DATE


DrugBank ID: db10632
DrugCentral: date
Synonymous : None



Drug Sentece Context


Table 1. Analysis of context sentence of date gene in 566 abstracts.

pmid sentence
31986261 No data on person-to-person or nosocomial transmission have been published to date.
31997390 To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok, Thailand) were analyzed.
32023775 We reviewed the currently available literature to provide up-to-date guidance on control measures to be implemented by public health authorities.
32031570 Retrospective, single-center case series of the 138 consecutive hospitalized patients with confirmed NCIP at Zhongnan Hospital of Wuhan University in Wuhan, China, from January 1 to January 28, 2020; final date of follow-up was February 3, 2020.
32037389 The remaining patient with severe pneumonia had shown signs of improvement by the cutoff date for data collection.
32056249 Based on the advice of the International Health Regulations Emergency Committee and the fact that to date 24 other countries also reported cases, the WHO Director-General declared that the outbreak of 2019-nCoV constitutes a Public Health Emergency of International Concern on 30 January 2020.
32079150 Using publicly available event-date data from the ongoing epidemic, the present study investigated the incubation period and other time intervals that govern the epidemiological dynamics of COVID-19 infections.
32083985 To date, CT findings have been recommended as major evidence for clinical diagnosis of COVID-19 in Hubei, China.
32087334 To date, there are no clinically approved vaccines or antiviral drugs available for these human coronavirus infections.
32105680 Clinicians should continue to follow the Centers for Disease Control and Prevention website to stay up to date with the latest information (https://www.cdc.gov/coronavirus/2019-nCoV/hcp/index.html).
32125362 Descriptive case series of the first 18 patients diagnosed with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection at 4 hospitals in Singapore from January 23 to February 3, 2020; final follow-up date was February 25, 2020.
32141588 To date, the outbreak has spread to most provinces in China and 25 other countries within a relatively short period.
32143502 Although the fatality rate of SARS-CoV-2 is currently lower than SARS-CoV, the virus seems to be highly contagious based on the number of infected cases to date.
32145719 To date, the controlling of outbreak of corona virus disease 2019 (COVID-19) has entered into a critical period in China.
32155789 Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety.
32166607 There have been around 96,000 reported cases of coronavirus disease 2019 (COVID-2019) and 3300 reported deaths to date (05/03/2020).
32167524 The final date of follow-up was February 13, 2020.
32171059 The four datasets we fitted to were: daily number of new internationally exported cases (or lack thereof), by date of onset, as of Jan 26, 2020; daily number of new cases in Wuhan with no market exposure, by date of onset, between Dec 1, 2019, and Jan 1, 2020; daily number of new cases in China, by date of onset, between Dec 29, 2019, and Jan 23, 2020; and proportion of infected passengers on evacuation flights between Jan 29, 2020, and Feb 4, 2020. […] We used an additional two datasets for comparison with model outputs: daily number of new exported cases from Wuhan (or lack thereof) in countries with high connectivity to Wuhan (ie, top 20 most at-risk countries), by date of confirmation, as of Feb 10, 2020; and data on new confirmed cases reported in Wuhan between Jan 16, 2020, and Feb 11, 2020.
32171869 Final date of follow-up was February 25, 2020.
32171872 The primary endpoint was a negative conversion rate of coronavirus from the date of COVID-19 diagnosis(day7, day14), and assessed whether the pneumonia was progressing or improving by chest CT (day7).
32173241 To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China.
32175421 Several studies have been done to estimate the basic reproduction number in the early phase of this outbreak, yet there are no reliable estimates of case fatality rate (CFR) for COVID-19 to date.
32176772 All patients were confirmed to be infected with SARS-CoV-2 and the final date of follow-up was February 4, 2020.
32178768 Contacts were people with exposure to a patient with COVID-19 on or after the patient’s symptom onset date.
32179124 No systematic reviews on COVID-19 have been published to date.
32180292 From reports of 32 women to date affected by COVID-19 in pregnancy, delivering 30 babies (one set of twins, three ongoing pregnancies), seven (22%) were asymptomatic and two (6%) were admitted to the intensive care unit (ICU), one of whom remained on extracorporeal membrane oxygenation. […] No maternal deaths have been reported to date. […] Compared with SARS and MERS, COVID-19 appears less lethal, acknowledging the limited number of cases reported to date and that one woman remains in a critical condition.
32183901 To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care.
32186952 However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS.
32196406 While these common sense points will always be helpful, it is important that you keep up to date with the advice being given by the Centers for Disease Control and Prevention (CDC) and NHS England and how it might affect you personally. […] These suggestions have been produced using the most up-to-date advice available to us from our Scientific and Medical Advisors and are not intended to replace or supersede advice you may have been given from your health care professional.
32196426 Expected final online publication date for the Annual Review of Virology, Volume 7 is September 29, 2020.
32205090 Evidencing eTCB effectiveness is Taiwan’s success to date in containing and controlling the community-hospital-community transmission cycle.
32210236 All data are geo-coded and, where available, include symptoms, key dates (date of onset, admission, and confirmation), and travel history.
32211816 This cohort study was conducted from January 20, 2020, to February 10, 2020, in a single center at Renmin Hospital of Wuhan University, Wuhan, China; the final date of follow-up was February 15, 2020.
32212779 To date, there is no scientific guideline regarding management of cancer patients in a background of coronavirus outbreak.<br />.
32213786 As the situation with COVID-19 rapidly unfolds, it is critical that obstetricians keep up to date.
32216717 The severity of CXR findings peaked at 10-12 days from the date of symptom onset.
32217113 To date, the outcomes of 55 pregnant women infected with COVID-19 and 46 neonates have been reported in the literature, with no definite evidence of vertical transmission.
32219428 The study was conducted at the infectious disease department, Shenzhen Third People’s Hospital in Shenzhen, China, from January 20, 2020, to March 25, 2020; final date of follow-up was March 25, 2020.
32220284 The final date of follow-up was Feb 12, 2020.
32224151 To date, the clinical characteristics of COVID-19-infected cancer patients are largely unknown.
32225133 Assuming an arithmetical growth in the second variation of the data, we present a cubic adjustment model in which we estimate over 100 000 cases at 120 days consistent with the data recorded to date.
32232520 Since our hospital received the first patient with COVID-19 in Singapore, our centre has managed 16 COVID-19 cases to date.
32232652 By the end of follow-up date (Mar. 3, 2020), there were 16 non-severe cases (64%) and 9 severe cases (36%), 5 cases were dead (20%).
32233034 To date, multiple position statements and guidelines have been issued by various professional organizations to recommend practices in endoscopic procedures.
32234451 Although related to the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), COVID-19 shows some peculiar pathogenetic, epidemiological and clinical features which have not been completely understood to date.
32234466 Coronavirus disease 2019 (COVID-19) originated in the city of Wuhan, Hubei Province, Central China, and has spread quickly to 72 countries to date.
32234728 Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date.
32235085 It spread rapidly and to date has killed 3,242 persons with more than 81,000 cases of infection in China and causing over 126,000 global cases and 5,414 deaths in 166 other countries around the world, especially Italy.
32240128 Among 23 (30%) residents with positive test results, 10 (43%) had symptoms on the date of testing, and 13 (57%) were asymptomatic.
32241244 To date, computed tomography (CT) findings have been recommended as major evidence for the clinical diagnosis of COVID-19 in Hubei, China.
32241328 Following this date, attention quickly increased and has remained high over time.
32245904 To date, no effective treatment has been identified and management for critically ill patients relies on management in intensive care units.
32247050 Based on recently published literatures, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infection.
32247326 We used the date of the fourth revision of the case definition (Jan 27) to divide the epidemic into two time periods (Dec 24 to Jan 27, and Jan 28 to Feb 17) as the date of symptom onset.
32250385 Date of final follow-up was March 25, 2020.
32250958 The aim of this paper is to describe the utilization of a dedicated mobile health (mHealth) platform to disseminate up-to-date and validated information about SARS-CoV-2 to all medical staff of the Children’s Hospital at the University Hospitals of Geneva.
32251794 To date, no specific treatment has been proven to be effective for SARS-CoV-2 infection.
32251848 This article delineates some of those challenges and the responses to them which are known, to date.
32252141 The purpose of this review is to summarize known-to-date information about SARS-CoV-2, transmission of SARS-CoV-2, and clinical features.
32254064 To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19.
32255382 Demographic, clinical, laboratory, and treatment data were collected and analyzed, and final date of follow-up was February 24, 2020.
32258351 It is imperative for public health practitioners and the One Health community to stay up to date on the most promising potential therapeutic options that are under investigation. […] Thus, the purpose of this review is to synthesize the knowledge to date about remdesivir as a therapeutic option for coronaviruses, with a special focus on information relevant to the One Health community.
32259155 The aim of this paper is to review all the up to date evidence, including experiences from China and Italy, to guide the safe management of such patients when undergoing gynaecological procedures.
32259279 Unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, cases with suspected COVID-19 that were not confirmed by a laboratory test, and unreported maternal or perinatal outcomes were excluded.
32264957 To date, we have found it is one of the greatest challenges to human beings in fighting against COVID-19 in the history, because SARS-CoV-2 is different from SARS-CoV and MERS-CoV in terms of biological features and transmissibility, and also found the containment strategies including the non-pharmaceutical public health measures implemented in China are effective and successful.
32265182 To date, there are no medical treatments for COVID-19 with proven effectiveness.
32267098 In this review article, we summarized the published literatures to date concerning four different aspects: (a) gastrointestinal manifestations of COVID-19 infection; (b) microbiologic and virological investigations; (c) the role of fecal-oral transmission; and (d) prevention/control infection in the digestive endoscopy room.
32269177 To date, only three centers have performed a catheterization on a confirmed COVID-19 positive patient.
32270371 To date, there is no specific therapy for COVID-19.
32270521 This research statistically analyzed the effect of sex, region, infection reasons, birth year, and released or diseased date on the reported numbers of recovered and deceased cases.
32271458 The proposed classifier used different seven variables, namely, country, infection reason, sex, group, confirmation date, birth year, and region.
32271722 In the four clusters for which the date of exposure could be determined, presymptomatic transmission occurred 1-3 days before symptom onset in the presymptomatic source patient.
32281052 However, no standard treatment for this disease has been discovered to date.
32281213 Although pre-clinical results are promising, till date, there is dearth of evidence to support the efficacy of CQ or HCQ in preventing COVID-19.
