Studies carried out to date on possible SARS-CoV2 drug targets highlight glycoprotein S, Mpro (main protease or protease type 3C), and a member of the transmembrane serine protease II families (TMPRSS2).
32556054 However, non-pharmacological approaches have proven to be the most efficient strategy to date.
32557011 To date, emerging anti-SARS-CoV-2 treatments are warranted to control epidemics.
32557847 Since December 2019, SARS-CoV-2 epidemic has spread all over the world.1 To date, few reports regarding the cutaneous involvement in COVID-19 have been published.2,3 Herein, we report a four cases series describing skin lesions probably related with COVID-19.
32558655 Sixth, following experiences to date in responding to the COVID-19 infodemic and the lessons from other disease outbreaks, infodemic management approaches should be further developed to support preparedness and response, and to inform risk mitigation, and be enhanced through data science and sociobehavioral and other research.
32558877 ACEI/ARB use was defined as prescription fillings 6 months prior to the index date.
32558916 Articles were excluded if they did not include specific ventilator allocation recommendations, were in draft status, did not include their state department of health, or were not the most up-to-date guideline.
32559308 Given the unknown effects that relaxation of social distancing measures will have on the infection rate, we review the evidence to date to see whether a history of haematological malignancy is associated with increased risk of COVID-19.
32559451 Consistent with previous modelling studies and country-specific COVID-19 responses to date, our analysis estimated that a high proportion of cases would need to self-isolate and a high proportion of their contacts to be successfully traced to ensure an effective reproduction number lower than 1 in the absence of other measures.
32560340 The high contagiousness of the virus, the strong impact on the health system of the various countries and the absence to date of treatments able to improve the prognosis of the disease make the introduction of a vaccine indispensable, even though there are currently no approved human coronavirus vaccines.
32560745 Identifier: IRCT20120225009124N4 version 1; Registration date: April 2 2020.
32562316 To date, the recently discovered SARS-CoV-2 virus has afflicted >6.9 million people worldwide and disrupted the global economy.
32562477 We finally perform a Monte Carlo simulation with 25,000 runs to evaluate a random uncertainty in the prediction of the date of a substantial reduction in the number of diagnosed daily cases per swab.
32562913 In 2019, a new coronavirus (SARS CoV2) infecting humans has emerged in Wuhan, China which caused an unprecedented pandemic involving at least 185 countries infecting 2.5 million people till date.
32562915 In general, based on existing data published to date, 80.9% of patients infected with the virus develop mild infection; 13.8% severe pneumonia; 4.7% respiratory failure, septic shock or multi-organ failure; 3% of these cases are fatal.
32563019 In this paper, we have reviewed the relevant knowledge based on up-to-date literature.
32563601 One thousand six hundred fifty-one of 3,369 patients tested have had SARS-CoV-2-positive results to date.
32563745 Protective factors included having sufficient medical resources, up-to-date and accurate information, and taking precautionary measures.
32564417 Some systemic and biologic psoriasis treatments [SBT] have been associated with an increased risk of infection.1 To date, more and more data regarding the risk of COVID-19 infection in patients receiving SBT becomes available.2-5 To enrich these data, we evaluated the frequency of severe COVID-19 infections, defined as hospitalisation or death, in psoriasis patients receiving SBT, especially during the 4 months following SBT initiation.
32565599 The review focuses on the various approaches adopted till date for developing effective therapeutic strategies including combination of drugs, vaccine therapy, and convalescent plasma therapy to combat this viral outbreak.
32565901 The Brazilian Gastrointestinal Tumours Group board of directors and members sought up-to-date scientific literature on each tumour type and discussed all recommendations by virtual meetings to provide evidence-based-and sometimes, expert opinion-recommendation statements.
32566128 During COVID-19 pandemic, allergists have the responsibility of balancing individual patients’ needs with public health issues, and innovative tools, such as telemedicine and digital medicine services, can be helpful to reduce the risk of viral spreading while delivering up-to-date personalized care.
32566234 Sequences were selected based on the travel history of the individual and the collection date.
32567995 Till date, no potential medicine/ drug is available to cure the infected persons from SARS-CoV-2.
32568499 We carry out a review of the little scientific evidence based mainly on the few publications available to date and on the recommendations of the main scientific societies regarding which patients should undergo surgery, when surgery should be performed and how patient visits should be organize.
32569196 All the above databases will be searched from the available date of inception until the latest issue.
32569422 The consensus to date is that most infants and children only have mild COVID-19 symptoms and few require intensive care.
32570240 To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown.
32570713 Little information on the SARS-CoV-2 virus in animals is available to date. […] Whereas no one husbandry animal case has been reported to date, which would have significant implications in food safety, companion animals play a role in COVID-19 epidemiology that opens up new questions.
32570819 The public relied on online sources, whether through official websites or phone-based applications, to acquire up-to-date health information, provide accurate instructions, and limit misinformation.
32570995 To date, there has been no definite therapy for COVID-19.
32571224 To date, there have been few reports of the varying degrees of illness caused by the COVID-19.
32571528 Our work also stresses the importance of reliable up to date epidemiological data in order to accurately assess the impact of Public Health policies on viral outbreak.
32571980 Detection of SARS-CoV-2 infections to date has relied heavily on RT-PCR testing. […] Combining excess ILI counts with the date of onset of community transmission in the US, we also show that the early epidemic in the US was unlikely to have been doubling slower than every 4 days.
32572816 To date May 5 2020, if we carry out a search in pubmed with the keyword “COVID-19”, more than 9000 papers appear.
32573501 To date, however, we know that COVID 19 affects numerous areas of the body (1,2).
32573538 To date, in the treatment of COVID-19 in different countries, a little more than 10 drugs are used.
32574109 Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 61 is January 8, 2021.
32574177 We first used case reports from Japan, Singapore, and Korea to investigate the date of flights of infected travelers.
32574232 However, to date, efforts at improving sanitary safety in toilet use have been insufficient.
32574277 There are, to date, no adequately powered prospective trials addressing this important question.
32574285 In conclusion, to date, no convincing evidence has been found for vertical transmission of SARS-CoV-2.
32574286 To date, many cases have been reported in the pediatric age group, most of which were from China.
32574303 Then, we consider the Lombardy case and calibrate the model with the number of dead individuals to date (May 5, 2020) and constrain the parameters on the basis of values reported in the literature.
32575505 Nevertheless, to date, the best/optimal method to screen HWs for SARS-CoV-2 infection is still under debate, and data on the prevalence of SARS-CoV-2 infection in HWs are still scarce.
32575763 Iran has faced one of the worst COVID-19 outbreaks in the world, and no studies to date have examined COVID-19-related stress in the general Iranian population.
32576386 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date.
32576468 In aviation after a prolonged period of absence from flying, this deficit in keeping skills and thinking up to date is known as being “out of currency” or “not current”.
32576811 The number of people infected up to the date of lockdown was also registered.
32578811 We use a time series analysis of deaths due to COVID-19 referenced to the date of deaths (as opposed to the date in which the test results were obtained). […] The use of a time series of deaths due to COVID-19 referenced to the date of the event allows a better understanding of the effects of the SDS on the progression of the COVID-19 epidemic in São Paulo State, Brazil.
32579306 Based on reports to date, neurological signs or symptoms appear in 30-50% of hospitalized COVID-19 patients, with higher incidence in those with more severe disease.
32579957 Up-to-date, a number of mechanisms have been postulated for COVID-19-associated cardiovascular damage including SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) activation, cytokine storm, hypoxemia, stress and cardiotoxicity of antiviral drugs.
32580535 Compared to scenario I, it was found that in scenario III, the cumulative number of patients would increase by 107 and the date of occurrence of the last patient would be delayed by 92 days.
32581810 To date, there are no specific therapeutic strategies for treatment of COVID-19.
32582324 To date, April 25, 2020, more than 2.4 million humans are infected and more than a hundred thousand deaths have been reported from more than 200 countries from COVID-19.
32582615 The final date of follow-up was March 6th, 2020.
32582739 We also estimate the fraction of the population that would be infected by the beginning of May, at the official date at which the lockdown should be relaxed.
32583671 To date, no cases have been reported on the effects of COVID-19 in laryngectomees.
32584779 To date, there is limited evidence on how the infodemic may have the potential to influence psychobehavioural responses to the crisis.
32584795 To date, data to assess the prevalence and severity of COVID-19 among pregnant U.S. women and determine whether signs and symptoms differ among pregnant and nonpregnant women are limited.
32586214 The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 is due to the ability of SARS-CoV-2 to invade endo¬thelial cells via angiotensin-converting enzyme 2 (ACE2), which is expressed on the endothelial cell surface.
32586323 This was a retrospective cohort study from electronic case records of the first 450 patients admitted to our hospital with PCR-confirmed COVID-19, 77% of the total inpatient caseload to date.
32586363 Registration date is April 14, 2020.
32586399 Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection (Thy-Support), Identifier: NCT04348513, date of trial registration: April 16, 2020, EudraCT Identifier: 2020-001623-13, date of trial registration: April 22, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32587651 No vaccine has been developed against the 2019-nCoV virus to date.
32588589 Case studies to-date indicate that this infection causes a mild illness (i.e. pneumonia or mild pneumonia) in approximately 80% of cases, and most cases recove; 14% have a more severe illness, 6% experience a critical illness. […] This article contains up-to-date information as at 04/04/2020.
32589600 To date, many biomarkers reflecting the main pathophysiological characteristics of the disease have been identified and associated with the risk of developing severe disease.
32590725 In the global coronavirus disease 2019 (COVID-19) pandemic, to date, delivery of critically ill pregnant patients has predominantly been by cesarean.
32591166 Although the number of studies to date is limited, LUS findings have demonstrated high diagnostic sensitivity and accuracy, comparable with those of chest computed tomography scans.
32591466 We summarize the immunogenicity of leading vaccine candidates tested to date in animals and humans, and discuss the outcome and interpretation of virus-challenge experiments in animals.
32591665 Publications up until the date of the literature search, 19th March 2020, were used.
32591667 Besides the clinical guidelines presented within the study, it also encourages further up-to-date and evidence-based management guidelines for patients with COVID-19.
32591712 This paper describes its evolution to date and the challenges encountered along the way.
32593065 To date, we have no French data about the psychiatric consequences of the Covid-19 pandemic and the confinement.
32013309 Coronavirus can cause respiratory syndrome which to date has affected about twelve thousand individuals, especially in China.
32164053 The first patient’ symptom onset date in the Daegu/NGP outbreak was assumed as January 22, 2020. […] The R according to the start date of the effect of preventive measures was estimated.
32380582 However, to date, knowledge, no observational study on spine surgeries during the pandemic has not been reported.
32450631 Excel was used to describe the relationship between clinical classification and age distribution, contact history and date of onset.
32455517 Up to date there is little known regarding the impact of this outbreak on spinal specialists’ daily clinical practice.
32593339 To date, few data on paediatric COVID-19 have been published, and most reports originate from China.
32593341 Physicians were encouraged to report cases prospectively and we permitted recent cases to be notified retrospectively when assigned a confirmed date of admission or initial clinical assessment, allowing identification of cases that occurred before notification portals were available.
32593519 Although scientists and researchers have been racing to develop specific therapeutic agents or vaccines against SARS-CoV-2 since the identification of the agent, either a drug or a vaccine has not been approved to treat or to prevent COVID-19 up to date.
32593564 We inquired about their COVID-19-related experiences and perspectives, documented opportunities for transmission, and assessed COVID-19’s perceived impacts to date.
32594928 The date of infection and infector-infectee pairs were inferred from the history of travel in Wuhan or exposed to confirmed cases.
32595070 To date, injecting drug use has been of primary concern in relation to harm reduction initiatives.
32595085 With a necessary cautionary note that the evidence around the links between Covid-19 and cardiovascular disease is accruing at a fast pace, to date we can conclude that: (a) the greater susceptibility of individuals with underlying cardiovascular conditions to develop more severe Covid-19 with higher mortality rate is likely to be confounded, in part, by age and the type of co-morbidities.
32599060 This last decade, the literature on remote home-based CR programs has been increasing, but to date only clinical research experiences have been implemented.
32599100 This study used publicly available data to examine gender, age, source of infection, date returned from Hubei, date of disease onset, date of first medical visit, date of final diagnosis, and date of recovery of COVID-19 cases.
32599811 We achieved the aim by (1) sampling Weibo users (geo-location = Wuhan, China) and Twitter users (geo-location = Lombardy, Italy); (2) fetching all the users’ published posts two weeks before and after the lockdown in each region (e.g., the lockdown date of Wuhan was 23 January 2020); (3) extracting the psycholinguistic features of these posts using the Simplified Chinese and Italian version of Language Inquiry and Word Count (LIWC) dictionary; and (4) conducting Wilcoxon tests to examine the changes in the psycholinguistic characteristics of the posts before and after the lockdown in Wuhan and Lombardy, respectively.
32600881 General surgery chief residents were most concerned about the potential delay in the date of board examinations, followed by not feeling adequately prepared for the board examinations and a possible delay in the graduation date.
32601708 The termination date of follow-up was 19 February 2020.
32603253 To date, physical distancing and good personal hygiene have been the only effective measures to limit spread.
32603900 Members of the Telemedicine Work Group in the American Academy of Allergy, Asthma & Immunology (AAAAI) completed a telemedicine literature review of online and Pub Med resources through May 9, 2020, to detail Pre-COVID-19 telemedicine knowledge and outline up-to-date telemedicine material.
32604138 In the largest cohort to date of PLWH and confirmed COVID-19, almost all had a comorbidity associated with severe disease, highlighting the importance of non-HIV risk factors in this population.
32605192 Analyzing the diagnostic methods, to date, virus nucleic acid RT-PCR represents the standard method used to ascertain the COVID-19 infection in living subjects and corpses, even if this technique has several criticisms: mainly, the staff should be highly specialized, working in high-throughput settings, able to handle high workloads and aware of health risks and the importance of the results.
32605363 To date, many serology LFAs have been developed, though none meet the performance requirements necessary for diagnostic use cases, primarily due to the relatively long delay between infection and seroconversion. […] To date, only a very small number of antigen-detecting LFAs have been developed.
32605549 Scientific studies to date have focused primarily on describing the clinical course of patients, identifying treatment options and developing vaccines.
32606050 To date, there are no effective antiviral medications for COVID-19.
32607332 To date, a limited number of studies have concentrated on the epidemiological and clinical characteristics of COVID-19 patients with different genders, clinical classification, and with or without basic diseases.
32607499 To date, there is no specific vaccine or treatment proven effective against this viral disease.
32607737 The COVID-19 pandemia due to the SARS-CoV-2 coronavirus, in its first 4 months since its outbreak, has to date reached more than 200 countries worldwide with more than 2 million confirmed cases (probably a much higher number of infected), and almost 200,000 deaths.
32608335 The onset date of the earliest COVID-19 case in this study was 25 January 2020.
32609079 To date, 110,000+ people in the United States have died from the COVID-19 pandemic.
32609085 This review represents the most up to date information published in the literature that is a must-know to every orthopedic surgeon.
32609825 Epidemiological parameters for COVID-19 were validated on a limited date range; where substantial uncertainties remained, multiple parameters were tested.
32609839 Most importantly, to date, no study, including this one, supports the view that smoking acts as a treatment intervention or prophylaxis to reduce the impact or ameliorate the negative health impacts of COVID-19.
32610808 The experience in the United Kingdom and Canada to date has not seen much uptake of health economics methods.
32610873 The indoor admitted patient’s information inclusive of demographic profile (age, sex, nationality, residence), date of confirmation for positive COVID-19 case, travel/ exposure history, date of recovery/ death, clinical features, co morbidities and treatment plan was recorded. […] 60.27% of patient population with underlying co morbid conditions were more prone to develop symptomatology complex as compared to that observed in patients with no co morbidity (18.42%). 116 patients had recovered with effective treatment till the date of data analysis. […] Time of recovery was counted from the date of positive report to 1st negative report of oropharyngeal sample by RT-PCR for COVID-19 with an average recovery time of 8.15 days.
32610879 This prompted physicians from across the world to use them in the present SARS-CoV- 2 pandemic that is currently sweeping the globe, with 5 million people already infected to date.
32611457 To date, there is not much information published addressing the cardiac workup and monitoring of children with COVID-19.
32611687 The present review summarizes up-to-date evidence addressing the frequently discussed clinical controversies regarding the use of immune checkpoint inhibitors (ICIs) in cancer patients with viral infections, including AIDS, hepatitis B and C, progressive multifocal leukoencephalopathy, influenza, and COVID-19.
32611746 No restriction regarding the publication date, setting or languages will be considered.
32611914 We described cases by time (epidemic curve by date of specimen collection; seven-day moving average), place (area map) and person (attack rate by age, sex and contact status), and trends were represented along with public health measures and events.
32614777 The variables analyzed were name, platform, country, language, category, cost, update date, size, version, number of downloads, developer, and purpose. […] The mean time between the date of the analysis and the date of the last update was 11.1 days (SD 11.0).
32614810 Respondents were contacted 14-21 days after SARS-CoV-2 testing and asked about their demographic characteristics, underlying chronic conditions, symptoms experienced on the date of testing, and potential exposures to SARS-CoV-2 during the 2 weeks before illness onset (or the date of testing among those who did not report symptoms at the time of testing).
32615862 To date, a large number of clinical trials addressing various aspects of COVID19 have been registered in the Chinese Clinical Trial Registry (ChiCTR), including more than 200 interventional studies.
32615871 To the best of our knowledge, no new infectious case of COVID-19 resulting from endoscopic procedures has been reported in China to date.
32616067 Time to diagnosis of positive COVID-19 disease (defined by record of date of symptoms onset and confirmed by laboratory test) RANDOMISATION: Participants will be randomised to either hydroxychloroquine dosed daily with weekly placebo, HCQ dosed weekly with daily placebo, or placebo dosed daily and weekly. […] V 1.0, 7th April 2020 EU Clinical Trials Register EudraCT Number: 2020-001331-26 Date of registration: 14th April 2020 Trial registered before first participant enrolment. […] The recruitment end date cannot yet be accurately predicted.
