COBICISTAT


DrugBank ID: db09065
DrugCentral: cobicistat
Synonymous :1,3-thiazol-5-ylmethyl [(2r,5r)-5-{[(2s)-2-({(2-isopropyl-1,3-thiazol-4-yl)methylcarbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate | cobicistat



Drug Sentece Context


Table 1. Analysis of context sentence of cobicistat gene in 8 abstracts.

pmid sentence
32277836 Both patients were treated with darunavir/cobicistat and hydroxychloroquine.
32279418 Hydroxychloroquine and lopinavir/ritonavir were started, and the antiviral drug was replaced with darunavir/cobicistat after two days for diarrhea.
32292805 In the absence of authorised pharmacological treatments, many antiretrovirals, including darunavir/cobicistat fixed combination, were used off-label in the hospital wards as life-treating medicines for COVID-19 patients. […] The data in this article indicate that darunavir/cobicistat suspensions compounded by pharmacists using as active ingredient a commercially available tablet can be stable at least for one week.
32306822 Cobicistat, ritonavir, lopinavir, and darunavir are in the top screened molecules from FDA approved drugs.
32479865 Prezcobix/Rezolsta is a fixed-dose combination of 800 mg of the HIV protease inhibitor darunavir (DRV) and 150 mg cobicistat, a CYP3A4 inhibitor, which is indicated in combination with other antiretroviral agents for the treatment of HIV infection. […] There are currently no definitive data on the safety and efficacy of DRV/cobicistat for the treatment of COVID-19.
32513289 Current use of CYP 3A4 or P-gp inhibitor drugs such as quinidine, amiodarone, diltiazem, spironolactone, verapamil, clarithromycin, erythromycin, itraconazole, ketoconazole, cyclosporine, tacrolimus, indinavir, ritonavir or cobicistat.