CALCITRIOL


DrugBank ID: db00136
DrugCentral: calcitriol
Synonymous :(1s,3r,5z,7e)-9,10-secocholesta-5,7,10-triene-1,3,25-triol | (1α,3β,5z,7e)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol | (5z,7e)-(1s,3r)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol | 1-alpha-25-dihydroxyvitamin d3 | 1,25-dhcc | 1,25-dihydroxycholecalciferol | 1α,25-dihydroxycholecalciferol | 1α,25-dihydroxyvitamin d3 | 1α,25(oh)2d3 | calcitriol | calcitriolum



Drug Sentece Context


Table 1. Analysis of context sentence of calcitriol gene in 3 abstracts.

pmid sentence
32597823 Although therapies selectively down-regulating both AhR and IDO1 are currently lacking, medications in clinical use such as dexamethasone may down-regulate both AhR and IDO1 genes, as calcitriol/vitamin D3 may down-regulate the AhR gene, and tocopherol/vitamin E may down-regulate the IDO1 gene. […] Supplementation of calcitriol should therefore be subjected to epidemiological studies and tested in prospective trials for prevention of CoV infections, as should tocopherol, whereas dexamethasone could be tried in interventional trials.
32779213 These properties are shared by calcitriol and the CYP11A1-generated non-calcemic hydroxyderivatives.
32848776 Initial candidate interventions include prophylaxis to augment epithelial defense (e.g., AT1 receptor blockade, type III and type I interferons, melatonin, calcitriol, camostat, and lopinavir) and to reduce viral load (e.g., remdesivir, ivermectin, emetine, Abelson kinase inhibitors, dopamine D2 antagonists, and selective estrogen receptor modulators).