32617010 Not enough systematic reviews on predictors of critical illness and mortality in COVID 19 have been published to date.
32617050 There have been approximately 7734185 reported cases, and 412369 reported deaths to date (09/June/2020).
32617169 To date, there are no especial therapeutic agents for COVID-19 infections.
32617313 Evidence generated to-date on the virulence and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suggests that COVID-19 may be considered a perfect storm, caused by a nature’s virtually perfect biological weapon.
32617365 The World Health Organization has declared COVID-19 a global pandemic, with a death toll of over 300,000 to date.
32619756 To date, the most commonly used method for identifying and confirming the virus is the laboratory-based reverse transcription-polymerase chain reaction (RT-PCR) test.
32621281 Recently, concern arose on unrecognized infections before this date.
32622375 Encephalitis has been described in eight patients to date, and Guillain-Barré syndrome in 19 patients.
32623176 Till date no medication or vaccine is available to cope with the COVID-19 infection and infection rate is increasing drastically across the globe.
32624494 To date, there has been no clear guideline endorsement of ward-based non-invasive pressure support (NIPS) for severely hypoxic patients who are deemed unlikely to benefit from invasive ventilation.
32624560 Socio-demographic and clinical data, aspects of the event-exposure (date, place, length and distance of exposure, use of PPE) and details of the contact person were collected.
32627172 The commonly used contact-tracing based estimation of incubation distribution is highly influenced by the individuals’ judgment on the possible date of exposure, and might lead to significant errors.
32627963 To date, the impact, timeline and duration of COVID-19 pandemic remains unknown and more than ever it is necessary to provide safe pathways for cancer patients.
32629147 Patients with a positive COVID-19 diagnosis were given a questionnaire consisting of general questions (age, sex, date of symptoms, smoking history, concomitant diseases), questions about the most obvious symptom at presentation (one option only), the severity and frequency of symptoms (general and ENT), and STL (recovery time and degree of recovery).
32630746 Up to date, neither an effective vaccine nor SARS-CoV-2 specific antiviral agents have been approved, but significant advances were enlisted in this direction by investigating repurposed approved drugs (ongoing clinical trials) or developing innovative antiviral drugs (preclinical and clinical studies).
32631426 April 1, 2020 would be a reasonable date to lift quarantine in Hubei and Wuhan.
32631442 The retrieval inception date was February 9, 2020.
32632766 Nevertheless, up to date, no drugs have been confirmed as a definitive treatment for COVID-19.
32632960 To date, no vaccines or effective therapeutics have been discovered yet that may successfully treat COVID-19 patients or contain the transmission of the virus.
32633720 By contrasting Electronic Health Record (EHR)-derived symptoms of COVID-19-positive (COVIDpos ; n = 2,317) versus COVID-19-negative (COVIDneg ; n = 74,850) patients for the week preceding the PCR testing date, we identify anosmia/dysgeusia (27.1-fold), fever/chills (2.6-fold), respiratory difficulty (2.2-fold), cough (2.2-fold), myalgia/arthralgia (2-fold), and diarrhea (1.4-fold) as significantly amplified in COVIDpos over COVIDneg patients.
32633997 To date, there is no recommended medical treatment, and supportive measures are a crucial part of management.
32634106 Descriptive data will include patient demographics, the radius of care, the time between the date of injury and initial visit, the average number of follow-up visits, and days until medically cleared for return-to-learn and return-to-play.
32634536 In these patients, the mean from the date of their first detectable result to attaining an undetectable result was 14.89 days.
32637738 Informed consent and Institutional Review Board approval was obtained prior to this study (196/2020BO2; Date of approval: 03/26/2020; Ethics Committee of the University of Tuebingen).
32638221 To date, many studies have discussed that the rationale behind its transmission potential is that viral RNA has unexpectedly been detected in multiple bodily fluids, with some samples having remained positive for extended periods of time.
32638896 Classical definition of myocarditis, supported by endomyocardial biopsy of inflammatory infiltrate, is rare; it has been observed in only one case report to date, and the virus has not been identified inside cardiomyocytes.Thus, the phenomenon that has been documented is acute myocardial injury, making it necessary to rule our obstructive coronary disease based on increased markers of myocardial necrosis, whether or not they are associated with ventricular dysfunction, likely associated with cytokine storms and other factors that may synergistically promote myocardial injury, such as sympathetic hyperactivation, hypoxemia, arterial hypotension, and microvascular thrombotic phenomena.Systemic inflammatory and myocardial phenomena following viral infection have been well documented, and they may progress to cardiac remodeling and myocardial dysfunction.
32639216 To date and to our knowledge, a small amount of reports describing a surgical department’s response to this unprecedented pandemic have been published, but a well-documented account from within the United Kingdom (UK) has not yet been reported in the literature.
32639466 We observed a greater proportion of hospitalized children requiring mechanical ventilation than has been reported to date.
32639598 This impact in the specific setting of transplantation and immunosuppression has been poorly explored to date.
32640723 The world is currently suffering from a pandemic which has claimed the lives of over 230,000 people to date.
32641154 TACTIC-R Protocol version number 2.0 date May 20, 2020, recruitment began May 7, 2020 and the end trial will be the date 18 months after the last patient’s last visit. […] The recruitment end date cannot yet be accurately predicted.
32641343 To date, symptomatic supportive care has been the most common treatment.
32642842 To date, no vaccines are available nor any specific treatment.
32642929 To date, however, training opportunities in this field have been limited, and residents may not be adequately prepared to provide high-quality telemedicine care.
32643136 To date, it is essential for all Specialists, clinicians and surgeons, to direct attention towards the study of this virus, to better clarify the spectrum of its neurological manifestations.
32644140 Patients were divided into 5 groups based on the date of their clinical presentation in relation to the COVID-19 pandemic.
32644275 To date, data is limited for medications that facilitate clinical improvement of COVID-19 infections.
32645207 To date, reports from China, United States and Europe did not reveal an higher risk of infection, either for rheumatoid arthritis, juvenile idiopathic arthritis nor for lupus erythematosus.
32645276 To date, the world has paid a high toll in this pandemic in terms of human lives lost, economic repercussions and increased poverty.
32645974 In an up-to-date format, we shed light on HCQ’s anecdotal function in stalling SARS-CoV-2 replication and immunomodulatory activities.
32646502 The protocol with code TAC-COVID-19, version 2.0 on date: April 16, 2020 is approved by the Spanish Drug Agency (AEMPS) and the local Ethics Committee.
32647526 To date, there are 12 case studies reporting 47 cases of CVD in COVID-19.
32647807 To date, preliminary evidence from case series is favorable as significant clinical, biochemical improvement and hospital discharge have been reported.
32648093 The final date of follow-up was Mar 31, 2020.
32648218 The study calculated that if we increase five times our testing capacity from the current date, the total registered cases will be reached to 137,370 and death tolls will increase up to 3090.
32648546 From the largest U.S. serosurvey to date, we estimated >2 million adult New York residents were infected through late March, with substantial disparities, although cumulative incidence remained less than herd immunity thresholds.
32648592 To date, there are no clear scientific data that preclude the use of non-steroidal anti-inflammatory drugs in the general population who may acquire COVID-19 or in those acutely infected with the virus.
32648973 To date, however, there is a very limited understanding of the extent and management of COVID-19-related conditions outside of the pulmonary system.
32649214 Volumes were evaluated by result date (3/16/2020 - 5/6/2020) and the average of received to verified turn-around-time (TAT) was calculated and compared for in-house and send-out testing, and different in-house testing methodologies.
32649222 Several biomarkers have been proposed to predict COVID-19 severity, but no definite interpretative criteria have been established to date for stratifying risk.
32649399 To date, over 180 PICUs have responded detailing 530 PICU admissions requiring over 3,467 days of PICU care with 30 deaths.
32649566 At the end of December, 2019, a new virus was named severe acute respiratory syndrome coronavirus 2 appeared in Wuhan, China, and the disease caused is called as coronavirus disease 2019 (COVID-19) by World Health Organization, which to date having infected more than 3,588,773 people worldwide, as well as causing 247,503 deaths.
32650818 Protocol version number: V3, 19.05.2020 Recruitment not yet started but is anticipated to begin by June 2020 and be complete by December 2020 TRIAL REGISTRATION: NCT04351516 , date: 17 April 2020 EudraCT: 2020-001482-37, date: 30 March 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32653015 To date, no specific treatment has convincingly demonstrated its efficacy.
32653432 Given the heterogeneous methods used in studies to date, we are unable to draw conclusions on the most efficacious and safe intervention for decontaminating surgical masks.
32653452 To date, no effective therapeutic is available to fight its associated disease, COVID-19.
32653819 To date, it is often considered obsolete giving the inadequacy to provide samples of a quality appropriate to the sophisticated diagnostic techniques available today.
32653906 No cases involving young patients have been presented to date.
32654024 While it is being recommended to carry out only the emergent procedures and to postpone the non-urgent ones to a later date, this article is meant to provide an insight into triage of the ENT procedures and the various precautions to be taken into account by the ENT surgeons while carrying out a procedure during the COVID-19 pandemic.
32654361 To date, despite the slow reopening, the government has decided to maintain school closures for the entire academic year, leaving the future of young people in uncertainty.
32656017 The output of the model is nearly instantaneous, producing an estimate of the census and the number of ventilators required in one, three, and seven days following the date on which the simulation is run.
32657527 We highlight challenges of outpatient and inpatient HIV care in the setting of the COVID-19 pandemic and present the largest detailed case series to date from the United States on HIV/SARS-CoV-2 coinfection, adding to limited global reports.
32657710 Evidence to date suggests that COVID-19 is efficiently passed from infected individuals via large droplets and hard-surface fomites.
32658096 To date, although neonatal infections with severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) have been described, none of these have been proven to be the result of vertical transmission of SARS-CoV-2.
32658132 To date, there are no centralized or compiled international COVID-19 guidelines for oculoplastic surgeons.
32658735 To date, no approved treatment regimen or vaccine is available to effectively attenuate or prevent the infection.
32658757 Up to this date, there is no scientific evidence that proves that a COVID-19 corpse is still infectious.
32658841 Convalescent plasma is the only antibody-based therapy available for COVID-19 patients to date.
32658858 We examined the trends in the percent increase in daily new cases from 7 days before to 30 days after the dates on which containment measures went into effect by continent, World Bank income classification, type of containment measures, effective date of containment measures, and number of confirmed cases on the effective date of the containment measures.
32658879 Lockdown and self-isolation are to date the only solution to limit the spread of recent outbreak of coronavirus disease (CoViD-19), highlighting the great advantage of home dialysis in a patient otherwise forced to travel from / to the dialysis center to receive this “life-saving” treatment. […] Peritoneal dialysis (PD) represents a type of home dialysis therapy not yet adequately implemented to date, in spite of safe and simple practice, as well as similar dialytic efficiency vs in-center hemodialysis.
32659292 To date, no vaccines or specific antiviral drugs have been approved for the treatment of this disease in clinic.
32660220 To estimate time-variant reproductive number (Rt) of coronavirus disease 19 based on either number of daily confirmed cases or their onset date to monitor effectiveness of quarantine policies. […] Using number of daily confirmed cases from January 23, 2020 to March 22, 2020 and their symptom onset date from the official website of the Seoul Metropolitan Government and the district office, we calculated Rt using program R’s package “EpiEstim”. […] For asymptomatic cases, their symptom onset date was considered as -2, -1, 0, +1, and +2 days of confirmed date. […] When we changed assumed onset date for asymptotic cases (-2 days to +2 days of the confirmed date), the results were comparable.
32660611 query=ALXN1210-COV-305 , Start date: 07 May 2020 FULL PROTOCOL: The full redacted protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32661780 The Italian College of Breast Radiologists by the Italian Society of Medical Radiology (SIRM) provides recommendations for breast care provision and procedural prioritization during COVID-19 pandemic, being aware that medical decisions must be currently taken balancing patient’s individual and community safety: (1) patients having a scheduled or to-be-scheduled appointment for in-depth diagnostic breast imaging or needle biopsy should confirm the appointment or obtain a new one; (2) patients who have suspicious symptoms of breast cancer (in particular: new onset palpable nodule; skin or nipple retraction; orange peel skin; unilateral secretion from the nipple) should request non-deferrable tests at radiology services; (3) asymptomatic women performing annual mammographic follow-up after breast cancer treatment should preferably schedule the appointment within 1 year and 3 months from the previous check, compatibly with the local organizational conditions; (4) asymptomatic women who have not responded to the invitation for screening mammography after the onset of the pandemic or have been informed of the suspension of the screening activity should schedule the check preferably within 3 months from the date of the not performed check, compatibly with local organizational conditions.
32661937 However, to date, mortality rate among children is low as they mostly suffer from a mild disease.
32662062 We have studied up-to-date knowledge about the clinical feature of the Novel coronavirus pandemic worth consideration by the urologist.
32662421 To date, no consistent evidence for the vertical transmission of SARS-CoV-2 exists.
32662525 As of the final follow-up date of this study, 240 (83.0%) patients were discharged from the hospital and 49 (17.0%) patients died.
32662615 Up to date few studies have actually assessed the impact of COVID-19 on the postoperative morbidity and mortality following emergency gastrointestinal surgery.
32662690 The coronavirus disease 2019 (COVID-19) pandemic has affected almost 2.5 million people worldwide with almost 170,000 deaths reported to date.
32662757 To date, 23 data collection partners are involved and the first data imports have been performed successfully.
32662814 To date, the number of COVID-19 patients worldwide has crossed over six million with over three hundred and seventy thousand deaths (according to the data from World Health Organization; updated on 2 June 2020).
32663708 To the best of our knowledge, till date only one compound has been identified and tested in-vivo as a potent inhibitor of Mpro protein, addressed as N3 (PubChem Compound CID: 6323191) and is known to bind irreversibly to Mpro suppressing its activity.
32664113 The study will provide up-to-date evidence of the effectiveness and safety of A&M for patients with COVID-19.
32664908 Pertinence has various dimensions, including whether the guidance applies to this professional, this patient and/or this setting, whether it is up-to-date, and whether the guidance addresses the situation the professional is facing.
32665039 Recruitment is ongoing - started April 20, 2020 and anticipated end date is July 30, 2021 TRIAL REGISTRATION: Identifier: ISRCTN14326006, registered April 14, 2020.
32665090 To date, there is no evidence of a higher incidence of COVID in patients with autoimmune rheumatic diseases and we support the approach of maintaining chronic rheumatological treatments.
32665091 The first week of this date range and the 10 weeks prior were used to derive the normal practice expected volume.
32665331 Similarly, we show that the apparent oscillation in mortality in the U.S. data are mostly an artifact of reporting, which disappears in data sets that record death by episode date, such as the NYC and LA data sets.
32665352 The PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang Data and Viper information databases will be searched from inception time to date without restricting research types to find relevant studies.
32666513 No study published to date has analyzed the characteristics of headache in these patients.
32666588 To date, available data are heterogeneous and scarce and mortality in LT recipients seems to be higher compared to normal population, but whether this is caused by altered immunological status, immunosuppression (IS), or underlying comorbidities has not yet been fully clarified. […] To date, 244 LT recipients have been reported as COVID-19-positive.
32666887 To date, no definitive treatments to the pandemic have been promoted.
32666912 The global impact on the clinical practice of manual therapy and education has to date not been explored. a questionnaire survey methodology was used.
32668041 The role of extracorporeal membrane oxygenation (ECMO) remains unknown, with the few publications to date lacking detailed patient information or management algorithms all while reporting excessive mortality.
32668803 SARS-CoV-2 infection/COVID-19 provides numerous therapeutic targets, each of them promising, but not leading to the success of therapy to date.
32669221 The definition and diagnostic/management criteria of sepsis have been modified several times but the mortality rate has not been improved until date.
32670391 Up to date, facts and figures of the total the confirmed cases, daily confirmed cases, total deaths, and daily deaths that have been reported in the Asian countries are provided.
32670517 To date, no definite link has been irrefutably found between a single infection and KD.
32671688 To date, the USA, Italy, Spain, France, Russia, and the UK have been hit the hardest by the virus.
32673296 Symptom data were analyzed by age group, sex, hospitalization status, and symptom onset date relative to expansion of testing guidelines on March 8, 2020 (3).
32674646 Data about timing of symptom onset and death (pregnancy or postpartum), gestational age, mode of birth, maternal age, comorbidities and/or risk factors, date of death, and place of death were retrieved when available.
32674969 However, to this date, there has been no clear evidence to suggest either way.
32675033 To date, however, no literature has focused on the clinical symptoms of emergency surgery patients with COVID-19 pneumonia. […] For this report, the final date of follow-up was February 5, 2020.
32676039 Up to date (2020 May 6) in Italy we had more than 28,000 deaths, while there were more than 205.000 infected.
32676080 As a result, there is no specific treatment available to date for CRS, and it is managed only symptomatically to support the deteriorating organ functions and maintain the blood pressure.
32676542 We searched the available literature to-date, and present the pathophysiology underlying increased morbidity and mortality of SARS-CoV-2 infection in the lungs, heart and kidneys in a highly illustrated presentation that is easy-to-understand for the clinician, researcher, and student alike.
32676882 To date, it’s not fully clear how COVID-19 may affect patients with hereditary bleeding disorders.
32678017 No effective treatment has been discovered to date.
32678672 Training efficiency was measuring by the days between the date of product shipment and the date of the first and final trainings.
32678949 To date, however, pregnant women do not appear to have a substantially increased risk of thrombotic complications related to COVID-19.
32679155 To date there are few reports of ST-segment elevation myocardial infarction (STEMI) caused by type 1 myocardial infarction in patients with COVID-19.
32679173 Unfortunately, no antiviral medications have been discovered to date as treatments for any of these diseases. […] By contrast, the HIV/AIDS pandemic has garnered consistent research investment since it began and resulted in drugs being developed within 7 years of its start date, with many more to follow.
