DANOPREVIR
DrugBank ID: db11779
DrugCentral: danoprevir
Synonymous : None
Drug Sentece Context
Table 1. Analysis of context sentence of danoprevir gene in 5 abstracts.
| pmid | sentence |
|---|---|
| 32501538 | Patients were divided into two groups according to different treatment plans (danoprevir and lopinavir/ritonavir). […] COVID-19 patients treated with danoprevir or lopinavir/ritonavir were all improved and discharged. […] Additionally, under the circumstance that there was no significant difference in patients’ general information between the two groups, we found that the mean time to achieve both negative nucleic acid testing and hospital stays of patients treated with danoprevir were significantly shorter than those of patients with lopinavir/ritonavir. […] Collectively, applying danoprevir is a good treatment plan for COVID-19 patients. |
| 32643436 | Initial findings from antivirals such as remdesivir, favipiravir, danoprevir or lopinavir with ritonavir are presented. |
| 32696811 | After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. |
| 32798373 | Among the drugs that are being tested in clinical trials for COVID-19, Danoprevir and Darunavir have the highest binding affinity for the target main protease of SARS-CoV-2. |
| 33235105 | Danoprevir boosted by ritonavir (Ganovo) is a potent hepatitis C virus (HCV) protease (NS3/4A) inhibitor, which was approved and marketed in China since 2018 to treat chronic hepatitis C patients. […] This is an open-label, single arm study evaluating the effects of danoprevir boosted by ritonavir on treatment naïve and experienced COVID-19 patients for the first time. […] Patients received danoprevir boosted by ritonavir (100 mg/100 mg, twice per day). […] The data showed that danoprevir boosted by ritonavir is safe and well tolerated in all patients. […] After initiation of danoprevir/ritonavir treatment, the first negative reverse real-time PCR (RT-PCR) test occurred at a median of 2 days, ranging from 1 to 8 days, and the obvious absorption in CT scans occurred at a median 3 days, ranging from 2 to 4 days. […] After 4 to 12-day treatment of danoprevir boosted by ritonavir, all enrolled 11 patients were discharged from the hospital. […] Our findings suggest that repurposing danoprevir for COVID-19 is a promising therapeutic option. |