CARNOSINE
DrugBank ID: db11695
DrugCentral: carnosine
Synonymous :l-carnosine
Drug Sentece Context
Table 1. Analysis of context sentence of carnosine gene in 6 abstracts.
| pmid | sentence |
|---|---|
| 32750366 | Having studied the available publications concerning the mechanisms of damage to tissues and organs of patients with COVID-19, as well as the available treatment strategies, we propose to investigate salicyl-carnosine as a potential drug for treating COVID-19 patients. […] In a recent study, we described the drug’s synthesis procedure, and showed that salicyl-carnosine possesses antioxidant, anti-inflammatory, and antiplatelet effects. […] Thus, we propose to consider salicyl-carnosine as a potential drug for the treatment of patients with severe cases of COVID-19 infection. |
| 32765939 | It is suggested that the non-toxic dipeptide carnosine (beta-alanyl-L-histidine) should be examined as a potential protective agent against COVID-19 infection and inflammatory consequences especially in the elderly. […] Carnosine is an effective anti-inflammatory agent which can also inhibit CD26 and ACE2 activity. |
| 33260592 | The current paper described how carnosine, a naturally occurring supplement, can be an effective drug candidate for coronavirus disease (COVID-19) on the basis of molecular docking and modeling to host ACE2 cocrystallized with nCoV spike protein. […] Carnosine emerged as the best-known drug candidate to match ACE2 inhibitor structure. […] Viral spike protein elements binding to ACE2 were retained in the best carnosine pose in SwissDock at 1.75 Angstroms. […] Out of the three main areas of attachment expected to the protein-protein structure, carnosine bound with higher affinity to two compared to the known ACE2 active site. […] Carnosine has promising inhibitory interactions with host ACE2 and nCoV spike protein and hence could offer a potential mitigating effect against the current COVID-19 pandemic. |