32679185 To date, some aspects remain to be investigate about the pathophysiology of this viral infection.
32679206 The guiding principles for restarting elective surgeries in a safe and acceptable manner include up-to-date disease awareness, projection and judicious management of equipment and facilities, effective human resource management, a fair and transparent system to prioritize cases, optimization of peri-operative workflows and continuous data gathering and clinical governance.
32680478 To date, the psychological impact of COVID-19 epidemic among family members of health care workers (HCWs) in China has been neglected.
32680658 Based on the official data available on the date of this work, and through the models described, we estimate a total of around 240.000 infected and 25.000 deaths at the end of the epidemic.
32680910 To date, pathologic analyses have been limited to patient reports and autopsy series.
32681089 The World Health Organization has stated “To date there has been no information nor evidence to suggest that the new coronavirus could be transmitted by mosquitoes”.
32681845 To date, coagulopathy has been found as a prominent feature of COVID-19 and severe coagulation dysfunction may be associated with poor prognosis.
32681968 Fever and cough are the most common symptoms of COVID-19 infection in the literature published to date.
32682491 To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling.
32683373 To date, oncology and surgery groups have only given instructions for addressing phases 1 and 2.
32683801 Although no randomized clinical trials have been published to date, it is interesting to explore potential modalities for treating COVID-19 in children, based on review articles, case reports, and recent guidelines.
32684674 To this date, there are no universal guidelines for musculoskeletal (MSK) care in the face of the coronavirus pandemic.
32687630 To date, these medications are not approved for the treatment of viral infections, and there are no well-controlled, prospective, randomized clinical studies or evidence to support their use in patients with coronavirus disease 2019 (COVID-19). […] In addition, this work presents data describing the proposed mechanisms of action against the severe acute respiratory distress syndrome coronavirus-2 and summarizes clinical efficacy to date.
32687823 Current survival is 96.3%, with only 1 death to date in more than 350 days of total ECMO support.
32687997 Water bodies receiving raw sewage may pose risk of infection but this has not been investigated to date.
32689586 Treatment was changed to enoxaparin and no thrombotic events were encountered to date.
32689925 We collected information on the date of publication, first author’s country, the title of the article, study design, study population, intervention and outcome, and key findings, and divided all research articles into two domains: physical and mental health impact.
32690074 EUDRACT number: 2020-001667-85; date of trial registration: 15 May 2020 Protocol registered on, registration number: NCT04361474 ; date of trial registration: 24 April 2020.
32690463 The aim of this study is to systematically review the data available to date regarding the potential risk posed to theatre staff by laparoscopy. […] The data and analysis reported in this study reflect the most up-to-date evidence available for the surgeon to assess risk towards healthcare staff.
32691024 In this review we summarize the most up to date literature around the association between COVID-19 and myocarditis and provide clinicians a practical framework about the clinical manifestations, diagnostic tools, and treatment options currently available.
32691236 To date, only smaller cohort studies or single cases have reported cerebrovascular events, seizures, meningoencephalitis, and immune-mediated neurological diseases, not suitable for quantitative analysis.
32692365 The number of infections in each site was estimated by extrapolating seroprevalence to site populations; estimated infections were compared with the number of reported coronavirus disease 2019 (COVID-19) cases as of last specimen collection date.
32692408 To date, some limited studies have been published on placentas from SARS-CoV-2-positive women.
32692580 To date, only dexamethasone and remdesivir have been shown to be effective, but several other promising candidates are in trials.
32692649 To date, there have been no cases of in-hospital spread to other patients or to professionals in this department.
32693023 To date, there is not any vaccine or specific antiviral medicine that can prevent or treat this virus.
32693652 To date, clinical evidence suggests lack of benefit from HCQ use for the treatment of hospitalized patients with COVID-19.
32694143 To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome have been described.
32694480 To date, there has not been literature discussing the process of resuming CFOP mission trips.
32695123 To date, there has been no mention of this dual connection between GSK-3 and SARs CoV2 in the literature.
32696735 To date, there have been no detailed reports of patients developing persistent psychotic symptoms following Coronavirus disease 2019 (COVID-19) infection.
32696830 COVID-19 in pregnant women may not be associated with the occurrence of preterm deliveries or the birth weight of the newborn children, however the evidence to date is very uncertain.
32698862 A systematic literature review of six databases (PubMed, Scopus, The Cochrane Central Register of Controlled Trials [CENTRAL], Science Direct, Web of Science and Google scholar) was carried out without any restrictions on date of publication to identify the reliability of saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients.
32699006 Long-term care (LTC) homes have been the epicentre of the coronavirus disease 2019 (COVID-19) pandemic in Canada to date.
32699423 To date, most studies have been conducted among inpatients with severe COVID-19.
32699691 Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has been used in some centers, but its role in the setting of COVID-19 infection is still unclear to date.
32703064 To date, countries have relied on the prevention of the disease through isolation, quarantine, and clinical care of affected individuals.
32703069 Rapid progress and advances have been made to date in the development of COVID-19 vaccines.
32703089 To, date no clear indications on how to treat patients with cancer with COVID-19 infection are available.
32705976 To date, only two treatments, remdesivir and dexamethasone, have demonstrated clinical efficacy through randomized controlled trials (RCTs) in seriously ill patients.
32706095 The information on daily temperature and humidity was obtained from world climate web “Time and Date”. […] The daily basis, mean temperature and humidity were recorded from the date of appearance of first case of COVID-19 in the region, Jan 29, 2020 to May 15, 2020.
32706371 The final date of follow-up was May 16, 2020.
32707965 To date, 38 cases have been reported, with other cases most likely undiagnosed mainly due to a lack of clinical awareness and diagnostic screening.
32708840 After its arrival in South America in February 2020, the virus has expanded throughout the region, infecting over 900,000 individuals with approximately 41,000 reported deaths to date.
32708858 To date, most evidence has come from renal transplantation, with about 45 patients reported thus far, and the current data from the ERA-EDTA (ERACODA) registry for transplanted patients and patients on Renal Replacement Therapy (RRT); as for those with glomerular diseases, data are lacking.
32708953 This short article intends to give an up-to-date glimpse of the pandemic from air quality and climate perspectives and calls for a follow-up discussion.
32710056 Liverpool University Dental Hospital (LUDH) responded by commencing an emergency dental service on the same date.
32711003 However, to date, there are no comprehensive studies aiming to explain the exact relationship between diabetes and COVID-19.
32713282 This broad spectrum of COVID-19 influence on kidney patients and kidney functions obviously necessitate an up to date management policy for nephrological care.
32713385 We analyzed biosecurity and disinfection standards at the dental office and dental health personnel to date, and their adaptation to the needs and way of working of each.
32713784 To date, no randomized trials have been published.
32713821 Very few cases of lung transplant patients affected by coronavirus disease 2019 (COVID-19) have been reported to date.
32715315 To date, Virus-CKB archived 65 antiviral drugs in the market, 107 viral-related targets with 189 available 3D crystal or cryo-EM structures and 2698 chemical agents reported for these target proteins.
32715498 However, to date, the quality of the evidence has not been systematically assessed.
32715512 To date, inpatient facilities for eating disorders (both medical stabilization units and higher level of care facilities) have not needed to consider how to translate services to electronic platforms, given that most of these programs have in-person staff.
32716647 We used the TriNetX platform to analyze 20 health care institutions that have relevant, up-to-date encounter data.
32716828 Date of EVT and symptom onset-to-groin puncture time were collected.
32716836 Analysis of the available literature to date suggests that, in addition to older age, patients with underlying co-morbidities including hypertension, diabetes, heart disease are at higher risk for severe disease with increased mortality.
32716900 We collected data on the patients’ date of MDPOA completion, use of advance care planning messaging, age, sex, and geographic location during the early phase of the COVID-19 pandemic (December 29, 2019, to May 30, 2020).
32717056 There have been limited published studies to date documenting the performance of SARS-CoV-2 antibody assays.
32717066 We identified adults hospitalized with COVID-19, where cohort entry was the date of hospitalization.
32717854 The emergence of the COVID-19 outbreak at the end of 2019, caused by the novel coronavirus SARS-CoV-2, has, to date, led to over 13.6 million infections and nearly 600,000 deaths.
32718020 Overall, the review aims at presenting update-to-date details, so as to enhance awareness of potential therapeutics, and thus, to catalyze their appropriate use in combating the pandemic.
32719490 Since the differences in the CoVID-19 morbidity and mortality may depend on the different timing of the epidemics in each country, we applied the date of first documented CoVID-19 in each country as a proxy of susceptibility, with a statistical control for population size effects. […] The prevalence of toxoplasmosis co-varies negatively, while the date of first CoVID-19 co-varies positively with GDP per capita across countries. […] Further, to control for the strong spatial autocorrelation among countries, we carried out a Spatial Structure Analyses of the relationships between the date of first CoVID-19, prevalence of toxoplasmosis, and GDP per capita.
32719673 Considering the importance of the ongoing coronavirus crisis, we decided to evaluate genomes of all coronaviruses sequenced to date (stated more broadly, the order Nidovirales) to determine if they contain non-canonical nucleic acid structures.
32719683 In such a rapid-paced field, up-to-date systematic studies and meta-analysis will aid the scientific community to separate hype from hope and offer an unbiased position to the society and governments.
32719737 The Coronavirus (2019-Cov-2) infection Covid-19 is highly contagious caused by single stranded RNA virus (+ssRNA) with nucleocapsid and spreading widely all across the world and responsible for more than 3.6 million morbidity and 0.25 million mortality No specific treatment is available till date.
32719874 We characterized symptom profiles on the date of first positive RT-PCR test and described progression of symptoms over time. […] Eight (17%) individuals were asymptomatic at the date of first positive RT-PCR collection; two (4%) had preceding symptoms that resolved and six (13%) subsequently developed symptoms.
32720611 Up-to-date information about principles for administration of statins, antithrombotics, and antiarrhythmics is presented.
32720703 It was named COVID-19, and to date, thousands of cases of infection and death are reported worldwide.
32721449 However, most of initiatives taken were based on various hypotheses and till date no successful treatments have been achieved.
32721782 In Florida, New York, and Massachusetts, there was a general downward trend of vehicle collisions and vehicle related injuries over this time period, with statistically significant association between number of total vehicle collisions vs. date (p < 0.001), as well as number of vehicle related injuries vs. date (p < 0.001).
32721808 Various explanations, based on demographic, social and climatic factors, have been suggested to account for this variability, but these remain unverified to date.
32722174 To date, numerous measures have been applied by the government and the medical community during the early stages of the COVID-19 outbreak including the reporting of methods for diagnostic testing, patient classification, the introduction of drive-through screening centers, COVID-19 preventive measures, implementation of government policies for the shortage of face masks, and entry restrictions.
32722715 A limitation of the model is that count data by date of onset are required, and these are not available in all countries.
32723442 To the best of author’s knowledge, there is no comprehensive review on COVID-19 till date.
32723447 The disease started as an epidemic in China in December 2019 that later achieved a pandemic potential spreading to over 210 countries with more than 3.5 million confirmed cases and close to 250,000 deaths till date.
32724171 SARS-CoV-2 itself is not a recombinant of any sarbecoviruses detected to date, and its receptor-binding motif, important for specificity to human ACE2 receptors, appears to be an ancestral trait shared with bat viruses and not one acquired recently via recombination. […] Bayesian evolutionary rate and divergence date estimates were shown to be consistent for these three approaches and for two different prior specifications of evolutionary rates based on HCoV-OC43 and MERS-CoV.
32724793 In this article, all reported cases to date were collected and classified under 6 major groups: maculopapular rash, urticaria, chilblain, vesicular lesions, livedo reticularis, and petechiae.
32725453 To date, the clinical importance of chronic liver diseases among COVID-19 infection has remained undefined.
32725833 To date, coronavirus disease 2019 (COVID-19) has infected millions of people worldwide.
32726185 The estimated date of SARS-CoV-2 introduction into Brazil was consistent with epidemiological data from the first case of a returned traveller from Lombardy, Italy.
32726230 To date, coronavirus disease-2019 (COVID-19) has spread to over 200 countries, leading to over 1.6 million cases and over 99,000 deaths.
32727613 Two hundred and seventy-fiveparticipants were recruited and completed first month follow-up until date. […] Thus, 275 is the total number of participants included until date.
32727861 To date, COVID-19 cases have been reported in 54 out of 55 African countries.
32728951 Up to date, after 6 weeks of systematic execution of swabs no physician, nurse or other individual of the staff has been found positive to COVID-19.
32729892 Models developed by the Institute for Health Metrics and Evaluation (IHME) were used to estimate the anticipated duration of suspension by using the date that no ventilators would be required to for COVID-19 patients.
32730095 To date, there is no effective medicine available in the market which is effective in COVID-19. […] Till date, it has claimed millions of death worldwide.
32730238 Interviews were conducted 14-21 days after the test date. […] Respondents were asked about demographic characteristics, baseline chronic medical conditions, symptoms present at the time of testing, whether those symptoms had resolved by the interview date, and whether they had returned to their usual state of health at the time of interview. […] Among 292 respondents, 94% (274) reported experiencing one or more symptoms at the time of testing; 35% of these symptomatic respondents reported not having returned to their usual state of health by the date of the interview (median = 16 days from testing date), including 26% among those aged 18-34 years, 32% among those aged 35-49 years, and 47% among those aged ≥50 years.
32732010 In conclusion, this is the largest case series to-date of COVID-19 positive patients presenting with STEMI and spans 4 countries.
32732190 Updates may occur for up to two years from the date of original publication.
32732316 To date, therapy and review of known paediatric patients with IBD has continued.
32732586 It is essential for both the clinicians and pathologists to maintain up-to-date knowledge of this continuously evolving topic in the midst of the current pandemic.
32734689 To date, the task force has approved 80 guidance statements: 36 with moderate and 44 with high consensus.
32734810 To date, effective treatment remains elusive.
32735524 Up-to-date scientific evidence in this field was described in the form of a narrative and easy-to-read review.
32735546 This ensures providing up to date evidence of the fast development of this disease.
32736407 From available published data to date, we can conclude that the prognosis of COVID-19 positive neonates is good with no mortality.
32736418 Methods: SEIR dynamics model was used to fit daily onset infections to search the start date of this resurgent COVID-19 epidemic in Beijing.
32736592 TACTIC-E Protocol version number 1.0 date May 27th, 2020. […] The end trial date will be 18 months after the last patient’s last visit and cannot be accurately predicted at this time.
32736597 Since up to date reduced evidence about COVID-19 infection epidemiology, the continuous update of diagnostic and therapeutic approaches, the sample size estimation could be updated after a one third of population will be recruited and eventually modified according to a substantial protocol amendment. […] The PROTECT trial is registered in the EudraCT database (no. 2020-001501-24) and in (NCT04363827), date of registration 24 April 2020.
32737627 The final follow-up date was March 2, 2020.
32738881 Thus, to track the current hotspots, and highlight future directions, we performed a bibliometric analysis to obtain an approximate scenario of COVID-19 to date.
32739397 Coronavirus Disease 2019 (COVID-19) has rapidly become a global pandemic, with over 1.8 million confirmed cases worldwide to date.
32740067 The effect of these guidelines on utilization of vitreoretinal care has not been explored to date.
32740374 Men reported the date they become concerned about COVID-19 and whether they engaged in sexual behavior with regular or casual partners or “fuckbuddies” in the 6 months before becoming concerned about COVID-19 (hereafter referred to as “before COVID-19”), and following the date, they become concerned about COVID-19 (hereafter referred to as “since COVID-19”). […] Before and since COVID-19 was based on individual participants’ own perceived date of becoming concerned about COVID-19.
32740530 To date, pancreatitis has not yet been reported in either acute SARS-CoV-2 infection in children or the subsequent inflammatory syndrome.
32740720 These finding comprise the most comprehensive report of COVID-19 tracheostomy decannulation to date and will assist service planning for future peaks of this pandemic.
32740858 To date, only remdesivir and dexamethasone have demonstrated a positive response in a prospective, randomized trial for the treatment of patients with COVID-19.
32740925 A review was conducted of 525 otolaryngology patients at a tertiary-care referral center with scheduled visits requiring rescheduling to a future date or a telemedicine visit.
32741719 The self-reports include the date of the transaction, the types of illicit drugs bought/sold, and whether the shipment of the illicit drugs succeeded, had issues (ex. unusually long delivery, an error in the type of drug shipped, quantity or concentration of the drug), or failed.
32742034 Delaying the start date of control measures by only 3 days would have increased the estimated 30 699 confirmed cases of COVID-19 by 1 March 2020 in regions outside Wuhan by 34.6% (to 41 330 people).
32742059 However, to date, there has been little investigation into the implications of the ‘Telegram’ application for online medical education and training.
32742564 To date, the safety and feasibility of stem cell and extracellular vesicles administration have been confirmed by numerous phase I/II trials in patients with COPD, acute respiratory distress syndrome, bronchial dysplasia, idiopathic pulmonary fibrosis, pulmonary artery hypertension, and silicosis.
32742978 This article reviews the characteristics of COVID-19-induced AKI largely based on up-to-date studies in the hope that it will be helpful in the current global fight against and treatment of COVID-19.
32742979 To date, all patients had been discharged successfully from Centro Hospitalar Conde de São Januário, a designated hospital to manage all COVID-19 patients in Macao.
32744757 To date, the outbreak of the novel coronavirus (COVID-19) has infected more than 5 million people and caused around 350 000 deaths globally.
32745593 To reduce the shortage of N95 respirators and surgical masks during the COVID-19 pandemic, stockpiled equipment beyond its expiry date could be released.
32746922 The severe acute respiratory syndrome virus SARS-CoV-2, a close relative of the SARS-CoV virus, is the cause of the recent COVID-19 pandemic affecting, to date, over 14 million individuals across the globe and demonstrating relatively high rates of infection and mortality.