32281330 Documents were screened following the inclusion criteria, and data were extracted in regard to registration date, study objective, type of design, sponsor, patient, sample size, intervention, and evaluation index.
32282022 No therapies have been shown effective to date.
32283052 To date, considerable knowledge gaps remain regarding the chest CT imaging features of COVID-19. […] We performed a systematic review and meta-analysis of results from published studies to date to provide a summary of evidence on detection of COVID-19 by chest CT and the expected CT imaging manifestations.
32283108 To date, the most promising broad-spectrum class of viral RdRp inhibitors are nucleoside analogues (NAs), with over 25 approved for the treatment of several medically important viral diseases.
32283185 To ensure availability of donor cells on the scheduled date of infusion, many sites now collect cryopreserve grafts before the start of pretransplant conditioning.
32285338 Few studies have been performed on viral transmission during surgery, but to date there is no study that demonstrates or can suggest the ability for a virus to be transmitted during surgical treatment whether open or laparoscopic.
32286607 To date, SARS-CoV-2 is known to enter the host cells via the angiotensin-converting enzyme 2 protein.
32288415 Furthermore, we propose the BAT model, which is composed of three parts: simulation of the return rush (Back), analytic hierarchy process (AHP) method, and technique for order preference by similarity to an ideal solution (TOPSIS) method, to figure out the best return date for university students.
32288418 We also evaluate the effectiveness of the quarantine measures and schedule the date to reopen Hubei Province.
32289472 To date, COVID-19 has affected over 944,181 people worldwide, resulting in over 47,312 reported deaths. […] As new findings emerge, there is an urgent need for up-to-date management guidelines.
32291505 To date there is no specific treatment available-the main goal of supportive therapy is to ascertain adequate oxygenation.
32291526 Several hypotheses have been proposed to date regarding the net effect of ACEI/ARB on COVID-19 infections.
32292517 No patient has died in our hospital to date.
32292529 As the epicentre of the initial outbreak, China has been updating the National COVID-19 Diagnostic and Treatment Guideline with up-to-date information about the disease. […] Medical professionals should diagnose and treat patients according to up-to-date guidelines.
32292686 To date, there is no specific therapy for COVID-19.
32292697 The Coronavirus disease 2019 (COVID-19) reminds us of the SARS outbreak in 2003, and up to date, corticosteroid is commonly administrated to severe patients with COVID-19.
32292826 While there is no intervention for the prevention or treatment of COVID-19 with proven clinical efficacy to date, tools to distil the current research landscape by intervention, level of evidence and those studies likely powered to address future research questions is essential.
32292911 Its accuracy has been 1.29% for the last day added and predicted by the 57 previous WHO situation reports (the date 18 March 2020).
32293020 Based on the evidence to date, there are several treatment options to consider for the relief of fever (acetaminophen, NSAID, oral glucocorticoids), cough (morphine), breathlessness (morphine, oxygen, fan), anxiety (benzodiazepines) and pain (NSAID, morphine).
32293875 Since the emergence of a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was firstly reported from Wuhan, China, to date, neither a specific vaccine nor antiviral drug against SARS-CoV-2 is available.
32294617 Individuals should get the most up to date information from the CDC website.].
32294718 To date, no case series have been published in Brazil.
32295811 Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date.
32298035 This document consolidates best available evidence to date and presents recommendations to minimize the risks of aerosolization and SARS-CoV-2 exposures in both the inpatient and outpatient settings.
32298149 The purpose of this article is to critically review some of the most frequently cited studies on the use of CT for detecting COVID-19. CONCLUSION. To date, the radiology literature on COVID-19 has consisted of limited retrospective studies that do not substantiate the use of CT as a diagnostic test for COVID-19.
32298480 FDA/EMA-approved monitoring guidelines, clinical practice guidelines, and relevant, up-to-date publications regarding initiation and monitoring of beta-blocker therapy were used to inform the recommendations.
32298767 But no studies to date have systematically described liver test abnormalities in patients with COVID-19.
32298982 and Aims: No valid treatment or preventative strategy has evolved till date to counter the SARS CoV 2 (Novel Coronavirus) epidemic that originated in China in late 2019 and have since wrought havoc on millions across the world with illness, socioeconomic recession and death.
32301746 Objectives The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to date, the epidemic has gradually spread to 209 countries worldwide with more than 1.5 million infected people and 100,000 deaths.
32302927 In radiology, much of the literature to date has focused on chest CT manifestations of COVID-19 (Zhou et al.
32302935 The COVID-19 pandemic is a major health crisis affecting several nations, with over 720,000 cases and 33,000 confirmed deaths reported to date.
32302954 The final date of follow-up was February 23, 2020.
32305269 The country might not be screening optimally, considering the number of COVID-19 tests conducted to date and the suspected cases who missed testing.
32305459 The most comprehensively tested case reported to date confirmed that the vertical transmission of COVID is unlikely, but still, more evidence is needed.
32307014 To date, there have been more than 1,260,000 COVID-19 patients, with a mortality rate of approximately 5.44%.
32308494 Most studies to date on COVID-19 have focused on disease etiology and the genomics of 2019-nCoV, with few reports on the epidemiologic and clinical characteristics of infected patients.
32310028 In this narrative review we discuss current evidence around detection of SARS-CoV-2 in human tears and forms of transmissions reported to date.
32310815 To date, we have enrolled 159 participants.
32312018 To our knowledge, there has been no prospective multicentre imaging study of COVID-19 to date.We proposed a hypothesis: There are some specific CT features on Chest CT of COVID-19 patients.
32312158 The widespread impact and chronicity of this pandemic makes it unique from any crisis faced by our training programs to date.
32313463 All cases reported to date have shown radiographic evidence of pneumonia. 2019-nCoV is diagnosed by real-time reverse transcriptase polymerase chain reaction.
32313660 To date, the anti-malaria drug hydroxychloroquine found to be a treatment option for SARS-CoV-2.
32313807 To date, only one case of GBS associated with this infection has been described.
32313824 No Food and Drug Administration approved treatment is available till date.
32313879 We estimate that Feb. 11, 2020 was the date with the highest transmission risk in Wuhan, which is consistent with the actual peak period of the reported case number (Feb.
32314868 Coronavirus disease 2019 (COVID-19), the worst pandemic in more than a century, has claimed >125,000 lives worldwide to date.
32315451 We did not apply any date limit or language limits.
32315963 Till to date, no epidemiological data on mental health problems due to outbreak of the COVID-19 and mass isolation were not available.
32317050 We analysed the sources, publication date, type and topic of the retrieved articles/studies.ResultsWe included 249 articles in this scoping review.
32317225 While clinical reports from China to date demonstrate that the majority of cases remain relatively mild and recover with supportive care, it is also crucial to be well prepared for severe cases warranting intensive care.
32320003 Among the 3066 patients who remained hospitalized at the final study follow-up date (median age, 65 years [IQR, 54-75]), the median follow-up at time of censoring was 4.5 days (IQR, 2.4-8.1).
32320509 The 10th of April saw the highest number of UK daily deaths (980) to date.
32321075 In 2020, hospitalizations for SARI, compiled from the date of the first confirmed case of COVID-19 up to the 12th week, exceeded the numbers observed during the same period in each of the previous 10 years.
32321524 To date, several drugs targeting RdRp enzymes are being employed for SARS-CoV-2 infection treatment.
32322159 While NIOSH has standardized N95 and N98 at 300nm, to-date there is no filter standards, nor special filter technologies, tailored for capturing airborne viruses and 100nm nano-aerosols.
32322398 The limited clinical data about the virus’s behavior to date, especially extrapulmonary symptoms, suggest that we should be aware of the possibility of initial cerebrovascular manifestations of COVID-19.
32322478 No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation.
32322654 To date, the world perhaps has never waited for the summer so impatiently in the entire Anthropocene, owing to the debate whether increasing temperature and humidity will decrease the environmental endurance of SARS-CoV-2.
32324358 As several healthcare interventions are essential even during pandemics, it is necessary for professionals working in such fields to get up-to-date information about the virus and its aspects that can influence patient care and suggested actions.
32327383 Ultrasound is highly sensitive in the detection of multiple lung pathologies which can be demonstrated in conjunction with COVID-19 however to date there are no specific, nor pathognomonic findings which relate to COVID-19 on ultrasound.
32328363 To date, data on the behavioral distress and psychiatric morbidity of those suspected or diagnosed with the 2019-nCoV and their treating health professionals are lacking.
32328367 Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling of patients worldwide.
32329432 Reverse transcriptase-polymerase chain reaction testing, our primary diagnostic tool to date, has sensitivity and timing concerns, owing to sampling/handling errors, as well as a complex virus-host interaction.
32329522 To date, the statistics of COVID-19 reported cases show that more than 80% of infected are mild cases of disease, around 14% of infected have severe complications, and about 5% are categorized as critical disease victims.
32333185 To date, biomedical forms of curative and preventative treatments for COVID-19 are at best limited.
32334502 To date, no definitive treatment orvaccine application exists for COVID-19.
32335244 COVID 19 been declared recently as a pandemic, to date has affected over 1,8881,365 with over 119,403 deaths in accordance to the global pandemic Real-Time Report.
32336927 In the last two decades, this is the 3rd deadliest Coronavirus pandemic, following SARS which lasted between 2002 and 2003 and Middle East Respiratory Syndrome (MERS) from 2012 till date.
32337148 She was successfully treated with coronary revascularization and stent placement, and remains on the ventilator to date as she quickly developed acute respiratory distress syndrome.
32337862 This article details the correct procedure required for effective hand hygiene and emphasises the need for nurses to keep up to date with evidence-based guidelines.
32339723 Afterward, instant fatality rate was calculated according to the number of deaths and cured cases on the same estimated diagnosis date.
32340050 To date, to our knowledge there are no studies regarding attitudes and experiences of outpatient medical personnel during a pandemic.
32341103 While relevant preclinical, experimental models to date favor a protective effect of RAAS-SCoV-axis inhibition on both lung injury and survival, clinical data related to the role of RAAS modulation in the setting of SARS-CoV-2 remains limited.
32341718 In the non-Hubei region of China it is expected that the epidemic will cease on the 30th of March 2020 and following this date no new confirmed patient will be expected.
32341913 This article addresses all information collected to date on the virus, in accordance with the guidelines of international health care institutions, and provides a comprehensive protocol for managing possible exposure to patients or those suspected of having coronavirus.
