DrugBank ID: db09010
DrugCentral: carmofur
Synonymous :carmofur

Drug Sentece Context

Table 1. Analysis of context sentence of carmofur gene in 4 abstracts.

pmid sentence
32382072 The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). […] Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of carmofur is covalently bound to catalytic Cys145, whereas its fatty acid tail occupies the hydrophobic S2 subsite. […] Carmofur inhibits viral replication in cells (EC50 = 24.30 μM) and is a promising lead compound to develop new antiviral treatment for COVID-19.