DrugBank ID: db01282
Synonymous :1-butanoic acid-2-(o-methyl-l-tyrosine)-1-carbaoxytocin | 1-butyric acid-2-(3-(p-methoxyphenyl)-l-alanine)oxytocin | carbetocin | carbetocina | carbetocino | carbetocinum | deamino-2-o-methyltyrosine-1-carbaoxytocin
Drug Sentece Context
Table 1. Analysis of context sentence of carbetocin gene in 6 abstracts.
|32809918||Using the Library of Integrated Network-Based Cellular Signatures (LINCS), we used the transcriptomic signature for carbetocin, an OXT agonist, and compared it to gene knockdown signatures of inflammatory (such as interleukin IL-1β and IL-6) and proimmune markers (including T cell and macrophage cell markers like CD40 and ARG1). […] We found that carbetocin’s transcriptomic signature has a pattern of concordance with inflammation and immune marker knockdown signatures that are consistent with reduction of inflammation and promotion and sustaining of immune response. […] This suggests that carbetocin may have potent effects in modulating inflammation, attenuating T cell inhibition, and enhancing T cell activation. […] Our results also suggest that carbetocin is more effective at inducing immune cell responses than either lopinavir or hydroxychloroquine, both of which have been explored for the treatment of COVID-19.|