32342026 Articles listed in PubMed and Google sources for up-to-date information.
32342849 This is to our knowledge the longest duration of viral shedding reported to date.
32343428 All contacts of three clusters have been isolated and no new confirmed cases have been identified to date.
32344456 The goal of this review is to provide up-to-date, evidence-based recommendations or expert opinion when evidence is limited, for performing regional anaesthesia procedures in patients with suspected or confirmed COVID-19 infection.
32344679 To date, there are no available vaccines or specific therapeutic drugs to treat the virus.
32345226 To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described.
32346490 To date, no licensed antiviral drugs or vaccines are available against COVID-19 although several clinical trials are underway to test possible therapies.
32347685 The first part focused on the epidemiology until that date.
32347743 No arrhythmogenic deaths were reported. Conclusions - In the largest reported cohort of COVID-19 patients to date treated with chloroquine/hydroxychloroquine {plus minus} azithromycin, no instances of TdP or arrhythmogenic death were reported.
32348045 To date, there is no evidence to support an increase in complications of COVID-19 in these patients.
32348588 To date, there is no evidence of any effective treatment for COVID-19.
32348591 This document provides clinical practice guidelines based on available evidence to date to balance the risks of SARS-CoV-2 exposure with the risks associated with dysphagia.
32348598 Patients should exercise social distancing, optimise co-morbidities and be up to date with influenza and pneumococcal vaccines.
32348627 From November 2019 to date, almost six thousand papers have been published on COVID-19, the disease caused by SARS-CoV-2 infection.
32350048 To date, there is limited comparison data for these different testing platforms.
32351037 The onset date of the first case in Shanghai was 28 December, with the peak appearing on 27 January.
32351056 The date of population expansion was calculated based on the expansion parameter tau ( τ) using the formula t= τ/2 u.
32351243 Multiple gastroenterology associations have issued guidance and statements that would help healthcare providers in navigating these unprecedented and difficult times, and the Saudi Gastroenterology Association has provided this statement in an effort to bring the most up to date information for the management of endoscopy units in terms of resources, manpower planning, scheduling, as well as infection control policies and leadership.
32353457 Most studies on previous respiratory virus epidemics to date suggest surgical masks are not inferior compared with N95 respirators in terms of protective efficacy among healthcare workers.
32353723 Three megacities were differentiated by the spatial patterns and quantities of infected communities, average cases per community, the percentages of imported cases, as well as the potential risks, although their COVID-19 infection situations have been preliminarily contained to date.
32356654 The impact of dietary patterns and the commensal microbiome on susceptibility to and severity of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has been largely ignored to date.
32356867 The final follow-up date was April 2, 2020.
32356910 This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date.
32357381 This article aims to provide an overview of the various methods and their evidence till date.
32358406 To date, 1 patient was discharged from hospital, while the other had been transferred to the rehabilitation department.
32359226 The results demonstrated that to date, neonatal COVID-19 infection is uncommon, generally acquired postnatally, and associated with favorable respiratory outcomes.
32359227 To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available.
32359819 Herein, we briefly describe the affects of COVID-19 on Interventional Radiology residency training and summarize up to date guidance by governing bodies and key stakeholders.
32360053 Patient information was collected and organized by date of visit, sex, age, and systemic disease history.
32360108 All data were reported at death or after a minimum of 14 days from date of admission with COVID-19 disease.
32360480 Further, chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may limit spread of SARS-CoV-2 and morbidity and mortality of COVID-19 pandemic.
32361446 Data started from 12 February 2020-09 April 2020 (the date on Covid-19 was detected in Spain).
32362424 In the largest number of cases described to date of hospitalized patients with SARS-CoV-2 disease (2019-nCoViD), 26% required care in an intensive care unit (ICU). […] This narrative literature review aims to gather the main contributions in the area of intensive care to date in relation to the epidemiology, clinic, diagnosis and management of 2019-nCoViD.
32365233 To date the group, comprising UK-based specialists in diabetes, pharmacy and psychology, have produced two sets of guidelines which will be continually revised as new evidence emerges.
32367558 To date, there are no data in the literature on the comorbid dermatologic diseases and COVID-19.
32367683 From November 1, 2019 to March 31, 2020, we compared outcome of patients admitted for acute ST-elevation MI (STEMI) and non-ST elevation MI (NSTEMI) before (group 1) and after (group 2) January 25, 2020 which was the date when Hong Kong hospitals launched emergency response measures to combat COVID-19.
32370766 To date, there is no specific anti-COVID-19 treatment.
32370984 The goal of the present article is to provide up-to-date information on potential mental health risks associated with exposure of health professionals to the COVID-19 pandemic. […] Stress may also be caused by organizational factors, such as depletion of personal protection equipment, concerns about not being able to provide competent care if deployed to new area, concerns about rapidly changing information, lack of access to up-to-date information and communication, lack of specific drugs, the shortage of ventilators and intensive care unit beds necessary to care for the surge of critically ill patients, and significant change in their daily social and family life.
32370986 Moreover, to date there is no evidence that ACEi or ARB administration facilitates SARS-COV2 cell entry by increasing ACE2 tissue expression in either animal or human studies.
32371558 To date there is no evidence from randomized controlled trials that any single therapy improves outcomes in patients infected with COVID-19.
32372877 To-date, unfortunately there are no test standards for nano-aerosols (≤100 nm).
32374903 The major mutation detected to date in the SARS-CoV-2 viral envelope spike protein, which is responsible for virus attachment to the host and is also the main target for host antibodies, is a mutation of an aspartate (D) at position 614 found frequently in Chinese strains to a glycine (G).
32375067 Under moderate control of scenario two, the number of infected people will increase by 1.43-1.55 times of that in scenario one, the date of the epidemic being controlled will be delayed by about 10 days, and Algeria, Nigeria, and Kenya are in accordance with this situation.
32375144 There is, to date, minimal, unconfirmed evidence of spontaneous vertical transmission, though it may theoretically be increased with some procedures.
32375488 The severe acute respiratory syndrome coronavirus 2 pandemic is to date affecting more than a million of patients and is challenging healthcare professionals around the world.
32375909 According to the contents of the reports, we recorded in detail the gender, age, first symptom date, death date, primary symptoms, chronic fundamental diseases, and other data of the patients, and carried out analyses and discussion.
32376350 Assuming a service restoration date of either June 1 or July 1, we calculated the need to perform 216% or 263% of monthly baseline volume, respectively, to clear the backlog in one month.
32377486 To date, the number of confirmed cases and deaths has risen exponentially in more than 200 countries, with an estimated crude mortality ratio of at least over 2%.
32377576 Chatbots, if effectively designed and deployed, could help us by sharing up-to-date information quickly, encouraging desired health impacting behaviors, and lessening the psychological damage caused by fear and isolation.
32377638 To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor is there an effective medicine for treating COVID-19, thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19.
32377709 To date, COVID‑19 has infected more than 3,000,000 people worldwide and killed more than 200,000 people.
32378464 A summary of available clinical guidelines with recommendations is presented, to provide community nurses with the up-to-date information required for protecting individuals living with a number of long-term conditions.
32378471 Much more serious than SARS-CoV in 2002, the current SARS-CoV-2 infection has been spreading to more than 213 countries, areas or territories and causing more than two million cases up to date (17 April 2020).
32378648 We provided a rapid review to critically assess the potential anti-coronavirus effect of remdesivir on COVID-19 and other coronaviruses based on the most up-to-date evidence.
32379077 Additionally, limited recommendations to date have been issued regarding scene investigative protocol, and there are a paucity of publications characterizing COVID-19 postmortem gross and histologic findings.
32381442 We highlight the value of engaging in humanitarian medical work, contributions of the hip and knee arthroplasty community to date, and future needs after the resolution of the pandemic.
32382737 To date, real-time RT-PCR is the only test able to confirm this infection.
32384153 With a run time of 15 to 20 minutes and first results being available in under 7 minutes for high RNA concentrations, the reported assay constitutes one of the fastest nucleic acid based detection methods for SARS-CoV-2 to date and may provide a simple to use alternative to RT-qPCR for first-line screening at the point of need.
32384397 Thirty-five children with COVID-19 infection matched for age, sex and date of admission, and who classified as non-severe type, were randomly selected from the hospital admissions.
32385799 To date, however, no specific recommendations are available for cardiothoracic robotic assisted surgery in COVID-19 positive patients.
32385985 The outbreak of coronavirus disease 2019 (COVID-19) is serious and there is no effective treatment to date.
32386435
  1. To date, previous cases reported urticaria as one of the cutaneous manifestations in COVID-19.(
32387384 The initial phase of the epidemic, from February 17th to March 23rd, 2020, is used to estimate the contact rates, infectious periods and mortality rate using both confirmed cases (by date of symptoms initiation), and daily mortality.
32387562 To date, the coding potential of SARS-CoV-2 remains partially unknown.
32387564 The first whole genome sequence was published on January 5 2020, and thousands of genomes have been sequenced since this date. […] We identify regions of the SARS-CoV-2 genome that have remained largely invariant to date, and others that have already accumulated diversity.
32389150 SARS-CoV-2, has been implicated in the largest recorded CoV outbreak to date.Initially the majority of COVID-19 cases were in China, but the virus has spread to more than 184 countries worldwide with the United States currently having more cases than any other country.
32389538 The service to date has been shown to be effective, safe, largely reproducible and reflective.
32389893 To date, the literature has predominantly consisted of case reports, case series, and systemic protocols for dealing with this deadly disease from a plethora of specialties with larger observational and randomized studies only now starting to emerge.
32391369 The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition.
32392282 The date of final follow-up was April 24, 2020.
32392288 While there is evidence that the burden of COVID-19 infection in hospitalized children is lesser than in their adult counterparts, to date, there are only limited reports describing COVID-19 in pediatric intensive care units (PICUs).
32393147 The groups that enable these inspirational collaborative accomplishments through their dedication, innovation, and imagination are the practicing physicians who have given freely and generously of their time and talents to help the whole health care community provide the most up-to-date care possible.
32393394 In these three MRT applications, potential cases of word misuse were evaluated by the regulator who then notified the practitioner to comply with existing regulations by a specific date. […] The MRT was then used on that date to determine compliance.
32393973 The case presentation is followed by a review of the literature to date on COVID-19 in regard to inflammatory bowel disease and pregnancy, respectively.
32395909 Medline was systematically searched using PubMed (search date March 19, 2020) for relevant studies in accordance with PRISMA guidelines.
32397511 To date, it is unclear why some patients develop severe symptoms.
32397688 To address this global crisis, up-to-date information on viral genomics and transcriptomics is crucial for understanding the origins and global dispersion of the virus, providing insights into viral pathogenicity, transmission, and epidemiology, and enabling strategies for therapeutic interventions, drug discovery, and vaccine development.