32747329 To avoid misuse of personal protective equipment (PPE), ensure health care workers’ safety, and avoid shortages, effective communication of up-to-date infection control guidelines is essential.
32748331 Although various clinical trials are being conducted on renin- angiotensin- system inhibitor, till to date there is no standard treatment protocol approved for critically ill COVID-19 positive cases with pre-existing hypertension.
32748582 To date, COVID-19, with its high infectivity, has killed more people than severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) combined (Wu and McGoogan, 2020).
32750135 The literature to date has focused heavily on issues surrounding the quality of seroprevalence tests and less on the sampling methods that ultimately drive the representativeness of resulting estimates.
32750378 To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings.
32750960 To slow the spread of virus infections and better respond for community mitigation, by advancing capabilities of artificial intelligence (AI) and leveraging the large-scale and up-to-date data generated from heterogeneous sources (e.g., disease related data, demographic, mobility and social media data), in this work, we propose and develop an AI-driven system (named α-Satellite), as an initial offering, to provide dynamic COVID-19 risk assessment in the United States.
32751633 To date, health disparities are associated with COVID-19 mortality among underserved populations.
32752129 Throughout this comprehensive review, we describe the similarities and differences between both conditions and the possible pathophysiological and therapeutic-based mechanisms leading to the low incidence and severity of COVID-19 reported in PAH/CTEPH patients to date.
32753143 To date, the effects of any pandemic on telestroke service lines have not been described.
32753375 The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated.
32754298 We, therefore, decided to conduct this assessment of AFP performance from 2012 to 2019 in the ESA sub-region have evidence documentation and support the certification process of the WHO AFRO region. we reviewed all reported acute flaccid paralysis (AFP) cases from 19 countries in the ESA sub region with the date of onset of paralysis from 1 January 2012 to 31 December 2019.
32754756 From the start date of the epidemic in Korea (18 February 2020), the time to peak and plateau were 15.2 and 25 days, respectively.
32755231 To date, there is no approved vaccine or specific therapy against COVID-19, but many trials are ongoing with some of them showing promising results.
32755724 According to clinical information, the incidence of vertical transmission of SARS-CoV-2 is limited to date. […] As the frequency and molecular mechanisms of intrauterine vertical transmission of SARS-CoV-2 have not been determined to date, intensive clinical examinations by repeated ultrasound and fetal heart rate monitoring are strongly recommended for pregnant women infected with COVID-19.
32755836 Till date, there is no approved medicine/treatment to cure COVID-19, whereas, vaccine development efforts are going on high priority.
32756480 To date, there are no therapies or vaccines that are proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] The most promising therapy to date is remdesivir, which is US Food and Drug Administration (FDA) approved for emergency use in adults and children hospitalized with severe suspected or laboratory-confirmed COVID-19.
32757751 We report the largest case series to date of cerebrovascular complications of COVID-19 and compare with stroke patients without infection. […] Demographic, clinical, laboratory, imaging, and outcome data were collected, and cases were compared with date-matched controls without COVID-19 from 1 year prior.
32758298 Date of trial registration: 10 July 2020.
32758659 The follow-up censoring date was 17 April 2020.
32759006 The Evidence possibly supporting or disputing this hypothesis is reviewed, however the major problem with the hypothesis is that to date no coronavirus has ever been isolated from arthropods.
32759645 The new respiratory infectious disease coronavirus disease 2019 (COVID-19) that originated in Wuhan, China, in December 2019 and caused by a new strain of zoonotic coronavirus, named severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), to date has killed over 630,000 people and infected over 15,000,000 worldwide.
32760206 COVID-19 is a public health emergency that has rapidly spread to over 200 countries and regions, and no effective treatment has been established to date.
32761248 Third, closure taxed personal coping resources but most were able to cope using thought-management (e.g., distraction, focusing on positives), getting mentally and physically fit for next treatments, strengthening their social network, and keeping up-to-date.
32761260 A date-matched control group (n = 205) of patients from 2019 was used for comparison.
32761402 Demographic and laboratory data closest to the CT date were recorded.
32761974 This invited commentary is a series of questions to Dr Mikhail Kazachkov, a pediatric pulmonologist at New York University, about his experiences to date in a major COVID-19 “hotspot” and his thoughts about how other pediatric pulmonologists facing this situation can best support their colleagues.
32762250 To date, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has infected nearly 600 times more people and resulted in 200 times more deaths relative to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) combined.
32762270 This systematic review presents up-to-date evidence on the use of telemedicine and provides data for organisations considering its use in the current COVID-19 pandemic and beyond.
32762411 To date, ∼463,000 people died worldwide due to this disease.
32762537 The ongoing pandemic COVID-19 (COrona Virus Immuno Deficiency-2019) which is caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-CoronaVirus-2) has emerged as a pandemic with 400,000 plus deaths till date.
32762735 Based on the scientific evidence accumulated to date, our view is that SARS-CoV-2 is not spread by the airborne route to any significant extent and the use of particulate respirators offers no advantage over medical masks as a component of personal protective equipment for the routine care of patients with COVID-19 in the health care setting.
32762834 Only limited evidence has been available to date on the accuracy of systematic low-dose chest computed tomography (LDCT) use in the diagnosis of COVID-19 in patients with non-specific clinical symptoms.
32763263 To date, the most utilized definition of ‘most at risk’ for COVID19 morbidity and mortality has focused on biological susceptibility to the virus.
32763338 For instance, numerical simulations suggest that if the lockdown measures in South Africa were implemented a week later than the 26 March, 2020 date it was implemented, this will result in the extension of the predicted peak time of the pandemic, and causing about 10% more cumulative deaths.
32764257 We explore why research to date has failed to show convincing evidence for environmental modulation of COVID-19, and discuss directions for future research.
32764417 Based on the current published evidence, herein we summarize the origin, genetics, epidemiology, clinical manifestations, preventions, diagnosis and up to date treatments of SARS-CoV-2 infections in comparison with those caused by SARS-CoV and MERS-CoV.
32764454 We herein provide a comprehensive and up-to-date overview of the role of ACE-2 and TMPRSS2 genes, as key entry elements as well as therapeutic targets for SARS-CoV-2 infection, which can help to better understand the applications and capacities of various remedial approaches for infected individuals, especially those with lung cancer.
32765185 Participants were asked whether they had experienced fever or other cold symptoms between February 17, 2020 and the date of the survey.
32766112 At the date of this evidence map´s publication, there is no evidence of specific treatments for COVID-19.
32766414 The date is two weeks after the government call of the Republic of Indonesia to carry out Physical Distancing to anticipate the COVID-19 Global Pandemic.
32766546 Only 3.6% of patients required an ICU admission and 1.7% were dead at the study’s cutoff date.
32766756 Date of hospitalization.
32766927 Using an online questionnaire, we asked Japanese board-certified radiologists to register their patients’ information including patient age and sex, the CT examination date, the results of PCR test for COVID-19 infection, CT findings, and the postal code of the medical institution that performed the CT.
32767355 The selection of the countries was based on the daily basis mean temperature from the date of appearance of the initial cases of COVID-19, Dec 29, 2019 to May 12, 2020. […] The data on the global outbreak of COVID-19, daily new cases and deaths were recorded from World Health Organization, and daily information on temperature and humidity was obtained from metrological web “Time and Date”.
32767742 To date, there have been no COVID-19 infections among the bronchoscopy team staff, whereas the overall Hospital staff COVID-19 prevalence rate has exceeded 13.5% (667/4949).
32768308 Children in the Asia-Pacific region, as with children all over the world to date, have fared better than older adults.
32769921 According to the retrieval strategies, randomized controlled trials (RCTs) on the Shufeng Jiedu capsule for COVID-19 were obtained from CNKI, WanFang, VIP, PubMed, Embase and Cochrane Library, regardless of publication date, or language.
32770414 To date, only few cases of GBS associated with this infection have been described.
32770825 To date, there are no proven effective therapies for this virus. […] To date, a considerable number of bacterial strains have been resistant to various antibiotics such as azithromycin, and the overuse could render those or other antibiotics even less effective.
32770973 To this date little information exists on the effects, clinical course and outcome of the COVID-19 among patients undergoing transplantation.
32771034 The intended completion date is December 31, 2020. […] Date of trial registration: May 26, 2020.
32771068 The current study protocol is version 1.0 (20 July 2020) TRIAL REGISTRATION: This study was prospectively registered in the ISRCTN registry (registration number ISRCTN43900695 , date of registration: 8 April 2020).
32771480 Factors predicting willingness to change and vaccinate included child’s up-to-date vaccination status (aOR 2.03, 95% CI 1.29-3.32, P = .003); caregivers’ influenza vaccine history (aOR 3.26, 95% CI 2.41-4.40, P < .010), and level of concern their child had COVID-19 (aOR 1.09, 95% CI 1.01-1.17, P = .022).
32771639 No study has evaluated whether the presence of antibodies to SARS-CoV-2 confers immunity to the infection relapse but however, to date, no human reinfections with SARS-CoV-2 have been confirmed.
32772318 Based on the date of declaration of national lockdown, the cohort was separated into two groups: ‘pre-COVID time’ (PCT), including 86 patients, and ‘COVID time’ (CT), consisting of 74 patients.
32772434 Our results show that urologists lack up-to-date knowledge of preferred protocols for personal protective equipment selection and use, social distancing, and coronavirus disease 2019 testing.
32773286 We provide and describe a cross-functional, collaborative on-the-ground adaptive application of eTCB initially piloted at two hospitals and subsequently reproduced at 16 additional hospitals and health systems in the US to date.
32773618 ICU follow-up programs or peer support groups remain important interventions to learn about and address the multifaceted challenges of critical illness survivorship, but there is little evidence of benefit to date.
32773996 As of this article’s publication date, COVID-19 has spread to approximately 200 countries and territories, with over 4.3 million infections and more than 290,000 deaths as it has escalated into a global pandemic.
32774009 We have not observed any mortality, to date in the Non NOF procedures carried out.
32774178 Given the high mortality rate and economic damage to various communities to date, great efforts must be made to produce successful drugs and vaccines against 2019-nCoV infection.
32774918 Using publicly available data for confirmed COVID-19 cases from the Korea Centers for Disease Control and Prevention from January 20, 2020, to April 30, 2020, we undertook descriptive analyses of cases stratified by sex, age group, place of exposure, date of confirmation, and province.
32775771 Here, we present steps taken to date to flatten the curve at the radiation oncology division of a tertiary cancer center with the goal of mitigating risk of exposure among patients and staff, and optimizing resource utilization.
32776298 To date no trial comparing hydroxychloroquine (HCQ) and lopinavir/ritonavir (LPV/RTV) has been performed.
32776573 This review was conducted to evaluate the impact of CPT in COVID-19 patients based on the publications reported to date.
32777758 To date, there are no confirmed specific therapies, and prevention and management of AKI should follow established guidelines.
32777861 This is the largest study of baseline immune seroconversion in maternity healthcare workers conducted to date and reveals that one out of six were seropositive, of whom one out of three were asymptomatic.
32778180 To date, there is a major lack of understanding of the transmission dynamics and epidemiological characteristics of the disease in India, inhibiting effective measures to control the pandemic.
32778421 To date, seven human CoVs were identified including the alpha-CoVs HCoVs-NL63 and HCoVs-229E and the beta-CoVs HCoVs-OC43, HCoVs-HKU1, the severe acute respiratory syndrome-CoV (SARS-CoV), the Middle East respiratory syndrome-CoV (MERS-CoV) and the novel virus that first appeared in December 2019 in Wuhan, China, and rapidly spread to 213 countries as of the writing this paper.
32779002 Of these, 25 were selected from the Google play store and Apple App store in India, and 19 each from the UK and US. 18 apps were developed for sharing up to date information on COVID-19, and 8 were used for contact tracing while 9 apps showed features of both.
32779309 Most up-to-date evidences about how SARS-CoV-2 affected patients especially in pregnancy were collected by conducting a comprehensive search of medical literature electronic databases.
32779341 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) is the biggest pandemic of our lifetime to date.
32780206 To date, the disease has affected almost all countries in the world. […] The DOTF has positioned us well to confront the many challenges to date.
32780376 To date, few data have been obtained of the prevalence of SARS-CoV-2-antibodies in general population and in asymptomatic outpatients in Germany.From March 26 to June 4 2020, 415 asymptomatic outpatients were tested prospectively in Northrhine-Westfalia (Germany), to detect SARS-CoV-2-IgG-antibodies.
32780415 The present paper is an up-to-date review that discusses the available research regarding the implications of coronavirus infection in COPD.
32781623 Intracranial bleeding was diagnosed on computed tomography (CT) of the brain within one month of the date of COVID-19 diagnosis.
32782784 To date, information about the clinical course of COVID-19 in pre-existing pulmonary arterial hypertension is lacking, and it is thus unknown whether pulmonary arterial hypertension belongs to the risk factors of severe COVID-19 disease.
32784826 Despite this, to date, very few studies have been performed concerning autoptic specimens.
32784922 Results: Although many agents have been proposed as possible treatment, to date, any of the potential drugs against SARS-CoV-2 has shown to be safe and effective for treating COVID-19.
32785155 The approach presented in this paper contributes to the establishment of a methodology framework that may equip decision-makers with up-to-date estimations of health crisis effects on economic parameters of food availability and access to staples in food-insecure communities.
32785162 In this review all the up-to-date findings, concerning the association between COVID-19 and cancer, are reported.
32785701 We have trained a machine learning model to analyze the correlation between SARS-CoV-2 test results and 20 routine laboratory tests collected within a 2-day period around the SARS-CoV-2 test date.
32789282 In light of the considerable COVID-19 disparities observed, this study sought to assess the race reporting and representation among COVID-19 therapeutic studies published to date. […] For each study, the date published, treatment investigated, study design, race/ethnicity of participants, sample size and study site were recorded. […] Six studies (n = 3, observational; n = 3, randomized clinical trial) have been published to date with participants in the United States.
32791241 However, research to date is at high risk of bias, and randomized control trials are desperately needed to determine the efficacy and safety of this therapeutic option.
32791259 To date, only 2 nurses working in China who contracted SARS-CoV-2 have died from COVID-19 in the early period of the epidemic (February 11 and 14, 2020).
32792167 To date, there are no approved antiviral drugs or vaccines against this transmissible disease.
32792492 The final follow-up date observed was April 15th, 2020.
32793245 However, to date, no licensed vaccine exists, neither for SARS-CoV-2 nor for the closely related SARS-CoV or Middle East respiratory syndrome-CoV.
32793722 To date, although many studies have reported on the computed tomography (CT) manifestations of COVID-19, the vascular enlargement sign (VES) of COVID-19 has not been deeply examined, with the few available studies reporting an inconsistent prevalence.
32793722 To date, although many studies have reported on the computed tomography (CT) manifestations of COVID-19, the vascular enlargement sign (VES) of COVID-19 has not been deeply examined, with the few available studies reporting an inconsistent prevalence.
32793722 To date, although many studies have reported on the computed tomography (CT) manifestations of COVID-19, the vascular enlargement sign (VES) of COVID-19 has not been deeply examined, with the few available studies reporting an inconsistent prevalence.
32793722 To date, although many studies have reported on the computed tomography (CT) manifestations of COVID-19, the vascular enlargement sign (VES) of COVID-19 has not been deeply examined, with the few available studies reporting an inconsistent prevalence.
32793722 To date, although many studies have reported on the computed tomography (CT) manifestations of COVID-19, the vascular enlargement sign (VES) of COVID-19 has not been deeply examined, with the few available studies reporting an inconsistent prevalence.
32793722 To date, although many studies have reported on the computed tomography (CT) manifestations of COVID-19, the vascular enlargement sign (VES) of COVID-19 has not been deeply examined, with the few available studies reporting an inconsistent prevalence.
32793722 To date, although many studies have reported on the computed tomography (CT) manifestations of COVID-19, the vascular enlargement sign (VES) of COVID-19 has not been deeply examined, with the few available studies reporting an inconsistent prevalence.
32793722 To date, although many studies have reported on the computed tomography (CT) manifestations of COVID-19, the vascular enlargement sign (VES) of COVID-19 has not been deeply examined, with the few available studies reporting an inconsistent prevalence.
32794454 Laboratory test alterations have been described in COVID-19 patients, but differences with other pneumonias have been poorly investigated to date, especially in Caucasian populations.
32794463 Currently, there are several experimental therapies with demonstrated in vitro activity against COVID-19 used in clinical practice, including hydroxychloroquine, remdesivir, interleukin-6 pathway inhibitors, and convalescent plasma; however, to date no agent has proven efficacy against COVID-19.
32795148 Up to date over a hundred crystallographic structures of SARS-CoV-2 Mpro have been deposited to Protein Data Bank.
32795149 As revealed in the summary independent-samples t test and Hedges’ g values, both Oceanian countries (Australia and New Zealand) reacted differently compared to the other countries, which may have played a role in their low death and infection rates to date.
32795214 Of each trial, medicines assessed, design, sample size, registration date, study start and study completion dates, and type of patients were registered. 106 trials were identified, 62 in Europe and 46 in the USA ─with two conducted in both regions.
32796045 Non-rheumatic controls were randomly sampled 1:1 and matched by age, sex and PCR date.
32798227 Explaining the present situation and best available statistics of the disease, the velocity the disease is spreading and our approximate predicted date its subsidence or partial remission.
32798444 Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history.
32800868 In the context of the COVID-19 worldwide pandemic, an up-to-date review of current challenges in addictions is necessary.
32802142 The SARS-CoV-2 infection has widely spread to become the greatest public health challenge to date, the COVID-19 pandemic.
32802586 Objective: In this brief review, the authors examine the latest available evidence to date regarding the neurological implications of COVID-19 and how the novel coronavirus might possibly impact patients with pre-existing neurological conditions.
32803146 The commonest cardiac presentation to date is acute heart failure resulting from biventricular or left ventricular hypokinesis and elevation of cardiac troponins.
