DANTROLENE
DrugBank ID: db01219
DrugCentral: dantrolene
Synonymous :1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin | dantrolene | dantroleno | dantrolenum
Drug Sentece Context
Table 1. Analysis of context sentence of dantrolene gene in 5 abstracts.
| pmid | sentence |
|---|---|
| 33090434 | Dantrolene, an FDA approved drug to treat malignant hyperthermia and muscle spasm, has been demonstrated to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediated toxicity of host cells. […] Dantrolene, as an inhibitor of RyRs, is expected to ameliorate these detrimental effects of SARS-CoV-2 in host cells. […] Additionally, dantrolene has also been shown to inhibit multiple cell or organ damage induced by hypoxia/ischemia, mitochondria damage, oxidative stresses, inflammation, impairment of autophagy and apoptosis, etc., which are often the causes of severity and mortality of COVID-19 patients. […] We have repurposed that dantrolene has a high potential at treating COVID-19 patients and reducing its morbidity and mortality. |
| 33557936 | The administration of dantrolene with muscle relaxation and anti-inflammatory function showed potential efficacy for rhabdomyolysis, high fever, and increased plasma inflammatory markers. […] Dantrolene is a ryanodine receptor antagonist and is used as an anti-inflammatory agent. […] The administration of dantrolene showed potential efficacy for rhabdomyolysis, high body temperature due to inflammation, and increased inflammatory markers. |