32398569 In this review, we summarize the epidemiologic and clinical features of children infected with SARS-CoV-2 reported in pediatric case series to date. […] Children rarely needed admission to intensive care units (3%), and to date, only a small number of deaths have been reported in children globally.
32399507 We estimated the reproduction number, R, during the early transmission phase in Lima from the daily series of imported and autochthonous cases by the date of symptoms onset as of March 30th, 2020. […] Prior to the implementation of the social distancing measures in Lima, the local incidence curve by the date of symptoms onset displays near exponential growth dynamics with the mean scaling of growth parameter, p, estimated at 0.9 (95%CI: 0.9,1.0) and the reproduction number at 2.3 (95% CI: 2.0, 2.5).
32399515 On the same date (also the date of this review), Africa had reported 5,999 confirmed cases, of which 3,838 (almost 65%) occurred in South Africa, Algeria, Egypt, Morocco and Tunisia, with the remaining 2,071 cases distributed unevenly across the other African countries.
32399995 To date, no study attempted to quantify the impact of the Covid-19 outbreak on incidence and treatment of acute stroke.
32402329 In the present paper, we provide an up-to-date review of the literature currently available on animal CoVs, focusing on the molecular mechanisms that are responsible for the emergence of novel CoV strains with different antigenic, biologic and/or pathogenetic features.
32403261 To date, most of the effective hand sanitizer products are alcohol-based formulations containing 62%-95% of alcohol as it can denature the proteins of microbes and the ability to inactivate viruses.
32404225 The country’s “go hard, go early” policy serves as an exemplar for the rest of the world to date. […] Though there has been no significant rise in referrals to secondary mental health services to date (4 May 2020), a rapid surge in mental health presentations is widely anticipated.
32404257 In the absence of concrete economic measures to date, and the scenario of economic uncertainty, we conclude that it is not possible to prevent gender-based violence in a comprehensive way, without considering the increase in unemployment, temporary and instability employment, economic dependency or the overload of household chores and reproductive tasks, among other elements that facilitate it.
32404498 We should adapt CME sessions to keep trainees up to date with core clinical competencies as they will continue to manage both COVID-19 and non-COVID-19 cases and this pandemic may last until year’s end.
32404630 To date there was one minor bleeding due to postoperative therapeutic anticoagulation.
32405603 Extracted data included author; date; study design; country; patient demographics; number of participants in severe and non-severe disease groups; prevalence of clinical gastrointestinal symptoms such as vomiting, nausea, diarrhoea, loss of appetite, abdominal pain, and belching; and digestive system comorbidities including liver disease and gastrointestinal diseases.
32406374 To date, the literature is widely heterogeneous regarding the loss of smell; therefore, we advise home isolation measures and/or social distancing, and to carry out diagnostic tests for SARS-CoV-2 when possible in those patients with sudden and severe loss of smell who cannot be promptly evaluated.
32408547 To date, there is no specific drug registered to combat the disease it causes, named coronavirus disease 2019 (COVID-19).
32410225 We urge policy-makers to ensure that nurses’ voices and perspectives are integrated into both local and global decision-making so as to minimize the structural injustices many nurses have faced to date.
32410714 The duration from the date of ICU admission to the study date was 11 (5-17) days, and the duration from onset of symptoms to the study date was 31 (24-36) days.
32410913 Children have had a relatively lower rate and a less serious course of infection as reported in the literature to date.
32412509 To date, there is no specific therapy for SARS-CoV-2 infection.
32413112 This estimate of excess cases represents 30.4% of the 716 total cases in those Iowa counties by that date.
32413502 In this comprehensive and up to date review we assess changes to working practices through the lens of each surgical specialty.
32414522 To the best of our knowledge, there was only one literature to date documented SARS-CoV-2 induced rhabdomyolysis as a late complication of COVID-19 patient.
32414622 To date, Coronavirus Disease 2019 (COVID-19) has affected at least 100,000 individuals worldwide, reaching thousands of mortalities (Zhou et al., 2020; World Health Organization, 2020).
32414678 To date, April 12, 2020, the virus has reached 209 nations, affecting 1.8 million people and causing more than 110,000 deaths.
32415519 Measures therefore need to be taken concerning the transmission of up to date and accurate information to medical students.
32415860 To date, data are limited regarding the trend of liver biochemistries over the course of illness.
32416074 Notably, RmYN02 shares 93.3% nucleotide identity with SARS-CoV-2 at the scale of the complete virus genome and 97.2% identity in the 1ab gene, in which it is the closest relative of SARS-CoV-2 reported to date.
32416357 Although to date, and by obvious reasons, the number of studies on this issue are still scarce, most results indicate that chronic exposure to air pollutants delays/complicates recovery of patients of COVID-19 and leads to more severe and lethal forms of this disease.
32416785 As a reference group, we randomly sampled ten patients per case, individually matched for age, sex, region (ie, Madrid), and date of admission to hospital (month and day; index date), from Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria (BIFAP), a Spanish primary health-care database, in its last available year (2018). […] We extracted information on comorbidities and prescriptions up to the month before index date (ie, current use) from electronic clinical records of both cases and controls.
32416984 We review our experience with the virus to date, our strategic approach to burn center function under these circumstances, and lessons learned.
32417380 Final date of follow-up was May 7, 2020.
32417802 The COVID-19 pandemic represents the greatest challenge to date faced by the medical community in the 21st century.
32418278 Hence, there is a need for simple, digestible, up-to-date, and accurate information on COVID-19 that is electronically disseminated and easy to obtain.
32418715 To date, no specific therapeutic drugs or vaccines are available to treat COVID-19 patients.
32418793 The 2013-2016 West Africa EBOV epidemic was the biggest EBOV outbreak to date.
32419769 To date, there have been zero incidences of radiographer healthcare worker transmission within our institution during the course of work.
32420652 To date, the coronavirus (COVID-19) outbreak that started in Wuhan, in the Hubei province of China, in late December 2019 seems to be eclipsing all of these previous infectious diseases in terms of its global reach and impact (Wang, Horby, Hayden, & Gao, 2020).
32420921 Italy is one of the most afflicted Country by this epidemic with 136,110 confirmed cases and 16,654 deaths on 9.4.2020 (at the same date, the Ministry of Health was reporting 143,626 cases).
32420923 From that date, the Regional Emergency Medical Services (EMS) Trust (AREU) of the Lombardy region decided to apply Business Intelligence (BI) to the management of EMS during the epidemic.
32421292
  1. What strategies have been employed to date and how successful have they been? […] The most widely adopted strategies for dealing with the COVID-19 pandemic to date have involved the epidemiological approach of encouraging good hygiene practices and social distancing, including orders to “shelter in place,” quarantine of high-risk individuals, and isolation of infected individuals.
32421858 A systematic review showed there was insufficient evidence to support the exclusive use of either CBEs or OBEs in assessment, however the studies conducted to date have rarely looked at high-stakes assessments due to concerns about the validity of OBEs1 .
32422341 The search strategy included clinical date published until May 9, 2020.
32423922 Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date.
32425316 This article, therefore, presents a critical review of hand sanitation approaches and products available on the market in light of the scientific evidence available to date.
32425470 To date, most of the medical literature, including Center for Disease Control guidelines, has relied on three necessary symptoms in making the diagnosis of COVID-19: fever, cough and shortness of breath.
32425484 From all the documents located, information was extracted on the date of publication, country of publication, type of study, assessment of the level of evidence and degree of recommendation, and results of interest to answer the research question.
32425486 A bibliographic search was conducted in the Medline, CINAHL, Scopus and WOS main databases, with no date limit and using the keywords “transmission”, “infection”, “contagious”, “spreads”, “coronavirinae”, “coronavirus”, “COVID 19”, “sars cov 2”, “nurses” and “nursing”.
32425490 A bibliographic search was made, without date limit, in Medline, CINAHL, PsycINFO, Scopus and Web of Science databases using the following keywords: “emotional management”; “health crisis” and “health crisis response”.
32425663 Published reports to date suggest that perinatal transmission of SARSCoV- 2 can occur but is rare.
32426202 VANISH has been utilized regularly in an anesthesia practice of 30+ providers and, to date, there have been no documented COVID-19 infections.
32426864 Up to date, a total of 1177 COVID-19 patients have been hospitalized.
32427103 To date, no work has assessed how this guidance differs across governments.
32428207 The median time to seropositivity observed for a reactive IgM and IgG result from the date of a positive PCR was 5 days (IQR: 2.75-9 days) and 4 days (IQR: 2.75-6.75 days), respectively.
32429249 When reviewing the literature it became obvious that keeping up-to-date with all relevant publications is almost impossible.
32429679 It would aid in emphasizing the up-to-date situation in a nutshell and the measures taken by the health sector of Pakistan to abate the risk of communication.
32430286 Here we review what is currently known on the mechanisms of action of CQ and HCQ as anti-viral, anti-inflammatory and anti-thrombotic drugs and discuss the up-to-date experimental evidence on the potential mechanisms of action of CQ/HCQ in Sars-Cov2 infection and the current clinical knowledge on their efficacy in the treatment of COVID-19 patients.
32430459 Based on one of the largest genome-wide association studies on type 2 diabetes mellitus (T2DM) to date (N = 898,130), T2DM was causally linked to raised ACE2 expression (P = 2.91E-03; MR-IVW).
32430840 To date, non-pharmacological interventions (NPI) have been the mainstay for controlling the coronavirus disease-2019 (COVID-19) pandemic. […] We employed a multivariate prediction model, based on up-to-date transmission and clinical parameters, to simulate outbreak trajectories in 16 countries, from diverse regions and economic categories.
32430957 We conducted a comprehensive literature search using PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure Database and Wan Fang Data until 20 April 2020 (studies were identified through PubMed alert after that date). […] Exclusion criteria were non-peer-reviewed or unpublished reports, unspecified date and location of the study, suspicion of duplicate reporting, and unreported maternal or perinatal outcomes.
32431120 The aim of the present study is to review the up-to-date professional literature dealing with the psychological impact of a pandemic outbreak on medical staff.
32432217 To date the FDA has given emergency use authorization (EUA) to 48 COVID-19 in vitro diagnostic tests and 21 high complexity molecular-based laboratory developed tests, as well as implemented policies that give broad authority to clinical laboratories and commercial manufacturers in the development, distribution, and use of COVID-19 diagnostic tests.
