CORDYCEPIN
DrugBank ID: db12156
DrugCentral: cordycepin
Synonymous : None
Drug Sentece Context
Table 1. Analysis of context sentence of cordycepin gene in 7 abstracts.
| pmid | sentence |
|---|---|
| 33090621 | Cordycepin is the major bioactive component extracted from Cordyceps militaris. […] In recent years, cordycepin has received increasing attention owing to its multiple pharmacological activities. […] This study reviews recent researches on the anti-inflammatory effects and the related activities of cordycepin. […] The results from our review indicate that cordycepin exerts protective effects against inflammatory injury for many diseases including acute lung injury (ALI), asthma, rheumatoid arthritis, Parkinson’s disease (PD), hepatitis, atherosclerosis, and atopic dermatitis. […] Cordycepin regulates the NF-κB, RIP2/Caspase-1, Akt/GSK-3β/p70S6K, TGF-β/Smads, and Nrf2/HO-1 signaling pathways among others. […] Several studies focusing on cordycepin derivatives were reviewed and found to down metabolic velocity of cordycepin and increase its bioavailability. […] Moreover, cordycepin enhanced immunity, inhibited the proliferation of viral RNA, and suppressed cytokine storms, thereby suggesting its potential to treat COVID-19 and other viral infections. […] From the collected and reviewed information, this article provides the theoretical basis for the clinical applications of cordycepin and discusses the path for future studies focusing on expanding the medicinal use of cordycepin. […] Taken together, cordycepin and its analogs show great potential as the next new class of anti-inflammatory agents. |
| 33225826 | Considering all these challenges, the main objective of the present study was to establish therapeutic potential of cordycepin against COVID-19 as a conventional therapeutic strategy. […] In the present study; molecular interaction study was performed to assess potential binding affinity of cordycepin with SARS-CoV-2 target proteins using computational approach. […] Additionally, network pharmacology was used to understand cordycepin-protein interactions and their associated pathways in human body. […] Cordycepin is under clinical trial (NCT00709215) and possesses structural similarity with adenosine except that, it lacks a 3’ hydroxyl group in its ribose moiety and hence it served as a poly(A) polymerase inhibitor and terminate premature protein synthesis. […] Additionally, it is known that functional RNAs of SARS-CoV-2 genome are highly 3’-plyadenylated and leading to synthesis of all viral proteins and if cordycepin can destabilize SARS-CoV-2 RNAs by inhibiting polyadenylation process then it may step forward in terms of inhibition of viral replication and multiplication in the host. […] Moreover, cordycepin showed strong binding affinity with SARS-CoV-2 spike protein (-145.3) and main proteases (-180.5) that further corroborate therapeutic potential against COVID-19. […] Since cordycepin has both pre-clinical and clinical information about antiviral activities, therefore; it is suggested to the world community to undertake repurposing cordycepin to test efficacy and safety for the treatment of COVID-19. |
| 33289334 | Furthermore, machine learning algorithm also revealed high applicability scores (0.42-0.47) of cordycepin. […] It is worth mentioning that the pharmacology network depicted the involvement of cordycepin in different pathways associated with bacterial and viral diseases including tuberculosis, hepatitis B, influenza A, viral myocarditis, and herpes simplex infection. […] The embedded pharmacophore features with cordycepin also suggested strong SAR. […] Cordycepin’s anti-SARS-CoV-2 activity indicated 65% (E-gene) and 42% (N-gene) viral replication inhibition after 48h of treatment. […] Since, cordycepin has both preclinical and clinical evidences on antiviral activity, in addition the present findings further validate and suggest repurposing potential of cordycepin against COVID-19. |