32803255 To date (29 April 2020), the Italian penitentiary system is housing 161 minors (147 males), most of them in pre-trial custody, as well as 50 children <3 y of age residing with their mothers in detention.
32806657 In 2002 and following years, the scenario changed dramatically with the advent of the new more pathogenic CoVs, including Severe Acute Respiratory Syndome (SARS-CoV-1), Middle Eastern respiratory syndrome (MERS)-CoV, and the new zoonotic SARS-CoV-2, likely originated from bat species and responsible for the present coronavirus disease (COVID-19), which to date has caused 15,581,007 confirmed cases and 635,173 deaths in 208 countries, including Italy.
32807047 At present, the world is facing a global pandemic threat of SARS-CoV-2 or COVID-19 and till date, there are no clinically approved vaccines or antiviral drugs available for the treatment of coronavirus infections.
32807209 Azithromycin was widely used to treat severe SARS-CoV and MERS-CoV, but to date, no randomised data are available in any coronavirus infections.
32809115 The date in which the number of daily new deaths will fall below the rate of 3 deaths per million - the average level in which some countries start to relax the stay-at-home measures - was estimated. […] If the daily new deaths curve was bending today (i.e., about 1250 deaths per day), the predicted date would be on July 5.
32810325 There is no standardised and up-to-date education model for urology residents in our country.
32810701 To evaluate the diagnostic and prognostic performance of CT in patients referred for COVID19 suspicion to a French university hospital, depending on symptoms and date of onset. […] Sensitivity, specificity, negative and positive predictive values of first and expert readings were calculated together with inter reader agreement, with results of RT-PCR as standard of reference and according to symptoms and onset date.
32810855 However, to date, prospective studies are lacking.
32811213 Telemedicine, slow to become established in many countries to date, has also revolutionized practice in the current environment.
32812834 The variation in mortality rates reported to date likely reflects differences in the severity of illness of the evaluated populations.
32812872 Control group consisted of patients with new fractures admitted to the hospital in the same date range in 2018 and 2019.
32812904 The emerging SARS-CoV-2, a novel human coronavirus, caused the COVID-19 pandemic, with more than 9.5 million cases and 484 000 known fatalities to date (June 24th, 2020).
32813298 The Odd Ratio (OR) of anaemia related to the severe condition of COVID-19 was 3.47(95% CI: 1.02-11.75, P=0.046) and 3.77 (95% CI:1.33-10.71, P=0.013) after adjustment for baseline date and laboratory indices, respectively.
32813575 To date, nearly 600 research units and companies have claimed to have completed the development of NAT reagents.
32813843 We were unable to find any review of the literature or analysis on ongoing registered clinical trials that reported diagnostic tests, therapeutics, vaccines and devices for COVID-19 along with estimated enrollment, participants’ ages, study type, start and completion date, status, treatment/intervention and country.
32814575 However, to date no specific guidelines or strategies about mental health services of migrant workers have been released.
32815174 For ICU practitioners, management of acute respiratory failure, hemodynamics, and cardiovascular complications certainly are the key for the best treatment of these patients but to date specific data on supportive ICU care for these patients are lacking, and current recommendations are based on existing evidence from other viral infections and general intensive care management.
32816200 Based on the published scientific evidence published to date, we summarized herein the effects of different potential therapies and up-to-date clinical trials.
32817375 Studies to date have now demonstrated that in patients with COVID-19, these drugs are associated with significant QTc prolongation, as well as reports of ventricular arrhythmias.
  • Coverage with ≥1 dose of HPV vaccine increased from 68.1% in 2018 to 71.5% in 2019, and the percentage of adolescents who were up to date† with the HPV vaccination series (HPV UTD) increased from 51.1% in 2018 to 54.2% in 2019.
32819955 The date when COVID-19 was declared an outbreak in Beijing was 20 January 2020.
32820179 Thousands of SARS-CoV-2 strains have been sequenced to date, providing a valuable opportunity to investigate the evolution of the virus on a global scale.
32820359 Since the majority of pain medicine centers have been closed to date, the question has arisen as to whether a resumption of regular care can be easily provided under the required protective measures.
32820868 To date, numerous studies have been conducted to evaluate the safety and efficacy of tissue engineering and regenerative medicine (TERM) products, including mesenchymal stem cells (MSCs), and their derivatives (eg, exosomes) for coronavirus infections, which could be applied for the COVID-19.
32821884 To date, no specific antiviral treatment has been confirmed.
32821939 The date of final follow-up was May 20, 2020.
32822426 To date, millions of infections and thousands of deaths have been reported worldwide, and the numbers continue to rise.
32822955 To date, the effects of the COVID-19 pandemic on neuro-trauma has not been reported.
32823901 In this review, we have compiled the up to date information about the origins, evolution, epidemiology, and pathogenesis of this disease.
32825737 To date, there are no vaccines or specific antiviral drugs to prevent or treat COVID-19.
32825816 None of these registered trial results was available during the timeframe of the pandemic, and the median date of publication was 213 days after the Public Health Emergency of International Concern ended.
32826322 However, to date, studies on protective immunity have been performed only in animal models and correlates of protection have not been established in humans.
32826332 Applying that logic to data on imported cases and local deaths in the United States through 12 March, we estimated that 108,689 (95% posterior predictive interval [95% PPI]: 1,023 to 14,182,310) infections occurred in the United States by this date.
32827728 Changes in encounter characteristics, viral testing patterns, and air pollution before and after Mar 17, 2020, the date public health interventions to limit viral transmission were enacted in Philadelphia, were assessed and compared with data from 2015 to 2019 as a historical reference.
32828135 Indeed, to date, a well-established therapy is still lacking.
32829231 Respondents felt that the most significant factor for work-related changes to mental health was keeping up to date with frequently changing guidelines and protocols related to COVID-19.
32829962 Through this review, we aim to provide an up-to-date summary of current evidence-based literature of hematological manifestations, their consequences and management including role of anticoagulation and drugs targeting cytokine storm in patients with SARS-CoV-2.
32831521 About 400,000 SARS-CoV2-positive patients have been declared ‘recovered’, although it is not clear to date what exactly that entails.
32831936 Till date, no pharmaceutical agent is known to manage in terms of prevention and treatment of coronavirus disease 2019 (COVID-19), the disease caused by a novel virus.
32832913 Relevant and up-to-date literature, media reports, and author experiences were included from Medline, national newspapers, and public clinical trial databases.
32833771 In this article, we explore the diagnostic modalities for COVID-19 based on the available information to date.
32834156 In the meantime, the number of reported new infections has been significantly reduced and the German healthcare system does not appear to be overburdened to date.
32834243 Here, we critically review the limited number of prototypes demonstrated to date that is based on a polymerase chain reaction (PCR) and has come close to fulfill this vision.
32834559 In real wastewater and in sewage sludge, to date studies on the influence of the different parameters on the inactivation of SARS-CoV-2 are not available.
32834573 Visualisation of reported data provides up-to-date condition monitoring, while daily model calibration allows for a continued and updated forecast of the current state of the pandemic.
32834581 Here we use an individual based model (IBM) to study how the duration, start date and intensity of quarantine affect the height and position of the peak of the infection curve.
32834582 We use the model to make predictions about the total expected number of infections in each country as well as the date when the number of infections will have reached 99% of this total.
32834603 A complete scenario is given to demonstrate the estimated pandemic life cycle along with the real data or history to date, which in turn divulges the predicted inflection point and ending phase of SARS-CoV-2.
32834902 This article aims at presenting an up-to-date review on the pathogenesis, diagnosis and complications of COVID-19 infection.
32834946 To date there are over 133 ongoing registered clinical studies on TCM/integrated traditional Chinese and Western medicine.
32834947 Unfortunately, neither drug nor vaccine has yet been approved to date to prevent and treat these diseases caused by CoVs.
32834948 There have been more than 4,400,000 reported cases of COVID-2019 and more than 300,000 reported deaths to date (16/05/2020). […] To date, there is no specific treatment proven effective against these viral infectious diseases.
32834995 We describe the measures implemented in the largest cancer centre in Singapore to continue optimal cancer care in spite of the ongoing pandemic, with no nosocomial infections reported in our centre to date.
32835062 To date, no drugs have demonstrated safety and efficacy in randomized controlled trials for patients with COVID-19.
32835090 To date, there is no approved therapeutics or effective treatment available to combat the outbreak.
32835123 However, no study to date has examined such climatic extensions for the growth or otherwise of the novel coronavirus in Africa.
32835135 To date there is no direct evidence from human or animal studies on the role of lung microbiome in modifying COVID-19 disease; however, related studies support that microbiome can play an essential role in developing immunity against viral infections.
32835962 We investigated the possibility that SARS-CoV-2 emerged in Italy earlier than that date, by analysing 40 composite influent wastewater samples collected - in the framework of other wastewater-based epidemiology projects - between October 2019 and February 2020 from five wastewater treatment plants (WWTPs) in three cities and regions in northern Italy (Milan/Lombardy, Turin/Piedmont and Bologna/Emilia Romagna).
32836410 This article sets out the advantages of this form of deliberation-which bears some similarity to certain types of citizen science-in the context of the UK government’s responses to Covid-19; both the confused decision making evident to date, and the forthcoming re-opening phases that will prioritise or advantage some constituencies over others.
32836447 This Viewpoint essay argues that timely, up-to-date surveys of public sector workers are an essential tool for identifying problems, resolving bottlenecks and enabling public sector workers to operate effectively during and in response to the challenges posed by the global pandemic.
32836712 Data of the date of onset, clinical details, laboratory results, history of travel, history of contact with positive case and control measures initiated were collected, analysed and compared.
32836859 However, to date there has been little attention given to what the consequences of the COVID-19 economic shock may be for the wildlife trade; the people who rely on it for their livelihoods; and the wildlife that is exploited. […] In this policy perspective, we argue that the links between the COVID-19 pandemic, rural livelihoods and wildlife are likely to be more complex, more nuanced, and more far-reaching, than is represented in the literature to date.
32836862 Our analyses show that, to date, differences in policy interventions have out-weighed socio-economic variation in explaining the range of death rates observed in the data.
32837029 However, to date, no study that we know of has identified what type of person is willing to fly during the COVID-19 pandemic.
32837097 Given the rapid pace of clinical information and discoveries, it is important for clinicians to be up to date with the latest, evidence-based treatment options available for this novel disease.
32837113 There are no approved antiviral drugs or vaccines for the treatment of human CoV infection to date.
32837119 Although after the continuous scientific efforts, we are still not having any specific drug or vaccine for the SARS-CoV-2 pathogen to date and there is an urgent need to develop a newer therapy to counter the COVID-19 global pandemic.
32837137 COVID-19 is a global health emergency and no clinically approved vaccines or antiviral drugs available to date.
32837219 There has been no vaccines or drugs available for the treatment of human coronavirus infections to date.
32837240 We outline the work to date on modelling spatially-explicit infective diseases and show that there are gaps that remain important to fill.
32837241 If relaxations are necessary, they should not be performed before this date and should be in small periods, no longer than 25 days.
32837280 The CPA week in comparison with date of lockdown and first reported case strongly correlates (Pearson’s r = - 0.86 to - 0.97) to cases, cases per unit area and cases per unit population, indicating earlier the mitigation strategy, lesser the number of cases.
32837391 To date, there have been zero health care worker transmissions in the department.
32837414 As our knowledge of the transmissibility of SARS-CoV-2 and the symptomatology and management of COVID-19 expands, orthopedic surgeons must remain up to date on the latest medical evidence and surgical perspectives.
32837583 However, a limited amount of research has been done to date in the context of how viral infections impact cancer at the cellular level and vice versa.
32837696 Italy has been the European country most affected by the COVID-19 pandemic to date and has been in social lockdown for the longest period of time compared to other countries outside China.
32837713 Proper understanding of the mechanics of the complex processes whereby the two-phase flow emitted by an infected individual disperses into the environment would allow us to infer from first principles the practical rules to be imposed on social distancing and on the use of facial and eye protection, which to date have been adopted on a rather empirical basis.
32837836 To date (22nd April 2020), the COVID-19 situation in Malta is a total confirmed cases of 444, of which 276 are active cases, 165 have recovered and there were three deaths.
32837847 To date, no specific drug for COVID-19 has been developed.
32837889 The COVID-19 pandemic has led to hardship for individuals across the globe, and research to-date has indicated a significant impact of the pandemic on mental health functioning.
32837947 While it is being recommended worldwide to postpone all elective surgeries to a later date, certain emergency procedures must be undertaken promptly but in a manner that minimizes the exposure of the surgeon and health care staff to the SARS-CoV-2.
32837950 Only 5 studies from the literature have mentioned any smell and taste disturbances after SARS-CoV-2 infection to date.
32838116 The American Academy of Sleep Medicine strongly urges sleep clinicians to continue postponing non-urgent care until a later date, if such a recommendation is made by state officials due to local conditions.
32838146 To date, few cases of COVID-19 meningitis have been confirmed, but it must remain in the differential diagnosis for patients with headache and fever.
32838153 Starting from Wuhan (China) where it was firstly reported, it rapidly spread to the rest of the world, causing a pandemic with more than 300,000 deaths to date.
32838159 To date, there is no definitive treatment for the new SARS-CoV-2 pandemic.
32838283 As the number of deaths due to COVID-19 is increasing rapidly and there is no specific treatment available to date, scientists are evaluating the effectiveness of already approved drugs as therapies against COVID-19, and the results were found to vary widely: from no significant effect being observed to a reduction in the time taken for clinical improvement.
32838300 Although artificial intelligence (AI)-based clinical decision support seemed to have matured, the application of AI-based tools for COVID-19 has been limited to date.
32838447 In this article, the data available to date are examined in order to provide better information, advice and treatment for pregnant women and newborns with SARS-CoV-2 and to provide suggestions for future research.
32838713 But exact biochemical mechanisms of these drugs towards COVID-19 have not been discovered to date.
32839288 To date, little is known on histopathological findings in patients infected with the new SARS-CoV2.
32839763 To date, the phenotypes of SARS-CoV-2-specific T cells remain poorly defined.
32839923 We conducted a retrospective observational study analysing all emergency visits occurring at a metropolitan psychiatric ED between March 19th and May 2nd 2019 and 2020 (the beginning/end date of the emergency state which Portugal was under due to COVID-19). […] Data regarding age, sex, diagnoses, admission date, discharge destiny and status were collected.
32840606 Based on the date of symptom onset in the remaining 41 cases, the period from exposure to illness ranged from 2 to 17 days.
32842849 The need to adapt to remote technology became the most difficult challenge to date for existing practice models.
32843098 The protocol with code 1264, version 3.0 on date: May 13, 2020 is approved by the local Ethics Committee.
32843598 To date, few early post-liver transplantation SARS-CoV-2 infected recipients have been published, but only one was an early postoperative infection.
32844105 The datasets mainly focus on two major fields, first one is First Case which consists of information of Date of First Case(s), Number of confirm Case(s) at First Day, Age of the patient(s) of First Case, Last Visited Country and the other one First Death information consist of Date of First Death and Age of the Patient who died first for every Country mentioning corresponding Continent.This dataset also can perform a bunch of predictions using Machine Learning applications, like -how fast the virus is spreading, affect rate, death rate, death rate and able to represent comparison between other pandemics.
32844133 We use the collected data of the new coronavirus pandemic reported up to date July 30, 2020 in India, the Syrian Arab Republic, the United States, France, Nigeria, Yemen, China and Russia.
32844985 This outbreak quickly reached a pandemic status, affecting at least 185 countries and territories to date on all continents.
32845250 The research team performed a literature review, searching relevant and up to date information from the literature.
32845868 Women were stratified into two groups based on date of delivery in relation to the start of the COVID-19 pandemic in New York (Mid-March 2020); those delivering before or during the COVID-19 pandemic.
32847926 No restriction regarding the language, publication date or setting will be employed.
32848729 The objectives of this review are to provide up-to-date information on the pharmacology and clinical research on CPMs in the treatment of COVID-19, discuss the research findings, and to better guide clinical application and scientific research on CPMs in the treatment of COVID-19.
32848893 Several studies till date have indicated a dysregulated host immune response as the major cause of COVID-19 induced mortality.
32849149 We suggest practical tips for both healthcare workers and organizations and embed this within up-to-date scientific literature.
32849666 To date the pathophysiology of COVID-19 remains unclear: this represents a factor determining the current lack of effective treatments.
32849867 The pathophysiology for SARS-CoV-2 has not been well elucidated, and diverse hypotheses to date have been proposed.
32849934 Despite high morbidity and mortality of ongoing coronavirus disease 2019 (COVID-19) pandemic, no specific therapy has been established till date.
32850925 To date, 20 (9%) patients have retested positive for SARS-CoV-2 RNA after recovering and being discharged.
32851129 To date, the studies that have been published show the presence of elevated D-dimer levels in both the adult and pediatric populations and the measured level correlates with disease severity.
32851910 Novel Coronavirus or SARS-CoV-2 has received worldwide attention due to the COVID-19 pandemic, which originated in Wuhan, China leading to thousands of deaths to date.
32852058 However, to date, no approved vaccines or drugs against CoV infections are available.
32852240 In particular, studies using validated olfactory tests are very rare to date.
32852721 ACEI/ARB use is not associated with either an increased or decreased risk of all-cause mortality, compared with CCB use, in the largest cohort of hospitalised COVID-19 patients exposed to these drugs studied to date.
32853310 To date all the drugs described in this review need clinical studies to validate their use.
32853663 In addition, to date incidence data are underestimated in all countries and to a lesser extent also mortality data.
32855070 Search items were considered from the nature of the articles, date of publication, aims and findings in relation to use of laparoscopic surgery during COVID-19. […] There is no scientific evidence to date for the transmission of COVID-19 by laparoscopic surgery.
32855187 In this clinical case series, we report our experience to date with neurologic complications of extracorporeal membrane oxygenation therapy for COVID-19 Acute Respiratory Distress Syndrome.