32433345 To date, several direct anti-SARS-CoV-2 agents have demonstrated promising in vitro and clinical efficacy.
32433799 According to the largest case series to date, most of the symptomatic patients complain of a mild respiratory syndrome (81%), while approximately 14% develop a severe disease requiring hospitalization and a further 5% need intensive care3 .
32434788 To date, there is no effective treatment.
32436005 In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic.
32437052 The data were obtained from the website of health organizations of 36 European countries and the website of WHO until the date of May 11, 2020.
32437340 Changes in vaccine doses administered to children and the effects of those changes on up-to-date status were examined for vaccinations recommended at milestone ages corresponding to the end of an Advisory Committee on Immunization Practices (ACIP) recommendation period for one or more vaccines (4).
32437912 To date, globally, over 30,000 people have died from this emerging disease.
32437930 We considered outbreak information where the first case registered in Marche with onset symptoms (26 February 2020) to the present date (20 April 2020).
32438330 As on date, no specific treatment is available for devastating COVID-19 (SARS-CoV-2) infection.
32438579 There were some family infections of coronavirus disease 2019 (COVID-19) in Taiwan to date.
32440666 To date, only a few studies have reported the distribution of lung lesions by segment.
32441351 To date, there is a paucity of patient selection criteria and prognosticators to facilitate decision making and enhance precious ICU capacity.
32441666 The final date of follow-up was March 20, 2020.
32442684 After this date, 39 patients with a diagnosis of cancer were operated on in our clinic.
32443459 To date, assays based on the reverse-transcription polymerase chain reaction (RT-PCR) in respiratory samples are the gold standard for COVID-19 diagnosis. […] To date, few studies have been conducted concerning the potential utilization of rapid testing for COVID-19, with some conflicting results. […] We can conclude that: (1) rapid diagnostic tests for COVID-19 are necessary, but should be adequately sensitive and specific; (2) few studies have been carried out to date; (3) the studies included are characterized by low numbers and low sample power, and (4) in light of these results, the use of available tests is currently questionable for clinical purposes and cannot substitute other more reliable molecular tests, such as assays based on RT-PCR.
32443871 With this prediction model, the overall infections, the infection peak, and date can accurately be predicted one week before they occur.
32444366 The final date of follow up was 5 May 2020.
32444393 The final date of follow-up was March 19, 2020.
32444460 Overall, 41% (8199/20 133) of patients were discharged alive, 26% (5165/20 133) died, and 34% (6769/20 133) continued to receive care at the reporting date. 17% (3001/18 183) required admission to high dependency or intensive care units; of these, 28% (826/3001) were discharged alive, 32% (958/3001) died, and 41% (1217/3001) continued to receive care at the reporting date.
32445776 To date, 23 confirmed cases of infections (0.4% of all HCWs) have been reported in a 30-day observation period.
32445839 The purpose of this review is to provide information, up-to-date as of the date of submission of the manuscript to the journal, on the various tests that have been developed, their scientific basis and their interpretation.
32447630 This review addresses the preliminary observations regarding the neurological disorders reported with COVID-19 to date and describes some of the disorders that are anticipated from prior experience with similar coronaviruses.
32449192 With over 4 700 000 infections to date across 188 countries and more than 310 000 deaths worldwide over the course of just 5 months, we were remarkably unprepared.[
32449374 To date, more comprehensive systematic reviews of laboratory findings on COVID-19 are missing.
32450087 To-date, there has not been a clear signal suggesting that asthma or treatment with inhaled steroids are a risk factor for severe COVID-19 disease.
32450344 To date, specific indications to treat this condition are lacking.
32451162 The last date of research for this study was April 4, 2020.
32451260 To date, there have been more than 2.3 million confirmed cases and more than 160,000 deaths globally caused by COVID-19.
32451301 Up to date, there are no reported deaths in pregnant women with Covid-19, while in the cases that have presented pneumonia because of Covid-19, the symptoms have been moderate and with a good prognosis in recovery.
32451351 We agree with the authors that, despite conflicting clinical data to date, it is possible that HCQ may have a protective effect in the setting of COVID-19.
32451367 There is great uncertainty regarding how countries’ characteristics will affect the spread of the epidemic; to date, there are few studies that attempt to predict the spread of the epidemic in African countries.
32451808 This global pandemic has affected almost the whole planet and caused the death of more than 315,131 patients as of the date of this article.
32452050 In this review, we provide a comprehensive and up-to-date overview of the different types of Clinical and Para-clinical diagnostic methods and their practical features, which can help understand better the applications and capacities of various diagnostic approaches for COVID-19 infected cases.
32452804 To our knowledge, this infoveillance study employs the largest, most comprehensive, and most fine-grained social media data to date to predict COVID-19 case counts in mainland China.
32452888 Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge.
32453411 The modelled epidemic with the full ban fitted the observed incidence of cases well, predicting 57 cases on March 6th in Australia, compared to 66 observed on this date, however we did not account for imported cases from other countries.
32453494 To date, few investigations have been carried out to ascertain the presence of SARS-CoV-2 in the seminal fluid with contrasting results.
32454808 No breast milk samples were positive for SARS-CoV-2 and, to date, there is no evidence on the presence of SARS-CoV-2 in breast milk of pregnant women with COVID-19.
32454981 Since no therapies have been formally approved and completely effective and safe to date, the best clinical choice is acquired only after consistent and fair communication and collaboration between licensed clinicians, researchers, regulatory authorities, manufacturers and patients.
32455534 To this date, no specific drugs or vaccines are available to treat SARS-CoV-2 despite its close relation to the SARS-CoV virus that caused a similar epidemic in 2003.
32455859 To date, despite no universal guidelines are available for dental procedures in pediatric dentistry during COVID-19 outbreak, routine dental practice should be postponed and only severe dental emergencies must be treated.
32456944 Most cases are managed as outpatients, however severe symptoms are also appearing and mortality to date is 16.2%.
32457048 We conducted a comparative cohort study of patients with rheumatic disease and COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR), compared in a 1:2 ratio with matched comparators on age, sex and date of COVID-19 diagnosis, between 1 March and 8 April 2020, at Partners HealthCare System in the greater Boston, Massachusetts area.
32458712 Only 187 urine samples have been reported to have been tested in the literature to date despite over 4 million cases of respiratory Covid 19 positive cases being reported worldwide.
32459192 The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 has been established to synthesize up-to-date information on the epidemiology, pathogenesis, and laboratory diagnosis and monitoring of COVID-19, as well as to develop practical recommendations on the use of molecular, serological, and biochemical tests in disease diagnosis and management.
32459675 First, they propose delaying the date that programs can access applicant data through the Electronic Residency Application Service, thereby affording students more time to complete clinical experiences, solidify their specialty decision, and strengthen their residency application.
32460208 Unfortunately, to date, there is no specific antiviral treatment for COVID-19.
32461194 This article, therefore, presents a critical review of hand sanitation approaches and products available on the market in light of the scientific evidence available to date.
32462701 These infection models have already been useful for studies of transmission and immunity, but to date only partially model the mechanisms implicated in human severe COVID-19.
32462756 A total of 166 patients receiving colorectal surgery from 20th December 2019 to 20th March 2020 at Department of General Surgery in Chinese General Hospital of People’s Liberation Army were enrolled, and further divided into two groups based on before or after admission date of 20th January 2020.
32463377 On that date there were 134,576 reported cases and 4,981 deaths worldwide.
32463716 To date, there has not been any broad assessment of urological surgery residency changes and concerns during the COVID-19 pandemic.
32464668 What explains the anemic global response to date?
32470120 In regression analyses controlling for demographic variables and survey date, older adult age was associated with perceiving larger risks of dying if getting COVID-19, but with perceiving less risk of getting COVID-19, getting quarantined, or running out of money, as well as less depression and anxiety.
32472683 Although RNA has been detected in various clinical samples, no reports to date have documented SARS-CoV-2 in human milk.
32472687 Characteristics of each season, including the rate of influenza-like illness (ILI), duration of epidemic, date of termination of epidemic, distribution of influenza virus strain and hospitalization were analyzed.
32473007 To date, no specific estimate of R0 for SARS-CoV-2 is available for healthcare settings.
32473151 Limited data exists to-date on the laboratory findings in children with COVID-19, warranting the conduction of this study, in which we pool the currently available literature data on the laboratory findings seen in children with mild and severe COVID-19.
32467561 To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19 and the current standard care relies on supportive treatments.
32468508 To date there are no studies in the literature that demonstrate its feasibility and efficacy in the context of the worldwide SARS-CoV-2 epidemic.
32470470 There are over 2118 on-going clinical trials underway, but to date none of these drugs have consistently proven effective.
32471004 The manifestations of COVID-19 in solid organ transplant recipients are only beginning to be understood with cases reported to date in transplant recipients on chronic immunosuppression.
32471009 There are now over 1 million confirmed cases of COVID-19 globally with more than 270,000 recorded deaths to date.
32474026 Till date, no drug has been approved for the treatment of this infection.
32474093 Indeed, in this review we discuss several neurologic aspects reported in the literature to date including the evidence and pathways of neuroinvasion in COVID-19 and the main neurologic disorders reported in the literature to date, as well as future perspectives and the potential long-term consequence of current neuroinfection in COVID-19 patients.
32474860 The last follow-up date was Feb.
32476001 In fact, within the SECURE-IBD database, there have been only 4 Greek IBD patients, to date, who have been reported as positive for SARS-CoV-2.
32476394 It was found out that to date there is very little data on the state of loro organs in patients with SARS-CoV-2 and no data on anosmia in the pediatric population.
32476607 Results were analysed in combination with sera collection date and clinical information.
32476796 In this review, we summarize the data on GI involvement to date, as well as the impact of COVID-19 on underlying GI diseases.
32479246 To date, no specific treatment has been proven to be effective for coronavirus disease 2019 (COVID-19).
32479632 To date, no report on COVID-19 pediatric patients in a large urban center with data on underlying comorbidities and co-infection for hospitalized cases has been published.
32479766 To date no evidence confirmed COVID-19 vertical transmission from infected pregnant mother to their fetus.
32479816 SARS-CoV-2 infection in pregnant women does not lead to fetus mortality, unlike other zoonotic coronaviruses such as SARS-CoV and MERS-CoV, and there is, to date, no evidence of intrauterine transmission to neonates.
32481690 This is especially true for the newly identified COVID-19 caused by SARS coronavirus 2 (SARS-CoV-2) for which, to date, no specific antiviral drugs or vaccines have been approved.
32481719 We summarize the most up-to-date information on the role of miRNAs in ASL homeostasis and host-pathogen interactions in the airway and discuss concepts for miRNA-directed therapy.
32485299 Using the Medicare POSPUF database, aerosol-generating procedures (AGPs) were mapped based on hospital referral regions, against up-to-date COVID-19 case distribution data, as of April 24, 2020.
32490842 This up-to-date analysis may elucidate the evolution of the COVID-19 pandemic in Italy.
32490972 The evidence generated on COVID-19 and ophthalmology to date is limited, although this is understandable given the circumstances.
32491297 To date the European experience with COVID-19 mortality has been different to the observed in China and Asia. […] We have adapted our predictive model of COVID-19-related mortality, which rested on the observed mortality within the first weeks of the outbreak and the date of the respective lockdown in each country.
32492529 To date, our hospital has treated thousands of COVID-19 positive patients and sits at the forefront of the United States response to this pandemic.
32493447 The name of the trial register is Iranian registry of clinical trial (IRCT), registration number is IRCT20120826010664N6, date of trial registration is April 7, 2020, FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32493460 The protocol version number is 1.0 and the date is 18 May 2020.
32493466 Here we estimate the effective reproduction number, Rt, of COVID-19 in Singapore from the publicly available daily case series of imported and autochthonous cases by date of symptoms onset, after adjusting the local cases for reporting delays as of March 17, 2020.
32493468 Secondary outcomes include mortality from the date of randomization until the last day of the study which will be the day all of the patients have had at least one of the following outcomes: 1) Improvement of two points on a seven-category ordinal scale. […] Duration of hospitalization from date of randomization until the date of hospital discharge or date of death from any cause, whichever comes first. […] Incidence of new mechanical ventilation uses from date of randomization until the last day of the study. […] Recruitment is finished, the start date of recruitment was on 9th April 2020 and the end date was on 14th April 2020.
32493475 Primary outcome will be measured until the end of treatment for each participant (until the date of the last dose taken by each patient). […] EU Clinical Trials Register: 2020-001530-35; Date of trial registration: 13th of April 2020; https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001530-35/ES FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32493478 Protocol version: 1.2 05 April 2020 Recruitment is ongoing, started March 31 and anticipated end date is September 30, 2020. […] ClinicalTrials.gov, Protocol Registry Number: NCT04328961 Date of registration: April 1, 2020, retrospectively registered FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32493740 To date, persuasive evidence of important benefit in COVID-19 does not exist for any antiviral treatments, although for each treatment evidence has not excluded important benefit.
32494546 To date, there is no approved targeted treatment, and many investigational therapeutic agents and vaccine candidates are being considered for the treatment of COVID-19.
32494567 To date (17th April 2020) a total of 2,230,439 cases of COVID-19; 150,810 cases of deaths and 564,210 recovered cases have been reported worldwide. […] To date, there is no vaccine or no specific treatment for COVID-19.
32494931 To date, there is no licensed treatment or approved vaccine to combat the coronavirus disease of 2019 (COVID-19), and the number of new cases and mortality multiplies every day.
32495333 Taiwan’s success to date is grounded in proactive preparedness and deployment by the government and effective teamwork among government agencies, medical institutions, enterprises, and the public.
32496101 Health care providers are experiencing potentially morally injurious events that may violate their moral code or values, yet almost no research has been conducted on moral injury among health care providers to date.
32496357 Only 1 mortality (4.8%) to date, in a critically-ill heart/kidney patient who had been in the ICU prior to diagnosis.
32496919 Yet, despite an explosion in the number and availability of serologic assays to test for antibodies against SARS-CoV-2, most have undergone minimal external validation to date.
32497806 Optimal management of infectious diseases is guided by up-to-date information at the individual and public health level.
32498138 We measured the period from the date of illness onset to the date of COVID-19 confirmation. […] The estimated median period between the date of symptom onset and the date of COVID-19 confirmation was 4 days (95% confidence interval, 1-12). […] There was a delay in COVID-19 confirmation from the date of illness onset among the cases linked to the Shincheonji religious group.
32498503 Approximately 1,016,128 reported cases, 211,615 recovered cases and 53,069 deaths of COVID-2019 have been reported to date (April 2, 2020).
32498731 The relative search volume was obtained for ‘Coronavirus’, ‘handwashing’, ‘face mask’ and symptom related keywords, for the United Kingdom, from the date of the first confirmed case until numbers peaked in April.
32498752 Average preventive measure interest was calculated for the query terms “hand sanitizer,” “hand washing,” “social distancing,” and “COVID testing.” We then calculated the delay in statewide SAH orders from March 1, 2020, to the date of issuance and by-state presidential voting percentage.
32499154 The viruses remain a threat till date and are of serious concern since no vaccine or specified drug therapy has been approbated for treating human coronaviruses.
32499832 To date, clinical evidence and guidelines based on reliable data and randomized clinical trials for the treatment of COVID-19 are lacking.
32500648 In this manuscript, our goal was to provide a “up-to-date” account on this topic, through analysis of current literature and sharing our experiences during this pandemic.
32501378 The latest version of human coronavirus said to be COVID-19 came out as a sudden pandemic disease within human population and in the absence of vaccination and proper treatment till date, it daunting threats heavily to human lives, infecting more than 12, 11, 214 people and death more than 67, 666 people in 208 countries across the globe as on April 06, 2020, which is highly alarming. […] When no treatment or vaccine is available till date and to avoid COVID-19 to be transmitted in the community, social distancing is the only way to prevent the disease, which is well taken into account in our novel epidemic models as a special compartment, that is, home isolation.
32501397 To date the potential impact of previous infection history has been poorly investigated as a potential determinant of risk.
32502054 The patient reported in this case report is the youngest case reported in Chengdu, China to date.
32502319 At the date of writing this editorial, there is now agreement amongst experts that the first wave of the United Kingdom’s (UK) COVID-19 pandemic is in decline (1).
32503304 To date, data on COVID-19-related death cases among physicians from different medical specialties are incomplete and scattered.
32503352 Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans; the second-largest and most deadly outbreak to date occurred in Saudi Arabia.
32503620 Recruitment began on 20/03/2020 and the date by which the recruitment is anticipated to be completed is 30/05/2020.
32503657 Trial participants, investigators, care givers, outcome assessors, and date analysts are not blinded to group assignment. 210 patients are expected to be enrolled and allocated according to the ratio of 2 (Favipiravir group, n=140): 1(regular treatment group, n=70). […] Protocol version number 3.0, 10th April 2020 First Patient, first visit 17th March 2020; recruitment end date anticipated June 1, 2020.
32503874 The secondary endpoints will be proportion of participants relieved from clinical symptoms defined at the time (in hours) from initiation of the study treatment, all-cause mortality, discharged date, frequency of respiratory progression and treatment-emergent adverse events.
32504135 To date, no report on LU and neonates with SARS-CoV-2 infection has been published.What is new:• This study adds evidence about LU findings in neonates with SARS-CoV-2 infection.
32505220 We describe China’s strategies for prevention and control of COVID-19 (containment and suppression) and their application, from the perspective of the COVID-19 experience to date in China.
32505678 We analyzed our surgical practice since March 14th when the lockdown was declared up to date, May 14th (2 months).
32506109 Pandemic enveloped RNA Novel Corona Virus’ 2019 (SARS-CoV-2) appears as a beating reed which induce overwhelming outbreak all over the world since November 2019 to till date.
32507006 We describe our experience as the Division of Arthroplasty in the hospital at the epicenter of the COVID-19 pandemic in Singapore.Patients and methods - The number of COVID-19 cases reported both nationwide and at our institution from February 2020 to date were reviewed.
32507030 To date, the reasons for this have been generically attributed to old age and underlying diseases.
32507546 To date, there are varying levels of agreement on the optimal triaging of urologic oncology cases.
32509205 The current study reviewed published evidence of clinical interventions of severe and critical COVID-19, aiming to provide an up-to-date reference for further clinical treatment.
32510978 In this review, we highlight what is known to date about coronavirus disease 2019 and cardiovascular risk, focusing in on the putative role of the endothelium in disease susceptibility and pathogenesis.
32511245 Although double-membrane vesicles (DMVs) appear to be a pan-CoV RO element, studies to date describe an assortment of additional CoV-induced membrane structures.
32511692 The final date of follow-up was May 22, 2020.
32511859 The ongoing COVID-19 pandemic has to date infected more than one million people and led to tens of thousands of deaths across the globe.
32511912 To date, no drug or vaccine has been approved to treat the severe disease caused by this coronavirus, COVID-19.
32511989 It resulted in the maintenance of a high-volume, high-quality thoracic surgical oncology program with no Covid-19 positive cases to date.
32512950 To date, there are no specific antiviral agents available for this disease, currently known as COVID-19.
32513062 Our multidisciplinary team, at the suggestion of a parent, hosted 3 virtual “town halls” in which families could ask questions directly of pediatric otolaryngology, pediatric pulmonology and case management in order to efficiently obtain factual evidence-based up-to-date advice.
32513231 Date of trial registration: April 10, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32513299 Trial participants, investigators, care givers, outcome assessors, and date analysts are not blinded to group assignment. 750 patients are expected to be enrolled and the cases are allocated according to the ratio of 2 (Anluohuaxian combined with regular treatment group):1 (regular treatment group). […] Actual Study Start Date: April 1, 2020 Estimated Primary Completion Date: June 1, 2020 Estimated Study Completion Date: December 1, 2020 TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT04334265.
32513308 ClinicalTrials.gov: NCT04359810 Date of trial registration: April 24, 2020 Retrospectively registered FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32513502 We collected epidemiological information about «time» (date of onset of symptoms), «place» (zip code), and «person» (gender, age).
32513514 However, there have been no vaccines approved in the world to date.
32515384 The current pandemic of COVID-19 has infected around 2.5 million people with more than 125,000 deaths across the globe till date, and numbers are still rising.
32515404 Here, we present an overview of the clinical trials that are currently being conducted or have concluded to date on COVID-19 globally. […] Collectively, there are 1,528 trials reported for COVID-19 to date.
32516704 A plethora of treatments has been or is being assessed, but to date, none has been proven effective.
32516817 Guidance has come from expert opinion, professional societies and public health agencies, but to date, there is no report on how obstetrical practices have adapted these recommendations to their local situations.
32517882 To date, no effective vaccine is available which can combat the infection caused by this virus.
32518743 Although a number of improvement measures are ongoing, however, no study to date has addressed Rohingyas’ self-adopted strategies to mitigate disaster risks.