32856766 To derive clinical sensitivity of PCR, we identified 209 PCR-positive SARS-CoV-2 patients with multiple PCR test results (624 total PCR tests) and calculated daily sensitivity from date of symptom onset or first positive test.
32858940 To date, no specific antiviral therapy is available for patients with SARS-CoV-2 infection.
32861744 In this review, we provide an up-to-date overview of the current knowledge of the enzymatic and cytokine-like effects of tPA and describe the role of tPA and plasminogen receptors in the regulation of the inflammatory response with emphasis on the cytokine storm syndrome such as observed during coronavirus disease 2019 or macrophage activation syndrome.
32863610 The resulting model allows one to infer, among others, the general peak date, the ending date, and the total number of cases as well as to compare the level of difficult imposed by the pandemic among territories.
32863612 Since the appearance of the first case of COVID-19 in Morocco on March, 02, 2020, the cumulative number of reported infectious cases continues to increase and, up to date, the peak-time of infection is not reached yet.
32863675 No cure is available for this condition till date.
32864070 The authors review the up-to-date scientific evidence of SARS-CoV-2 transmission to demystify and explain the exposure control options available for ophthalmic workplace and offer insights from an industrial hygiene standpoint.
32864104 Literature reviews of research exploring school closure to date have focused upon epidemiological effects; there is an unmet need for research that considers the multiplicity of potential impacts of school closures. […] While dependent upon the nature of epidemics experienced to date, we aim for the model to provide a starting point for theorising about school closures in general, and as part of a wider system that is influenced by contextual and population factors.
32864299 Till date, no drugs have been discovered to treat COVID-19 patients, and therefore, a considerable amount of interest has been shown in repurposing the existing drugs. […] The existing literature hints that till date, the role of CQ/HCQ in COVID-19 may be sceptical, and further studies are warranted for obtaining a therapeutic option that could be effectively used across the world to rise out from this pandemic.
32864545 To date, there is no knowledge of the role children (prepubescent, ages 9-13 years) play as “silent” vectors of the virus, with themselves being asymptomatic.
32864575 Although frantic global efforts for developing safe and effective prophylactic and therapeutic agents are on, no licensed antiviral treatment or vaccine exists till date.
32864815 However, the huge amount of studies makes it challenging to keep up to date with the literature on COVID-19 therapeutic development.
32865556 The primary outcome was the percentage change in COVID-19 cases 5 days from the exposure date.
32867008 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a new public health problem, with a total of 10.577.263 documented COVID-19 cases worldwide and 513.441 deaths up to the present date.
32867137 In this review, we will examine the cardiac involvement associated with SARS-CoV-2 infection, focusing on the pathophysiological mechanism underlying manifestations and their clinical implication, taking into account the main scientific papers published to date.
32867149 While food insecurity (FI) has been extensively studied in many countries, there have been few empirical contributions in Poland to date.
32867349 Neither therapeutic agents nor vaccines have been developed to date, which is a major drawback in controlling the present global pandemic of COVID-19 caused by SARS coronavirus 2 (SARS-CoV-2) and has resulted in more than 20,439,814 cases and 744,385 deaths.
32867852 Clinical Trials Registry of India: CTRI/2020/05/025067 (prospectively registered) Date of registration: 6th May 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32868092 To date, none are FDA approved beyond emergency use authorization (EUA), and 2.
32869558 In conclusion, this study showed the up-to-date evidence of treatment options for COVID-19 that is helpful for the therapy selection and the development of further guidelines and recommendations.
32870117 None of the surgical providers involved in tracheotomy for patients with COVID-19 demonstrated positive antibody seroconversion or developed SARS-CoV-2-related symptoms to date.
32870407 To date, no therapy has demonstrated efficacy in COVID-19.
32870512 An up-to-date understanding of how best to target this therapy (e.g. arterial partial pressure of oxygen (PaO2) or peripheral oxygen saturation (SpO2) aim) in these patients is urgently required.
32870721 To address this, programs should consider hosting informal virtual gatherings, create videos that highlight the resident experience, and ensure that program websites are up-to-date.
32871864 Electronic databases of PubMed, MEDLINE, Google Scholar, Web of science, Cochrane Library, EMBASE, CNKI, CMB, and Wangfang database from the inception to present will be comprehensively and systematically searched without limitations of language, date, and publication status.
32871977 This systematic review findings will summarize up-to-date evidence for that CM is more effective and safe as adjunctive treatment for patients with COVID-19.
32872017 Two independent reviewers will search the following databases of the China Biology Medicine disc, China National Knowledge Infrastructure, China Science and Technology Periodical Database, Wanfang database, Embase, PubMed, and Cochrane Library from the date of conception to June 1, 2020.
32872048 Two independent reviewers searches the databases of the China Biology Medicine disc, China National Knowledge Infrastructure, China Science and Technology Periodical Database, Wanfang Database, PubMed, Embase, and Web of Science from the date of conception to June 30, 2020.
32872736 We performed a case-control study that utilized up-to-date data on the South Korean population provided by the Korean National Health Insurance System.
32873235 To date, few studies have investigated bacterial superinfections in COVID-19 patients.
32873480 To date, it includes viral conjunctivitis, immune conjunctivitis, and oculomotor palsies (OCP) due to the novel coronavirus.
32873575 Updates may occur for up to two years from the date of original publication.
32873583 The median date of NPI implementation in Canada was Mar.
32874038 Moreover, there have been no reported cases of SARS-CoV-2 transmission through tonometry to date.
32874430 Since it was a discovery, COVID-19 has spread to several countries and to this date, affecting about 2,329,651 people and caused about 160,721 deaths.
32874585 To date, little is known on the impact of the pandemic on this population, particularly within the UK.
32874663 We profiled the first 147 cases referring to sex, age, place of residence, probable country of infection, return day to Romania, COVID-19 confirmation date and the probable modes of COVID-19 transmissions.
32874698 According to the Ministry of Health and population of The Government of Nepal, as of June 20, 2020, out of a total of 8,605 laboratory confirmed cases reported to date, the pattern shows that most of the cases fell into the cohort of 21-30 years (37.72%), followed by 11-20 years (24.35 %), 31-40 years (21.97%) and 41-50 years (9.2%). […] To date Nepal has recorded a total of twenty-two deaths.
32874745 Several studies to date have suggested worse outcomes occur in patients with elevated troponin levels. […] Additionally, there have been concerns raised regarding COVID-19-related myocarditis, of which reported biopsy-proven cases to date appear to be rare.
32874851 COVID-19 posed a major public health threat on China with a cumulative number of cases over 89,000 (data cut-off date: August 9th, 2020).
32874863 The analysis on the excess deaths also shows that the impact in deaths is far higher than the official numbers reported to date for some countries.
32874996 From the enactment of COVID-19 mitigation policies to the date of survey completion, 90.1% of fellows had performed fewer than 20 cases. […] Also, 10 respondents’ intended practice start date was being delayed by their employer.
32875276 To date, there are about 18.8 million infected people and about 700,000 deaths.
32875494 In the largest study of SNFs to date, SARS-CoV-2 infections were detected among both employees and residents.
32875509 Public health messaging to date may not be effectively reaching vulnerable communities.
32875950 To the best of our knowledge, till date only one compound has been identified and tested in-vitro as a potent inhibitor of 3CLpro protein, addressed as N3 (PubChem Compound CID: 6323191) and is known to bind irreversibly to 3CLpro suppressing its activity.
32876275 No filters related to date, language or publication status were applied.
32876277 To date, several scientific publications have revealed a concentration of up to 60% of deaths attributed to COVID-19 in such institutions.
32876296 In particular, from February 26, 2020 (date of the first COVID-19 case reported in Brazil) until June 18, 2020, Brazil reported 124 maternal deaths.
32876623 To date, Remdesivir has been the only antiviral authorized by FDA as therapy for emergency use.
32876694 The trials were conducted in 12 countries from February 26, 2020, to June 9, 2020, and the date of final follow-up was July 6, 2020.
32877383 To date, no information is available on the risk of contagion from the peritoneal fluid with which surgeons can come into contact during the abdominal surgery on COVID-19 patients.
32877391 To date, more than seventeen million confirmed cases and more than half a million died worldwide from COVID-19.
32877395 To date, some scientific publications provide initial evidence that SARS-CoV-2 can be detected in the air, thus assuming a further route of infection, that airborne, although these results are to be considered preliminary and they need careful interpretation.
32877867 Although some studies have already been undertaken into the subject of health-focused inequality in the cities of developing countries, the spatial inequity in hospital accessibility has rarely been discussed to date.
32877985 To date, there has been relatively little published research on the mental health impacts of COVID-19 for the general public at the beginning of the U.S.’ experience of the pandemic, or the factors associated with stress, anxiety, depression, and post-traumatic growth during this time.
32878480 To date, no study has examined whether an increased fraction of inspired oxygen (FiO2) may affect the expression of SARS-CoV-2 entry receptors and co-receptors, including ACE2 and the transmembrane serine proteases TMPRSS1, TMPRSS2, and TMPRSS11D.
32878619 There was a visible difference by discharge status, with patients who were discharged alive having longer LoS than those who died during their admission, but no trend associated with study date.
32878641 To date, August 30, 2020, no effective, proven therapeutic antibodies or specific drugs, and vaccines have turned up.
32879801 Experts suggest that almost everyone in China is susceptible to SARS-CoV-2 infection, and to date, there are no effective treatments.
32880078 As society is running against the time to combat the COVID-19, we present here a comprehensive review dealing with up-to-date information of therapeutics or drug regimens being utilized by physicians to treat COVID-19 patients along with in-depth discussion of mechanism of action of these drugs and their targets.
32880263 However, much of the local debate to date has centred on questions surrounding whether regulatory approval processes are limiting access to serological tests, and has not paused to consider the intrinsically limiting impact of underlying fundamental biology and immunology on where and how different COVID-19 serological tests can usefully be deployed in the response to the current pandemic.
32880407 Accurate, up-to-date data are the bedrock of effective public health responses, including in the context of the suffering caused by COVID-19.
32880635 Despite this, there has been little research to date on the relationship between loneliness and COVID-19 preventive behaviours.
32880651 Treatment changes were defined by changes in vitamin D type and dose between the date of the last vitamin D level measurement and the date of COVID-19 testing.
32881007 This review was conducted to evaluate the impact of glucocorticoid therapy in patients with COVID-19 based on the publications reported to date.
32881055 However infections in neonates are higher than in older children, according to the largest population-based study to date, and this means that infants may also face a higher risk of severe respiratory failure (1).
32881976 To date, most studies have focused on the effect of COVID-19 on kidney function, whereas data regarding kidney function on the COVID-19 prognosis is scarce.
32882184 To date, reports have identified 5main categories: acral lesions, vesicular rashes, urticarial rashes, maculopapular rashes, and livedoid and necrotic lesions.
32882393 We included all adult human studies (>20 subjects) regardless of language, region or publication date or status.
32882434 Each analysis was performed using two different calculations of CFR: according to the calendar date and according to the days since the outbreak of the first confirmed case. […] We thus explored an innovative and original calculation of CFR, concurrently based on the date of the first confirmed case as well as on a daily basis. […] For the first time, we showed that using meta-analyses according to the calendar date and days since the outbreak of the first confirmed case, were different.
32884603 While only a few in vitro studies have pointed to some efficacy of these drugs as a prophylactic against COVID-19, to date, there are no clinical studies that have established any clinical efficacy of these drugs as a prophylactic.
32885278 Whereas anesthesiologists may be primarily concerned with airway and respiratory management, the COVID-19 data accumulated to date indicate that primary and/or secondary cardiovascular complications are common.
32886249 Demographic data, comorbidities, ASA grade and date of death (if applicable) were collected.
32888676 All personnel in charge of colorectal surgery units nationwide received a survey (from February to April, 2020) with eight questions divided into three sections-cessation date of colorectal cancer surgeries, number of patients waiting for treatment, and use of neoadjuvant therapy to postpone surgery.
32890139 To date, there are no studies that compared the disease severity of COVID-19 in SOT recipients with nontransplant patients.
32890343 There is perception that this phenomenon has involved also surgical emergency, but no extensive data have been presented to date.
32890353 The COVID-19 epidemic has been a major global public health problem during past months in Italy and in several other Countries and on the date of publication of this article, is still a serious public health problem.
32890356 The aim of this paper is to enhance the importance of providing up to date informations about nicotine and tobacco use in connection with the SARS-CoV-2-related conditions.
32890371 In the case of a convergent inversion a mid-callosal clash will result, which is observable in psychoses as a mid-callosal high-flow-spot simultaneously with hyper-perfusions of branches and “backwatering” of pial vessels with reactive waste - till date interpreted psycho-mathematically.
32890516 Telehealth initiatives have been started in 64.3% of facilities to date for on-treatment (29.6%) and posttreatment (34.8%) patients.
32891160 The intended completion date is 15th January 2021. […] Date of trial registration: 11 May 2020.
32892500 In many countries, the pandemic had experienced two waves to date.
32893532 To date, infection control measures for COVID-19 have been focusing on the involvement of the respiratory system.
32894436 To date in Ireland, over 3300 patients have been admitted to acute hospitals as a result of infection with COVID-19.
32894621 Lung ultrasound has become an important tool in diagnosis and follow-up of patient with COVID-19 infection.Here we review available, up to date literature on ultrasound use for COVID-19 suspected pediatric patients and contrast it to published findings in adult patients.
32894641 To date, no recipients have developed posttransplant COVID-19.
32894747 In this viewpoint, we highlight evidence regarding the increased potential of AYA to transmit SARS-CoV-2 that, to date, has received little attention, discuss adolescent and young adult specific considerations for future COVID-19 control measures, and provide applied programmatic suggestions.
32894838 To date, there have been few reports of kidney biopsy findings in the context of AKI in COVID-19 infection.
32895056 The date of approval is 18th June 2020.
32895596 These findings add an important perspective to the emerging literature on the efficacy of shelter-in-place orders, which to date is dominated by studies of the United States.
32895747 Physicians face the challenging task of keeping up with the most up-to-date information on COVID-19.
32895900 To date, most MSC-based preclinical and clinical trials targeted immune-mediated and inflammatory diseases.
32896226 Till date, there is no vaccination or drugs been approved for the treatment by the World Health Organisation.
32897389 The reported SARS-CoV-2 Simoa antigen assay is the first to detect viral antigens in the plasma of COVID-19 positive patients to date.
32898149 NSAID users (defined as individuals having filled a prescription for NSAIDs up to 30 days before the SARS-CoV-2 test) were matched to up to 4 non-users on calendar week of the test date and propensity scores based on age, sex, relevant comorbidities, and use of selected prescription drugs.
32901229 To date, several modes of transmission such as droplet, contact, airborne, blood borne, and fomite have been described as plausible.
32901580 Neuropsychologists need to understand the potential cognitive and psychological sequelae of COVID-19 and the impact of the interventions (e.g., ICU, ventilation) that have been used in treating patients with severe forms of the illness.Method: We briefly review the literature regarding the neurological and neuropsychological effects of similar coronaviruses, the limited information that has been published to date on COVID-19, and the literature regarding the long-term cognitive and psychological effects of undergoing treatment in the intensive care unit (ICU).
32901696 Here, we estimate the probable onset date of the community spread of SARS-CoV-2 for heavily affected countries from Western Europe and the Americas on the basis of the cumulative number of deaths reported during the early stage of the epidemic.
32902087 A literature search in the PubMed and Scopus databases was conducted, till the cut-off date of 24th July 2020, using the following terms: “skin” or “cutaneous” or “urticaria” or “urticarial,” and “COVID-19” or coronavirus disease.
32902338 To date, research on preferred interpersonal distances suggests that social distancing could induce discomfort, heighten arousal, and decrease social signaling in the short term.
32902940 To date, there is no valid medication or vaccination.
32903258 Secondary outcomes were ICU transfer, intubation, in-hospital mortality, discharge, length of stay, and daily trend of SpO2/FiO2 (SF) ratio from the index date.
32903391 To date, no studies have taken into consideration the possible secondary effect of mechanical ventilation on brain recovery and outcomes.
32904353 To predict the number of active cases, deaths and recovery, date wise analysis of current data was done and necessary parameters like daily recovery, daily deaths, increase rate of covid-19 cases were included.
32904494 Most participants (92.2%) identified elderly individuals as one of the high-risk groups for severe complications and death while 89.5% identified supportive therapy and life support as recommended management options to date.
32904707 In particular, SARS-CoV-2 spread rapidly over the globe affecting nearly 25.000.000 people up to date.
32904875 Key recommendations specific to the COVID-19 pandemic include providing up-to-date, health literate, concise information about preventing COVID-19 and accessing care including telehealth.
32905064 In this article, we present new datasets to track the extent to which multilateral financial institutions are meeting these goals, and conduct a preliminary assessment of progress to date.
32905098 Our analysis shows that with no lockdown around 2.1 million people might get infected during the peak of spread around 2 months from the date the lockdown was first enforced in KSA (March 25th).
32905786 To date, there is little published data regarding the presentation and severity of illnesses during the coronavirus disease 2019 pandemic.
32906151 These data are the highest seroprevalence rates observed to date and highlight the significant burden of asymptomatic infection.
32907635 Protocol version 3.0, 18 May 2020 Recruiting start date: June 2020.
32907638 Duration of hospitalisation: Days from the date of enrolment to the date of discharge 3.
32907693 Between the 31st of December 2019 and the 30th of August 2020 (date of this article), the novel coronavirus and its corresponding infection, COVID-19, more than 25 million cases and 843,158 deaths have been registered.
32909171 This comprehensive review aimed to: identify all up-to-date original publications relating to urology and COVID-19, characterise where publications were from, and outline what topics were investigated.
32909890 Her symptoms and pericardial effusion resolved, and she was discharged to home 3 days later on ibuprofen and colchicine with instruction to quarantine at home for 14 days from the date of her positive testing for COVID-19.
32910251 To our knowledge, cases of spinal epidural abscess in COVID-19 patients have not been reported to date.
32910604 To date, we have limited information on the operations performed on these patients.
32912089 COVID-19 has to date affected over 5 million people worldwide and caused in excess of 300000 deaths.
32912356 The older population is the most vulnerable to serious complications from this illness and over 90% of deaths due to COVID-19 to date have been in patients over the age of 65.
32915172 To date, there is a lack of reliable study data on the care for patients with complex respiratory, atopic, and allergic diseases in times of an imminent infection risk from SARS-CoV-2.
32915657 One approach organizations may take to tackle this involves issuing raw data publicly for collaboration with other organizations in order to spark discussion, collectively experiment and stay up to date with advances in scientific knowledge.
32916509 To date, maximal precautions to prevent coronavirus infection should be maintained in MS/NMOSD patients already exposed to COVID-19 during anti-CD20 therapy.
32917259 The date of approval is 14th April 2020.
32918792 In the absence of mechanical ventilation, the timing of the dose was related to the patient’s date of admission only.
32920231 This article outlines the role of African civil society in safeguarding gains registered to date in sexual and reproductive health and the response to HIV.
32920233 To date, the rapid spread of the newly emerged coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has affected over 3.8 million people across the globe.
32921700 Cases were classified as transmitted before or after the decree according to the date of last contact with a COVID-19 case or, if this date was unavailable, we used the date of onset of symptoms considering the incubation period.
32921705 The mortality rate of COVID-19 was 4.71% in the normal Iranian population compared to 18.6% in β-thalassemias (P: <0.001) at the same date.
32921707 Because of this rapid increase in infected people scientists wonder whether SARS-CoV-2 was already highly circulating in Lombardy before such date.
32921710 A digital search was performed in Medline and Web of Science, using the keywords “coronavirus disease 2019” OR “COVID-19” OR “severe acute respiratory disease 2” OR “SARS-CoV-2” AND “recurrence” OR “repositivization” OR “retesting”, without date or language restrictions.
32921717 To date, more than 9,000 academic papers have been published since December 2019.
32921732 To date, it is only clear that no drug can alone cope with all the problems posed by SARS-CoV-2 infection and effective antivirals and inflammatory drugs must be given together to reduce COVID-19 clinical manifestations.
32921865 The association between COVID-19 cases and climate indicators in London, UK were analysed statistically employing published data from national health services, UK and Time and Date AS based weather data.
32922769 Till date, no definite treatment for COVID-19 has been discovered.
32923299 Lumbar spine and femur proximal bone mineral density (BMD) were measured at the last follow-up date (May 25 to June 30, 2020; 0M) and six (6M) and 12 months (12M) before the last follow-up using dual-energy X-ray absorptiometry.
32923450 To date, there is no specific anti-SARS-CoV-2 drug.
32923601 We relate this reduction to two of the government’s actions: the announcement of the first report in each province and the date of a province’s lockdown.
32924650 Limits were put on date to obtain articles between December 2019 to May 2020 (the time at which the search was performed). 776 articles were identified and screened.
32924707 Retrospective, single-center case series of the 66 hemodialysis patients with confirmed COVID-19 from 1 January to 5 March 2020; the final date of follow-up was 25 March 2020.
32924965 After finding the first positive cases, the question arose whether the virus had entered Hungary and caused infections before this date.
32925114 To date there is no clear evidence of vertical transmission of the virus before birth.
32926160 Yet, to date, there are no longitudinal studies that examined whether the pandemic affects PA levels and what factors help people remain physically active during lockdown.
32926171 With over 9,000 completed surveys from every US state and over 70 countries worldwide, to our knowledge this is the largest pandemic messaging study to date.
32926211 Studies published to date have also reported abdominal imaging findings including small and large bowel wall thickening, fluid-filled colon, pneumatosis intestinalis, pneumoperitoneum, intussusception, and ascites.
32927628 However, to date, children, especially neonates, have been relatively spared from the devastating consequences of this infection.
32929403 To date, clinical outcomes appear reassuring, but data related to important long-term outcomes are missing or not yet reported.
32930523 More than ten million patients worldwide have been diagnosed with coronavirus disease 19 (COVID-19) to date (WHO situation report, 1st July 2020).
32932582 To date, no information is available about care dependency.
32932612 To date, only hypotheses have been raised to explain this difference, so it is of great importance to describe the presentation of this disease among children.
32932930 Few publications to date describe using these drugs in COVID-19.
32933552 The registration date is 31 May 2020.
32934635 Since the COVID-19 outbreak is up to date existed, therefore this report is considered as interim guidelines for airway management of the suspected/confirmed patients.
32935873 Neuropathological examination of brain tissue at autopsy will be essential to establish the neuro-invasive potential of the SARS-CoV-2 virus but, to date, there have been few detailed studies.
32936466 Although in 2016 the GPEI expected to globally coordinate cessation of the remaining OPV serotypes (1 and 3) by 2021, continuing transmission of serotype 1 wild polioviruses to date makes those plans obsolete.
32936947 The date of the search was 1 June 2020.
32936948 The date of the search was 1 June 2020.
32936949 The date of the search was 1 June 2020.
32938496 Protocol Code: SARTRE Protocol Date: May 05th 2020. […] Start of recruitment: August, 2020 End of recruitment: May, 2021 TRIAL REGISTRATION: Identifier: EudraCT Number: 2020-002037-15 ; Registration date: 26 May 2020.
32938901 MATERIAL AND METHODS A total of 243 patients with STEMI who underwent PCI were consecutively enrolled and divided into 2 groups according to the date, before or after the pandemic.
32938937 To date, there is no treatment for coronavirus infections, making the development of therapies to prevent future epidemics of paramount importance.
32939911 To date, there are no reports on Magnetic Resonance Imaging (MRI) findings in patients with persistent anosmia or hyposmia due to COVID-19.
32940705 The CDC COVID-19 Information Management Repository was created to address the need for PH and health-care stakeholders at local and national levels to easily obtain access to comprehensive and up-to-date information management resources.
32941066 The main exposure was survey completion date (March 10-16, 2020).
32941252 To date, nearly 80,000 users from 132 countries have accessed the curriculum. […] As understanding of the COVID-19 pandemic is constantly changing, the student authors’ immediate goal is to keep the curriculum up to date in the months to come.
32941461 The further the onset of symptoms was from the date of collection, the greater the sensitivity. […] The sensitivity of COVID-PRESTO® test ranged from 10.00% for patients having experienced their 1st symptoms from 0 to 5 days ago to 100% in patients where symptoms had occurred more than 15 days before the date of tests.
32942705 To date, there are limited reports describing differences in clinical, laboratory, and radiological characteristics between asymptomatic and symptomatic infection, and between younger and older pediatric patients.
32942796 To date, there has been no review of all the clinical trials that have assessed the safety and efficacy of MSC therapy in organ failure commonly seen in seriously complicated COVID-19 patients.
32943228 To date, there are limited data available on the analytical performance of emerging commercially available assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and integration of these assays into laboratory workflows.
32943287 To date, little evidence is available about the effect of lockdown release in terms of adolescent health from the perspective of an emergency department (ED).
32943630 Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear.
32943888 To date, no specific vaccine or drug has been proven to be effective against SARS-CoV-2 infection.
32944292 Coronavirus disease 2019 (COVID-19) is a debilitating viral infection and, to date, 628,903 people have died from it, numbers that cannot yet be compared to the 50 million who died in the 1918 flu pandemic.
32945643 Novel coronavirus disease (COVID-19) has affected nearly 7 million individuals and claimed more than 0.4 million lives to date.
32945710 The prescription was not documented in the oxygen section of the drug chart (n = 37, 56.1%, p = 0.389), nor did it have the physicians signature (n = 40, 60.6%, p = 0.110) nor date (n = 46, 69.7%, p = 0.002).
32945766 The regression model also included vectors of fixed effects for the day of the week, the calendar date, and the zip code of residence.
32946270 Conclusions The existing literature on cognitive sequela of COVID-19 infection is small to date, but much can be learned from similar viral infections and disorders.
32947121 To date, the published data has analyzed the seroprevalence of COVID-19 infection in the general population, but not in cancer patients.
32947927 Several promising therapeutics are under investigation to the overall prognosis of COVID-19 patients with high risk of cardiovascular impairment, nevertheless to date, none have shown proven clinical efficacy.
32948577 We classified trials according to intervention type, and report key trial characteristics including recruitment status, location, funder type, target enrolment number, intervention model (single group, randomised or sequential assignment) and projected completion date.
32948856 Relative to these indicators, SARS-CoV-2 RNA concentrations in sludge were 0-2 d ahead of SARS-CoV-2 positive test results by date of specimen collection, 0-2 d ahead of the percentage of positive tests by date of specimen collection, 1-4 d ahead of local hospital admissions and 6-8 d ahead of SARS-CoV-2 positive test results by reporting date.
32949606 Up to date, they are tested for a number of other disorders including the broad spectrum of viruses.
32952250 However, to date, researchers have not considered how demographics and personality could interact to influence COVID-19 coping responses.
32952300 The limit of detection (LOD) of the clinical specimen was 200 copies/mL, which is the lowest LOD among the published RNA measurement of SARS-CoV-2 to date.
32952823 To date, 42 African countries imposed lockdowns on movements and activities.
32952854 To date, COVID-19 infection has led to about 165000 deaths in 150 countries.
32952855 To date, several clinical trials have been registered to assess the safety, efficacy, and therapeutic potential of MSCs in COVID-19.
32954247 To date, there have been no published review of therapeutics in the pregnant patient infected with SARS-CoV-2.
32956164 Some digital tools have been used as components of SUD research in the past; however, no published clinical trial in SUDs to-date has been entirely virtual.
32956550 To date, there is limited evidence that these informal healthcare providers receive support from community-based nurses.
32957036 Survivors of critical illness and ARDS often experience neurocognitive impairment but, to date, there is scant literature correlating radiographic hypoxic brain injury to hypoxemia related to ARDS.
32957894 Vaccines and antiviral medications are still under trial to prevent or treat infections of human coronavirus (HCoV) till date.
32958069 To date, only a few neonatal early-onset sepsis by SARS-COV-2 has been reported worldwide.
32959032 When applied to the COVID-19 Open Research Dataset (CORD-19), dimensionality reduction suggests that COVID-19 studies to date are primarily clinical-, modeling- or field-based, in contrast to the vast quantity of laboratory-driven research for other (non-COVID-19) coronavirus diseases.
32959455 Finally, we discuss emerging evidence supporting the reduction in mortality in patients with COVID-19 with the use of corticosteroids, while tabulating up-to-date information on the safety of various investigational therapies for COVID-19.
32959547 The final follow-up date was May 19, 2020.
32960646 To date, there are no scientific papers offering disease and/or recovery profiling for patients with dysphagia and coronavirus disease 2019.
32960938 During the outbreak of COVID-19 and up to the present date, there have been no confirmed cases of COVID-19 in this hospital thanks to strict protocols for infection prevention and control.
32961082 No vaccine against any human coronavirus is available to date.
32962613 The article highlights an up-to-date progress in studies of structure and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic.
32962623 To date, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of individuals around the world.
32963441 This description is up to date as of now, but as more experiences are pouring from different corners of the world, almost every day, newer knowledge and information will crop up by the time this article is published.
32963819 Several treatment strategies are currently under investigation for COVID-19, but none of them have been proved to be safe and effective to date.
32964098 Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available.
32964657 A total of 81 polymerase chain reaction (PCR)-confirmed COVID-19 positive subjects, of whom 54 self-reported smell loss, were prospectively recruited ≤5 days from diagnosis date between May 8, 2020, and July 8, 2020.
32965017 The information on daily temperature and humidity was obtained from world climate web “Time and Date”. […] The daily cases, deaths, temperature and humidity were recorded from the date of appearance of first case of “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)” in the European region, from Jan 27, 2020 to July 17, 2020.
32965378 The implementation’s timing considered both the chronological date and the epidemiological timing, based on the time since the 10th case or 1st death from COVID-19 in each state.
32966809 The reader should take advantage of the most up-to-date information when making clinical decisions.
32967005 Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.
32967179 To date, there is no specific medicine or vaccine available against this pandemic disease.
32967466 However, to date, only a few data are available on the impact of COVID-19 pandemic on ophthalmological care in different health care systems, its future consequences in terms of disability, and access to sight-saving cures for many patients.
32967538 Data from available research were used to estimate parameters for the calculation of population attributable risk for COVID-19 deaths reported to date. […] Assuming Trump’s pronouncement to have caused 25%, 50%, and 75% of the non-use of masks, estimates of Trump-attributable COVID-19 deaths to date would be, respectively, 4,244, 8,356, or 12,202.
32969125 To date there are no randomised trial data on its use in any novel coronavirus infection, although a large number of trials are currently in progress.
32969846 The expected number (predicted period) was assumed based on the linear trend of trauma activations seen in the prior 3 years (2017 to 2019) for the same date range (March 20, 2020 to May 14, 2020).
32969952 Mobility exposure: indicator of order enactment by March 29, 2020 (date of mobility data collection).
32970560 To help equip frontline emergency clinicians with up-to-date protocols throughout the evolving COVID-19 crisis, our team set out to create a dynamic digital tool that centralized and standardized resources from a broad range of platforms across our hospital.
32970655 The COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) (3) collects data on hospitalized pregnant women with laboratory-confirmed SARS-CoV-2, the virus that causes COVID-19; to date, such data have been limited.
32970935 This review gathers the available evidence on the global spread of CoVs in wild birds to date.
32972300 Furthermore, compounding these concerns is the inadequate supply of personal protective equipment, decreased hospital capacity, and paucity of effective treatments or vaccines to date for COVID-19.
32972778 In this article, we describe the mental health outcomes known to date in regard to the novel coronavirus disease 2019 pandemic for obstetric patients and their providers as well as therapeutic approaches, including our novel embedded mental health service, to address these mental health needs.
32972861 Studies to date support the safety-and increasingly the efficacy-of CCP to treat COVID-19.
32973066 To monitor the spreading of COVID-19 in Italy from February 24th to March 13th (the date of the Italian lockdown), official daily data for PM10 levels were collected from all Italian provinces between February 9th and February 29th, taking into account the maximum lag period (14 days) between the infection and diagnosis.
32973526 To date no specific antiviral drug have been approved for COVID-19, so the treatment of the disease is mainly focused on symptomatic treatment and supportive care.
32974019 We have outlined the common neurological manifestations in COVID-19 (information are up-to-date as of June 2020) and discussed the possible pathogenetic mechanisms and management options.
32974268 To date, no vaccine or definitive treatment is available to defeat the virus and therapies are mainly based on existing drugs used to treat other conditions.
32974860 Drawing on a health and human rights framework, this commentary explores several features of the Canadian response to date that raise human rights concerns.
32975182 These results suggest that a larger number of people have been infected than the counts detected by surveillance to date; nevertheless, the results suggest the large majority of the general population in Addis Ababa currently is susceptible to COVID-19.
32977074 The extent of the impact of COVID-19 has not been well characterized in large samples of PwMS to date.
32977525 The purpose of this review paper is to summarize the main approaches developed to date in the chemical and photodynamic inactivation of human and animal viruses using porphyrins and their analogues and to analyze and discuss the information on viral targets and antiviral activity of porphyrins, chlorins, of their conjugates with organic/inorganic compounds obtained in the last 10-15 years in order to identify the most promising areas.
32978111 In order to understand more fully the challenges and successes of technology-enabled care to date, a national survey of practice across hand units in the UK was conducted.
32978207 Retrospective cohort study of 516 patients consecutively admitted for COVID-19 to two Italian tertiary hospitals located in Northern and Central Italy were collected from 22 February 2020 (date of first admission) to 10 April 2020.
32978313 To date, there are no U.S. […] To date, there are no approved prophylactics or therapeutics available for COVID-19.
32978339 The COVID-19 pandemic has had variable impacts in the WHO South-East Asia Region to date, but in the countries most affected there has been targeted diversion and repurposing of tuberculosis services, health-care workers and diagnostic equipment.
32978344 Effective communication of essential, accurate and up-to-date information regarding COVID-19 prevention and control is essential in this population - especially for men, older age groups and those lacking formal education.
32978347 To date, application of the three-step analysis to data from countries of the region has signalled potential inadequacies of testing strategies.
32978702 The data lock point date was 7 June 2020.
32979305 To date, research on the indirect impact of the COVID-19 pandemic on the health of the population and the health-care system is scarce.
32979667 To date, in vivo effectiveness of PVP-I against SARS-CoV-2 has yet to be established and possible risks of its direct use on upper aerodigestive mucosa of children must be weighed.
32979987 The index date (start of follow-up) for both cohorts was March 1, 2020; follow-up lasted until May 6, 2020. […] For the COPD cohort, individuals were eligible if they were aged 35 years or older, had COPD, were a current or former smoker, and were prescribed an ICS or long-acting β agonist plus long-acting muscarinic antagonist (LABA-LAMA) as combination therapy within the 4 months before the index date. […] For the asthma cohort, individuals were eligible if they were aged 18 years or older, had been diagnosed with asthma within 3 years of the index date, and were prescribed an ICS or short-acting β agonist (SABA) only within the 4 months before the index date. […] We identified 148 557 people with COPD and 818 490 people with asthma who were given relevant respiratory medications in the 4 months before the index date.
32981492 In Victoria, 97% of cases (621) were locally acquired and were mostly reported from residential aged care facilities; and 3% of cases (19) were reported as under investigation at the date of extract this reporting period.
32981871 All OMFS programs (100%) implemented guidelines to suspend elective and nonurgent surgical procedures and limited ambulatory clinic visits by third week of March, with the average date being March 16, 2020 (date range March 8-23).
32981876 To date, there are no specific guidelines to optimize telemedicine encounters in oral and maxillofacial surgery.
32982078 Based on our projection results, the probable peak date is estimated to be on August 1, 2020 with approximately 1073 (95 % C I : 714 - 1654) daily confirmed cases.