32520031 To date, no specific drug has been discovered for the treatment of COVID-19 and hence, people are in a state of anxiety.
32520135 Medical Uniforms date back from medieval times.
32520235 We chose the date of the first COVID-19 case to April 25, 2020, as the training period, and April 26 to May 3, 2020, as the test period.
32520285 In order to account for the stage of the pandemic, the baseline date was defined as the day in which the 10th death was reported.
32521062 To date there is limited information on how COVID-19 affects patients with a history migraine.
32521557 About 70 % of patients seem to experience a reduction of smell and taste in the course of the disease, with most of the studies published to date based on questionnaires and anamnestic data. […] A distinction between taste and taste disorders, i. e. a distinction between retronasal aroma taste and the olfactory system from the dysfunction of taste capsules and the further cranial nerves, was mostly not made in the studies available to date.
32522513 While much of the emphasis in obstetrics and gynecology to date has been on the as yet uncertain impacts of COVID-19 in pregnancy and on changes to surgical management, the pandemic has broad implications for ambulatory gynecologic care as well.
32523137 To date there are nearly 3 million people infected and more than 250,000 deaths caused by the disease worldwide. […] In Mexico, the first case was detected in February 2020, and to date there are 26,616 confirmed cases and 2,961 deaths throughout the country.
32523927 Coronavirus disease 2019 (COVID-19) complications include disseminated coagulation and thrombosis, but, to the best of our knowledge, the literature to date on these manifestations has been limited.
32524645 This process requires up-to-date drug information to ensure optimum use, particularly safety and efficacy profiles of the medications, until convincing evidence is reported.
32524746 To date, the world is struggling to find a cure/vaccination to this deadly virus.
32525558 To date, understanding whether acquired immunity and presence of anti SARS-Cov2 antibodies protects against reinfection is one the most important focus of the scientific community [1-2].
32525707 Hotline clinicians provided New Yorkers with clinical assessment and guidance, registered them for home symptom monitoring, connected them to social services, and provided a source of up-to-date answers to COVID-19 questions.
32526560 Details on the onset date of clinical symptoms, throat swab conversion, and course of disease were collected from medical records retrospectively.
32526721 For countries that showed a strong slowdown in the rate of infections we have extrapolated the expected saturation of the total number of infections and the expected final date.
32527257 To date, an ongoing experimental therapy with monoclonal antibody against the IL-6 receptor in Italy seems to have beneficial effects on severe lung disease and prognosis in patients with Covid-19 infection.
32527341 The clinical data of COVID-19 patients treated in the Second People’ Hospital of Fuyang City from January 20th to February 18th in 2020 were retrospective analyzed, including the demographic and epidemiological date, vital signs and hematology indexes, etc. on admission.
32529866 With limited knowledge about SARS-CoV-2, no approved treatment or vaccine is available till date.
32530314 To date its adoption for Amyotrophic Lateral Sclerosis (ALS) care is still in a preliminary stage.
32530816 For anosmia and ageusia, we assessed whether the respective GT correlated with Covid-19 cases and deaths both throughout 2020 and specifically before March 16, 2020 (i.e., the date when the media started reporting that those symptoms could be associated with Covid-19).
32531138 To date, little is known about the viral shedding duration, clinical course and treatment efficacy of COVID-19 near Hubei Province, China.
32531777 Much of the work carried out to date involves the differentiation of bacterial and viral sources of infection and often the detection of bacterial and viral co-infection.
32532356 Patients screening commenced on 16th April and an estimated date of the recruitment of the final participants will be around end of July. .
32532596 At the time of publication, this review offers the most up-to-date recommendations for clinical practitioners in radiology departments, including radiographers.
32532802 Of countries that have undertaken suppression to date, lower income countries have acted earlier.
32532933 To date, seven known strains of HCoVs belonging to four genera (i.e., α?, β?, γ, and δ-CoV) have been recognized; the latest one has been identified as the SARS-CoV-2. […] To date, despite the whole world effort to review various aspects of SARS-CoV-2, including epidemiology, clinical manifestations, diagnosis, and treatment options, there are still gaps in the knowledge of this disease and many issues remain unclear.
32532942 No systematic reviews have been published on this topic to date.
32533062 Coronavirus infections of multiple origins have spread to date worldwide, causing severe respiratory diseases. […] It has created a severe worldwide outbreak beginning in late 2019, leading to date to over 4 million cases globally.
32533197 To date, there is no specific treatment for COVID-19 induced AKI.
32533777 To date, no data have ever been reported to reflect the clinical features of Corona Virus Disease 2019 (COVID-19) among these patients with pre-existing ILD.
32534175 A hypothetical three-part prevention, diagnostic, and treatment approach based on an up-to-date scientific literature review for COVID-19 is proposed.
32534210 The clinical outcomes of these operative patients were monitored up to 12 May 2020, the final date of follow-up, a minimum of 15 days after all patients were discharged from the hospital.
32534465 With the success of slowing disease spread in many countries to date, and reduced workload due to limitations on elective surgery in many institutions, there is more time and opportunity to be proactive in implementing measures to mitigate or minimise potential adverse psychological effects and improve, restore and preserve the wellbeing of the workforce now and for years to come.
32535955 To date it has resulted in ~6.5 million confirmed cases and caused almost 400,000 related deaths worldwide.
32536205 The evidence to date indicates that CGM offers promise as an effective tool for monitoring hospitalized patients.
32537425 To date, no cases of human pancreatitis have been identified as related to a COVID-19 infection, although multiple other gastrointestinal symptoms have been described.
32537561 This review is correct as of the date published and will be updated as more diagnostic tests come to light.
32538276 To date, there is no confirmed treatment or vaccine prevention strategy against COVID-19.
32538809 Review of relevant manuscript published up to date, draft creation correctedt hough modified nominal group until final corrected manuscript.
32540268 This study considers up-to-date information on the biological determinants shared by COVID-19 and renal disease, and aims to provide evidence-based recommendations for the clinical management of RCC patients with COVID-19.
32540369 Daily numbers of confirmed cases of each category were plotted by date of onset, and the epidemic form of each category was inferred.
32540737 There is no evidence to date that pioglitazone upregulates ACE2 in the alveolar cells; rather, there is evidence from animal studies of upregulation of ACE2 in insulin sensitive tissues, which might have a protective effect on lung injury.
32541085 To date, no medication supported by randomized clinical trials has been approved for the treatment of COVID-19.
32541496 The evidence to date of Chinese medicine in treatment of coronavirus-related pneumonia will be systematically reviewed and meta-analyzed.
32542188 To-date (4-22-2020) it affected over 2.6 million people and resulted in nearly 200,000 death worldwide mainly due to severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2).
32542213 Numerous studies are ongoing focusing on anticytokine therapies, antibiotics, and antiviral agents, but none to date have focused on treating the underlying thrombotic coagulopathy in an effort to improve respiratory failure in COVID-19.
32542402 It is vital that public health officials provide clear and up-to-date information about protective measures and crucial communications to respond to information-seeking behavior across NYC.
32544281 To date, no data have ever been reported to reflect the prevalence of Corona Virus Disease 2019 (COVID-19) among these outpatients.
32544725 However, the present detailed report of up-to-date knowledge on this topic can provide a useful source for further studies focusing on more deepened investigations of SARS-CoV-2 behaviour in the environment.
32544872 In this commentary we perform a bibliometric review of the available academic literature about COVID-19 in the top 20-ranked ENT journal, with the goal of providing an overview of what has been published to date and encouraging a shift towards quantitative research.
32544884 There is, however, no effective antiviral drug that can be used to treat COVID-19 to date.
32545925 To date, there have been reports of neurologic manifestations in COVID-19 patients including ischemic strokes, Guillain-Barre Syndrome and anosmia.
32546458 The ongoing pandemic of Covid-19 caused by the SARS-CoV-2 virus has infected more than 6 million all over the world and has caused more than 3.8 lakh fatalities till date(1) Health workers are the frontline responders and are exposed to a plethora of health hazards.
32547323 Rationale: Up to date, the exploration of clinical features in severe COVID-19 patients were mostly from the same center in Wuhan, China.
32547911 In the opinion of the medical societies of hygiene and pediatrics undersigning the present statement, the analyses published to date regarding transmission of SARS-CoV-2 and the course of CoVid-19 show that children play a much less significant role in the spread of the virus than do adults. […] According to the findings available to date, not only do children and adolescents less frequently fall ill with CoVid-19, they also generally become less severely ill than do adults.
32549076 To date there is no study that demonstrates or can suggest the ability for a virus to be transmitted during surgical treatment whether open, laparoscopic or robotic.
32549337 Case confirmation was not performed in all hospitalized patients, but 72.15% of hospitalized patients had favorable outcomes to date.
32549531 Despite initial difficulties in management of such patients, the constant increase of literature in the field is to date clarifying some questions from clinicians.
32550040 To date, no evidence shows that ACEIs or ARBs increase the susceptibility and mortality of patients infected with SARS-CoV-2, and hence, it is not advisable to discontinue such drugs in patients with cardiovascular disease.
32552509 Visit volumes were assessed weekly and practice patterns were compared before and after March 15, 2020, as this was the date of a major statewide stay-at-home order in Ohio. Results: Before March 15 the mean in-person visit per week was 5129.4 and decreased to 866.7 after that date.
32552659 With the large numbers of undifferentiated patients managed by the ED to date, more than 820 patients with COVID-19 have been identified in the hospital.
32552751 To date, there is no available literature on the clinical data on COVID-19 patients in Iran.
32552794 Finally, we estimate the date when the first infected case occurred in Wuhan. […] The date of first infection is estimated as 30 November 2019.
32553503 In summary, based on the currently available evidences and as recommended by several medical societies, ACEi or ARB should not be systematically discontinued because to date no safety signal was raised with the use of these drugs.
32553562 Up to date, a lot of reports have shown that olfactory dysfunction is related to viral infections but no exact mechanism, clinical course, and definite treatment have been discovered, which is also same in COVID-19.
32554861 This study is a retrospective, single-center case series of the 238 consecutive hospitalized patients with confirmed COVID-19 at the First Hospital of Changsha city, China, from 01/21 to 02/14, 2020; the final date of follow-up was 02/27, 2020.
32554901 The most commonly used CFR is thecase fatality ratio, typically constructed using the estimated number of deaths to date divided by the estimated total number of confirmed infected cases to date.