32982082 To date, there is no definite answer about whether people who recover from COVID-19 can be reinfected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
32982514 Since the new measures were implemented, to date there have only been three new confirmed cases of COVID-19 infection, no cases of medical staff infection, and no COVID-19-related deaths at the hospital.
32982616 Although previous outbreaks of human coronaviruses (CoVs) such as SARS and MERS stimulated research, there are, to date, no antiviral therapeutics available that specifically target these kinds of viruses.
32983694 Data were also stratified by date and comparison was made between the intra-COVID-period (March and April 2020), pre-COVID period (March and April 2019), and peri-COVID period (January and February 2020).
32984764 A systematic review was done to analyze the clinical profile and outcomes in a total of 45 cases of new-onset ITP in COVID-19 patients described in literature until date.
32984766 To date, many medical schools have successfully transitioned their educational environment to emergency remote teaching and assessments.
32984987 To date, COVID-19 had spread to almost 235 countries and territories due to its highly infectious nature.
32985046 To date, no studies have been conducted examining how this fear of COVID-19 contributes to health, well-being and work outcomes in frontline nurses.
32986137 To date the severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), known as COVID-19, is for clinicians the most difficult global therapeutic problem.
32986989 Uninfected pregnant women (controls) were matched to coronavirus disease 2019 cases on a 2:1 ratio based on delivery date.
32987008 However, initial reports of ECMO use in patients with COVID-19 described very high mortality and there have been no large, international cohort studies of ECMO for COVID-19 reported to date.
32987103 To date, the pandemic of COVID-19 causes 11.8 million cases and about 545481 deaths in the world.
32987167 Novel coronavirus disease-19 (COVID-19) has spread worldwide, and to date presence of the virus has been recorded in 215 countries contributing 0.43 million of death.
32987177 Absolute numbers of COVID-19 cases and deaths reported to date in the sub-Saharan Africa (SSA) region have been significantly lower than those across the Americas, Asia, and Europe.
32987551 Our findings suggest that if the lock-down date in Wuhan is earlier, the infectious cases are fewer. […] Moreover, we reveal the effects of city lock-down date on the final scale of cases: if the date is advanced two days, the cases may decrease one half (67, 95% CI: 66-68); if the date is delayed for two days, the cases may reach about 196 (95% CI: 193-199).
32988772 In this review, the authors discuss up-to-date advances in immune-based therapy for COVID-19.
32991223 A seamless Phase I/II design has been applied in multiple COVID-19 vaccine studies to date.
32991879 To date, COVID-19 has caused about 935,000 deaths in more than 200 countries.
32992359 The present comprehensive review aims to show the full extent of what is known to date and provide a more thorough view on the effects of SARS-CoV2 in pregnancy.
32993013 To date, no study has evaluated the impact of Covid-19 on safety culture.
32993173 Overall, we aim at presenting up-to-date details of anti-COVID-19 therapeutics so as to catalyze their potential effective use in fighting the pandemic.
32993921 Analysis was performed between two groups, Group A: patients presenting prior to the national lockdown date; and Group B: patients presenting after the national lockdown date.
32994047 The COVID-19 pandemic in Cuba was addressed through an integrated all-society action plan that to date has been largely successful with a low incidence of COVID-19 and mortality rates several-fold lower than worldwide averages.
32994757 Up to date, more than one hundred natural PIAs, while only nine natural PQAs had been described.
32995051 To date, several thousand HWs globally have been reported as infected with the severe acute respiratory syndrome coronavirus 2 virus that causes the disease.
32995681 The proposed model was enforced to obtain estimates of important quantities such as the reproductive rate and the average infection period, along with the more likely date when the pandemic peak may occur.
32995682 By the use of a SEIRD mathematical model with age division, we predict the infection and death curves, stating the peak date for Brazil and above states.
32997344 To date, the coronavirus disease 2019 (COVID-19) has a worldwide distribution.
32997370 To date it remains unclear whether hyperCKemia is due to a virus-triggered inflammatory response or direct muscle toxicity.
32997373 The participants were divided into three successive temporal groups based on their date of CT examination.
32997699 As a result of the influx of clinical trials, researchers, clinicians, and the lay public, now more than ever, face a significant challenge in keeping up-to-date with the rapid rate of discoveries and advances. […] The freely available, novel resources present up-to-date relevant biological information and insights in a robust, accessible manner, illustrating their invaluable potential to aid researchers overcome COVID-19 and save hundreds of thousands of lives.
32997739 To date, there is little data on possible IgA-mediated autoimmune responses.
32997812 To date, however, the utility of such immunoassays remains unclear.
32998162 Unfortunately, data on SARS-CoV-2 viral presence in oocytes of infected individuals are not available to date.
32998992 The search yielded 2504 citations published between January and February 2020 or an unspecified date, 109 of which remained for extraction after screening.
33000592 With these goals, the themes presented in this “mosaic” of topics include - Cardiovascular involvement in genetic syndromes, SIDS and infectious, endocrine, kidney, storage or autoimmune diseases. - Pulmonary hypertension and patent ductus arteriosus in premature infants. - Cardiovascular risk in obese or hypertensive children. - Bicupid aortic valve and aortic dysfunction - Covid 19 and heart disease in childhood I thank the Researchers and Professors of Catanzaro, Palermo, Pavia, Brescia, Taormina and Messina University for their interesting and up-to-date scientific contributions, and I hope the information gathered in this issue will be useful to the reader.
33000640 To date, this process has avoided the worst-case scenario of intra-hospital epidemic outbreak.
33001783 To date, only a few articles have been published that comprehensively describe the multisystemic imaging manifestations of COVID-19.
33002041 To date, several clinical laboratory parameters associated with Coronavirus disease 2019 (COVID-19) severity have been reported.
33002611 Up-to-date trials were identified by the authors through searches of Medline, Embase, Cochrane Library, Web of Science,, and medRxiv from inception up to 14 September 2020.
33003471 To date, sporadic studies have demonstrated that innate immune mechanisms, specifically neutrophilia, NETosis, and neutrophil-associated cytokine responses, are involved in COVID-19 pathogenesis; however, our understanding of the exact nature of this aspect of host-pathogen interaction is limited.
33003648 The highly contagious COVID-19 infection has affected millions of people to date and has led to hundreds of thousands of deaths worldwide.
33004166 Based on up-to-date research and psychological diagnostic manuals of Diagnostic and Statistical Manual of Mental Disorders, 5th edition and International Classification of Diseases, 11th revision, we describe associated psychological disorders and experiences that may arise related to COVID-19.
33004545 To date, 33 papers have been identified as unsuitable for public use and either retracted, withdrawn, or noted with concern.
33004712 To date, no specific treatments are available for COVID-19 and its life-threatening complication.
33004773 Three pediatric deaths have been reported in Italy to date.
33005518 To date, there have been some reports linking severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to widespread tissue injury; however, there have been no reports so far on the effect of the parathyroid gland.
33006163 A literature search was performed to provide the most up-to-date information on the pathophysiology, coagulopathy, risk of VTE, and prevention and treatment of VTE in patients with COVID-19.
33006169 The COVID-19 pandemic represents one of the most challenging healthcare scenarios faced to date.
33006936 In our viewpoint, we aim to present the relative literature to date and outline our ongoing analyses of the highly affected and diverse stroke populations in San Antonio and Austin, Texas, to answer a simple question: where did all our stroke patients go?
33006938 The system was rapidly developed and is being used on a large scale with more than 65,000 registered patients to date.
33007400 To date, no anti-viral therapy has proven its efficacy considering randomized trials.
33007742 However, there are still no vaccines or medications available till date against SARS coronaviruses which is an urgent requirement to control the current pandemic like situations.
33008440 In this single-center, retrospective observational study, we included all cases with chronic infective wounds that came to our hospital between the full outbreak of the COVID-19 in China (January 23, 2020) and the latest date prior to posting (20 April 2020).
33009736 We used a data set where each point was an expression not of a single day, but of a longer period of time (date-points method).
33009800 In the eight weeks prior to relaxation, mean Rt declined by 0.012 units per day (95% CI, -0.013 to -0.012), and 46/51 jurisdictions achieved Rt < 1.0 by the date of relaxation.
33010461 To date, SARS-CoV-2 (the virus that causes COVID-19) has spread to almost every region of the world, infecting millions and resulting in the deaths of hundreds of thousands of people.
33011225 To date, there is one study confirming that the infectivity of SARS-CoV-2 in water for people was null based on the absence of cytopathic effect (CPE) in infectivity tests.
33011594 Since the first report in December 2019, the novel coronavirus (COVID-19) has spread to most parts of the world, with over 21.5 million people infected and nearly 768,000 deaths to date. […] In this article, we present the up-to-date evidence and discussions on sewage-associated transmission of COVID-19, and highlighted the roles of sewage overflow and sewage-contaminated aerosols in two publicized events of community outbreaks.
33012500 Two groups were created: 6 weeks before (Group A) and 6 weeks after (Group B) the date elective surgeries were postponed in Massachusetts for COVID-19.
33012886 Guidelines are set within a well-scientific evidence and available recommendations up to date.
33012988 To date, studies on COVID-19 have consistently shown that pediatric patients generally have relatively milder cytokine release syndrome and lower mortality rates than adults.
33013004 Against a backdrop of heightened uncertainty, up-to-date and reliable information is more important than ever, both for regulators and this sector.
33014380 To date, more than 300 clinical trials have been conducted on various antiviral drugs, and immunomodulators are being evaluated at various stages of COVID-19.
33015425 To date, many models have been proposed which estimate the transmission risk of COVID-19 in terms of time; however, its dependency on space dimensions has been ignored.
33015546 The most encouraging treatment to date is suggested to be with the help of remdesivir, hydroxychloroquine, and many such repurposed drugs. […] No treatments have been demonstrated as accurate and dependable to date.
33015822 The daily temperature and humidity figures were obtained from the weather web “Time and Date”. […] The daily cases, deaths, temperature and humidity were recorded from the date of appearance of first case of “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)” in the African region, from Feb 14 to August 2, 2020.
33015938 It is to date the only approved antiviral for treating COVID-19.
33017195 To date, only a limited number of public assessments of local mass vaccination operational capabilities have been conducted.
33017479 References for this review were identified by searches within PubMed without any date restrictions.
33017611 To that end, we have examined the scientific literature to date regarding the viability of SARS-CoV-2 on surfaces and fluids or under different environmental conditions (temperature, precipitation and UV radiation).
33019397 All the above databases will be searched from the available date of inception until the latest issue.
33019921 Till date, SARS-CoV-2 infection is still spreading, representing a major threat to public health, where several control measures are being practiced in order to culminate its spread.
33019935 COVID-19 originated in Wuhan, the capital of Hubei, China in December 2019 and, to date, has spread to at least 187 countries.
33020340 To date, there is still no vaccine or specific antiviral treatment for COVID-19.
33020343 To date, no specific therapeutic drugs are available to treat COVID-19 infection.
33020695 Till date more than 0.948 million deaths out of 30.369 million confirmed cases are reported by WHO.
33020707 To date, neither a specific antiviral drug nor a clinically effective vaccine is available.
33020722 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the recent pandemic COVID-19, is reported to have originated from bats, with its intermediate host unknown to date.
33020732 To date, qualitative olfactory testing has been performed only in a very few cohort studies on COVID-19 patients.
33021206 To date we have collected eight samples from seven subjects.
33022569 Since the emergence of SARS-CoV2, to date, no effective antiviral drug has been approved to treat the disease, and no vaccine against SARS-CoV2 is available.
33023050 It should be remembered that the impact of COVID-19 on the health condition of patients with CBD is unknown to date.
33023358 However, no studies have profoundly investigated these cells in COVID-19 patients to date. γδ T cells can be safely expanded in vivo using existing inexpensive FDA-approved drugs such as bisphosphonate, in order to test its protective immune response to SARS-CoV-2.
33023552 To the best of the authors knowledge, to this date very little data exists on COVID-19 in a pediatric patient with liver transplantation.
33024072 A total of 285 patients with SARS and 2850 controls without SARS (1:10) matched for sex, age, insurance premium, comorbidities, residential regions, level of medical care, and index date were selected between February 25 and June 15, 2003 from the Inpatient Database Taiwan’s National Health Insurance Research Database.
33027035 We plotted mean daily steps and the prevalence of low daily steps (≤1,500 steps/day) 30 days before (reference period) and 30 days after (epidemic period) January 21, 2020 (date of the first COVID-19 case diagnosed in Changsha), and compared it with the same corresponding period from 2019.
33027152 We summarize lessons learned from the HIV epidemic that offer insights about how the response to COVID-19 can be improved, especially in the United States which has incurred one quarter of world’s infections to date.
33027847 There have been no reports of infection of dental staff or patients during dental treatment in China to date.
33029094 However, the pharmacological mechanism of SFJDC still remains vague to date.
33029620 This review summarizes evidence-to-date on the duration of infectivity of SARS-CoV-2, and how this has informed evolving public health recommendations on when it is safe to discontinue isolation precautions.
33030209 In addition, no studies have examined whether national distributions of these factors are associated with epidemic experiences to date. […] Both types of national risk profiles correlate meaningfully with countries’ COVID-19 mortality experiences to date.
33031639 With hundreds of studies published daily on COVID-19, for example, we struggle to find, stay up-to-date, and synthesize information-all hampering evidence-informed decision making.
33031856 To date, there are no approved vaccines or therapies for COVID-19.
33032335 In Saudi Arabia, more than 100, 000 cases of COVID-19 have been reported, and more than 4,000 in Al Hofuf to date.
33032593 To the date this paper was drafted, 38 articles were found, of which 9 satisfied our inclusion criteria.
33032740 Here, we describe mechanistic links between influenza and COVID-19 infection and the risk of acute cardiovascular events, summarize the data to date on the potential cardioprotective effects of influenza vaccines, and describe the ongoing influenza vaccine cardiovascular outcomes trials, highlighting important lessons learned that are applicable to COVID-19.
33032877 Two papers review schools: reported clusters to date globally and the specific preparations made by one specific Maltese school to try to avoid/dampen any outbreaks in the school.
33032969 This highlights the urgent need to identify high-risk individuals to offer psychological support and provide up to date information on the pandemic.
33033170 There is a shortage of effective therapeutic strategies or preventative vaccines for this disease to date.
33033561 To date, there is no effective antiviral therapy for COVID-19 patients, and therapeutic strategies are based on experience treating previously recognized coronaviruses.
33035176 To date, only anecdotal evidence has been available to indicate if the hypothesis of archetype reuse across templates is feasible and scalable.
33035234 Additionally, the association of the antibody response with both the severity of disease and the date after onset of symptoms was analyzed.
33035628 This is the largest reported cohort of CLD and cirrhosis patients with SARS-CoV-2 infection to date.
33036052 To date, more than 3.4 million people have been infected throughout the world. […] Against the background of a rapidly accumulating knowledge base on SARS-CoV-2, 68 expert authors of the current DGVS guidelines for Crohn’s disease and ulcerative colitis took part in a virtual meeting to compile up-to-date, practice-orientated recommendations aimed at improving the care of patients with IBD.
33036662 Registration date is 23 May 2020.
33036812 At our main “HOT” site, from a total of 371 separate patient encounters by date of study, 72 patient encounters (19%) were COVID-19 positive at time of exam.
33038433 To date, with the exception of intravenous Remdesivir and dexamethasone, which have modest effects in moderate to severe COVID-19, no strong clinical evidence supports the efficacy and safety of any other drugs against SARS-CoV-2.
33039230 Globally, more than 12 million people have been infected with COVID -19 infection till date with more than 500,000 fatalities.
33039952 After this date, patients were administered 1000 IU/d oral vitamin D3, 150 mg/d oral magnesium, and 500 mcg/d oral vitamin B12 upon admission if they did not require oxygen therapy.
33040042 With many regions suspending the provision of non-essential healthcare services, there is a risk that patients with common treatable illnesses do not receive prompt treatment, leading to more serious and complex presentations at a later date.
33041326 However, the pharmacokinetics and tissue distributions of the parent drug and its active metabolites have been poorly characterized to date.
33041633 By fitting the extended model to the real detected data during the lockdown, an optimization algorithm is used to derive the optimal parameters, the initial condition and the epidemics start date of regions in France.
33041830 To date, there are no proven drugs or vaccines against this virus.
33042602 There is a paucity of published studies to date that investigate how display type affects pathologist performance, with more research necessary in order to develop standards and minimum specifications for displays in digital pathology.
33042952 To date, there have only been a total of 92 indigenous COVID-19 cases confirmed in the Gansu Province, which is considered to be a consequence of the strict screening approach applied during the outbreak.
33043030 However, to date, there is no sufficient evidence of the effectiveness of any researched therapy.
33043784 To date, millions of confirmed cases and hundreds of thousands of deaths have been reported worldwide, and there are currently no medical countermeasures available to prevent or treat the disease.
33044199 Please relate the information to the date on which it was written.
33047475 To date, little is known about the duration and effectiveness of immunity as well as possible adverse late effects after an infection with SARS-CoV-2.
33047816 We placed no restrictions on the language or date of publication.
33048300 This has drawn sharp criticism within the scientific community, with the approval being granted on the basis of a relatively small phase II trial, without conduct of a conventional phase III trial, and lacking availability of the claimed supportive real-world evidence in the public domain to date.
33048801 To date, however, there is no evidence of HIV infection worsening the evolution and prognosis of COVID-19.
33048824 The outcome of the model for the patient’s application was the length of time from the date of hospitalization to the date of the first usage of an oxygen supplement.
33048825 Given the potential of undermining global efforts in COVID-19 disease control, up-to-date public health strategies are required to counter proliferation of misinformation.
33049279 Although numerous antiviral and anti-parasitic drugs are under clinical trials to combat this pandemic, to date, neither a specific treatment nor any successful vaccine has been established, urging researchers to identify any potential candidate for combating the disease.
33049563 As on date, the traditional polymerized chain reactions (PCR), lateral flow devices (LFID) and enzyme linked immunosorbent assays (ELISA) are being adapted for the detection of this deadly virus.