32555565 In order to evaluate this trend, we analyzed the literature data published since the beginning of the COVID-19 pandemic to date, in addition to our intensive cardiac care unit (ICCU) experience.
32555974 Studies carried out to date on possible SARS-CoV2 drug targets highlight glycoprotein S, Mpro (main protease or protease type 3C), and a member of the transmembrane serine protease II families (TMPRSS2).
32556054 However, non-pharmacological approaches have proven to be the most efficient strategy to date.
32557011 To date, emerging anti-SARS-CoV-2 treatments are warranted to control epidemics.
32557847 Since December 2019, SARS-CoV-2 epidemic has spread all over the world.1 To date, few reports regarding the cutaneous involvement in COVID-19 have been published.2,3 Herein, we report a four cases series describing skin lesions probably related with COVID-19.
32558655 Sixth, following experiences to date in responding to the COVID-19 infodemic and the lessons from other disease outbreaks, infodemic management approaches should be further developed to support preparedness and response, and to inform risk mitigation, and be enhanced through data science and sociobehavioral and other research.
32558877 ACEI/ARB use was defined as prescription fillings 6 months prior to the index date.
32558916 Articles were excluded if they did not include specific ventilator allocation recommendations, were in draft status, did not include their state department of health, or were not the most up-to-date guideline.
32559308 Given the unknown effects that relaxation of social distancing measures will have on the infection rate, we review the evidence to date to see whether a history of haematological malignancy is associated with increased risk of COVID-19.
32559451 Consistent with previous modelling studies and country-specific COVID-19 responses to date, our analysis estimated that a high proportion of cases would need to self-isolate and a high proportion of their contacts to be successfully traced to ensure an effective reproduction number lower than 1 in the absence of other measures.
32560340 The high contagiousness of the virus, the strong impact on the health system of the various countries and the absence to date of treatments able to improve the prognosis of the disease make the introduction of a vaccine indispensable, even though there are currently no approved human coronavirus vaccines.
32560745 Identifier: IRCT20120225009124N4 version 1; Registration date: April 2 2020.
32562316 To date, the recently discovered SARS-CoV-2 virus has afflicted >6.9 million people worldwide and disrupted the global economy.
32562477 We finally perform a Monte Carlo simulation with 25,000 runs to evaluate a random uncertainty in the prediction of the date of a substantial reduction in the number of diagnosed daily cases per swab.
32562913 In 2019, a new coronavirus (SARS CoV2) infecting humans has emerged in Wuhan, China which caused an unprecedented pandemic involving at least 185 countries infecting 2.5 million people till date.
32562915 In general, based on existing data published to date, 80.9% of patients infected with the virus develop mild infection; 13.8% severe pneumonia; 4.7% respiratory failure, septic shock or multi-organ failure; 3% of these cases are fatal.
32563019 In this paper, we have reviewed the relevant knowledge based on up-to-date literature.
32563601 One thousand six hundred fifty-one of 3,369 patients tested have had SARS-CoV-2-positive results to date.
32563745 Protective factors included having sufficient medical resources, up-to-date and accurate information, and taking precautionary measures.
32564417 Some systemic and biologic psoriasis treatments [SBT] have been associated with an increased risk of infection.1 To date, more and more data regarding the risk of COVID-19 infection in patients receiving SBT becomes available.2-5 To enrich these data, we evaluated the frequency of severe COVID-19 infections, defined as hospitalisation or death, in psoriasis patients receiving SBT, especially during the 4 months following SBT initiation.
32565599 The review focuses on the various approaches adopted till date for developing effective therapeutic strategies including combination of drugs, vaccine therapy, and convalescent plasma therapy to combat this viral outbreak.
32565901 The Brazilian Gastrointestinal Tumours Group board of directors and members sought up-to-date scientific literature on each tumour type and discussed all recommendations by virtual meetings to provide evidence-based-and sometimes, expert opinion-recommendation statements.
32566128 During COVID-19 pandemic, allergists have the responsibility of balancing individual patients’ needs with public health issues, and innovative tools, such as telemedicine and digital medicine services, can be helpful to reduce the risk of viral spreading while delivering up-to-date personalized care.
32566234 Sequences were selected based on the travel history of the individual and the collection date.
32567995 Till date, no potential medicine/ drug is available to cure the infected persons from SARS-CoV-2.
32568499 We carry out a review of the little scientific evidence based mainly on the few publications available to date and on the recommendations of the main scientific societies regarding which patients should undergo surgery, when surgery should be performed and how patient visits should be organize.
32569196 All the above databases will be searched from the available date of inception until the latest issue.
32569422 The consensus to date is that most infants and children only have mild COVID-19 symptoms and few require intensive care.
32570240 To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown.
32570713 Little information on the SARS-CoV-2 virus in animals is available to date. […] Whereas no one husbandry animal case has been reported to date, which would have significant implications in food safety, companion animals play a role in COVID-19 epidemiology that opens up new questions.
32570819 The public relied on online sources, whether through official websites or phone-based applications, to acquire up-to-date health information, provide accurate instructions, and limit misinformation.
32570995 To date, there has been no definite therapy for COVID-19.
32571224 To date, there have been few reports of the varying degrees of illness caused by the COVID-19.
32571528 Our work also stresses the importance of reliable up to date epidemiological data in order to accurately assess the impact of Public Health policies on viral outbreak.
32571980 Detection of SARS-CoV-2 infections to date has relied heavily on RT-PCR testing. […] Combining excess ILI counts with the date of onset of community transmission in the US, we also show that the early epidemic in the US was unlikely to have been doubling slower than every 4 days.
32572816 To date May 5 2020, if we carry out a search in pubmed with the keyword “COVID-19”, more than 9000 papers appear.
32573501 To date, however, we know that COVID 19 affects numerous areas of the body (1,2).
32573538 To date, in the treatment of COVID-19 in different countries, a little more than 10 drugs are used.
32574109 Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 61 is January 8, 2021.
32574177 We first used case reports from Japan, Singapore, and Korea to investigate the date of flights of infected travelers.
32574232 However, to date, efforts at improving sanitary safety in toilet use have been insufficient.
32574277 There are, to date, no adequately powered prospective trials addressing this important question.
32574285 In conclusion, to date, no convincing evidence has been found for vertical transmission of SARS-CoV-2.
32574286 To date, many cases have been reported in the pediatric age group, most of which were from China.
32574303 Then, we consider the Lombardy case and calibrate the model with the number of dead individuals to date (May 5, 2020) and constrain the parameters on the basis of values reported in the literature.
32575505 Nevertheless, to date, the best/optimal method to screen HWs for SARS-CoV-2 infection is still under debate, and data on the prevalence of SARS-CoV-2 infection in HWs are still scarce.
32575763 Iran has faced one of the worst COVID-19 outbreaks in the world, and no studies to date have examined COVID-19-related stress in the general Iranian population.
32576386 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date.
32576468 In aviation after a prolonged period of absence from flying, this deficit in keeping skills and thinking up to date is known as being “out of currency” or “not current”.
32576811 The number of people infected up to the date of lockdown was also registered.
32578811 We use a time series analysis of deaths due to COVID-19 referenced to the date of deaths (as opposed to the date in which the test results were obtained). […] The use of a time series of deaths due to COVID-19 referenced to the date of the event allows a better understanding of the effects of the SDS on the progression of the COVID-19 epidemic in São Paulo State, Brazil.
32579306 Based on reports to date, neurological signs or symptoms appear in 30-50% of hospitalized COVID-19 patients, with higher incidence in those with more severe disease.
32579957 Up-to-date, a number of mechanisms have been postulated for COVID-19-associated cardiovascular damage including SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) activation, cytokine storm, hypoxemia, stress and cardiotoxicity of antiviral drugs.
32580535 Compared to scenario I, it was found that in scenario III, the cumulative number of patients would increase by 107 and the date of occurrence of the last patient would be delayed by 92 days.
32581810 To date, there are no specific therapeutic strategies for treatment of COVID-19.
32582324 To date, April 25, 2020, more than 2.4 million humans are infected and more than a hundred thousand deaths have been reported from more than 200 countries from COVID-19.
32582615 The final date of follow-up was March 6th, 2020.
32582739 We also estimate the fraction of the population that would be infected by the beginning of May, at the official date at which the lockdown should be relaxed.
32583671 To date, no cases have been reported on the effects of COVID-19 in laryngectomees.
32584779 To date, there is limited evidence on how the infodemic may have the potential to influence psychobehavioural responses to the crisis.
32584795 To date, data to assess the prevalence and severity of COVID-19 among pregnant U.S. women and determine whether signs and symptoms differ among pregnant and nonpregnant women are limited.
32586214 The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 is due to the ability of SARS-CoV-2 to invade endo¬thelial cells via angiotensin-converting enzyme 2 (ACE2), which is expressed on the endothelial cell surface.
32586323 This was a retrospective cohort study from electronic case records of the first 450 patients admitted to our hospital with PCR-confirmed COVID-19, 77% of the total inpatient caseload to date.
32586363 Registration date is April 14, 2020.
32586399 Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection (Thy-Support), ClinicalTrials.gov Identifier: NCT04348513, date of trial registration: April 16, 2020, EudraCT Identifier: 2020-001623-13, date of trial registration: April 22, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1).
32587651 No vaccine has been developed against the 2019-nCoV virus to date.
32588589 Case studies to-date indicate that this infection causes a mild illness (i.e. pneumonia or mild pneumonia) in approximately 80% of cases, and most cases recove; 14% have a more severe illness, 6% experience a critical illness. […] This article contains up-to-date information as at 04/04/2020.
32589600 To date, many biomarkers reflecting the main pathophysiological characteristics of the disease have been identified and associated with the risk of developing severe disease.
32590725 In the global coronavirus disease 2019 (COVID-19) pandemic, to date, delivery of critically ill pregnant patients has predominantly been by cesarean.
32591166 Although the number of studies to date is limited, LUS findings have demonstrated high diagnostic sensitivity and accuracy, comparable with those of chest computed tomography scans.
32591466 We summarize the immunogenicity of leading vaccine candidates tested to date in animals and humans, and discuss the outcome and interpretation of virus-challenge experiments in animals.
32591665 Publications up until the date of the literature search, 19th March 2020, were used.
32591667 Besides the clinical guidelines presented within the study, it also encourages further up-to-date and evidence-based management guidelines for patients with COVID-19.
32591712 This paper describes its evolution to date and the challenges encountered along the way.
32593065 To date, we have no French data about the psychiatric consequences of the Covid-19 pandemic and the confinement.